Prem Puri


Prem Puri

Newman Clinical Research Professor

Professor Prem Puri is the Newman Clinical Research Professor at the UCD School of Medicine and Medical Science. He was the Director of Research at the National Children’s Research Centre (NCRC) from 1989–2009, and President of the NCRC from 2009–2016. He is currently the President of the World Federation of Associations of Paediatric Surgeons (WOFAPS) Foundation. He is Past President of the World Federation of Associations of Pediatric Surgeons (WOFAPS), and Past President of the European Paediatric Surgeons Association (EUPSA). He is Editor-in-Chief of Paediatric Surgery International, and is also on the Editorial Board of several other journals. He was a member of the Health Research Board of Ireland from 2010–2015.

Professor Puri is known internationally for his research into underlying mechanisms causing birth defects, and innovative treatments, which have benefited children all over the world. He has been a visiting professor to many leading universities all over the world, and invited speaker at 230 international scientific meetings. He has published 10 books, 141 chapters in textbooks and over 600 articles in peer-reviewed journals. His research work has been cited over 12,000 times in peer-reviewed articles.

Prem Puri

Newman Clinical Research Professor

Dr Anne Marie O’Donnell
Position: Senior Research Fellow

Dr John Darlow
Position: Senior Research Fellow
John.darlow@olchc.ie

Dr Hiroki Nakamura
Position: Research Fellow
hinakamu@juntendo.ac.jp

The structural and molecular basis of congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the term infant. It occurs about 1 in 2500 births. A diaphragmatic defect permits passage of abdominal viscera into the fetal thorax causing pulmonary hypoplasia, which is the principal contributor to the high mortality of CDH. The high morbidity and mortality in CDH is attributed to severe pulmonary hypoplasia and persistent pulmonary hypertension. The pathogenesis of the diaphragmatic defect and associated pulmonary hypoplasia and persistent pulmonary hypertension is not clearly understood.

Pathogenesis of Hirschsprung’s disease

Hirschsprung’s disease (HD) is a relatively common cause of intestinal obstruction in the newborn, occurring in 1 in 5,000 live births. It is characterized by abnormal development of the nerve supply to varying lengths of the large bowel prior to birth. The gold standard treatment for HD is an operation to remove the diseased bowel to restore normal bowel function. Despite a properly performed operation, a substantial proportion (35-48%) of patients suffer from persisting bowel symptoms such as constipation, soiling and an inflammatory condition of the bowel known as enterocolitis. The mechanisms underlying persistent symptoms post-surgery are poorly understood and understudied. We hypothesis that the ganglionic pulled-through bowel in HD is abnormal.

Genetics of Vesicoureteric Reflux

Primary vesicoureteric reflux (VUR), the reverse flow of urine from bladder to kidneys, is the most common urological anomaly in children. Associated kidney problems, known as reflux nephropathy, are the most common cause of childhood hypertension and renal failure, despite improvements in treatment of VUR. VUR is familial and highly genetically heterogeneous, and there are many questions that need answering. In some children, VUR resolves spontaneously, but in others it does not. Some have associated congenital renal dysplasia (poorly developed kidney) and some do not. Urinary tract infections are more common in children who have VUR than in those who do not, but while some of the children develop kidney scarring, others do not. In some, the scarring may cause raised blood pressure and may progress to kidney failure, but in others it does not. The aim of this project is to identify the genes and mutations that cause VUR.



