| Millar J, Ozaki E, Campbell S, Duckett C, Doyle S, Cole LM, 2022 Dec 9, Multiomic Mass Spectrometry Imaging to Advance Future Pathological Understanding of Ocular Disease. Metabolites, DOI: 10.3390/metabo12121239 |
| Corey TM, Woodley VV, O'Connor M, Connolly E, Doyle S, Shrader S, Phipps C, Isaac K, Lawrence M, 2022 Aug 1, Evaluation of the Dose-Dependent Inflammatory Response and No-Observable Adverse Effect Level of Intravitreal Endotoxin in the African Green Monkey. Transl Vis Sci Technol, DOI: 10.1167/tvst.11.8.17 |
| Kelly AM, Leech JM, Doyle SL, McLoughlin RM, 2022 Jul, Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation. PLoS Pathog, DOI: 10.1371/journal.ppat.1010647 |
| Gibbons L, Ozaki E, Greene C, Trappe A, Carty M, Coppinger JA, Bowie AG, Campbell M, Doyle SL, 2022, SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration. Front Neurosci, DOI: 10.3389/fnins.2022.852114 |
| Brennan K, Craven S, Cheung M, Kane D, Noone E, O'Callaghan J, Molloy EJ, Walsh PT, McAuliffe FM, Doyle SL, 2022 Sep, Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in pediatric vaccines. J Leukoc Biol, DOI: 10.1002/JLB.5A0521-242R |
| Ozaki E, Delaney C, Campbell M, Doyle SL, 2022 Apr, Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration. Exp Eye Res, DOI: 10.1016/j.exer.2022.108953 |
| Mulfaul K, Doyle SL, 2021 Feb 20, In vitro Measurement of Membrane Attack Complex in RPE Cells. Bio Protoc, DOI: 10.21769/BioProtoc.3916 |
| Delaney C, Farrell M, Doherty CP, Brennan K, O'Keeffe E, Greene C, Byrne K, Kelly E, Birmingham N, Hickey P, Cronin S, Savvides SN, Doyle SL, Campbell M, 2021 Feb 5, Attenuated CSF-1R signalling drives cerebrovascular pathology. EMBO Mol Med, DOI: 10.15252/emmm.202012889 |
| Doyle SL, 2020 Aug 18, The Persistence of Privilege for a Healthy Retina. Immunity, DOI: 10.1016/j.immuni.2020.07.022 |
| Ozaki E, Gibbons L, Neto NG, Kenna P, Carty M, Humphries M, Humphries P, Campbell M, Monaghan M, Bowie A, Doyle SL, 2020 May, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration. Life Sci Alliance, DOI: 10.26508/lsa.201900618 |
| Useckaite Z, Ward MP, Trappe A, Reilly R, Lennon J, Davage H, Matallanas D, Cassidy H, Dillon ET, Brennan K, Doyle SL, Carter S, Donnelly S, Linnane B, McKone EF, McNally P, Coppinger JA, 2020 Jun, Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis. Thorax, DOI: 10.1136/thoraxjnl-2019-214027 |
| Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL, 2020 Feb 18, Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. Cell Rep, DOI: 10.1016/j.celrep.2020.01.064 |
| Brint E, Kamradt T, Doyle SL, 2019, Editorial: IL-1 Family Members in Health and Disease. Front Immunol, DOI: 10.3389/fimmu.2019.02596 |
| Ui Mhaonaigh A, Coughlan AM, Dwivedi A, Hartnett J, Cabral J, Moran B, Brennan K, Doyle SL, Hughes K, Lucey R, Floudas A, Fearon U, McGrath S, Cormican S, De Bhailis A, Molloy EJ, Brady G, Little MA, 2019, Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies. Front Immunol, DOI: 10.3389/fimmu.2019.02603 |
| Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT, 2019 Sep 5, Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nat Commun, DOI: 10.1038/s41467-019-11944-w |
| Hudson N, Celkova L, Hopkins A, Greene C, Storti F, Ozaki E, Fahey E, Theodoropoulou S, Kenna PF, Humphries MM, Curtis AM, Demmons E, Browne A, Liddie S, Lawrence MS, Grimm C, Cahill MT, Humphries P, Doyle SL, Campbell M, 2019 Aug 8, Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy. JCI Insight, DOI: 10.1172/jci.insight.130273 |
| Fahey E, Doyle SL, 2019, IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis. Front Immunol, DOI: 10.3389/fimmu.2019.01426 |
| Campbell M, Doyle SL, 2019 Jun, Current perspectives on established and novel therapies for pathological neovascularization in retinal disease. Biochem Pharmacol, DOI: 10.1016/j.bcp.2019.04.029 |
| Brennan K, O'Leary BD, Mc Laughlin D, Kinlen D, Molloy EJ, Cody D, Paran S, McAuliffe FM, Hogan AE, Doyle SL, 2019 Jul, Nucleic acid cytokine responses in obese children and infants of obese mothers. Cytokine, DOI: 10.1016/j.cyto.2019.03.015 |
| Brennan K, Lyons C, Fernandes P, Doyle S, Houston A, Brint E, 2019 Feb, Engagement of Fas differentially regulates the production of LPS-induced proinflammatory cytokines and type I interferons. FEBS J, DOI: 10.1111/febs.14727 |
