Ulla G. Knaus


Ulla G. Knaus

Professor of Immunobiology

Professor Knaus’s background in pharmacy at ETH Zürich, Switzerland, natural product science at the Ludwigs-Maximilians-University Munich, Germany, and in immunology at the Scripps Research Institute, USA, provides the basis for directing her discovery efforts in fundamental and translational research. Reactive oxygen species (ROS) are required for all cellular functions. Understanding when, where, and how much ROS are produced by a particular enzyme provides the basis for benefit-risk assessment in health and disease. Professor Knaus’s laboratory contributes to alleviating disease by providing novel insights into ROS regulation, how ROS maintain or readjust homeostasis, and how altered ROS levels will promote disease. Her current focus is on ROS as a chemical communication strategy in infections and inflammatory disease.

Reactive Oxygen Species (ROS) in Health and Disease

Ulla G. Knaus

Professor of Immunobiology

Dr Ashish Singh
Position: Postdoctoral Researcher

Role:
Ashish is interested in redox signaling in inflammation

Role:
Emily is a paediatric gastroenterologist in training, who studies Crohn’s disease-associated fibrosis

ROS signalling in the Lung

Study of a family of enzymes which generate reactive oxygen species (ROS) in the respiratory tract. This work has been expanded to include other mucosal barriers such as the intestinal epithelium. Our main areas of interest are ROS effects on immune defence and inflammatory tissue injury.

Connecting ROS to fibrosis in Crohn’s disease

This study combines research on paediatric specimen with animal studies to understand the redox-initiated progression from chronic inflammation to fibrotic strictures in Crohn’s disease.