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Morini F, Zani A, Conforti A, van Heurn E, Eaton S, Puri P, Rintala R, Lukac M, Kuebler JF, Friedmacher F, Wijnen R, Tovar JA, Pierro A, Bagolan P, EUPSA Network Office., 2018 Jun 5, Erratum to: Current Management of Congenital Pulmonary Airway Malformations: A "European Pediatric Surgeons' Association" Survey. Eur J Pediatr Surg, DOI: 10.1055/s-0038-1660778
Puri P, 2018 Jul, In memoriam: Professor Alois F. Schärli. Pediatr Surg Int, DOI: 10.1007/s00383-018-4278-5
Friedmacher F, Colhoun E, Puri P, 2018 Mar 15, Endoscopic Injection of Dextranomer/Hyaluronic Acid as First-Line Treatment in 851 Consecutive Children with High Grade Vesicoureteral Reflux: Efficacy and Long-Term Results. J Urol, DOI: 10.1016/j.juro.2018.03.074
Jain AK, le Roux CW, Puri P, Tavakkoli A, Gletsu-Miller N, Laferrère B, Kellermayer R, DiBaise JK, Martindale RG, Wolfe BM, 2018 Feb, Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut. JPEN J Parenter Enteral Nutr, DOI: 10.1002/jpen.1121
Nakamura H, Tomuschat C, Coyle D, O'Donnel AM, Lim T, Puri P, 2018 Feb, Altered goblet cell function in Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-017-4178-0
Darlow JM, Darlay R, Dobson MG, Stewart A, Charoen P, Southgate J, Baker SC, Xu Y, Hunziker M, Lambert HJ, Green AJ, Santibanez-Koref M, Sayer JA, Goodship THJ, Puri P, Woolf AS, Kenda RB, Barton DE, Cordell HJ, 2018 Jan 8, Publisher Correction: Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux. Sci Rep, DOI: 10.1038/s41598-017-17992-w
Long AM, Bunch KJ, Knight M, Kurinczuk JJ, Losty PD, BAPS-CASS., 2018 Jan 4, Early population-based outcomes of infants born with congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/archdischild-2017-313933
Puri P, 2018 Jan, Editorial. Pediatr Surg Int, DOI: 10.1007/s00383-017-4220-2
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2018 Mar, Gata-6 expression is decreased in diaphragmatic and pulmonary mesenchyme of fetal rats with nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-017-4219-8
Darlow JM, Darlay R, Dobson MG, Stewart A, Charoen P, Southgate J, Baker SC, Xu Y, Hunziker M, Lambert HJ, Green AJ, Santibanez-Koref M, Sayer JA, Goodship THJ, Puri P, Woolf AS, Kenda RB, Barton DE, Cordell HJ, 2017 Nov 6, Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux. Sci Rep, DOI: 10.1038/s41598-017-15062-9
Tani G, Tomuschat C, O'Donnell AM, Coyle D, Puri P, 2017 Oct, Increased population of immature enteric glial cells in the resected proximal ganglionic bowel of Hirschsprung's disease patients. J Surg Res, DOI: 10.1016/j.jss.2017.05.062
Nakamura H, Lim T, Puri P, 2018 Feb, Probiotics for the prevention of Hirschsprung-associated enterocolitis: a systematic review and meta-analysis. Pediatr Surg Int, DOI: 10.1007/s00383-017-4188-y
Nakamura H, Zimmer J, Lim T, Puri P, 2018 Feb, Increased CaSR and TRPC6 pulmonary vascular expression in the nitrofen-induced model of congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-017-4191-3
Nakamura H, Lim T, Puri P, 2018 Feb, Inflammatory bowel disease in patients with Hirschsprung's disease: a systematic review and meta-analysis. Pediatr Surg Int, DOI: 10.1007/s00383-017-4182-4
Puri P, 2018 Feb, The 30th international symposium on paediatric surgical research. Pediatr Surg Int, DOI: 10.1007/s00383-017-4177-1
Hunziker M, O'Donnell AM, Puri P, 2017 Dec, Platelet-derived growth factor receptor alpha-positive cells: a new cell type in the human ureteropelvic junction. Pediatr Res, DOI: 10.1038/pr.2017.193
