Séamus HusseyPrincipal Investigator and Consultant Gastroenterologist
A graduate of UCC, Prof Hussey initially trained at Children’s Health Ireland at Crumlin (formerly Our Lady’s Children’s Hospital, Crumlin), before completing a fellowship in academic paediatric gastroenterology, hepatology and nutrition at the Hospital for Sick Children (Sickkids), Toronto, Canada.
His research fellowship was in cell biology and immunology at the University of Toronto, focusing on the role of autophagy in bacterial infections, including Helicobacter pylori, and in the pathogenesis of inflammatory bowel disease. He was appointed as a consultant gastroenterologist at Children’s Health Ireland at Crumlin, in 2010, a senior lecturer at the RCSI in 2016, and associate clinical professor at UCD & RCSI in 2016.
Professor Hussey leads the DOCHAS research programme, which has been funded by, and based at, the NCRC since its inception. DOCHAS, the Irish word for hope, is Ireland’s first prospective study of paediatric inflammatory bowel diseases. This research platform enables clinical and translational research into the causes and outcomes of paediatric IBD. Since its launch in 2012, DOCHAS has enabled development of successful collaborations with local, national and international clinicians and scientists. Currently there are over 10 active clinical and translational research projects that have evolved from DOCHAS.
Séamus HusseyPrincipal Investigator and Consultant Gastroenterologist
Dr. Sarah Cooper
Position: Clinical Research Coordinator
Role:
Sarah coordinates our clinical research studies including recruitment and follow up of patients, liaises with PIs and collaborators and oversees the work of our research assistants.
A prospective translational research study of the causes and outcomes of paediatric inflammatory bowel disease in Ireland. Patients are followed from the time of referral throughout their patient journey. Information regarding their disease subtype, their treatment and their clinical outcomes over time is recorded. Biological samples (taken pre-treatment) are vital for the translational studies that stem from DOCHAS.
This is a prospective European study of the incidence of deaths and malignancies in patients up to age 26 years who were diagnosed with IBD before age 18 years.
This project stems from the DOCHAS study, and will ascertain the prevalence of food related allergies in patients with IBD.
This study looks for clues to the causes and outcomes of IBD by looking for changes in the oral microbial flora before and following treatments in patients with IBD.
This is a collaborative study, led by Dr Patrick Walsh, which seeks to elucidate the role of the IL-36 protein family in the cause and outcome of ulcerative colitis.
This is a collaborative study with Profs Ulla Knaus and Billy Bourke that seeks to explore the potential role of Nox4 in fibrostenotic Crohn disease.
This is a collaborative study investigating whether Infliximab has changed the national history of Acute Severe Colitis.
The purpose of this study is to determine whether induction and maintenance of remission in Crohn’s Disease can be achieved with a new dietary strategy that involves only 2 weeks of Exclusive Enteral Nutrition (EEN) with Modulen and 12 weeks of an exclusion diet involving selected table foods. This novel approach will be compared to the gold standard dietary regime involving 8 weeks of EEN.
This project stems from the DOCHAS study and looks at outcomes, including remission, required interventions and infliximab failure, in standard vs escalated infliximab induction regimens.
It is known that patients with IBD are at increased risk of thrombotic events. This collaborative study, led by Dr. Roger Preston, probes for potential differences in coagulation pathways in patients with IBD vs control patients.
The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.
