Rehill AM, Leon G, McCluskey S, Schoen I, Hernandez-Santana Y, Annett S, Klavina P, Robson T, Curtis AM, Renné T, Hussey S, O'Donnell JS, Walsh PT, Preston RJS, 2023 Oct 20, Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability. J Thromb Haemost, DOI: 10.1016/j.jtha.2023.10.006 |
Wang Z, Zhou Y, Xiao X, Liu A, Wang S, Preston RJS, Zaytseva YY, He G, Xiao W, Hennig B, Deng P, 2023 Dec 15, Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions. Environ Pollut, DOI: 10.1016/j.envpol.2023.122756 |
Fogarty H, Ahmad A, Atiq F, Doherty D, Ward S, Karampini E, Rehill A, Leon G, Byrne C, Geoghegan R, Conroy H, Byrne M, Budde U, Schneppenheim S, Sheehan C, Ngwenya N, Baker RI, Preston RJS, Tuohy E, McMahon C, O'Donnell JS, 2023 Nov 28, VWF-ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion. Blood Adv, DOI: 10.1182/bloodadvances.2023010824 |
Preston RJS, 2023 Sep 21, New targeted therapy for hemophilia. Blood, DOI: 10.1182/blood.2023021385 |
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, O' Brien EC, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, O' Donnell JS, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ, 2023 Jul 20, Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nat Commun, DOI: 10.1038/s41467-023-40034-1 |
O'Donnell JS, Fleming H, Noone D, Preston RJS, 2023 Dec, Unraveling coagulation factor-mediated cellular signaling. J Thromb Haemost, DOI: 10.1016/j.jtha.2023.06.019 |
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ, 2023 Jun 14, Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nat Commun, DOI: 10.1038/s41467-023-39174-1 |
Englert H, Göbel J, Khong D, Omidi M, Wolska N, Konrath S, Frye M, Mailer RK, Beerens M, Gerwers JC, Preston RJS, Odeberg J, Butler LM, Maas C, Stavrou EX, Fuchs TA, Renné T, 2023, Targeting NETs using dual-active DNase1 variants. Front Immunol, DOI: 10.3389/fimmu.2023.1181761 |
O'Donnell JS, Byrne C, Preston RJS, 2023 Mar, Von Willebrand factor-inflammation crosstalk in deep vein thrombosis. J Thromb Haemost, DOI: 10.1016/j.jtha.2022.11.038 |
Karampini E, Fogarty H, Elliott S, Morrin H, Bergin C, O'Sullivan JM, Byrne M, Martin-Loeches I, Mallon PW, Curley GF, Glavey S, Baker RI, Lavin M, Preston RJS, Cheallaigh CN, Ward SE, O'Donnell JS, 2023 Feb, Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19. Res Pract Thromb Haemost, DOI: 10.1016/j.rpth.2023.100085 |
Elsheikh E, Lavin M, Heck LA, Larkin N, Mullaney B, Doherty D, Kennedy M, Keenan C, Guest T, O'Mahony B, Fazavana J, Fallon PG, Preston RJS, Gormley J, Ryan K, O'Connell NM, Singleton E, Byrne M, McGowan M, Roche S, Doyle M, Crowley MP, O'Shea SI, Reipert BM, Johnsen JM, Pipe SW, Di Paola J, Turecek PL, O'Donnell JS, iPATH study group, 2023 May, Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor. J Thromb Haemost, DOI: 10.1016/j.jtha.2023.01.013 |
Ward SE, Guest T, Byrne C, Lopes P, O'Sullivan JM, Doherty D, O'Connell D, Gutierrez Llaneza S, Chion A, Fazavana J, Fallon PG, Preston RJS, Johnsen JM, Pipe SW, Turecek PL, O'Donnell JS, iPATH Study Group, 2023 Apr, Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report. Arterioscler Thromb Vasc Biol, DOI: 10.1161/ATVBAHA.122.317807 |
Klavina PA, Leon G, Curtis AM, Preston RJS, 2022 Dec 22, Dysregulated haemostasis in thrombo-inflammatory disease. Clin Sci (Lond), DOI: 10.1042/CS20220208 |