Morini F, Zani A, Conforti A, van Heurn E, Eaton S, Puri P, Rintala R, Lukac M, Kuebler JF, Friedmacher F, Wijnen R, Tovar JA, Pierro A, Bagolan P, 2018 Feb, Current Management of Congenital Pulmonary Airway Malformations: A "European Pediatric Surgeons' Association" Survey. Eur J Pediatr Surg, DOI: 10.1055/s-0037-1604020
Zimmer J, Takahashi T, Hofmann AD, Puri P, 2018 Feb, Downregulated Elastin Microfibril Interfacer 1 Expression in the Pulmonary Vasculature of Experimental Congenital Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0037-1604026
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2018 Feb, Decreased Expression of Integrin Subunits α3, α6, and α8 in the Branching Airway Mesenchyme of Nitrofen-Induced Hypoplastic Lungs. Eur J Pediatr Surg, DOI: 10.1055/s-0037-1604022
Tomuschat C, O'Donnell AM, Coyle D, Puri P, 2018 Mar, Reduction of hydrogen sulfide synthesis enzymes cystathionine-β-synthase and cystathionine-γ-lyase in the colon of patients with Hirschsprungs disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2017.06.011
Nakamura H, Zimmer J, Puri P, 2018 Feb, Decreased Rac1 Cardiac Expression in Nitrofen-Induced Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0037-1604025
Henderson D, Zimmer J, Nakamura H, Puri P, 2017 Aug, Hirschsprung's disease in twins: a systematic review and meta-analysis. Pediatr Surg Int, DOI: 10.1007/s00383-017-4110-7
Nakamura H, Henderson D, Puri P, 2017 Aug, A meta-analysis of clinical outcome of intestinal transplantation in patients with total intestinal aganglionosis. Pediatr Surg Int, DOI: 10.1007/s00383-017-4107-2
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2017 Jun, Down-regulation of N-deacetylase-N-sulfotransferase-1 signaling in the developing diaphragmatic vasculature of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2017.03.036
Bradnock TJ, Knight M, Kenny S, Nair M, Walker GM, British Association of Paediatric Surgeons Congenital Anomalies Surveillance System., 2017 Aug, Hirschsprung's disease in the UK and Ireland: incidence and anomalies. Arch Dis Child, DOI: 10.1136/archdischild-2016-311872
Tomuschat C, O'Donnell AM, Coyle D, Dreher N, Kelly D, Puri P, 2017 May, NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2017.01.046
Zimmer J, Takahashi T, Hofmann AD, Puri P, 2017 May, Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2017.01.016
Takahashi T, Zimmer J, Friedmacher F, Puri P, 2017 May, Follistatin-like 1 expression is decreased in the alveolar epithelium of hypoplastic rat lungs with nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2017.01.020
Lopez-Rivera E, Liu YP, Verbitsky M, Anderson BR, Capone VP, Otto EA, Yan Z, Mitrotti A, Martino J, Steers NJ, Fasel DA, Vukojevic K, Deng R, Racedo SE, Liu Q, Werth M, Westland R, Vivante A, Makar GS, Bodria M, Sampson MG, Gillies CE, Vega-Warner V, Maiorana M, Petrey DS, Honig B, Lozanovski VJ, Salomon R, Heidet L, Carpentier W, Gaillard D, Carrea A, Gesualdo L, Cusi D, Izzi C, Scolari F, van Wijk JA, Arapovic A, Saraga-Babic M, Saraga M, Kunac N, Samii A, McDonald-McGinn DM, Crowley TB, Zackai EH, Drozdz D, Miklaszewska M, Tkaczyk M, Sikora P, Szczepanska M, Mizerska-Wasiak M, Krzemien G, Szmigielska A, Zaniew M, Darlow JM, Puri P, Barton D, Casolari E, Furth SL, Warady BA, Gucev Z, Hakonarson H, Flogelova H, Tasic V, Latos-Bielenska A, Materna-Kiryluk A, Allegri L, Wong CS, Drummond IA, D'Agati V, Imamoto A, Barasch JM, Hildebrandt F, Kiryluk K, Lifton RP, Morrow BE, Jeanpierre C, Papaioannou VE, Ghiggeri GM, Gharavi AG, Katsanis N, Sanna-Cherchi S, 2017 Feb 23, Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. N Engl J Med, DOI: 10.1056/NEJMoa1609009
