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Terence Prendiville

Terence Prendiville

Consultant Paediatric Cardiologist

Contact

Terence.prendiville@olchc.ie

Dr Prendiville is a clinical paediatric cardiologist with a collaborative sub-specialty interest in caring for families with Inherited Cardiac Conditions (ICC) in addition to children with congenital heart disease. As part of a multi-disciplinary team, he works with the Sudden Cardiac Death Taskforce of the Irish Heart Foundation and the National Paediatric Mortality Registry to advocate for advances in clinical care, and to understand the rare causes of unexpected death in the young. He participates in combined paediatric and adult ICC clinics with adult colleagues and contribute cases for discussion at our monthly cardiogenetics conference. Dr Prendiville completed a research masters in Boston Children’s Hospital/Harvard Medical School, studying the role of master cardiac transcription factor regulators in a transgenic murine model utilising rAAV9 viral vectors and stem cell technologies. His current research interests relate to modelling human (patient-specific) cardiac ion channel disease through translational collaboration with the Regenerative Medicine Institute, at NUI Galway. Through shared-care sub-specialty clinics in Dublin, they recruit families affected by conditions such as Long QT syndrome who kindly donate skin biopsy samples. Through a process of re-programming, a patient’s skin cells become beating heart cells (cardiomyocytes) whose properties and function can be safely studied and ‘repaired’ in the lab.