| Brennan K, O'Leary BD, Mc Laughlin D, Breen EP, Connolly E, Ali N, O'Driscoll DN, Ozaki E, Mahony R, Mulfaul K, Ryan AM, Ni Chianain A, McHugh A, Molloy EJ, Hogan AE, Paran S, McAuliffe FM, Doyle SL, 2018 Aug 15, Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation. J Immunol, DOI: 10.4049/jimmunol.1700956 |
| Mulfaul K, Rhatigan M, Doyle S, 2018, Toll-Like Receptors and Age-Related Macular Degeneration. Adv Exp Med Biol, DOI: 10.1007/978-3-319-75402-4_3 |
| Connolly E, Rhatigan M, O'Halloran AM, Muldrew KA, Chakravarthy U, Cahill M, Kenny RA, Doyle SL, 2018 Dec, Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population. Br J Ophthalmol, DOI: 10.1136/bjophthalmol-2017-311673 |
| Theodoropoulou S, Copland DA, Liu J, Wu J, Gardner PJ, Ozaki E, Doyle SL, Campbell M, Dick AD, 2017 Jan, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye. J Pathol, DOI: 10.1002/path.4816 |
| Husebye H, Doyle SL, 2016, Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors. Methods Mol Biol, DOI: 10.1007/978-1-4939-3335-8_4 |
| Doyle SL, López FJ, Humphries P, Adamson P, Campbell M, 2015 Dec, Author Response: The Role of IL-18 in the Treatment of AMD. Invest Ophthalmol Vis Sci, DOI: 10.1167/iovs.15-18714 |
| Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M, 2015 Aug, IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates. Invest Ophthalmol Vis Sci, DOI: 10.1167/iovs.15-17264 |
| Celkova L, Doyle SL, Campbell M, 2015 Jan 14, NLRP3 Inflammasome and Pathobiology in AMD. J Clin Med, DOI: 10.3390/jcm4010172 |
| Ozaki E, Campbell M, Doyle SL, 2015, Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives. J Inflamm Res, DOI: 10.2147/JIR.S51250 |
| Doyle SL, Adamson P, López FJ, Humphries P, Campbell M, 2014 Dec 23, Interleukin-18 bioactivity and dose: data interpretation at a crossroads. Invest Ophthalmol Vis Sci, DOI: 10.1167/iovs.14-15786 |
| Doyle SL, Adamson P, López FJ, Humphries P, Campbell M, 2014 Dec, Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med, DOI: 10.1038/nm.3741 |
| Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG, 2014 Dec 15, TRAM is required for TLR2 endosomal signaling to type I IFN induction. J Immunol, DOI: 10.4049/jimmunol.1401605 |
| Campbell M, Doyle S, Humphries P, 2014 Oct, IL-18: a new player in immunotherapy for age-related macular degeneration? Expert Rev Clin Immunol, DOI: 10.1586/1744666X.2014.950231 |
| Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M, 2014 Apr 2, IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration. Sci Transl Med, DOI: 10.1126/scitranslmed.3007616 |
| Ozaki E, Campbell M, Kiang AS, Humphries M, Doyle SL, Humphries P, 2014, Inflammation in age-related macular degeneration. Adv Exp Med Biol, DOI: 10.1007/978-1-4614-3209-8_30 |
| Kenny EF, Quinn SR, Doyle SL, Vink PM, van Eenennaam H, O'Neill LA, 2013, Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin. PLoS One, DOI: 10.1371/journal.pone.0074103 |
| Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA, 2013 Aug 30, Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15. J Biol Chem, DOI: 10.1074/jbc.M113.469122 |
| Campbell M, Doyle SL, 2013 Sep, An eye on the future of inflammasomes and drug development in AMD. J Mol Med (Berl), DOI: 10.1007/s00109-013-1050-0 |
| Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, 2012 May, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med, DOI: 10.1038/nm.2717 |
| Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, 2012 Feb 28, The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. Nat Commun, DOI: 10.1038/ncomms1706 |
| McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, 2010 Jul 2, IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem, DOI: 10.1074/jbc.M110.102111 |
| O'Neill LA, Bryant CE, Doyle SL, 2009 Jun, Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev, DOI: 10.1124/pr.109.001073 |
| Palsson-McDermott EM, Doyle SL, McGettrick AF, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T, O'Neill LA, 2009 Jun, TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol, DOI: 10.1038/ni.1727 |
| Doyle SL, Jefferies CA, Feighery C, O'Neill LA, 2007 Dec 21, Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem, DOI: 10.1074/jbc.M707682200 |
| Doyle SL, O'Neill LA, 2006 Oct 30, Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol, DOI: 10.1016/j.bcp.2006.07.010 |
| Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA, 2006 Apr 14, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem, DOI: 10.1074/jbc.M508892200 |