O'Donnell AM, Coyle D, Puri P, 2017 Jul, Decreased expression of Kv7 channels in Hirchsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.12.028
Coyle D, Doyle B, Murphy JM, O'Donnell AM, Gillick J, Puri P, 2016 Nov, Expression of connexin 26 and connexin 43 is reduced in Hirschsprung's disease. J Surg Res, DOI: 10.1016/j.jss.2016.08.010
Zani A, Eaton S, Morini F, Puri P, Rintala R, Heurn EV, Lukac M, Bagolan P, Kuebler JF, Friedmacher F, Wijnen R, Tovar JA, Hoellwarth ME, Pierro A, EUPSA Network Office., 2017 Feb, European Paediatric Surgeons' Association Survey on the Management of Hirschsprung Disease. Eur J Pediatr Surg, DOI: 10.1055/s-0036-1593991
Tomuschat C, O'Donnell AM, Coyle D, Puri P, 2017 Feb, Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-016-4011-1
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2017 Feb, Expression of T-box transcription factors 2, 4 and 5 is decreased in the branching airway mesenchyme of nitrofen-induced hypoplastic lungs. Pediatr Surg Int, DOI: 10.1007/s00383-016-4005-z
Zimmer J, Takahashi T, Hofmann AD, Puri P, 2017 Feb, Decreased Endoglin expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr Surg Int, DOI: 10.1007/s00383-016-4004-0
Tomuschat C, O'Donnell AM, Coyle D, Dreher N, Kelly D, Puri P, 2016 Nov, Altered expression of a two-pore domain (K2P) mechano-gated potassium channel TREK-1 in Hirschsprung's disease. Pediatr Res, DOI: 10.1038/pr.2016.140
Puri P, 2016 Dec, The 29th international symposium on paediatric surgical research. Pediatr Surg Int, DOI: 10.1007/s00383-016-3981-3
Takahashi T, Zimmer J, Friedmacher F, Puri P, 2016 Dec, Expression of Prx1 and Tcf4 is decreased in the diaphragmatic muscle connective tissue of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.09.007
Zimmer J, Takahashi T, Hofmann AD, Puri P, 2016 Dec, Downregulation of Forkhead box F1 gene expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-016-3967-1
Tomuschat C, O'Donnell AM, Coyle D, Puri P, 2016 Dec, Increased Act1/IL-17R expression in Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-016-3980-4
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2016 Dec, Decreased Desmin expression in the developing diaphragm of the nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr Surg Int, DOI: 10.1007/s00383-016-3968-0
O'Donnell AM, Coyle D, Puri P, 2016 Nov, Altered expression of retinoblastoma 1 in Hirschsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.07.020
Alvarez LA, Kovačič L, Rodríguez J, Gosemann JH, Kubica M, Pircalabioru GG, Friedmacher F, Cean A, Ghişe A, Sărăndan MB, Puri P, Daff S, Plettner E, von Kriegsheim A, Bourke B, Knaus UG, 2016 Sep 13, NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1605443113
Zimmer J, Takahashi T, Hofmann AD, Puri P, 2017 Feb, Imbalance of NFATc2 and KV1.5 Expression in Rat Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0036-1587589
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2017 Feb, Fibrillin-1 Expression Is Decreased in the Diaphragmatic Muscle Connective Tissue of Nitrofen-Induced Congenital Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0036-1587586
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2016 Oct, Decreased expression of hepatocyte growth factor in the nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-016-3944-8
O'Donnell AM, Coyle D, Puri P, 2016 Nov, Decreased expression of NEDL2 in Hirschsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.06.016