Terence Prendiville

Consultant Paediatric Cardiologist

Contact

Terence.prendiville@olchc.ie

Stem cell modelling of inherited heart rhythm disorders

Patients donate skin biopsy samples that are cultured and ‘re-programmed’ into heart cells via a stem cell intermediate. This allows patient-specific research on the electrical function of a particular person’s heart cell and the potential to study the effects of genetic manipulation of that heart cell. This is accomplished through a process of gene editing, utilising relatively new genome editing technology known as CRISPR/Cas9. The engineered heart cells form a beating mass of cells in a cultured dish that behave very similarly to the heart organ. Electrical activity of this beating mass of cells can be carefully recorded by a multi-electrode array, akin to an electrocardiogram a patient would have done in clinic.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Prendiville T, Leahy A, Quinlan L, Saleh A, Shanahan E, Gabr A, Peters C, Casserly I, O'Connor M, Galvin R, 2022 Jan 11, Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review. BMJ Open, DOI: 10.1136/bmjopen-2021-049216
Liu M, Ge N, Zhang J, Yang M, Yang F, Krawczyk J, Ward D, McInerney V, O'Brien T, Shen S, Prendiville T, 2021 Oct, Derivation and characterization of two human induced pluripotent stem cell lines (NUIGi004-A) and (NUIGi012-A) from two patients with LQT2 disease. Stem Cell Res, DOI: 10.1016/j.scr.2021.102555
Weiss L, Keaney J, Szklanna PB, Prendiville T, Uhrig W, Wynne K, Kelliher S, Ewins K, Comer SP, Egan K, O'Rourke E, Moran E, Petrov G, Patel A, Lennon Á, Blanco A, Kevane B, Murphy S, Ní Áinle F, Maguire PB, 2021 Oct, Nonvalvular atrial fibrillation patients anticoagulated with rivaroxaban compared with warfarin exhibit reduced circulating extracellular vesicles with attenuated pro-inflammatory protein signatures. J Thromb Haemost, DOI: 10.1111/jth.15434
Norrish G, Topriceanu C, Qu C, Field E, Walsh H, Ziółkowska L, Olivotto I, Passantino S, Favilli S, Anastasakis A, Vlagkouli V, Weintraub R, King I, Biagini E, Ragni L, Prendiville T, Duignan S, McLeod K, Ilina M, Fernández A, Bökenkamp R, Baban A, Drago F, Kubuš P, Daubeney PEF, Chivers S, Sarquella-Brugada G, Cesar S, Marrone C, Medrano C, Alvarez Garcia-Roves R, Uzun O, Gran F, Castro FJ, Gimeno JR, Barriales-Villa R, Rueda F, Adwani S, Searle J, Bharucha T, Siles A, Usano A, Rasmussen TB, Jones CB, Kubo T, Mogensen J, Reinhardt Z, Cervi E, Elliott PM, Omar RZ, Kaski JP, 2021 Mar 27, The role of the electrocardiographic phenotype in risk stratification for sudden cardiac death in childhood hypertrophic cardiomyopathy. Eur J Prev Cardiol, DOI: 10.1093/eurjpc/zwab046
Prendiville T, Tanner R, Jacobsen AP, Margey R, McGorrian C, Casserly IP, 2021 Mar, Safety of Conscious Sedation for Transcatheter Aortic Valve Replacement Without an Anesthetist. J Invasive Cardiol, DOI: 10.1093/eurjpc/zwab046
Wallace E, Howard L, Liu M, O'Brien T, Ward D, Shen S, Prendiville T, 2019 Oct, Long QT Syndrome: Genetics and Future Perspective. Pediatr Cardiol, DOI: 10.1007/s00246-019-02151-x
Norrish G, Ding T, Field E, Ziólkowska L, Olivotto I, Limongelli G, Anastasakis A, Weintraub R, Biagini E, Ragni L, Prendiville T, Duignan S, McLeod K, Ilina M, Fernández A, Bökenkamp R, Baban A, Kubuš P, Daubeney PEF, Sarquella-Brugada G, Cesar S, Marrone C, Bhole V, Medrano C, Uzun O, Brown E, Gran F, Castro FJ, Stuart G, Vignati G, Barriales-Villa R, Guereta LG, Adwani S, Linter K, Bharucha T, Garcia-Pavia P, Rasmussen TB, Calcagnino MM, Jones CB, De Wilde H, Toru-Kubo J, Felice T, Mogensen J, Mathur S, Reinhardt Z, O'Mahony C, Elliott PM, Omar RZ, Kaski JP, 2019 Sep 1, Development of a Novel Risk Prediction Model for Sudden Cardiac Death in Childhood Hypertrophic Cardiomyopathy (HCM Risk-Kids). JAMA Cardiol, DOI: 10.1001/jamacardio.2019.2861
Breatnach CR, Aggarwal V, Al-Alawi K, McMahon CJ, Franklin O, Prendiville T, Oslizlok P, Walsh K, Qureshi AM, Kenny D, 2019 Jun 1, Percutaneous axillary artery approach for ductal stenting in critical right ventricular outflow tract lesions in the neonatal period. Catheter Cardiovasc Interv, DOI: 10.1002/ccd.28302
Kenny D, Prendiville T, Walsh KP, McGuinness J, 2018 Mar, Sequential Melody Valve Insertion After Repair of Tetralogy of Fallot Atrioventricular Septal Defect. Ann Thorac Surg, DOI: 10.1016/j.athoracsur.2017.09.044
Breatnach CR, Cleary A, Prendiville T, Crumlish K, Murchan H, McMahon CJ, 2018 Jan, Prevalence of Subclinical Enteric Alpha-1-Antitrypsin Loss in Children with Univentricular Circulation Following Total Cavopulmonary Connection. Pediatr Cardiol, DOI: 10.1007/s00246-017-1720-8
Johnston NF, Prendiville T, McMahon CJ, 2018 Feb, 3D printing of severe hypertrophic cardiomyopathy in a child with Rasopathy. Ir J Med Sci, DOI: 10.1007/s11845-017-1646-4
Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A, 2017 Apr 10, EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife, DOI: 10.7554/eLife.24570
Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT, 2015, Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One, DOI: 10.1371/journal.pone.0128105
Prendiville T, Jay PY, Pu WT, 2014 Oct 1, Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med, DOI: 10.1101/cshperspect.a013946
Prendiville TW, Ma Q, Lin Z, Zhou P, He A, Pu WT, 2014 Aug 5, Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp, DOI: 10.3791/51566
McMahon CJ, Prendiville T, Nolke L, 2014 Feb, Pre-operative identification of an anomalous left coronary artery from the pulmonary artery in association with tetralogy of Fallot and an aortopulmonary window. Cardiol Young, DOI: 10.1017/S1047951113000255
Prendiville TW, Barton LL, Thompson WR, Fink DL, Holmes KW, 2010 Oct, Heterotaxy syndrome: defining contemporary disease trends. Pediatr Cardiol, DOI: 10.1007/s00246-010-9764-z
Shahdadpuri R, Prendiville T, Nölke L, McMahon CJ, 2009 Feb, Berry syndrome in association with familial limb malformation. Ir Med J, DOI: 10.1007/s00246-010-9764-z
McMahon CJ, Murchan H, Prendiville T, Burch M, 2007 Sep-Oct, Parvovirus B19 infection associated with dilated cardiomyopathy in patients with previous anthracycline exposure. Pediatr Cardiol, DOI: 10.1007/s00246-006-0147-4
McMahon CJ, Murchan H, Prendiville T, Burch M, 2007 Jul-Aug, Long-term support with milrinone prior to cardiac transplantation in a neonate with left ventricular noncompaction cardiomyopathy. Pediatr Cardiol, DOI: 10.1007/s00246-007-0020-0

Funding Agency:NCRC – Innovation Award
Project Title:Human Stem Cell Modelling of Cardiac Ion Channelopathies
Start Date/End Date:2016
Funding Agency:NCRC – Innovation Award
Project Title:Rescuing cardiac and neuronal ion channelopathy phenotype through applied genome editing technologies.
Start Date/End Date:2017
Funding Agency:Irish Research Council (Enterprise Partnership Scheme Postdoctoral Fellowship for recipient Min Liu)
Project Title:Human Stem Cell Modelling of Long QT Syndrome
Start Date/End Date:2017 to 2019
Name:Professor Sanbing Shen
Position:Professor of Fundamental Stem Cell Biology, REMEDI, NUI Galway.
Role:Prof Sanbing Shen is a co-investigator on stem cell research as it relates to patient-specific reprogrammed cardiomyocytes.
Name:Professor Tim O’Brien
Position:Director, REMEDI, NUI Galway.
Role:Prof Tim O’Brien provides research oversight in partnership with REMEDI as the programme’s director.