| Ryan N, Cooper S, Dominik A, Quinn S, Broderick A, Bourke B, Hussey S, 2023 Aug, Outcomes of Tofacitinib Use in an Irish Pediatric Cohort. JPGN Rep, DOI: 10.1097/PG9.0000000000000332 |
| Tal N, Tzivinikos C, Gasparetto M, Serban DE, Zifman E, Hojsak I, Ledder O, Yerushalmy Feler A, Rolandsdotter H, Aloi M, Bramuzzo M, Buderus S, Lionetti P, Norsa L, Norden C, Urlep D, Romano C, Shaoul R, Martinez-Vinson C, Karoliny A, De Greef E, Kang B, VIčková E, Alvisi P, Kori M, Tavares M, Weiss B, Hussey S, Qamhawi ME, Palomino Pérez LM, Henderson P, Parmar R, Miele E, Rinawi F, Lozano-Ruf A, Zamvar V, Kolho KL, Shouval DS, Pediatric IBD Porto Group of ESPGHAN, 2023 Jul 1, Clinical Features and Natural History of Paediatric Patients with Ulcerative Proctitis: A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN. J Crohns Colitis, DOI: 10.1093/ecco-jcc/jjad111 |
| Stenke E, Stallard L, Cooper S, Dominik A, Pilkington A, Sugrue S, O'Sullivan M, McDermott M, Quinn S, Broderick A, Bourke B, Hussey S, 2023 May 1, Mucosal Atrophy Predicts Poorer Outcomes in Pediatric Ulcerative Colitis-A National Inception Cohort Study. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000003746 |
| Marcovitch L, Focht G, Carmon N, Tersigni C, Ledder O, Lev-Tzion R, Church PC, Hyams JS, Baldassano RN, Bousvaros A, Mack DR, Hussey S, Otley A, Croft NM, Kappelman MD, Griffiths AM, Turner D, 2023 Apr, Development and Validation of the TUMMY-UC: A Patient-Reported Outcome for Pediatric Ulcerative Colitis. Gastroenterology, DOI: 10.1053/j.gastro.2022.12.006 |
| Elmaghrawy K, Fleming P, Fitzgerald K, Cooper S, Dominik A, Hussey S, Moran GP, 2023 Apr 19, The Oral Microbiome in Treatment-Naïve Paediatric IBD Patients Exhibits Dysbiosis Related to Disease Severity that Resolves Following Therapy. J Crohns Colitis, DOI: 10.1093/ecco-jcc/jjac155 |
| Cleary NM, O'Gorman A, 2022 Sep 14, Hyaluronidase for localised infusion site reaction during continuous subcutaneous infusion. BMJ Support Palliat Care, DOI: 10.1136/spcare-2022-003909 |
| Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD, Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K, 2022 Sep, Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation. Gastroenterology, DOI: 10.1053/j.gastro.2022.05.037 |
| Castelli G, Piemontese L, Quinn R, Aerts J, Elsner P, Ertsen M, Hussey S, Filho WL, Limones N, Mpofu B, Neufeld DG, Ngugi K, Ngwenya N, Parker A, Ryan C, de Trincheria J, Villani L, Eisma J, Bresci E, 2022 Sep 10, Sand dams for sustainable water management: Challenges and future opportunities. Sci Total Environ, DOI: 10.1016/j.scitotenv.2022.156126 |
| Leon G, Hernandez Santana YE, Irwin N, Giannoudaki E, O'Neill S, Csizmadia I, Gogarty M, Lee TJ, Ruane D, Long A, Fallon PG, Hussey S, Walsh PT, 2022 Mar, IL-36 cytokines imprint a colitogenic phenotype on CD4(+) T helper cells. Mucosal Immunol, DOI: 10.1038/s41385-022-00488-w |
| Saiz-Gonzalo G, Hanrahan N, Rossini V, Singh R, Ahern M, Kelleher M, Hill S, O'Sullivan R, Fanning A, Walsh PT, Hussey S, Shanahan F, Nally K, O'Driscoll CM, Melgar S, 2021, Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis. Front Immunol, DOI: 10.3389/fimmu.2021.655960 |
| Stallard L, Hussey S, 2021, Endoscopic and Histologic Predictors of Outcomes in Pediatric Ulcerative Colitis-Caveat Emptor. Front Pediatr, DOI: 10.3389/fped.2021.678132 |
| Giannoudaki E, Gargan S, Hussey S, Long A, Walsh PT, 2021, Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease. Front Pediatr, DOI: 10.3389/fped.2021.640497 |