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Aviello G, Knaus UG, 2018 Jul, NADPH oxidases and ROS signaling in the gastrointestinal tract. Mucosal Immunol, DOI: 10.1038/s41385-018-0021-8
O'Neill S, Mathis M, Kovačič L, Zhang S, Reinhardt J, Scholz D, Schopfer U, Bouhelal R, Knaus UG, 2018 Jun 8, Quantitative interaction analysis permits molecular insights into functional NOX4 NADPH oxidase heterodimer assembly. J Biol Chem, DOI: 10.1074/jbc.RA117.001045
Singh AK, Hertzberger RY, Knaus UG, 2018 Jun, Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis. Redox Biol, DOI: 10.1016/j.redox.2018.02.003
Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC, 2018 Apr 1, Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis. QJM, DOI: 10.1093/qjmed/hcx243
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A, 2018 Apr, Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. Redox Biol, DOI: 10.1016/j.redox.2017.10.001
Schwerd T, Bryant RV, Pandey S, Capitani M, Meran L, Cazier JB, Jung J, Mondal K, Parkes M, Mathew CG, Fiedler K, McCarthy DJ, WGS500 Consortium., Oxford IBD cohort study investigators., COLORS in IBD group investigators., UK IBD Genetics Consortium., Sullivan PB, Rodrigues A, Travis SPL, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J, INTERVAL Study., Russell RK, Wilson DC, Kelsen JR, Cornall R, Denson LA, Kugathasan S, Knaus UG, Serra EG, Anderson CA, Duerr RH, McGovern DP, Cho J, Powrie F, Li VS, Muise AM, Uhlig HH, 2018 Mar, NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease. Mucosal Immunol, DOI: 10.1038/mi.2017.74
Parlato M, Charbit-Henrion F, Hayes P, Tiberti A, Aloi M, Cucchiara S, Bègue B, Bras M, Pouliet A, Rakotobe S, Ruemmele F, Knaus UG, Cerf-Bensussan N, 2017 Aug, First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease. Gastroenterology, DOI: 10.1053/j.gastro.2016.12.053
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A, 2017 Oct, European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol, DOI: 10.1016/j.redox.2017.05.007
Knaus UG, Hertzberger R, Pircalabioru GG, Yousefi SP, Branco Dos Santos F, 2017 Jan 2, Pathogen control at the intestinal mucosa - H2O2 to the rescue. Gut Microbes, DOI: 10.1080/19490976.2017.1279378
Zhdanov AV, Aviello G, Knaus UG, Papkovsky DB, 2017 Feb, Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential. Biochim Biophys Acta Gen Subj, DOI: 10.1016/j.bbagen.2016.10.023
Alvarez LA, Kovačič L, Rodríguez J, Gosemann JH, Kubica M, Pircalabioru GG, Friedmacher F, Cean A, Ghişe A, Sărăndan MB, Puri P, Daff S, Plettner E, von Kriegsheim A, Bourke B, Knaus UG, 2016 Sep 13, NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1605443113
Pircalabioru G, Aviello G, Kubica M, Zhdanov A, Paclet MH, Brennan L, Hertzberger R, Papkovsky D, Bourke B, Knaus UG, 2016 May 11, Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection. Cell Host Microbe, DOI: 10.1016/j.chom.2016.04.007
Aviello G, Knaus UG, 2017 Jun, ROS in gastrointestinal inflammation: Rescue Or Sabotage? Br J Pharmacol, DOI: 10.1111/bph.13428
Hayes P, Dhillon S, O'Neill K, Thoeni C, Hui KY, Elkadri A, Guo CH, Kovacic L, Aviello G, Alvarez LA, Griffiths AM, Snapper SB, Brant SR, Doroshow JH, Silverberg MS, Peter I, McGovern DP, Cho J, Brumell JH, Uhlig HH, Bourke B, Muise AA, Knaus UG, 2015 Sep 1, Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol, DOI: 10.1016/j.jcmgh.2015.06.005
O'Neill S, Brault J, Stasia MJ, Knaus UG, 2015 Dec, Genetic disorders coupled to ROS deficiency. Redox Biol, DOI: 10.1016/j.redox.2015.07.009
Mikhed Y, Görlach A, Knaus UG, Daiber A, 2015 Aug, Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair. Redox Biol, DOI: 10.1016/j.redox.2015.05.008
Kim HJ, Magesh V, Lee JJ, Kim S, Knaus UG, Lee KJ, 2015 Jun 30, Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4. Oncotarget, DOI: 10.18632/oncotarget.3843
Königs V, Jennings R, Vogl T, Horsthemke M, Bachg AC, Xu Y, Grobe K, Brakebusch C, Schwab A, Bähler M, Knaus UG, Hanley PJ, 2014 Oct 31, Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility. J Biol Chem, DOI: 10.1074/jbc.M114.563270
Jennings RT, Strengert M, Hayes P, El-Benna J, Brakebusch C, Kubica M, Knaus UG, 2014 Jun 5, RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness. Blood, DOI: 10.1182/blood-2014-02-557843
Jennings RT, Knaus UG, 2014, Neutrophil migration through extracellular matrix. Methods Mol Biol, DOI: 10.1007/978-1-62703-845-4_13
Jennings RT, Knaus UG, 2014, Rho family and Rap GTPase activation assays. Methods Mol Biol, DOI: 10.1007/978-1-62703-845-4_6
Strengert M, Jennings R, Davanture S, Hayes P, Gabriel G, Knaus UG, 2014 Jun 10, Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection. Antioxid Redox Signal, DOI: 10.1089/ars.2013.5353
