Séamus Hussey


Séamus Hussey

Principal Investigator and Consultant Gastroenterologist

A graduate of UCC, Dr Hussey initially trained at Our Lady’s Children’s Hospital, Crumlin, before completing a fellowship in academic paediatric gastroenterology, hepatology and nutrition at the Hospital for Sick Children (Sickkids), Toronto, Canada.

His research fellowship was in cell biology and immunology at the University of Toronto, focusing on the role of autophagy in bacterial infections, including Helicobacter pylori, and in the pathogenesis of inflammatory bowel disease. He was appointed as a consultant gastroenterologist at Our Lady’s Children’s Hospital, Crumlin, in 2010, an honorary senior lecturer at the RCSI in 2016, and associate clinical professor at UCD in 2016.

Dr Hussey leads the DOCHAS research programme, which has been funded by, and based at, the NCRC since its inception. DOCHAS, the Irish word for hope, is Ireland’s first prospective study of paediatric inflammatory bowel diseases. This research platform enables clinical and translational research into the causes and outcomes of paediatric IBD. Since its launch in 2012, DOCHAS has enabled development of successful collaborations with local, national and international clinicians and scientists. Currently there are over 10 active clinical and translational research projects that have evolved from DOCHAS.

Séamus Hussey

Principal Investigator and Consultant Gastroenterologist

Dr Sadhbh O’Neill
Position: Position: Clinical Research Coordinator
Sadhbh.oneill@ncrc.ie

Role:
Sadhbh helps to coordinate our clinical research studies, including recruitment and follow up of patients, and provides assistance to those undertaking research in our department.

Alison O’Sullivan
Position: Research Assistant
Alison.osullivan@ncrc.ie

Role:
Alison helps to coordinate and support the recruitment and follow up of patients involved in DOCHAS related studies, and provides assistance to those undertaking research in our department.

Determinants and Outcomes in Children and Adolescents with IBD (DOCHAS)

A prospective study of the causes and outcomes of paediatric inflammatory bowel disease in Ireland. Patients are followed from the time of referral throughout their patient journey. Information regarding their disease subtype, their treatment and their clinical outcomes over time is recorded. Biological samples (taken pre-treatment) are vital for the translational studies that stem from DOCHAS.

Paediatric Cancer and Mortality Study

This is a prospective European study of the incidence of deaths and malignancies in patients up to age 26 years who were diagnosed with IBD before age 18 years.

Allergy in IBD study

This project stems from the DÓCHAS study, and will ascertain the prevalence of food related allergies in patients with IBD.

Oral microbiome in IBD

This study looks at the baseline oral microbial flora in treatment naïve patients with IBD and will track potential changes in the oral flora over time.

The role of IL-36a in ulcerative colitis

This is a collaborative study, led by Dr Pat Walsh, which seeks to elucidate the role of the IL-36 protein family in the cause and outcome of ulcerative colitis.

Role of Nox4 in Crohn disease

This is a collaborative study with Profs Ulla Knaus and Billy Bourke that seeks to explore the potential role of Nox4 in fibrostenotic Crohn disease.



