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Roger Preston

Roger Preston

Lecturer in Vascular Biology

Contact

rogerpreston@rcsi.ie

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The Preston Lab is part of the Irish Centre for Vascular Biology and Department of Molecular and Cellular Therapeutics at Royal College of Surgeons in Ireland (RCSI), based at St Stephen’s Green, Dublin.

The research in our lab is focused on enhancing our understanding of coagulation factor biology and function, and using these insights to develop novel therapeutics for vascular dysfunction and inflammatory disease.

Roger Preston obtained his BSc. (Hons) in Molecular Biology from University of Aberdeen (2000), completed an MSc. in Bioengineering at the University of Strathclyde (2001), then attained his PhD at Imperial College London (2004). He has received several individual fellowship awards, including a Health Research Board Research Fellowship (2007), a Science Foundation Ireland Starting Investigator Research Grant (2009), and a Haematology Association of Ireland Scholar Award (2010). His research has been recognized by international research awards including the Novo Nordisk ‘Access-To-Insight’ Research Prize (2010), Bayer Hemophilia Award Program Early Career Investigator Award (2013), Daiichi-Sankyo Irish Heart Foundation Award (2015), and Bayer Hemophilia Special Project award (2016).

Dr Roger Preston and his research team (RCSI 2018)

He was appointed Assistant Professor in Immunology at Trinity College Dublin in 2012, then moved to the Royal College of Surgeons in Ireland in 2016. At RCSI, he is a Lecturer in Vascular Biology in the Department of Molecular and Cellular Therapeutics. He was formerly the Scientific Secretary of the Haematology Association of Ireland (2015-2017) and currently serves on the Editorial Board of Seminars in Thrombosis and Haemostasis (2015-present) and Research and Practice in Thrombosis and Haemostasis (2016-present). His research group is currently funded by awards from Science Foundation Ireland, Bayer Healthcare, and the National Children’s Research Centre.

Roger Preston

Lecturer in Vascular Biology

Contact

rogerpreston@rcsi.ie

Twitter

Google Scholar

Engineered recombinant activated protein C as a novel therapeutic agent for children with inflammatory bowel disease

The number of children with paediatric inflammatory bowel disease (PIBD) in Ireland has surged in the last 15 years. Current treatments for children with IBD are often ineffective so new approaches that expand the repertoire of efficacious treatments for PIBD are required. In this study, we will assess whether children with IBD attending OLCHC for treatment exhibit impaired anticoagulant and anti-inflamamtory pathway activity in their intestinal lining compared to healthy children. These studies will shed new light on the role of the PC pathway in regulating IBD development in children.

Novel therapeutic approach to counter vaso-occlusive crisis in sickle cell disease using engineered activated protein C

