Caitríona (Tríona) Lally


Caitríona (Tríona) Lally

Professor in Bioengineering

Professor Caitríona Lally is a Professor in Bioengineering within the Department of Mechanical and Manufacturing Engineering and Principal Investigator in the Trinity Centre for Bioengineering (TCBE) in Trinity College Dublin (TCD). She received her BEng (Mechanical Engineering) and MEng (Biomedical Engineering) degrees from University of Limerick and in 2004 she obtained a PhD from Trinity College Dublin in the area of arterial biomechanics and cardiovascular stenting. Immediately following her Ph.D., she took up a lecturing position in the School of Mechanical & Manufacturing Engineering at Dublin City University, and was appointed senior lecturer in 2014. She returned to TCD in 2015 as a Professor in Bioengineering.

Professor Lally leads a multidisciplinary research group focused on arterial tissue mechanics, vascular imaging, vascular mechanobiology and tissue engineering. Her goal is to gain critical insights into the role of mechanics in cardiovascular diseases, with particular focus on load induced remodelling and regeneration of arterial tissues at the material and cell level. She aims to develop novel diagnostic techniques for early detection of vascular degeneration and intravascular medical devices for the treatment of vascular disease.

Caitríona (Tríona) Lally

Professor in Bioengineering

Dr. Orla McGee
Position: Postdoctoral Researcher
mcgeeo@tcd.ie

Role:
Researcher

3D printing patient specific nitinol stents for paediatric patients (3DP4Paeds)