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Oliva S, Thomson M, de Ridder L, Martín-de-Carpi J, Van Biervliet S, Braegger C, Dias JA, Kolacek S, Miele E, Buderus S, Bronsky J, Winter H, Navas-López VM, Assa A, Chong SKF, Afzal NA, Smets F, Shaoul R, Hussey S, Turner D, Cucchiara S, 2018 Sep, Endoscopy in Pediatric Inflammatory Bowel Disease: A Position Paper on Behalf of the Porto IBD Group of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002092
Oliva S, Thomson M, de Ridder L, Martín-de-Carpi J, Van Biervliet S, Braegger C, Dias JA, Kolacek S, Miele E, Buderus S, Bronsky J, Winter H, Navas López VM, Assa A, Chong SK, Afzal NA, Smets F, Shaoul R, Hussey S, Turner D, Cucchiara S, 2018 Aug 2, Endoscopy in Pediatric Inflammatory Bowel Disease: A Position Paper on Behalf of the Porto IBD Group of the Espghan. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002092
Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, de Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos KH, Croft N, Navas-López VM, Wilson DC, Lawrence S, Russell RK, 2018 Aug, Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Evidence-based Consensus Guideline From the European Crohn's and Colitis Organization and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002036
Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, de Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos K, Croft N, Navas-López V, Wilson DC, Lawrence S, Russell RK, 2018 Aug, Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002035
Joosse ME, Aardoom MA, Kemos P, Turner D, Wilson DC, Koletzko S, Martin-de-Carpi J, Fagerberg UL, Spray C, Tzivinikos C, Sladek M, Shaoul R, Roma-Giannikou E, Bronsky J, Serban DE, Ruemmele FM, Garnier-Lengline H, Veres G, Hojsak I, Kolho KL, Davies IH, Aloi M, Lionetti P, Hussey S, Veereman G, Braegger CP, Trindade E, Wewer AV, Hauer AC, de Vries ACH, Sigall Boneh R, Sarbagili Shabat C, Levine A, de Ridder L, Paediatric IBD Porto group of ESPGHAN., 2018 Sep, Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN. Aliment Pharmacol Ther, DOI: 10.1111/apt.14893
Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos KH, Croft N, Navas-López VM, Wilson DC, Lawrence S, Russell RK, 2018 May 30, Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis; An Evidence-based Consensus Guideline from ECCO and ESPGHAN. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002036
Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos K, Croft N, Navas-López V, Wilson DC, Lawrence S, Russell RK, 2018 May 30, Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care- an Evidence-Based Guideline from ECCO and ESPGHAN. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002035
Akintimehin AO, O'Neill RS, Ring C, Raftery T, Hussey S, 2018, Outcomes of a National Cohort of Children with Acute Severe Ulcerative Colitis. Front Pediatr, DOI: 10.3389/fped.2018.00048
Lawley M, Wu JW, Navas-López VM, Huynh HQ, Carroll MW, Chen M, Medvedev P, Day AS, Hussey S, Sigall-Boneh R, Levine A, Wine E, 2018 Aug, Global Variation in Use of Enteral Nutrition for Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000001946
Cohen-Dolev N, Sladek M, Hussey S, Turner D, Veres G, Koletzko S, Martin de Carpi J, Staiano A, Shaoul R, Lionetti P, Amil Dias J, Paerregaard A, Nuti F, Pfeffer Gik T, Ziv-Baran T, Ben Avraham Shulman S, Sarbagili Shabat C, Sigall Boneh R, Russell RK, Levine A, 2018 Feb 28, Differences in Outcomes Over Time With Exclusive Enteral Nutrition Compared With Steroids in Children With Mild to Moderate Crohn's Disease: Results From the GROWTH CD Study. J Crohns Colitis, DOI: 10.1093/ecco-jcc/jjx150
Hussey S, 2017 Aug, Editorial: changing nature of paediatric IBD-new insights from Irish data. Author's reply. Aliment Pharmacol Ther, DOI: 10.1111/apt.14192
Coughlan A, Wylde R, Lafferty L, Quinn S, Broderick A, Bourke B, Hussey S, DOCHAS Study., 2017 Jun, A rising incidence and poorer male outcomes characterise early onset paediatric inflammatory bowel disease. Aliment Pharmacol Ther, DOI: 10.1111/apt.14070
Lafferty L, Tuohy M, Carey A, Sugrue S, Hurley M, Hussey S, 2017 Feb, Outcomes of exclusive enteral nutrition in paediatric Crohn's disease. Eur J Clin Nutr, DOI: 10.1038/ejcn.2016.210
Marcovitch L, Nissan A, Mack D, Otley A, Hussey S, Mclean B, Lewis M, Croft N, Barakat FM, Griffiths AM, Turner D, 2017 Mar, Item Generation and Reduction Toward Developing a Patient-reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000001259
Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT, 2016 Sep, IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation. Mucosal Immunol, DOI: 10.1038/mi.2015.134
Kutty J, Hussey S, Broderick AM, Quinn S, Bourke B, 2015 May, HLA testing for coeliac disease in Ireland? Ir Med J, DOI: 10.1038/mi.2015.134