Sickle cell disease (SCD) is a significant cause of global paediatric illness and death. SCD causes red blood cells to bind to other blood cells and block blood vessels, which can cause painful sickle cell ‘crises’ and stroke to occur. There are only a limited number of therapies currently available to treat SCD. The objective of this study is to evaluate the role of activated protein C (APC), a blood protein with anticoagulant and anti-inflammatory activity, in controlling SCD, with a view to utilising engineered activated protein C variants as potential therapies for the treatment of SCD-associated blood vessel damage. This study will utilise the newly-established biobank of paediatric SCD blood samples collected as part of the Sickle Vascular Ireland Consortium (SiVIC) study to investigate the role of defective protein C pathway activity in SCD-associated vascular inflammation and occlusion. Specifically, we propose to determine whether the protein C pathway is impaired in individuals with SCD at different disease stages and treatment and investigate whether activated protein C has the potential to mitigate the key molecular events that contribute to SCD blood vessel dysfunction, such as inflammation, blood cell binding to sticky blood vessels and uncontrolled blood coagulation. SCD is a significant cause of global paediatric illness and death. Children with SCD are subject to painful crises, anaemia and stroke. Unfortunately, there is a limited understanding of the molecular events that lead to blood vessel occlusions that contribute to crises and therefore a limited number of effective SCD therapies. This study aims to test new therapeutic approaches to reduce the painful symptoms of SCD and meet the urgent, unmet need for novel therapies to enhance care of children with SCD.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Rehill AM, Leon G, McCluskey S, Schoen I, Hernandez-Santana Y, Annett S, Klavina P, Robson T, Curtis AM, Renné T, Hussey S, O'Donnell JS, Walsh PT, Preston RJS, 2023 Oct 20, Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability. J Thromb Haemost, DOI: 10.1016/j.jtha.2023.10.006
Wang Z, Zhou Y, Xiao X, Liu A, Wang S, Preston RJS, Zaytseva YY, He G, Xiao W, Hennig B, Deng P, 2023 Dec 15, Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions. Environ Pollut, DOI: 10.1016/j.envpol.2023.122756
Fogarty H, Ahmad A, Atiq F, Doherty D, Ward S, Karampini E, Rehill A, Leon G, Byrne C, Geoghegan R, Conroy H, Byrne M, Budde U, Schneppenheim S, Sheehan C, Ngwenya N, Baker RI, Preston RJS, Tuohy E, McMahon C, O'Donnell JS, 2023 Nov 28, VWF-ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion. Blood Adv, DOI: 10.1182/bloodadvances.2023010824
Preston RJS, 2023 Sep 21, New targeted therapy for hemophilia. Blood, DOI: 10.1182/blood.2023021385
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, O' Brien EC, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, O' Donnell JS, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ, 2023 Jul 20, Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nat Commun, DOI: 10.1038/s41467-023-40034-1
O'Donnell JS, Fleming H, Noone D, Preston RJS, 2023 Dec, Unraveling coagulation factor-mediated cellular signaling. J Thromb Haemost, DOI: 10.1016/j.jtha.2023.06.019
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ, 2023 Jun 14, Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nat Commun, DOI: 10.1038/s41467-023-39174-1
Englert H, Göbel J, Khong D, Omidi M, Wolska N, Konrath S, Frye M, Mailer RK, Beerens M, Gerwers JC, Preston RJS, Odeberg J, Butler LM, Maas C, Stavrou EX, Fuchs TA, Renné T, 2023, Targeting NETs using dual-active DNase1 variants. Front Immunol, DOI: 10.3389/fimmu.2023.1181761
O'Donnell JS, Byrne C, Preston RJS, 2023 Mar, Von Willebrand factor-inflammation crosstalk in deep vein thrombosis. J Thromb Haemost, DOI: 10.1016/j.jtha.2022.11.038
Karampini E, Fogarty H, Elliott S, Morrin H, Bergin C, O'Sullivan JM, Byrne M, Martin-Loeches I, Mallon PW, Curley GF, Glavey S, Baker RI, Lavin M, Preston RJS, Cheallaigh CN, Ward SE, O'Donnell JS, 2023 Feb, Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19. Res Pract Thromb Haemost, DOI: 10.1016/j.rpth.2023.100085
Elsheikh E, Lavin M, Heck LA, Larkin N, Mullaney B, Doherty D, Kennedy M, Keenan C, Guest T, O'Mahony B, Fazavana J, Fallon PG, Preston RJS, Gormley J, Ryan K, O'Connell NM, Singleton E, Byrne M, McGowan M, Roche S, Doyle M, Crowley MP, O'Shea SI, Reipert BM, Johnsen JM, Pipe SW, Di Paola J, Turecek PL, O'Donnell JS, iPATH study group, 2023 May, Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor. J Thromb Haemost, DOI: 10.1016/j.jtha.2023.01.013
Ward SE, Guest T, Byrne C, Lopes P, O'Sullivan JM, Doherty D, O'Connell D, Gutierrez Llaneza S, Chion A, Fazavana J, Fallon PG, Preston RJS, Johnsen JM, Pipe SW, Turecek PL, O'Donnell JS, iPATH Study Group, 2023 Apr, Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report. Arterioscler Thromb Vasc Biol, DOI: 10.1161/ATVBAHA.122.317807