Konrath S, Mailer RK, Beerens M, Englert H, Frye M, Kuta P, Preston RJS, Maas C, Butler LM, Roest M, de Laat B, Renné T, 2022, Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood. Front Cardiovasc Med, DOI: 10.3389/fcvm.2022.1008410 |
Cervantes-Silva MP, Carroll RG, Wilk MM, Moreira D, Payet CA, O'Siorain JR, Cox SL, Fagan LE, Klavina PA, He Y, Drewinski T, McGinley A, Buel SM, Timmons GA, Early JO, Preston RJS, Hurley JM, Finlay DK, Schoen I, Javier Sánchez-García F, Mills KHG, Curtis AM, 2022 Dec 5, The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing. Nat Commun, DOI: 10.1038/s41467-022-34897-z |
Drakeford C, Aguila S, Roche F, Hokamp K, Fazavana J, Cervantes MP, Curtis AM, Hawerkamp HC, Dhami SPS, Charles-Messance H, Hackett EE, Chion A, Ward S, Ahmad A, Schoen I, Breen E, Keane J, Murphy R, Preston RJS, O'Sullivan JM, Sheedy FJ, Fallon P, O'Donnell JS, 2022 Nov 3, von Willebrand factor links primary hemostasis to innate immunity. Nat Commun, DOI: 10.1038/s41467-022-33796-7 |
Fogarty H, Ward SE, Townsend L, Karampini E, Elliott S, Conlon N, Dunne J, Kiersey R, Naughton A, Gardiner M, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, Baker RI, Cheallaigh CN, O'Donnell JS, Irish COVID-19 Vasculopathy Study (iCVS) Investigators, 2022 Oct, Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction. J Thromb Haemost, DOI: 10.1111/jth.15830 |
Leon G, Rehill AM, Preston RJS, 2022 Sep 1, The protein C pathways. Curr Opin Hematol, DOI: 10.1097/MOH.0000000000000726 |
Ariëns RA, Hunt BJ, Agbani EO, Ahnström J, Ahrends R, Alikhan R, Assinger A, Bagoly Z, Balduini A, Barbon E, Barrett CD, Batty P, Carneiro JDA, Chan WS, de Maat M, de Wit K, Denis C, Ellis MH, Eslick R, Fu H, Hayward CPM, Ho-Tin-Noé B, Klok FA, Kumar R, Leiderman K, Litvinov RI, Mackman N, McQuilten Z, Neal MD, Parker WAE, Preston RJS, Rayes J, Rezaie AR, Roberts LN, Rocca B, Shapiro S, Siegal DM, Sousa LP, Suzuki-Inoue K, Zafar T, Zhou J, 2022 Jul, Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress. Res Pract Thromb Haemost, DOI: 10.1002/rth2.12747 |
O'Regan N, Gegenbauer K, Gleeson EM, Fukudome K, O'Sullivan JM, Drakeford C, Dalton N, Chion A, Brophy TM, Smith OP, Preston RJS, O'Donnell JS, 2022 Aug 1, Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria. Haematologica, DOI: 10.3324/haematol.2021.280450 |
Ryan TAJ, Preston RJS, O'Neill LAJ, 2022 Mar 31, Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants. Biochem J, DOI: 10.1042/BCJ20210522 |
Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2021 Dec 1, Correction: SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin. J Immunol, DOI: 10.4049/jimmunol.2100907 |
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T, 2021 Sep 22, Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nat Commun, DOI: 10.1038/s41467-021-25888-7 |
Fogarty H, Townsend L, Morrin H, Ahmad A, Comerford C, Karampini E, Englert H, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, McGonagle D, Ni Cheallaigh C, Baker RI, Renné T, Ward SE, O'Donnell JS, Irish COVID-19 Vasculopathy Study (iCVS) investigators, 2021 Oct, Persistent endotheliopathy in the pathogenesis of long COVID syndrome. J Thromb Haemost, DOI: 10.1111/jth.15490 |
Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2021 Jul 15, SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin. J Immunol, DOI: 10.4049/jimmunol.2100237 |
Rehill AM, McCluskey S, O'Donnell JS, Dockal M, Preston RJS, iPATH Study Group, 2021 Mar, Heterogeneity in Bleeding Tendency and Arthropathy Development in Individuals with Hemophilia. Semin Thromb Hemost, DOI: 10.1055/s-0041-1723769 |
Preston RJS, O'Sullivan JM, 2021 Mar, Personalized Approaches to the Treatment of Hemostatic Disorders. Semin Thromb Hemost, DOI: 10.1055/s-0041-1723800 |
Rehill AM, Preston RJS, 2020 Sep, A new thrombomodulin-related coagulopathy. J Thromb Haemost, DOI: 10.1111/jth.14987 |
O'Sullivan JM, Gonagle DM, Ward SE, Preston RJS, O'Donnell JS, 2020 Aug, Endothelial cells orchestrate COVID-19 coagulopathy. Lancet Haematol, DOI: 10.1016/S2352-3026(20)30215-5 |
Gleeson EM, Rehill AM, Willis Fox O, Ni Ainle F, McDonnell CJ, Rushe HJ, McCluskey S, O'Donnell JS, Preston RJS, 2020 Jun 9, Apolipoprotein A-I enhances activated protein C cytoprotective activity. Blood Adv, DOI: 10.1182/bloodadvances.2019001316 |
Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ, 2019 Oct 1, Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep, DOI: 10.1016/j.celrep.2019.08.072 |
Willis Fox O, Preston RJS, 2020 Jan, Molecular basis of protease-activated receptor 1 signaling diversity. J Thromb Haemost, DOI: 10.1111/jth.14643 |
O'Donnell JS, O'Sullivan JM, Preston RJS, 2019 Jul, Advances in understanding the molecular mechanisms that maintain normal haemostasis. Br J Haematol, DOI: 10.1111/bjh.15872 |
Preston RJS, O'Sullivan JM, O'Donnell JS, 2019 Jul, Advances in understanding the molecular mechanisms of venous thrombosis. Br J Haematol, DOI: 10.1111/bjh.15869 |
Aguila S, Lavin M, Dalton N, Patmore S, Chion A, Trahan GD, Jones KL, Keenan C, Brophy TM, O'Connell NM, Ryan K, Byrne M, Nolan M, Patel A, Preston RJS, James P, Di Paola J, O'Sullivan JM, O'Donnell JS, 2019 Apr 4, Increased galactose expression and enhanced clearance in patients with low von Willebrand factor. Blood, DOI: 10.1182/blood-2018-09-874636 |
Preston RJS, Lisman T, 2018 Mar, Extrahemostatic Functions of Platelets and Coagulation Factors. Semin Thromb Hemost, DOI: 10.1055/s-0037-1612624 |
Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion A, O'Donnell JS, 2018 Feb 22, A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance. Blood, DOI: 10.1182/blood-2017-06-787853 |
McDonnell CJ, Soule EE, Walsh PT, O'Donnell JS, Preston RJS, 2018 Mar, The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease. Semin Thromb Hemost, DOI: 10.1055/s-0037-1608910 |
O'Sullivan JM, Preston RJS, Robson T, O'Donnell JS, 2018 Mar, Emerging Roles for von Willebrand Factor in Cancer Cell Biology. Semin Thromb Hemost, DOI: 10.1055/s-0037-1607352 |
Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, Preston RJS, Budde U, James P, Di Paola J, O'Donnell JS, 2017 Nov 23, Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels. Blood, DOI: 10.1182/blood-2017-05-786699 |
Gleeson EM, McDonnell CJ, Soule EE, Willis Fox O, Rushe H, Rehill A, Smith OP, O'Donnell JS, Preston RJS, 2017 Nov, A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective protease-activated receptor 1 signaling. J Thromb Haemost, DOI: 10.1111/jth.13807 |