Zimmer J, Tomuschat C, Puri P, 2016 Aug, Long-term results of transanal pull-through for Hirschsprung's disease: a meta-analysis. Pediatr Surg Int, DOI: 10.1007/s00383-016-3908-z
Tomuschat C, Zimmer J, Puri P, 2016 Aug, Laparoscopic-assisted pull-through operation for Hirschsprung's disease: a systematic review and meta-analysis. Pediatr Surg Int, DOI: 10.1007/s00383-016-3910-5
Friedmacher F, Puri P, 2016 Aug, Current practice patterns of rectal suction biopsy in the diagnostic work-up of Hirschsprung's disease: results from an international survey. Pediatr Surg Int, DOI: 10.1007/s00383-016-3907-0
O'Donnell AM, Coyle D, Puri P, 2016 Sep, Decreased Nav1.9 channel expression in Hirschsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.05.007
Coyle D, Murphy JM, Doyle B, O'Donnell AM, Gillick J, Puri P, 2016 May 21, Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis. World J Gastroenterol, DOI: 10.3748/wjg.v22.i19.4662
O'Donnell AM, Coyle D, Puri P, 2016 Mar 28, Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon. World J Gastroenterol, DOI: 10.3748/wjg.v22.i12.3335
Tomuschat C, O'Donnell AM, Coyle D, Dreher N, Kelly D, Puri P, 2016 Jun, Altered expression of ATP-sensitive K(+) channels in Hirschsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.02.060
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2016 Jun, Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.02.050
Coyle D, O'Donnell AM, Gillick J, Puri P, 2016 May, Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.02.018
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2016 May, Increased c-kit and stem cell factor expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2016.02.007
Kutasy B, Friedmacher F, Pes L, Coyle D, Doi T, Paradisi F, Puri P, 2016 Apr, Antenatal retinoic acid administration increases trophoblastic retinol-binding protein dependent retinol transport in the nitrofen model of congenital diaphragmatic hernia. Pediatr Res, DOI: 10.1038/pr.2015.256
Takahashi H, Kutasy B, Friedmacher F, Takahashi T, Puri P, 2016 Feb, Expression of hepatic lipid droplets is decreased in the nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-015-3827-4
Puri P, 2016 Jan, The 28th International Symposium on Paediatric Surgical Research. Pediatr Surg Int, DOI: 10.1007/s00383-015-3805-x
Duess JW, Puri P, Thompson J, 2016 Jan, Impaired cytoskeletal arrangements and failure of ventral body wall closure in chick embryos treated with rock inhibitor (Y-27632). Pediatr Surg Int, DOI: 10.1007/s00383-015-3811-z
Mc Laughlin D, Murphy P, Puri P, 2016 Jan, Notochord manipulation does not impact oesophageal and tracheal formation from isolated foregut in 3D explant culture. Pediatr Surg Int, DOI: 10.1007/s00383-015-3809-6
Tareen F, Mc Laughlin D, Cianci F, Hoare SM, Sweeney B, Mortell A, Puri P, 2016 Jan, Abdominal radiography is not necessary in children with intussusception. Pediatr Surg Int, DOI: 10.1007/s00383-015-3817-6
Zimmer J, Takahashi T, Duess JW, Hofmann AD, Puri P, 2016 Feb, Upregulation of S1P1 and Rac1 receptors in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-015-3825-6
Hofmann AD, Zimmer J, Takahashi T, Gosemann JH, Puri P, 2016 Feb, The Role of Activin Receptor-Like Kinase 1 Signaling in the Pulmonary Vasculature of Experimental Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0035-1566105
Takahashi T, Friedmacher F, Zimmer J, Puri P, 2016 Feb, Mesenchymal expression of the FRAS1/FREM2 gene unit is decreased in the developing fetal diaphragm of nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-015-3824-7