| Elmaghrawy K, Hussey S, Moran GP, 2020, The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers? Front Pediatr, DOI: 10.3389/fped.2020.620254 |
| Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MI, Garay JAR, Lee SH, Guttman DS, Griffiths A, Moayyedi P, Panaccione R, Huynh H, Steinhart HA, Aumais G, Dieleman LA, Turner D, CCC IBD GEM Project research team, Paterson AD, Croitoru K, 2020 Oct 15, Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn's disease subjects. BMC Med Genet, DOI: 10.1186/s12881-020-01115-w |
| Stenke E, Aviello G, Singh A, Martin S, Winter D, Sweeney B, McDermott M, Bourke B, Hussey S, Knaus UG, 2020 Oct, NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation. Redox Biol, DOI: 10.1016/j.redox.2020.101752 |
| Ricciuto A, Aardoom M, Orlanski-Meyer E, Navon D, Carman N, Aloi M, Bronsky J, Däbritz J, Dubinsky M, Hussey S, Lewindon P, Martín De Carpi J, Navas-López VM, Orsi M, Ruemmele FM, Russell RK, Veres G, Walters TD, Wilson DC, Kaiser T, de Ridder L, Turner D, Griffiths AM, Pediatric Inflammatory Bowel Disease–Ahead Steering Committee, 2021 Jan, Predicting Outcomes in Pediatric Crohn's Disease for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program. Gastroenterology, DOI: 10.1053/j.gastro.2020.07.065 |
| Orlanski-Meyer E, Aardoom M, Ricciuto A, Navon D, Carman N, Aloi M, Bronsky J, Däbritz J, Dubinsky M, Hussey S, Lewindon P, Martin De Carpi J, Navas-López VM, Orsi M, Ruemmele FM, Russell RK, Veres G, Walters TD, Wilson DC, Kaiser T, de Ridder L, Griffiths A, Turner D, 2021 Jan, Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program. Gastroenterology, DOI: 10.1053/j.gastro.2020.07.066 |
| Crealey M, Byrne A, Hussey S, 2021 Jan, Prevalence of IgE mediated food allergy in children with inflammatory bowel disease. Pediatr Allergy Immunol, DOI: 10.1111/pai.13343 |
| Leon G, Hussey S, Walsh PT, 2021 Feb 16, The Diverse Roles of the IL-36 Family in Gastrointestinal Inflammation and Resolution. Inflamm Bowel Dis, DOI: 10.1093/ibd/izaa232 |
| Jongsma MME, Winter DA, Huynh HQ, Norsa L, Hussey S, Kolho KL, Bronsky J, Assa A, Cohen S, Lev-Tzion R, Van Biervliet S, Rizopoulos D, de Meij TGJ, Shouval DS, Wine E, Wolters VM, Martinez-Vinson C, de Ridder L, Paediatric IBD Porto Group of ESPGHAN, 2020 Dec, Infliximab in young paediatric IBD patients: it is all about the dosing. Eur J Pediatr, DOI: 10.1007/s00431-020-03750-0 |
| Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD, Crohn’s and Colitis Canada Genetic Environmental Microbial Project Research Consortium, CCC GEM Project recruitment site directors include Maria Abreu, Croitoru K, 2020 Dec, Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease. Gastroenterology, DOI: 10.1053/j.gastro.2020.08.005 |
| Sandys N, Loomes C, Keane A, Hussey S, Broderick A, McDermott M, O'Sullivan M, Bourke B, 2020 Oct, Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002879 |
| Wine E, El-Matary W, Critch J, Navas-López VM, Hussey S, 2020, Editorial: Pediatric Inflammatory Bowel Diseases: Looking to the Future. Front Pediatr, DOI: 10.3389/fped.2020.00056 |
| Collins A, Mannion R, Broderick A, Hussey S, Devins M, Bourke B, 2019, Gabapentin for the treatment of pain manifestations in children with severe neurological impairment: a single-centre retrospective review. BMJ Paediatr Open, DOI: 10.1136/bmjpo-2019-000467 |