Alvarez LA, Bourke B, Pircalabioru G, Georgiev AY, Knaus UG, Daff S, Corcionivoschi N, 2013, Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity. PLoS One, DOI: 10.1371/journal.pone.0075534
Hayes P, Knaus UG, 2013 May 20, Balancing reactive oxygen species in the epigenome: NADPH oxidases as target and perpetrator. Antioxid Redox Signal, DOI: 10.1089/ars.2012.4895
Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B, 2012 Jul 19, Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe, DOI: 10.1016/j.chom.2012.05.018
Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM, 2012 Jun 19, Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1120755109
Munson JM, Fried L, Rowson SA, Bonner MY, Karumbaiah L, Diaz B, Courtneidge SA, Knaus UG, Brat DJ, Arbiser JL, Bellamkonda RV, 2012 Mar 28, Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Med, DOI: 10.1126/scitranslmed.3003016
von Löhneysen K, Noack D, Hayes P, Friedman JS, Knaus UG, 2012 Mar 16, Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus. J Biol Chem, DOI: 10.1074/jbc.M111.332494
Strengert M, Knaus UG, 2011, Analysis of epithelial barrier integrity in polarized lung epithelial cells. Methods Mol Biol, DOI: 10.1007/978-1-61779-191-8_13
Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ, 2011 Oct 1, Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med, DOI: 10.1016/j.freeradbiomed.2011.06.011
von Löhneysen K, Noack D, Wood MR, Friedman JS, Knaus UG, 2010 Feb, Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization. Mol Cell Biol, DOI: 10.1128/MCB.01393-09
Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG, 2009 Apr 15, Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci, DOI: 10.1242/jcs.044123
Lehmann M, Noack D, Wood M, Perego M, Knaus UG, 2009, Lung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integrity. PLoS One, DOI: 10.1371/journal.pone.0004755
Manukyan M, Nalbant P, Luxen S, Hahn KM, Knaus UG, 2009 Mar 15, RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol, DOI: 10.4049/jimmunol.0802280
von Löhneysen K, Noack D, Jesaitis AJ, Dinauer MC, Knaus UG, 2008 Dec 12, Mutational analysis reveals distinct features of the Nox4-p22 phox complex. J Biol Chem, DOI: 10.1074/jbc.M804200200
Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, Knaus UG, 2008 Sep 5, Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem, DOI: 10.1074/jbc.M709108200
Knaus UG, Bamberg A, Bokoch GM, 2007, Rac and Rap GTPase activation assays. Methods Mol Biol, DOI: 10.1007/978-1-59745-467-4_5
Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG, 2008 Aug 21, P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene, DOI: 10.1038/onc.2008.131
Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM, 2008 Apr 1, PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac. J Cell Sci, DOI: 10.1242/jcs.016121
Luxen S, Belinsky SA, Knaus UG, 2008 Feb 15, Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res, DOI: 10.1158/0008-5472.CAN-07-5782
Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM, 2007 Nov 30, Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem, DOI: 10.1074/jbc.M704754200
Lombardo E, Alvarez-Barrientos A, Maroto B, Boscá L, Knaus UG, 2007 Mar 15, TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling. J Immunol, DOI: 10.1074/jbc.M704754200
Zhu Y, Marchal CC, Casbon AJ, Stull N, von Löhneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, Dinauer MC, 2006 Oct 13, Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity. J Biol Chem, DOI: 10.1074/jbc.M607191200
Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Wood MR, Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM, Janda KD, Ulevitch RJ, 2006 Sep 29, N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. J Biol Chem, DOI: 10.1074/jbc.M606613200
Perry BN, Govindarajan B, Bhandarkar SS, Knaus UG, Valo M, Sturk C, Carrillo CO, Sohn A, Cerimele F, Dumont D, Losken A, Williams J, Brown LF, Tan X, Ioffe E, Yancopoulos GD, Arbiser JL, 2006 Oct, Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice. J Invest Dermatol, DOI: 10.1038/sj.jid.5700413
Ruse M, Knaus UG, 2006, New players in TLR-mediated innate immunity: PI3K and small Rho GTPases. Immunol Res, DOI: 10.1385/IR:34:1:33
Martyn KD, Kim MJ, Quinn MT, Dinauer MC, Knaus UG, 2005 Dec 1, p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood, DOI: 10.1182/blood-2005-03-0859
Chan AY, Coniglio SJ, Chuang YY, Michaelson D, Knaus UG, Philips MR, Symons M, 2005 Nov 24, Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene, DOI: 10.1038/sj.onc.1208909
Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, Knaus UG, 2006 Jan, Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal, DOI: 10.1016/j.cellsig.2005.03.023
Teusch N, Lombardo E, Eddleston J, Knaus UG, 2004 Jul 1, The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription. J Immunol, DOI: 10.1016/j.cellsig.2005.03.023
