Terence Prendiville

Consultant Paediatric Cardiologist

Contact

Dr Prendiville is a clinical paediatric cardiologist with a collaborative sub-specialty interest in caring for families with Inherited Cardiac Conditions (ICC) in addition to children with congenital heart disease. As part of a multi-disciplinary team, he works with the Sudden Cardiac Death Taskforce of the Irish Heart Foundation and the National Paediatric Mortality Registry to advocate for advances in clinical care, and to understand the rare causes of unexpected death in the young. He participates in combined paediatric and adult ICC clinics with adult colleagues and contribute cases for discussion at our monthly cardiogenetics conference. Dr Prendiville completed a research masters in Boston Children’s Hospital/Harvard Medical School, studying the role of master cardiac transcription factor regulators in a transgenic murine model utilising rAAV9 viral vectors and stem cell technologies. His current research interests relate to modelling human (patient-specific) cardiac ion channel disease through translational collaboration with the Regenerative Medicine Institute, at NUI Galway. Through shared-care sub-specialty clinics in Dublin, they recruit families affected by conditions such as Long QT syndrome who kindly donate skin biopsy samples. Through a process of re-programming, a patient’s skin cells become beating heart cells (cardiomyocytes) whose properties and function can be safely studied and ‘repaired’ in the lab.

Terence Prendiville

Consultant Paediatric Cardiologist

Contact

Terence.prendiville@olchc.ie

Dr. Min Liu
Position: Irish Research Council (IRC) Enterprise Partnership Postdoctoral Researcher (IRC & NCRC co-funded)
M.LIU@nuigalway.ie

Role:
Role: Min Liu, based at REMEDI, is responsible for stem cell culture and molecular biology for donated skin cell samples.

Stem cell modelling of inherited heart rhythm disorders

Patients donate skin biopsy samples that are cultured and ‘re-programmed’ into heart cells via a stem cell intermediate. This allows patient-specific research on the electrical function of a particular person’s heart cell and the potential to study the effects of genetic manipulation of that heart cell. This is accomplished through a process of gene editing, utilising relatively new genome editing technology known as CRISPR/Cas9. The engineered heart cells form a beating mass of cells in a cultured dish that behave very similarly to the heart organ. Electrical activity of this beating mass of cells can be carefully recorded by a multi-electrode array, akin to an electrocardiogram a patient would have done in clinic.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Kenny D, Prendiville T, Walsh KP, McGuinness J, 2018 Mar, Sequential Melody Valve Insertion After Repair of Tetralogy of Fallot Atrioventricular Septal Defect. Ann Thorac Surg, DOI: 10.1016/j.athoracsur.2017.09.044

Breatnach CR, Cleary A, Prendiville T, Crumlish K, Murchan H, McMahon CJ, 2018 Jan, Prevalence of Subclinical Enteric Alpha-1-Antitrypsin Loss in Children with Univentricular Circulation Following Total Cavopulmonary Connection. Pediatr Cardiol, DOI: 10.1007/s00246-017-1720-8

Johnston NF, Prendiville T, McMahon CJ, 2018 Feb, 3D printing of severe hypertrophic cardiomyopathy in a child with Rasopathy. Ir J Med Sci, DOI: 10.1007/s11845-017-1646-4

Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A, 2017 Apr 10, EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife, DOI: 10.7554/eLife.24570

Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT, 2015, Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One, DOI: 10.1371/journal.pone.0128105

Prendiville T, Jay PY, Pu WT, 2014 Oct 1, Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med, DOI: 10.1101/cshperspect.a013946

Prendiville TW, Ma Q, Lin Z, Zhou P, He A, Pu WT, 2014 Aug 5, Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp, DOI: 10.3791/51566

McMahon CJ, Prendiville T, Nolke L, 2014 Feb, Pre-operative identification of an anomalous left coronary artery from the pulmonary artery in association with tetralogy of Fallot and an aortopulmonary window. Cardiol Young, DOI: 10.1017/S1047951113000255

Prendiville TW, Barton LL, Thompson WR, Fink DL, Holmes KW, 2010 Oct, Heterotaxy syndrome: defining contemporary disease trends. Pediatr Cardiol, DOI: 10.1007/s00246-010-9764-z

Shahdadpuri R, Prendiville T, Nölke L, McMahon CJ, 2009 Feb, Berry syndrome in association with familial limb malformation. Ir Med J, DOI: 10.1007/s00246-010-9764-z

McMahon CJ, Murchan H, Prendiville T, Burch M, 2007 Sep-Oct, Parvovirus B19 infection associated with dilated cardiomyopathy in patients with previous anthracycline exposure. Pediatr Cardiol, DOI: 10.1007/s00246-006-0147-4

McMahon CJ, Murchan H, Prendiville T, Burch M, 2007 Jul-Aug, Long-term support with milrinone prior to cardiac transplantation in a neonate with left ventricular noncompaction cardiomyopathy. Pediatr Cardiol, DOI: 10.1007/s00246-007-0020-0

Funding Agency:	NCRC – Innovation Award
Project Title:	Human Stem Cell Modelling of Cardiac Ion Channelopathies
Start Date/End Date:	2016

Funding Agency:	NCRC – Innovation Award
Project Title:	Rescuing cardiac and neuronal ion channelopathy phenotype through applied genome editing technologies.
Start Date/End Date:	2017

Funding Agency:	Irish Research Council (Enterprise Partnership Scheme Postdoctoral Fellowship for recipient Min Liu)
Project Title:	Human Stem Cell Modelling of Long QT Syndrome
Start Date/End Date:	2017 to 2019

Name:	Professor Sanbing Shen
Position:	Professor of Fundamental Stem Cell Biology, REMEDI, NUI Galway.
Role:	Prof Sanbing Shen is a co-investigator on stem cell research as it relates to patient-specific reprogrammed cardiomyocytes.

Name:	Professor Tim O’Brien
Position:	Director, REMEDI, NUI Galway.
Role:	Prof Tim O’Brien provides research oversight in partnership with REMEDI as the programme’s director.