Children with heart deformities may require correction to their cardiac anatomy using medical devices such as stents. Stents are metal mesh devices which are implanted in arteries or veins to maintain them open. Currently, such stents are mostly manufactured for adult patients and so use of these devices in children often requires modification of the devices which can limit their safety and effectiveness. In this project we aim to develop a technique whereby stents can be 3D printed from a highly novel material which is very suitable for use in medical devices. These devices will be printed to fit the individual child’s anatomy and will therefore be more likely to provide a better clinical outcome in the long-term.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Mathieu PS, Fitzpatrick E, Di Luca M, Cahill PA, Lally C, 2019 Nov 6, Resident multipotent vascular stem cells exhibit amplitude dependent strain avoidance similar to that of vascular smooth muscle cells. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2019.10.185
Schipani R, Nolan DR, Lally C, Kelly DJ, 2019 Sep 8, Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering. Connect Tissue Res, DOI: 10.1080/03008207.2019.1656720
Clarkin OM, Wu B, Cahill PA, Brougham DF, Banerjee D, Brady SA, Fox EK, Lally C, 2019 Aug 1, Novel injectable gallium-based self-setting glass-alginate hydrogel composite for cardiovascular tissue engineering. Carbohydr Polym, DOI: 10.1016/j.carbpol.2019.04.016
Gaul RT, Nolan DR, Lally C, 2018 Nov 16, The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo. J Biomech, DOI: 10.1016/j.jbiomech.2018.10.006
Whelan A, Duffy J, Gaul RT, O'Reilly D, Nolan DR, Gunning P, Lally C, Murphy BP, 2019 Feb, Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium. J Mech Behav Biomed Mater, DOI: 10.1016/j.jmbbm.2018.09.038
Gaul RT, Nolan DR, Ristori T, Bouten CVC, Loerakker S, Lally C, 2018 Sep 1, Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp. Acta Biomater, DOI: 10.1016/j.actbio.2018.06.037
Ghasemi M, Nolan DR, Lally C, 2018 Dec, An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development. Biomech Model Mechanobiol, DOI: 10.1007/s10237-018-1054-3
Shahid SS, Gaul RT, Kerskens C, Flamini V, Lally C, 2017 Nov 9, Quantifying the ultrastructure of carotid arteries using high-resolution micro-diffusion tensor imaging-comparison of intact versus open cut tissue. Phys Med Biol, DOI: 10.1088/1361-6560/aa9159
Brady SA, Fox EK, Lally C, Clarkin OM, 2017 Nov 15, Optimisation of a novel glass-alginate hydrogel for the treatment of intracranial aneurysms. Carbohydr Polym, DOI: 10.1016/j.carbpol.2017.08.016
Gaul RT, Nolan DR, Lally C, 2017 Nov, Collagen fibre characterisation in arterial tissue under load using SALS. J Mech Behav Biomed Mater, DOI: 10.1016/j.jmbbm.2017.07.036
Galvin E, O'Brien D, Cummins C, Mac Donald BJ, Lally C, 2017 Jun, A strain-mediated corrosion model for bioabsorbable metallic stents. Acta Biomater, DOI: 10.1016/j.actbio.2017.04.020
Galvin E, Cummins C, Yoshihara S, Mac Donald BJ, Lally C, 2017 Aug, Plastic strains during stent deployment have a critical influence on the rate of corrosion in absorbable magnesium stents. Med Biol Eng Comput, DOI: 10.1007/s11517-016-1584-8
Flamini V, Creane AP, Kerskens CM, Lally C, 2015 Jan, Imaging and finite element analysis: a methodology for non-invasive characterization of aortic tissue. Med Eng Phys, DOI: 10.1016/j.medengphy.2014.10.006
Campbell EM, Cahill PA, Lally C, 2012 Oct, Investigation of a small-diameter decellularised artery as a potential scaffold for vascular tissue engineering; biomechanical evaluation and preliminary cell seeding. J Mech Behav Biomed Mater, DOI: 10.1016/j.jmbbm.2012.06.001
Flamini V, Kerskens C, Simms C, Lally C, 2013 Jun, Fibre orientation of fresh and frozen porcine aorta determined non-invasively using diffusion tensor imaging. Med Eng Phys, DOI: 10.1016/j.medengphy.2012.08.008
Zahedmanesh H, Van Oosterwyck H, Lally C, 2014, A multi-scale mechanobiological model of in-stent restenosis: deciphering the role of matrix metalloproteinase and extracellular matrix changes. Comput Methods Biomech Biomed Engin, DOI: 10.1080/10255842.2012.716830
Colombo A, Guha S, Mackle JN, Cahill PA, Lally C, 2013 Aug, Cyclic strain amplitude dictates the growth response of vascular smooth muscle cells in vitro: role in in-stent restenosis and inhibition with a sirolimus drug-eluting stent. Biomech Model Mechanobiol, DOI: 10.1007/s10237-012-0433-4