| Levine A, Chanchlani N, Hussey S, Ziv-Baran T, Escher JC, Amil Dias J, Veres G, Koletzko S, Turner D, Kolho KL, Paerregaard A, Staiano A, Lionetti P, Nuti F, Sladek M, Shaoul R, Lazowska-Prezeorek I, Martin de Carpi J, Sigall Boneh R, Pfeffer Gik T, Cohen-Dolev N, Russell RK, 2020 Jan 1, Complicated Disease and Response to Initial Therapy Predicts Early Surgery in Paediatric Crohn's Disease: Results From the Porto Group GROWTH Study. J Crohns Colitis, DOI: 10.1093/ecco-jcc/jjz111 |
| Krauthammer A, Tzivinikos C, Assa A, Miele E, Strisciuglio C, Urlep D, Serban ED, Singh A, Winter HS, Russell RK, Hojsak I, Malham M, Navas-López VM, Croft NM, Lee HM, Ledder O, Shamasneh I, Hussey S, Huynh HQ, Wine E, Shah N, Sladek M, de Meij TG, Romano C, Dipasquale V, Lionetti P, Afzal NA, Aloi M, Lee K, Martín-de-Carpi J, Yerushalmy-Feler A, Subramanian S, Weiss B, Shouval DS, 2019 Dec 10, Long-term Outcomes of Paediatric Patients Admitted With Acute Severe Colitis- A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN. J Crohns Colitis, DOI: 10.1093/ecco-jcc/jjz092 |
| Ziv-Baran T, Hussey S, Sladek M, Amil Dias J, Martin de Carpi J, Miele E, Veres G, Lionetti P, Koletzko S, Nuti F, Paerregaard A, Kolho KL, Russell RK, Shaoul R, Weiner D, Sigall Boneh R, Escher J, Finnby L, Turner D, Levine A, 2018 Dec, Response to treatment is more important than disease severity at diagnosis for prediction of early relapse in new-onset paediatric Crohn's disease. Aliment Pharmacol Ther, DOI: 10.1111/apt.15016 |
| Collins A, Nolan E, Hurley M, D'Alton A, Hussey S, 2018, Anorexia Nervosa Complicating Pediatric Crohn Disease-Case Report and Literature Review. Front Pediatr, DOI: 10.3389/fped.2018.00283 |
| Oliva S, Thomson M, de Ridder L, Martín-de-Carpi J, Van Biervliet S, Braegger C, Dias JA, Kolacek S, Miele E, Buderus S, Bronsky J, Winter H, Navas-López VM, Assa A, Chong SKF, Afzal NA, Smets F, Shaoul R, Hussey S, Turner D, Cucchiara S, 2018 Sep, Endoscopy in Pediatric Inflammatory Bowel Disease: A Position Paper on Behalf of the Porto IBD Group of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002092 |
| Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, de Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos KH, Croft N, Navas-López VM, Wilson DC, Lawrence S, Russell RK, 2018 Aug, Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Evidence-based Consensus Guideline From the European Crohn's and Colitis Organization and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002036 |
| Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, de Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos K, Croft N, Navas-López V, Wilson DC, Lawrence S, Russell RK, 2018 Aug, Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002035 |
| Joosse ME, Aardoom MA, Kemos P, Turner D, Wilson DC, Koletzko S, Martin-de-Carpi J, Fagerberg UL, Spray C, Tzivinikos C, Sladek M, Shaoul R, Roma-Giannikou E, Bronsky J, Serban DE, Ruemmele FM, Garnier-Lengline H, Veres G, Hojsak I, Kolho KL, Davies IH, Aloi M, Lionetti P, Hussey S, Veereman G, Braegger CP, Trindade E, Wewer AV, Hauer AC, de Vries ACH, Sigall Boneh R, Sarbagili Shabat C, Levine A, de Ridder L, Paediatric IBD Porto group of ESPGHAN, 2018 Sep, Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN. Aliment Pharmacol Ther, DOI: 10.1111/apt.14893 |
| Akintimehin AO, O'Neill RS, Ring C, Raftery T, Hussey S, 2018, Outcomes of a National Cohort of Children with Acute Severe Ulcerative Colitis. Front Pediatr, DOI: 10.3389/fped.2018.00048 |