Tomuschat C, O'Donnell AM, Coyle D, Puri P, 2016 Jan, Reduced expression of voltage-gated Kv11.1 (hERG) K(+) channels in aganglionic colon in Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-015-3807-8
Coyle D, Kelly DA, O'Donnell AM, Gillick J, Puri P, 2016 Feb, Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-015-3822-9
Zani A, Eaton S, Puri P, Rintala R, Lukac M, Bagolan P, Kuebler JF, Friedmacher F, Hoellwarth ME, Wijnen R, Tovar JA, Pierro A, EUPSA Network Office., 2016 Feb, International Survey on the Management of Congenital Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0035-1564713
Takahashi T, Friedmacher F, Puri P, 2016 Feb, Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0035-1559884
Coyle D, O'Donnell AM, Corcionivoschi N, Gillick J, Puri P, 2015 Nov, Rho-kinase expression in Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-015-3762-4
Mc Laughlin D, Puri P, 2015 Aug, Familial Hirschsprung's disease: a systematic review. Pediatr Surg Int, DOI: 10.1007/s00383-015-3730-z
Tomuschat C, Puri P, 2015 Aug, RET gene is a major risk factor for Hirschsprung's disease: a meta-analysis. Pediatr Surg Int, DOI: 10.1007/s00383-015-3731-y
Duess JW, Puri P, 2015 Aug, Syndromic Hirschsprung's disease and associated congenital heart disease: a systematic review. Pediatr Surg Int, DOI: 10.1007/s00383-015-3744-6
Friedmacher F, Puri P, 2015 Sep, Rectal suction biopsy for the diagnosis of Hirschsprung's disease: a systematic review of diagnostic accuracy and complications. Pediatr Surg Int, DOI: 10.1007/s00383-015-3742-8
Coyle D, Puri P, 2015 Aug, Hirschsprung's disease in children with Mowat-Wilson syndrome. Pediatr Surg Int, DOI: 10.1007/s00383-015-3732-x
Zimmer J, Puri P, 2015 Sep, Knockout mouse models of Hirschsprung's disease. Pediatr Surg Int, DOI: 10.1007/s00383-015-3747-3
O'Donnell AM, Coyle D, Puri P, 2015 May 14, Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease. World J Gastroenterol, DOI: 10.3748/wjg.v21.i18.5635
Takahashi T, Friedmacher F, Takahashi H, Hofmann AD, Puri P, 2015 Jun, Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2015.03.058
Hofmann AD, Takahashi T, Duess J, Gosemann JH, Puri P, 2015 Jun, Increased expression of activated pSTAT3 and PIM-1 in the pulmonary vasculature of experimental congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2015.03.007
Duess JW, Zani-Ruttenstock EM, Garriboli M, Puri P, Pierro A, Hoellwarth ME, 2015 May, Outcome of right-sided diaphragmatic hernia repair: a multicentre study. Pediatr Surg Int, DOI: 10.1007/s00383-015-3695-y
Coyle D, O'Donnell AM, Puri P, 2015 Oct, Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2015.01.013
Hofmann AD, Friedmacher F, Takahashi T, Gosemann JH, Puri P, 2015 May, Increased pulmonary vascular expression of receptor for advanced glycation end products (RAGE) in experimental congenital diaphragmatic hernia. J Pediatr Surg, DOI: 10.1016/j.jpedsurg.2015.02.024
Zani A, Eaton S, Puri P, Rintala R, Lukac M, Bagolan P, Kuebler JF, Hoellwarth ME, Wijnen R, Tovar J, Pierro A, EUPSA Network., 2015 Feb, International survey on the management of necrotizing enterocolitis. Eur J Pediatr Surg, DOI: 10.1055/s-0034-1387942
Takahashi H, Kutasy B, Pes L, Paradisi F, Puri P, 2015 Jan, Decidual β-carotene-15,15'-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3621-8
Puri P, 2014 Dec, The 27th International Symposium on Paediatric Surgical Research. Pediatr Surg Int, DOI: 10.1007/s00383-014-3604-9
Friedmacher F, Hofmann AD, Takahashi T, Takahashi H, Kutasy B, Puri P, 2014 Dec, Prenatal administration of all-trans retinoic acid upregulates leptin signaling in hypoplastic rat lungs with experimental congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3605-8