Klavina PA, Leon G, Curtis AM, Preston RJS, 2022 Dec 22, Dysregulated haemostasis in thrombo-inflammatory disease. Clin Sci (Lond), DOI: 10.1042/CS20220208
Konrath S, Mailer RK, Beerens M, Englert H, Frye M, Kuta P, Preston RJS, Maas C, Butler LM, Roest M, de Laat B, Renné T, 2022, Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood. Front Cardiovasc Med, DOI: 10.3389/fcvm.2022.1008410
Cervantes-Silva MP, Carroll RG, Wilk MM, Moreira D, Payet CA, O'Siorain JR, Cox SL, Fagan LE, Klavina PA, He Y, Drewinski T, McGinley A, Buel SM, Timmons GA, Early JO, Preston RJS, Hurley JM, Finlay DK, Schoen I, Javier Sánchez-García F, Mills KHG, Curtis AM, 2022 Dec 5, The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing. Nat Commun, DOI: 10.1038/s41467-022-34897-z
Drakeford C, Aguila S, Roche F, Hokamp K, Fazavana J, Cervantes MP, Curtis AM, Hawerkamp HC, Dhami SPS, Charles-Messance H, Hackett EE, Chion A, Ward S, Ahmad A, Schoen I, Breen E, Keane J, Murphy R, Preston RJS, O'Sullivan JM, Sheedy FJ, Fallon P, O'Donnell JS, 2022 Nov 3, von Willebrand factor links primary hemostasis to innate immunity. Nat Commun, DOI: 10.1038/s41467-022-33796-7
Fogarty H, Ward SE, Townsend L, Karampini E, Elliott S, Conlon N, Dunne J, Kiersey R, Naughton A, Gardiner M, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, Baker RI, Cheallaigh CN, O'Donnell JS, Irish COVID-19 Vasculopathy Study (iCVS) Investigators, 2022 Oct, Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction. J Thromb Haemost, DOI: 10.1111/jth.15830
Leon G, Rehill AM, Preston RJS, 2022 Sep 1, The protein C pathways. Curr Opin Hematol, DOI: 10.1097/MOH.0000000000000726
Ariëns RA, Hunt BJ, Agbani EO, Ahnström J, Ahrends R, Alikhan R, Assinger A, Bagoly Z, Balduini A, Barbon E, Barrett CD, Batty P, Carneiro JDA, Chan WS, de Maat M, de Wit K, Denis C, Ellis MH, Eslick R, Fu H, Hayward CPM, Ho-Tin-Noé B, Klok FA, Kumar R, Leiderman K, Litvinov RI, Mackman N, McQuilten Z, Neal MD, Parker WAE, Preston RJS, Rayes J, Rezaie AR, Roberts LN, Rocca B, Shapiro S, Siegal DM, Sousa LP, Suzuki-Inoue K, Zafar T, Zhou J, 2022 Jul, Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress. Res Pract Thromb Haemost, DOI: 10.1002/rth2.12747
O'Regan N, Gegenbauer K, Gleeson EM, Fukudome K, O'Sullivan JM, Drakeford C, Dalton N, Chion A, Brophy TM, Smith OP, Preston RJS, O'Donnell JS, 2022 Aug 1, Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria. Haematologica, DOI: 10.3324/haematol.2021.280450
Ryan TAJ, Preston RJS, O'Neill LAJ, 2022 Mar 31, Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants. Biochem J, DOI: 10.1042/BCJ20210522
Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2021 Dec 1, Correction: SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin. J Immunol, DOI: 10.4049/jimmunol.2100907
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T, 2021 Sep 22, Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nat Commun, DOI: 10.1038/s41467-021-25888-7
Fogarty H, Townsend L, Morrin H, Ahmad A, Comerford C, Karampini E, Englert H, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, McGonagle D, Ni Cheallaigh C, Baker RI, Renné T, Ward SE, O'Donnell JS, Irish COVID-19 Vasculopathy Study (iCVS) investigators, 2021 Oct, Persistent endotheliopathy in the pathogenesis of long COVID syndrome. J Thromb Haemost, DOI: 10.1111/jth.15490
Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2021 Jul 15, SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin. J Immunol, DOI: 10.4049/jimmunol.2100237
Rehill AM, McCluskey S, O'Donnell JS, Dockal M, Preston RJS, iPATH Study Group, 2021 Mar, Heterogeneity in Bleeding Tendency and Arthropathy Development in Individuals with Hemophilia. Semin Thromb Hemost, DOI: 10.1055/s-0041-1723769
Preston RJS, O'Sullivan JM, 2021 Mar, Personalized Approaches to the Treatment of Hemostatic Disorders. Semin Thromb Hemost, DOI: 10.1055/s-0041-1723800
Rehill AM, Preston RJS, 2020 Sep, A new thrombomodulin-related coagulopathy. J Thromb Haemost, DOI: 10.1111/jth.14987
O'Sullivan JM, Gonagle DM, Ward SE, Preston RJS, O'Donnell JS, 2020 Aug, Endothelial cells orchestrate COVID-19 coagulopathy. Lancet Haematol, DOI: 10.1016/S2352-3026(20)30215-5
Gleeson EM, Rehill AM, Willis Fox O, Ni Ainle F, McDonnell CJ, Rushe HJ, McCluskey S, O'Donnell JS, Preston RJS, 2020 Jun 9, Apolipoprotein A-I enhances activated protein C cytoprotective activity. Blood Adv, DOI: 10.1182/bloodadvances.2019001316
Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ, 2019 Oct 1, Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep, DOI: 10.1016/j.celrep.2019.08.072
Willis Fox O, Preston RJS, 2020 Jan, Molecular basis of protease-activated receptor 1 signaling diversity. J Thromb Haemost, DOI: 10.1111/jth.14643
O'Donnell JS, O'Sullivan JM, Preston RJS, 2019 Jul, Advances in understanding the molecular mechanisms that maintain normal haemostasis. Br J Haematol, DOI: 10.1111/bjh.15872