Bourke B, Hussey S, 2015 Mar, Chronic infections of the small intestine. Curr Opin Gastroenterol, DOI: 10.1097/MOG.0000000000000153
Stenke E, Hussey S, 2014 Oct, Ulcerative colitis: management in adults, children and young people (NICE Clinical Guideline CG166). Arch Dis Child Educ Pract Ed, DOI: 10.1136/archdischild-2013-305512
Dunne MR, Elliott L, Hussey S, Mahmud N, Kelly J, Doherty DG, Feighery CF, 2013, Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease. PLoS One, DOI: 10.1371/journal.pone.0076008
Connolly M, Menown IB, Hussey S, Cinnamond N, Damani L, 2013 Jun, The dronedarone shared-care clinical model and database: a coordinated paradigm to optimize management of evolving clinical recommendations. Adv Ther, DOI: 10.1007/s12325-013-0037-0
Crowley E, Bourke B, Hussey S, 2013 Feb, How to use Helicobacter pylori testing in paediatric practice. Arch Dis Child Educ Pract Ed, DOI: 10.1136/archdischild-2012-301642
Fouhy F, Guinane CM, Hussey S, Wall R, Ryan CA, Dempsey EM, Murphy B, Ross RP, Fitzgerald GF, Stanton C, Cotter PD, 2012 Nov, High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Chemother, DOI: 10.1128/AAC.00789-12
Raju D, Hussey S, Jones NL, 2012 Sep, Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans. Autophagy, DOI: 10.4161/auto.21007
McLean S, Sheehy-Skeffington B, O'Leary N, O'Gorman A, 2013 Mar, Pharmacological management of co-morbid conditions at the end of life: is less more? Ir J Med Sci, DOI: 10.1007/s11845-012-0841-6
Hope B, Shahdadpuri R, Dunne C, Broderick AM, Grant T, Hamzawi M, O'Driscoll K, Quinn S, Hussey S, Bourke B, 2012 Jul, Rapid rise in incidence of Irish paediatric inflammatory bowel disease. Arch Dis Child, DOI: 10.1136/archdischild-2011-300651
Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL, 2012 May, Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology, DOI: 10.1053/j.gastro.2012.01.043
Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B, 2011 Jun, Disease outcome for children who present with oral manifestations of Crohn's disease. Eur Arch Paediatr Dent, DOI: 10.1053/j.gastro.2012.01.043
Ramjeet M, Hussey S, Philpott DJ, Travassos LH, 2010 Sep, 'Nodophagy': New crossroads in Crohn disease pathogenesis. Gut Microbes, DOI: 10.4161/gmic.1.5.13295
Hussey S, Wall R, Gruffman E, O'Sullivan L, Ryan CA, Murphy B, Fitzgerald G, Stanton C, Ross RP, 2011, Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates. Int J Microbiol, DOI: 10.1155/2011/130574
McDonnell MM, McGuigan E, McElhinney J, McTeggart M, McClure D, 2009 Sep, An analysis of the palliative care education needs of RGNs and HCAs in nursing homes in Ireland. Int J Palliat Nurs, DOI: 10.12968/ijpn.2009.15.9.44257
Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhães JG, Yuan L, Soares F, Chea E, Le Bourhis L, Boneca IG, Allaoui A, Jones NL, Nuñez G, Girardin SE, Philpott DJ, 2010 Jan, Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol, DOI: 10.1038/ni.1823
Hussey S, Travassos LH, Jones NL, 2009 Aug, Autophagy as an emerging dimension to adaptive and innate immunity. Semin Immunol, DOI: 10.1016/j.smim.2009.05.004
Wall R, Ross RP, Ryan CA, Hussey S, Murphy B, Fitzgerald GF, Stanton C, 2009, Role of gut microbiota in early infant development. Clin Med Pediatr, DOI: 10.1016/j.smim.2009.05.004
Hussey S, Bourke B, Broderick A, Phelan E, McDermott M, 2008 Jul, Cryptogenic, multifocal, ulcerous, and stenosing enteritis as a manifestation of enterocolic venopathy. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0b013e3181661ad1
Hussey S, Terebiznik MR, Jones NL, 2008 May, Autophagy: healthy eating and self-digestion for gastroenterologists. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0b013e3181617895
Wall R, Hussey SG, Ryan CA, O'Neill M, Fitzgerald G, Stanton C, Ross RP, 2008 Jan, Presence of two Lactobacillus and Bifidobacterium probiotic strains in the neonatal ileum. ISME J, DOI: 10.1038/ISMEJ.2007.69
Enright F, Boyle T, Murphy J, 2007 Jan, Babies behind bars; an Irish perspective. Ir Med J, DOI: 10.1038/ISMEJ.2007.69
Wall R, Fitzgerald G, Hussey S, Ryan T, Murphy B, Ross P, Stanton C, 2007 Jan, Genomic diversity of cultivable Lactobacillus populations residing in the neonatal and adult gastrointestinal tract. FEMS Microbiol Ecol, DOI: 10.1111/j.1574-6941.2006.00202.x
Hussey SG, Ryan CA, Murphy BP, 2004 Nov, Comparison of three manual ventilation devices using an intubated mannequin. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2003.047712
Rosberg-Cody E, Ross RP, Hussey S, Ryan CA, Murphy BP, Fitzgerald GF, Devery R, Stanton C, 2004 Aug, Mining the microbiota of the neonatal gastrointestinal tract for conjugated linoleic acid-producing bifidobacteria. Appl Environ Microbiol, DOI: 10.1128/AEM.70.8.4635-4641.2004