Hofmann AD, Takahashi T, Duess JW, Gosemann JH, Puri P, 2014 Dec, Increased pulmonary vascular expression of Krüppel-like factor 5 and activated survivin in experimental congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3606-7
Takahashi T, Friedmacher F, Takahashi H, Hofmann AD, Puri P, 2015 Jan, Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3620-9
Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB, Hadfield KD, Rahal JS, Gardiner NJ, Tanley SW, Lewis MA, Sites E, Angle B, Alves C, Lourenço T, Rodrigues M, Calado A, Amado M, Guerreiro N, Serras I, Beetz C, Varga RE, Silay MS, Darlow JM, Dobson MG, Barton DE, Hunziker M, Puri P, Feather SA, Goodship JA, Goodship TH, Lambert HJ, Cordell HJ, UK VUR Study Group., Saggar A, Kinali M, 4C Study Group., Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS, 2015 Apr, Urinary tract effects of HPSE2 mutations. J Am Soc Nephrol, DOI: 10.1681/ASN.2013090961
Takahashi T, Friedmacher F, Takahashi H, Daniel Hofmann A, Puri P, 2015 Feb, Lysyl oxidase expression is decreased in the developing diaphragm and lungs of nitrofen-induced congenital diaphragmatic hernia. Eur J Pediatr Surg, DOI: 10.1055/s-0034-1386644
Hofmann A, Gosemann JH, Takahashi T, Friedmacher F, Duess JW, Puri P, 2014 Aug, Imbalance of caveolin-1 and eNOS expression in the pulmonary vasculature of experimental diaphragmatic hernia. Birth Defects Res B Dev Reprod Toxicol, DOI: 10.1002/bdrb.21117
Takahashi T, Friedmacher F, Takahashi H, Hofmann AD, Puri P, 2014 Sep, Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3557-z
Friedmacher F, Fujiwara N, Hofmann AD, Takahashi H, Gosemann JH, Puri P, 2014 Oct, Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3549-z
Mc Laughlin D, Friedmacher F, Puri P, 2014 Aug, The impact of Clostridium difficile on paediatric surgical practice: a systematic review. Pediatr Surg Int, DOI: 10.1007/s00383-014-3543-5
Duess JW, Hofmann AD, Puri P, 2014 Aug, Prevalence of Hirschsprung's disease in premature infants: a systematic review. Pediatr Surg Int, DOI: 10.1007/s00383-014-3540-8
Hofmann AD, Duess JW, Puri P, 2014 Aug, Congenital anomalies of the kidney and urinary tract (CAKUT) associated with Hirschsprung's disease: a systematic review. Pediatr Surg Int, DOI: 10.1007/s00383-014-3529-3
Coyle D, Friedmacher F, Puri P, 2014 Aug, The association between Hirschsprung's disease and multiple endocrine neoplasia type 2a: a systematic review. Pediatr Surg Int, DOI: 10.1007/s00383-014-3538-2
Kutasy B, Pes L, Friedmacher F, Paradisi F, Puri P, 2014 Oct, Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia. Pediatr Surg Int, DOI: 10.1007/s00383-014-3525-7

Please visit PubMed for more information on Prem Puri's publications

Funding Agency:Enterprise Ireland
Project Title:Medical Device for Non-invasive Measurement of Urinary Reflux in Children (MURiC)
Start Date/End Date:01/12/2013 – 01/12/2017
Total Awarded:€710,000 with collaborators from Biomedical engineering, University of Galway to develop a medical device for non-invasive measurement of kidney reflux in children.
Role:Co-PI
Funding Agency:Health Research Board
Project Title:Prevention of Postoperative Persistent Bowel Symptoms in Patients with Hirschsprung's Disease
Start Date/End Date:2016-2019
Total Awarded:€301,869
Funding Agency:Health Research Board
Project Title:Genetic basis of reflux nephropathy-related hypertension and renal failure in children
Start Date/End Date:2014-2017
Total Awarded:€329,900