Preston RJS, O'Sullivan JM, O'Donnell JS, 2019 Jul, Advances in understanding the molecular mechanisms of venous thrombosis. Br J Haematol, DOI: 10.1111/bjh.15869
Aguila S, Lavin M, Dalton N, Patmore S, Chion A, Trahan GD, Jones KL, Keenan C, Brophy TM, O'Connell NM, Ryan K, Byrne M, Nolan M, Patel A, Preston RJS, James P, Di Paola J, O'Sullivan JM, O'Donnell JS, 2019 Apr 4, Increased galactose expression and enhanced clearance in patients with low von Willebrand factor. Blood, DOI: 10.1182/blood-2018-09-874636
Preston RJS, Lisman T, 2018 Mar, Extrahemostatic Functions of Platelets and Coagulation Factors. Semin Thromb Hemost, DOI: 10.1055/s-0037-1612624
Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion A, O'Donnell JS, 2018 Feb 22, A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance. Blood, DOI: 10.1182/blood-2017-06-787853
McDonnell CJ, Soule EE, Walsh PT, O'Donnell JS, Preston RJS, 2018 Mar, The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease. Semin Thromb Hemost, DOI: 10.1055/s-0037-1608910
O'Sullivan JM, Preston RJS, Robson T, O'Donnell JS, 2018 Mar, Emerging Roles for von Willebrand Factor in Cancer Cell Biology. Semin Thromb Hemost, DOI: 10.1055/s-0037-1607352
Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, Preston RJS, Budde U, James P, Di Paola J, O'Donnell JS, 2017 Nov 23, Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels. Blood, DOI: 10.1182/blood-2017-05-786699
Gleeson EM, McDonnell CJ, Soule EE, Willis Fox O, Rushe H, Rehill A, Smith OP, O'Donnell JS, Preston RJS, 2017 Nov, A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective protease-activated receptor 1 signaling. J Thromb Haemost, DOI: 10.1111/jth.13807
Preston RJS, O'Donnell JS, 2017 Jul 27, Microbiome influences von Willebrand factor. Blood, DOI: 10.1182/blood-2017-06-789156
O'Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O'Donnell JS, 2016 Dec, N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor. J Thromb Haemost, DOI: 10.1111/jth.13537
Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS, 2016 Oct 13, N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance. Blood, DOI: 10.1182/blood-2016-04-709436
Heurich M, Preston RJ, O'Donnell VB, Morgan BP, Collins PW, 2016 Sep, Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thromb Res, DOI: 10.1016/j.thromres.2016.07.017
O'Sullivan JM, Jenkins PV, Rawley O, Gegenbauer K, Chion A, Lavin M, Byrne B, O'Kennedy R, Preston RJ, Brophy TM, O'Donnell JS, 2016 May, Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII. Arterioscler Thromb Vasc Biol, DOI: 10.1161/ATVBAHA.115.306915
O'Sullivan JM, Preston RJ, O'Regan N, O'Donnell JS, 2016 May 12, Emerging roles for hemostatic dysfunction in malaria pathogenesis. Blood, DOI: 10.1182/blood-2015-11-636464
O'Regan N, Moxon C, Gegenbauer K, O'Sullivan JM, Chion A, Smith OP, Preston RJ, Brophy TM, Craig AG, O'Donnell JS, 2016 Apr, Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria. Thromb Haemost, DOI: 10.1160/TH15-10-0796
Quinn LM, Drakeford C, O'Donnell JS, Preston RJ, 2015 Aug, Engineering activated protein C to maximize therapeutic efficacy. Biochem Soc Trans, DOI: 10.1042/BST20140312
O'Regan N, Gegenbauer K, O'Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O'Donnell JS, 2016 Mar 3, A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood, DOI: 10.1182/blood-2015-07-654921
Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG, 2016 Feb, The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism. FASEB J, DOI: 10.1096/fj.15-277822
Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ, 2015 Aug 13, Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury. Blood, DOI: 10.1182/blood-2015-03-632877
Rawley O, O'Sullivan JM, Chion A, Keyes S, Lavin M, van Rooijen N, Brophy TM, Fallon P, Preston RJ, O'Donnell JS, 2015 May, von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo. J Thromb Haemost, DOI: 10.1111/jth.12875
Kevane B, Donnelly J, D'Alton M, Cooley S, Preston RJ, Ní Ainle F, 2014 Jul, Risk factors for pregnancy-associated venous thromboembolism: a review. J Perinat Med, DOI: 10.1515/jpm-2013-0207
McGrath RT, van den Biggelaar M, Byrne B, O'Sullivan JM, Rawley O, O'Kennedy R, Voorberg J, Preston RJ, O'Donnell JS, 2013 Dec 12, Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. Blood, DOI: 10.1182/blood-2013-04-496851
Gleeson EM, O'Donnell JS, Hams E, Ní Áinle F, Kenny BA, Fallon PG, Preston RJ, 2014 Jan, Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells. Haematologica, DOI: 10.3324/haematol.2013.086918
Preston RJ, Rawley O, Gleeson EM, O'Donnell JS, 2013 May 9, Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities. Blood, DOI: 10.1182/blood-2012-10-415000
Gleeson EM, O'Donnell JS, Preston RJ, 2012 Mar, The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. Cell Mol Life Sci, DOI: 10.1007/s00018-011-0825-0
Ní Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ, 2011 Jan 14, Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem, DOI: 10.1074/jbc.M110.159475