| Lawley M, Wu JW, Navas-López VM, Huynh HQ, Carroll MW, Chen M, Medvedev P, Day AS, Hussey S, Sigall-Boneh R, Levine A, Wine E, 2018 Aug, Global Variation in Use of Enteral Nutrition for Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000001946 |
| Cohen-Dolev N, Sladek M, Hussey S, Turner D, Veres G, Koletzko S, Martin de Carpi J, Staiano A, Shaoul R, Lionetti P, Amil Dias J, Paerregaard A, Nuti F, Pfeffer Gik T, Ziv-Baran T, Ben Avraham Shulman S, Sarbagili Shabat C, Sigall Boneh R, Russell RK, Levine A, 2018 Feb 28, Differences in Outcomes Over Time With Exclusive Enteral Nutrition Compared With Steroids in Children With Mild to Moderate Crohn's Disease: Results From the GROWTH CD Study. J Crohns Colitis, DOI: 10.1093/ecco-jcc/jjx150 |
| Hussey S, 2017 Aug, Editorial: changing nature of paediatric IBD-new insights from Irish data. Author's reply. Aliment Pharmacol Ther, DOI: 10.1111/apt.14192 |
| Coughlan A, Wylde R, Lafferty L, Quinn S, Broderick A, Bourke B, Hussey S, DOCHAS Study, 2017 Jun, A rising incidence and poorer male outcomes characterise early onset paediatric inflammatory bowel disease. Aliment Pharmacol Ther, DOI: 10.1111/apt.14070 |
| Lafferty L, Tuohy M, Carey A, Sugrue S, Hurley M, Hussey S, 2017 Feb, Outcomes of exclusive enteral nutrition in paediatric Crohn's disease. Eur J Clin Nutr, DOI: 10.1038/ejcn.2016.210 |
| Marcovitch L, Nissan A, Mack D, Otley A, Hussey S, Mclean B, Lewis M, Croft N, Barakat FM, Griffiths AM, Turner D, 2017 Mar, Item Generation and Reduction Toward Developing a Patient-reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000001259 |
| Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT, 2016 Sep, IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation. Mucosal Immunol, DOI: 10.1038/mi.2015.134 |
| Kutty J, Hussey S, Broderick AM, Quinn S, Bourke B, 2015 May, HLA testing for coeliac disease in Ireland? Ir Med J, DOI: 10.1038/mi.2015.134 |
| Bourke B, Hussey S, 2015 Mar, Chronic infections of the small intestine. Curr Opin Gastroenterol, DOI: 10.1097/MOG.0000000000000153 |
| Stenke E, Hussey S, 2014 Oct, Ulcerative colitis: management in adults, children and young people (NICE Clinical Guideline CG166). Arch Dis Child Educ Pract Ed, DOI: 10.1136/archdischild-2013-305512 |
| Dunne MR, Elliott L, Hussey S, Mahmud N, Kelly J, Doherty DG, Feighery CF, 2013, Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease. PLoS One, DOI: 10.1371/journal.pone.0076008 |
| Connolly M, Menown IB, Hussey S, Cinnamond N, Damani L, 2013 Jun, The dronedarone shared-care clinical model and database: a coordinated paradigm to optimize management of evolving clinical recommendations. Adv Ther, DOI: 10.1007/s12325-013-0037-0 |
| Crowley E, Bourke B, Hussey S, 2013 Feb, How to use Helicobacter pylori testing in paediatric practice. Arch Dis Child Educ Pract Ed, DOI: 10.1136/archdischild-2012-301642 |
| Fouhy F, Guinane CM, Hussey S, Wall R, Ryan CA, Dempsey EM, Murphy B, Ross RP, Fitzgerald GF, Stanton C, Cotter PD, 2012 Nov, High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob Agents Chemother, DOI: 10.1128/AAC.00789-12 |
| Raju D, Hussey S, Jones NL, 2012 Sep, Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans. Autophagy, DOI: 10.4161/auto.21007 |
| McLean S, Sheehy-Skeffington B, O'Leary N, O'Gorman A, 2013 Mar, Pharmacological management of co-morbid conditions at the end of life: is less more? Ir J Med Sci, DOI: 10.1007/s11845-012-0841-6 |