Funding Agency:National Children’s Research Centre
Project Title:Defining the significance of altered IL-36 family expression in paediatric ulcerative colitis
Start Date/End Date:2017-2020
Funding Agency:National Children’s Research Centre
Project Title:Towards targeting NOX4 for intestinal fibrosis in Crohn’s disease
Start Date/End Date:2017-2020
Funding Agency:Health Research Board
Project Title:Preclinical evaluation of a novel therapeutic strategy for Ulcerative Colitis
Start Date/End Date:2016-2019
Funding Agency:National Children’s Research Centre
Project Title:Determinants and Outcomes in Children and Adolescents with IBD
Start Date/End Date:2012-2020
Name:Dr Pat Walsh
DepartmentImmunology
Institution:Trinity College Dublin
Country:Ireland
Name:Prof Billy Bourke
DepartmentPaediatric Gastroenterology
Institution:UCD
Country:Ireland
Name:Prof Ulla Knaus
DepartmentConway Institute
Institution:UCD
Country:Ireland
Name:Dr Gary Moran
DepartmentMicrobiology
Institution:TCD
Country:Ireland
Name:Prof Arie Levine
DepartmentPaediatric Gastroenterology
Institution:Wolfson, Tel Aviv
Country:Israel

Current Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
DOCHASDeterminants and Outcomes in Children and Adolescents with IBDNon-Interventional StudyNCRCAcademic - Investigator Led
Oral MicrobiomeThe oral microbiome in Children with New-Onset IBDNon-Interventional Studyn/aAcademic - Investigator Led
TUMMY UCPatient Reported Outcomes in Paediatric Ulcerative Colitis StudyNon-Interventional StudyIzaak Walton Killam Health CentreAcademic - Investigator Led
CAPEA Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA (Adalimumab) in Paediatric Patients With Moderately to Severely Active Crohn's DiseaseNon-Interventional Clinical TrialAbbVieIndustry Sponsored
GEMA Multidisciplinary Human Study on the Genetic, Environmental and Microbial Interactions that Cause Inflammatory Bowel disease (IBD)Non-Interventional StudyMount Sinai HospitalAcademic - Investigator Led
M-EENModified Exclusive Enteral Nutrition with the Crohn's Disease Exclusion Diet for Induction and Maintenance of Remission and RebiosisNon-Interventional Clinical TrialWolfson Medical CenterAcademic - Collaborative Group
iNEOPICSThe interNational Early Onset Paediatric IBD Cohort StudyNon-Interventional StudyThe Hospital For Sick Children TorontoAcademic - Collaborative Group
TUMMY CDPatient Reported Outcomes in Paediatric Crohns Disease StudyNon-Interventional StudyIzaak Walton Killam Health Centre, HalifaxAcademic - Investigator Led
VEDOKIDS studyPredicting response to Vedolizumab in Pediatric Inflammatory Bowel Diseases including drug levels: a multi‐center prospective Pan‐ European cohort study (P‐ECCO and ESPGHAN)Non-Interventional StudyESPHGANAcademic - Collaborative Group
CFLDThe Natural History of Cystic Fibrosis Liver Disease- Refining the PhenotypeNon-Interventional StudyHealth Research BoardAcademic - Investigator Led

Previous Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
ASCAn investigation as to whether Infliximab has changed the national history of Acute Severe ColitisNon-Interventional Studyn/aAcademic - Investigator Led
RAPID IBDRetrospective study on pharmacokinetic infliximab data in young IBD patientsNon-Interventional Studyn/aAcademic - Investigator Led
EoEEstablishing the national incidence and prevalence of Eosinophilic Oesphagitis in Ireland over the last ten years and a description of its natural historyNon-Interventional Studyn/aAcademic - Investigator Led
GROWTH CD StudyGrowth Study: Factors predicting relapse and adverse outcomes early in newly diagnosed paed' Crohn Disease a prospective, multi centre prognostication study by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) ‘Porto’ GroupNon-Interventional StudyESPHGANAcademic - Collaborative Group