Please visit PubMed for more information on Roger Preston's publications

    • Bayer HealthCare Pharmaceuticals Hemophilia Award Program – International Special Project Awardee (2017).
    • Guest Editor – Seminars in Thrombosis and Haemostasis Special Issue – ‘Extra Haemostatic Roles for Platelets and Coagulation Factors’. (2017)
    • Associate Editor – Research and Practice in Thrombosis and Haemostasis (2016-present)
    • Associate Editor – Seminars in Thrombosis and Haemostasis. (2015-present)
    • Ad hoc invited reviewer for Blood, Journal of Biological Chemistry, Journal of Thrombosis and Haemostasis, Biochemistry, Thrombosis and Haemostasis, Vascular Pharmacology and Thrombosis Research and others (2006-present).
    • Scientific Secretary of Haematology Association of Ireland (2014-2017).
    • Science Foundation Ireland Career Development Awardee (2016).
    • Daiichi-Sankyo Irish Heart Foundation Bursary Award Winner (2016).
    • Bayer HealthCare Pharmaceuticals Hemophilia Award Program – International Early Career Investigator Award (2013)
    • Novo Nordisk Access-To-Insight International Research Prize
    • Haematology Association of Ireland Inaugural Scholar Award (2010).
    • Science Foundation Ireland Starting Investigator Research Grant Awardee (2009).
    • Health Research Board Research Fellowship Award (2007).