Maher E, Creane A, Lally C, Kelly DJ, 2012 Aug, An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue. J Mech Behav Biomed Mater, DOI: 10.1016/j.jmbbm.2012.03.001
Brackmann C, Dahlberg JO, Vrana NE, Lally C, Gatenholm P, Enejder A, 2012 May, Non-linear microscopy of smooth muscle cells in artificial extracellular matrices made of cellulose. J Biophotonics, DOI: 10.1002/jbio.201100141
Maher E, Early M, Creane A, Lally C, Kelly DJ, 2012 May 11, Site specific inelasticity of arterial tissue. J Biomech, DOI: 10.1016/j.jbiomech.2012.02.026
Creane A, Maher E, Sultan S, Hynes N, Kelly DJ, Lally C, 2012 Jul, A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations. Biomech Model Mechanobiol, DOI: 10.1007/s10237-011-0358-3
Zahedmanesh H, Lally C, 2012 Mar, A multiscale mechanobiological modelling framework using agent-based models and finite element analysis: application to vascular tissue engineering. Biomech Model Mechanobiol, DOI: 10.1007/s10237-011-0316-0
Maher E, Creane A, Sultan S, Hynes N, Lally C, Kelly DJ, 2011 Sep, Inelasticity of human carotid atherosclerotic plaque. Ann Biomed Eng, DOI: 10.1007/s10439-011-0331-4
Guha S, Cullen JP, Morrow D, Colombo A, Lally C, Walls D, Redmond EM, Cahill PA, 2011 Sep, Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res Cardiol, DOI: 10.1007/s00395-011-0189-5
Creane A, Maher E, Sultan S, Hynes N, Kelly DJ, Lally C, 2011 Dec, Prediction of fibre architecture and adaptation in diseased carotid bifurcations. Biomech Model Mechanobiol, DOI: 10.1007/s10237-010-0277-8
Colombo A, Zahedmanesh H, Toner DM, Cahill PA, Lally C, 2010 Aug, A method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments. J Mech Behav Biomed Mater, DOI: 10.1016/j.jmbbm.2010.04.003
Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, 2010 Jun 28, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents. Philos Trans A Math Phys Eng Sci, DOI: 10.1098/rsta.2010.0071
Zahedmanesh H, John Kelly D, Lally C, 2010 Aug 10, Simulation of a balloon expandable stent in a realistic coronary artery-Determination of the optimum modelling strategy. J Biomech, DOI: 10.1016/j.jbiomech.2010.03.050
Creane A, Maher E, Sultan S, Hynes N, Kelly DJ, Lally C, 2010 Apr, Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. Comput Biol Med, DOI: 10.1016/j.compbiomed.2010.02.006
Maher E, Creane A, Sultan S, Hynes N, Lally C, Kelly DJ, 2009 Dec 11, Tensile and compressive properties of fresh human carotid atherosclerotic plaques. J Biomech, DOI: 10.1016/j.jbiomech.2009.07.032
Prendergast PJ, Lally C, Lennon AB, 2009 May, Finite element modelling of medical devices. Med Eng Phys, DOI: 10.1016/j.medengphy.2009.03.002
Zahedmanesh H, Lally C, 2009 Apr, Determination of the influence of stent strut thickness using the finite element method: implications for vascular injury and in-stent restenosis. Med Biol Eng Comput, DOI: 10.1007/s11517-009-0432-5
Pericevic I, Lally C, Toner D, Kelly DJ, 2009 May, The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents. Med Eng Phys, DOI: 10.1016/j.medengphy.2008.11.005
Early M, Lally C, Prendergast PJ, Kelly DJ, 2009 Feb, Stresses in peripheral arteries following stent placement: a finite element analysis. Comput Methods Biomech Biomed Engin, DOI: 10.1080/10255840903065043
Lally C, Dolan F, Prendergast PJ, 2005 Aug, Cardiovascular stent design and vessel stresses: a finite element analysis. J Biomech, DOI: 10.1016/j.jbiomech.2004.07.022
Lally C, Reid AJ, Prendergast PJ, 2004 Oct, Elastic behavior of porcine coronary artery tissue under uniaxial and equibiaxial tension. Ann Biomed Eng, DOI: 10.1114/b:abme.0000042224.23927.ce
Prendergast PJ, Lally C, Daly S, Reid AJ, Lee TC, Quinn D, Dolan F, 2003 Oct, Analysis of prolapse in cardiovascular stents: a constitutive equation for vascular tissue and finite-element modelling. J Biomech Eng, DOI: 10.1115/1.1613674

Funding Agency:National Children's Research Centre
Project Title:3D printing patient specific nitinol stents for paediatric patients (3DP4Paeds)
Start Date/End Date:May 2019
Total Awarded:€50,000
Role:Principal Investigator
Name:Professor Damien Kenny
DepartmentConsultant Congenital Cardiologist, Our Lady’s Children’s Hospital Crumlin and RCSI Honorary Clinical Associate Professor
Institution:Our Lady’s Children’s Hospital Crumlin & RCSI
Country:Ireland
Name:Professor Moataz Atallah
DepartmentProfessor of Advanced Materials Processing, School of Metallurgy and Materials,
Institution:University of Birmingham
Country:United Kindgom