Bokoch GM, Knaus UG, 2003 Sep, NADPH oxidases: not just for leukocytes anymore! Trends Biochem Sci, DOI: 10.1016/S0968-0004(03)00194-4
Shalom-Barak T, Knaus UG, 2002 Oct 25, A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. J Biol Chem, DOI: 10.1074/jbc.M206650200
Price MO, McPhail LC, Lambeth JD, Han CH, Knaus UG, Dinauer MC, 2002 Apr 15, Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood, DOI: 10.1074/jbc.M206650200
Price MO, Atkinson SJ, Knaus UG, Dinauer MC, 2002 May 24, Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem, DOI: 10.1074/jbc.M200061200
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG, 2000 Dec, Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol, DOI: 10.1038/82797
King CC, Reilly AM, Knaus UG, 2000, Purification and in vitro activities of p21-activated kinases. Methods Enzymol, DOI: 10.1038/82797
Wen Y, Gu J, Knaus UG, Thomas L, Gonzales N, Nadler JL, 2000 Jul 15, Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase. Biochem J, DOI: 10.1038/82797
Knaus UG, 2000, Rho GTPase signaling in inflammation and transformation. Immunol Res, DOI: 10.1385/IR:21:2-3:103
Mira JP, Benard V, Groffen J, Sanders LC, Knaus UG, 2000 Jan 4, Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci U S A, DOI: 10.1385/IR:21:2-3:103
Fazal N, Knaus UG, Sabeh F, Gamelli RL, McNulty JA, Sayeed MM, 1999 Dec, Enhanced expression of neutrophil NADPH oxidase components in intestine of rats after burn injury. Shock, DOI: 10.1385/IR:21:2-3:103
Lopes LR, Hoyal CR, Knaus UG, Babior BM, 1999 May 28, Activation of the leukocyte NADPH oxidase by protein kinase C in a partially recombinant cell-free system. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Knaus UG, Bokoch GM, 1998 Aug, The p21Rac/Cdc42-activated kinases (PAKs). Int J Biochem Cell Biol, DOI: 10.1385/IR:21:2-3:103
Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH, 1998 Aug 21, Structural requirements for PAK activation by Rac GTPases. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Jones SL, Knaus UG, Bokoch GM, Brown EJ, 1998 Apr 24, Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Bokoch GM, Reilly AM, Daniels RH, King CC, Olivera A, Spiegel S, Knaus UG, 1998 Apr 3, A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J, 1997 Mar 1, Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol, DOI: 10.1385/IR:21:2-3:103
Brzeska H, Knaus UG, Wang ZY, Bokoch GM, Korn ED, 1997 Feb 18, p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I. Proc Natl Acad Sci U S A, DOI: 10.1385/IR:21:2-3:103
Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG, 1996 Oct 18, Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Ding J, Knaus UG, Lian JP, Bokoch GM, Badwey JA, 1996 Oct 4, The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Bokoch GM, Vlahos CJ, Wang Y, Knaus UG, Traynor-Kaplan AE, 1996 May 1, Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem J, DOI: 10.1385/IR:21:2-3:103
Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM, 1995 Oct 13, Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM, 1995 Jul 14, Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science, DOI: 10.1385/IR:21:2-3:103
Knaus UG, Bokoch GM, 1995, Purification of Rac2 from human neutrophils. Methods Enzymol, DOI: 10.1385/IR:21:2-3:103
Bokoch GM, Knaus UG, 1994 Feb, The role of small GTP-binding proteins in leukocyte function. Curr Opin Immunol, DOI: 10.1385/IR:21:2-3:103
Bokoch GM, Knaus UG, 1994 Jan, Ras-related GTP-binding proteins and leukocyte signal transduction. Curr Opin Hematol, DOI: 10.1385/IR:21:2-3:103
Heyworth PG, Knaus UG, Settleman J, Curnutte JT, Bokoch GM, 1993 Nov, Regulation of NADPH oxidase activity by Rac GTPase activating protein(s). Mol Biol Cell, DOI: 10.1385/IR:21:2-3:103
Heyworth PG, Knaus UG, Xu X, Uhlinger DJ, Conroy L, Bokoch GM, Curnutte JT, 1993 Mar, Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. Mol Biol Cell, DOI: 10.1385/IR:21:2-3:103
Chuang TH, Xu X, Knaus UG, Hart MJ, Bokoch GM, 1993 Jan 15, GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Knaus UG, Heyworth PG, Kinsella BT, Curnutte JT, Bokoch GM, 1992 Nov 25, Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem, DOI: 10.1385/IR:21:2-3:103
Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM, 1991 Dec 6, Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science, DOI: 10.1385/IR:21:2-3:103

Name:Professor Billy Bourke
DepartmentMedicine, Gastroenterology
Institution:Our Lady’s Children’s Hospital Crumlin, University College Dublin
Country:Ireland
Name:Dr Séamus Hussey
DepartmentMedicine, Gastroenterology
Institution:Our Lady’s Children’s Hospital Crumlin, University College Dublin
Country:Ireland
Name:Professor Nadine Cerf-Bensussan
DepartmentLaboratory of Intestinal Immunity
Institution:L’Institut Imagine, INSERM
Country:France