Preston RJS, O'Donnell JS, 2017 Jul 27, Microbiome influences von Willebrand factor. Blood, DOI: 10.1182/blood-2017-06-789156 |
O'Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O'Donnell JS, 2016 Dec, N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor. J Thromb Haemost, DOI: 10.1111/jth.13537 |
Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS, 2016 Oct 13, N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance. Blood, DOI: 10.1182/blood-2016-04-709436 |
Heurich M, Preston RJ, O'Donnell VB, Morgan BP, Collins PW, 2016 Sep, Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thromb Res, DOI: 10.1016/j.thromres.2016.07.017 |
O'Sullivan JM, Jenkins PV, Rawley O, Gegenbauer K, Chion A, Lavin M, Byrne B, O'Kennedy R, Preston RJ, Brophy TM, O'Donnell JS, 2016 May, Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII. Arterioscler Thromb Vasc Biol, DOI: 10.1161/ATVBAHA.115.306915 |
O'Sullivan JM, Preston RJ, O'Regan N, O'Donnell JS, 2016 May 12, Emerging roles for hemostatic dysfunction in malaria pathogenesis. Blood, DOI: 10.1182/blood-2015-11-636464 |
O'Regan N, Moxon C, Gegenbauer K, O'Sullivan JM, Chion A, Smith OP, Preston RJ, Brophy TM, Craig AG, O'Donnell JS, 2016 Apr, Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria. Thromb Haemost, DOI: 10.1160/TH15-10-0796 |
Quinn LM, Drakeford C, O'Donnell JS, Preston RJ, 2015 Aug, Engineering activated protein C to maximize therapeutic efficacy. Biochem Soc Trans, DOI: 10.1042/BST20140312 |
O'Regan N, Gegenbauer K, O'Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O'Donnell JS, 2016 Mar 3, A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood, DOI: 10.1182/blood-2015-07-654921 |
Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG, 2016 Feb, The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism. FASEB J, DOI: 10.1096/fj.15-277822 |
Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ, 2015 Aug 13, Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury. Blood, DOI: 10.1182/blood-2015-03-632877 |
Rawley O, O'Sullivan JM, Chion A, Keyes S, Lavin M, van Rooijen N, Brophy TM, Fallon P, Preston RJ, O'Donnell JS, 2015 May, von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo. J Thromb Haemost, DOI: 10.1111/jth.12875 |
Kevane B, Donnelly J, D'Alton M, Cooley S, Preston RJ, Ní Ainle F, 2014 Jul, Risk factors for pregnancy-associated venous thromboembolism: a review. J Perinat Med, DOI: 10.1515/jpm-2013-0207 |
McGrath RT, van den Biggelaar M, Byrne B, O'Sullivan JM, Rawley O, O'Kennedy R, Voorberg J, Preston RJ, O'Donnell JS, 2013 Dec 12, Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. Blood, DOI: 10.1182/blood-2013-04-496851 |
Gleeson EM, O'Donnell JS, Hams E, Ní Áinle F, Kenny BA, Fallon PG, Preston RJ, 2014 Jan, Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells. Haematologica, DOI: 10.3324/haematol.2013.086918 |
Preston RJ, Rawley O, Gleeson EM, O'Donnell JS, 2013 May 9, Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities. Blood, DOI: 10.1182/blood-2012-10-415000 |
Gleeson EM, O'Donnell JS, Preston RJ, 2012 Mar, The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. Cell Mol Life Sci, DOI: 10.1007/s00018-011-0825-0 |
Ní Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ, 2011 Jan 14, Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem, DOI: 10.1074/jbc.M110.159475 |