| Hope B, Shahdadpuri R, Dunne C, Broderick AM, Grant T, Hamzawi M, O'Driscoll K, Quinn S, Hussey S, Bourke B, 2012 Jul, Rapid rise in incidence of Irish paediatric inflammatory bowel disease. Arch Dis Child, DOI: 10.1136/archdischild-2011-300651 |
| Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL, 2012 May, Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology, DOI: 10.1053/j.gastro.2012.01.043 |
| Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B, 2011 Jun, Disease outcome for children who present with oral manifestations of Crohn's disease. Eur Arch Paediatr Dent, DOI: 10.1007/BF03262800 |
| Ramjeet M, Hussey S, Philpott DJ, Travassos LH, 2010 Sep, 'Nodophagy': New crossroads in Crohn disease pathogenesis. Gut Microbes, DOI: 10.4161/gmic.1.5.13295 |
| Hussey S, Wall R, Gruffman E, O'Sullivan L, Ryan CA, Murphy B, Fitzgerald G, Stanton C, Ross RP, 2011, Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates. Int J Microbiol, DOI: 10.1155/2011/130574 |
| McDonnell MM, McGuigan E, McElhinney J, McTeggart M, McClure D, 2009 Sep, An analysis of the palliative care education needs of RGNs and HCAs in nursing homes in Ireland. Int J Palliat Nurs, DOI: 10.12968/ijpn.2009.15.9.44257 |
| Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhães JG, Yuan L, Soares F, Chea E, Le Bourhis L, Boneca IG, Allaoui A, Jones NL, Nuñez G, Girardin SE, Philpott DJ, 2010 Jan, Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol, DOI: 10.1038/ni.1823 |
| Hussey S, Travassos LH, Jones NL, 2009 Aug, Autophagy as an emerging dimension to adaptive and innate immunity. Semin Immunol, DOI: 10.1016/j.smim.2009.05.004 |
| Wall R, Ross RP, Ryan CA, Hussey S, Murphy B, Fitzgerald GF, Stanton C, 2009, Role of gut microbiota in early infant development. Clin Med Pediatr, DOI: 10.4137/cmped.s2008 |
| Hussey S, Bourke B, Broderick A, Phelan E, McDermott M, 2008 Jul, Cryptogenic, multifocal, ulcerous, and stenosing enteritis as a manifestation of enterocolic venopathy. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0b013e3181661ad1 |
Please visit PubMed for more information on Séamus Hussey's publications
| Funding Agency: | National Children’s Research Centre |
| Project Title: | Defining the significance of altered IL-36 family expression in paediatric ulcerative colitis |
| Start Date/End Date: | 2017-2020 |
| Funding Agency: | National Children’s Research Centre |
| Project Title: | Towards targeting NOX4 for intestinal fibrosis in Crohn’s disease |
| Start Date/End Date: | 2017-2020 |
| Funding Agency: | National Children’s Research Centre |
| Project Title: | Determinants and Outcomes in Children and Adolescents with IBD |
| Start Date/End Date: | 2012-2021 |
| Funding Agency: | AbbVie |
| Project Title: | A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of Humira (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn’s Disease (CD) - (CAPE) |
| Start Date/End Date: | 2017-2028 |
| Funding Agency: | Crohn's and Colitis Canada |
| Project Title: | A Multidisciplinary Human Study on the Genetic, Environmental and Microbial (GEM) Interactions that Cause IBD |
| Start Date/End Date: | 2014-2020 |
| Funding Agency: | Wolfson Medical Center |
| Project Title: | Modified Exclusive Enteral Nutrition with the Crohn's Disease Exclusion Diet for Induction and Maintenance of Remission and Rebiosis - DIETOMICS CD (M-EEN) |
| Start Date/End Date: | 2018-2021 |
| Funding Agency: | ESPHGAN |
| Project Title: | Predicting response to Vedolizumab in Pediatric Inflammatory Bowel Diseases including drug levels: a multi‐center prospective Pan‐ European cohort study (P‐ECCO and ESPGHAN) - VEDOKIDS |
| Start Date/End Date: | 2017-2024 |
| Name: | Dr Pat Walsh |
| Department | Immunology |
| Institution: | Trinity College Dublin |
| Country: | Ireland |
| Name: | Prof Billy Bourke |
| Department | Paediatric Gastroenterology |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Prof Ulla Knaus |
| Department | Conway Institute |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Dr Gary Moran |
| Department | Microbiology |
| Institution: | TCD |
| Country: | Ireland |
| Name: | Prof Arie Levine |
| Department | Paediatric Gastroenterology |
| Institution: | Wolfson, Tel Aviv |
| Country: | Israel |
| Name: | Dr Roger Preston |
| Department | Irish Centre for Vascular Biology |
| Institution: | RCSI |
| Country: | Ireland |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| DOCHAS | Determinants and Outcomes in Children and Adolescents with IBD | Non-Interventional Study | ||
| Oral Microbiome | The oral microbiome in Children with New-Onset IBD | Non-Interventional Study | ||
| TUMMY UC | Patient Reported Outcomes in Paediatric Ulcerative Colitis Study | Non-Interventional Study | Izaak Walton Killam Health Centre | Academic - Investigator Led |
| CAPE | A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA (Adalimumab) in Paediatric Patients With Moderately to Severely Active Crohn's Disease | Non-Interventional Clinical Trial | AbbVie | Industry Sponsored |
| GEM | A Multidisciplinary Human Study on the Genetic, Environmental and Microbial Interactions that Cause Inflammatory Bowel disease (IBD) | Non-Interventional Study | Mount Sinai Hospital | Academic - Investigator Led |
| DIETOMICS CD (M-EEN) | Modified Exclusive Enteral Nutrition with the Crohn's Disease Exclusion Diet for Induction and Maintenance of Remission and Rebiosis | Non-Interventional Clinical Trial | Wolfson Medical Center | Academic - Collaborative Group |
| iNEOPICS | The interNational Early Onset Paediatric IBD Cohort Study | Non-Interventional Study | The Hospital For Sick Children Toronto | Academic - Collaborative Group |
| TUMMY CD | Patient Reported Outcomes in Paediatric Crohns Disease Study | Non-Interventional Study | Izaak Walton Killam Health Centre, Halifax | Academic - Investigator Led |
| VEDOKIDS study | Predicting response to Vedolizumab in Pediatric Inflammatory Bowel Diseases including drug levels: a multi‐center prospective Pan‐ European cohort study (P‐ECCO and ESPGHAN) | Non-Interventional Study | ESPHGAN | Academic - Collaborative Group |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| ASC | An investigation as to whether Infliximab has changed the national history of Acute Severe Colitis | Non-Interventional Study | ||
| RAPID IBD | Retrospective study on pharmacokinetic infliximab data in young IBD patients | Non-Interventional Study | ||
| EoE | Establishing the national incidence and prevalence of Eosinophilic Oesphagitis in Ireland over the last ten years and a description of its natural history | Non-Interventional Study | ||
| GROWTH CD Study | Growth Study: Factors predicting relapse and adverse outcomes early in newly diagnosed paed' Crohn Disease a prospective, multi centre prognostication study by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) ‘Porto’ Group | Non-Interventional Study | ESPHGAN | Academic - Collaborative Group |