| Sullivan GP, Davidovich P, Muñoz-Wolf N, Ward RW, Hernandez Santana YE, Clancy DM, Gorman A, Najda Z, Turk B, Walsh PT, Lavelle EC, Martin SJ, 2022 Dec 23, Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement. Sci Immunol, DOI: 10.1126/sciimmunol.ade5728 |
| Bone R, Fennell BJ, Tam A, Sheldon R, Nocka K, Varghese S, Chang CS, Hawerkamp HC, Yeow A, Saunders SP, Hams E, Walsh PT, Cunningham O, Fallon PG, 2022 Oct, Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation. Antib Ther, DOI: 10.1093/abt/tbac022 |
| Matarazzo L, Hernandez Santana YE, Walsh PT, Fallon PG, 2022 Jun, The IL-1 cytokine family as custodians of barrier immunity. Cytokine, DOI: 10.1016/j.cyto.2022.155890 |
| Hense JD, Garcia DN, Isola JV, Alvarado-Rincón JA, Zanini BM, Prosczek JB, Stout MB, Mason JB, Walsh PT, Brieño-Enríquez MA, Schadock I, Barros CC, Masternak MM, Schneider A, 2022 Jun, Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary. Geroscience, DOI: 10.1007/s11357-022-00573-9 |
| Leon G, Hernandez Santana YE, Irwin N, Giannoudaki E, O'Neill S, Csizmadia I, Gogarty M, Lee TJ, Ruane D, Long A, Fallon PG, Hussey S, Walsh PT, 2022 Mar, IL-36 cytokines imprint a colitogenic phenotype on CD4(+) T helper cells. Mucosal Immunol, DOI: 10.1038/s41385-022-00488-w |
| Saiz-Gonzalo G, Hanrahan N, Rossini V, Singh R, Ahern M, Kelleher M, Hill S, O'Sullivan R, Fanning A, Walsh PT, Hussey S, Shanahan F, Nally K, O'Driscoll CM, Melgar S, 2021, Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis. Front Immunol, DOI: 10.3389/fimmu.2021.655960 |
| Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2021 Jul 15, SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin. J Immunol, DOI: 10.4049/jimmunol.2100237 |
| Giannoudaki E, Gargan S, Hussey S, Long A, Walsh PT, 2021, Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease. Front Pediatr, DOI: 10.3389/fped.2021.640497 |
| O'Connor EB, Muñoz-Wolf N, Leon G, Lavelle EC, Mills KHG, Walsh PT, Porter RK, 2020, UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation. PLoS One, DOI: 10.1371/journal.pone.0239713 |
| Leon G, Hussey S, Walsh PT, 2021 Feb 16, The Diverse Roles of the IL-36 Family in Gastrointestinal Inflammation and Resolution. Inflamm Bowel Dis, DOI: 10.1093/ibd/izaa232 |
| Hernández-Santana YE, Leon G, St Leger D, Fallon PG, Walsh PT, 2020 Apr, Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice. Life Sci Alliance, DOI: 10.26508/lsa.201900586 |
| Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT, 2019 Sep 5, Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nat Commun, DOI: 10.1038/s41467-019-11944-w |
| Hernandez-Santana YE, Giannoudaki E, Leon G, Lucitt MB, Walsh PT, 2019 Sep, Current perspectives on the interleukin-1 family as targets for inflammatory disease. Eur J Immunol, DOI: 10.1002/eji.201848056 |
| Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG, 2019 Oct, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy, DOI: 10.1111/all.13801 |
| Boland AJ, Gangadharan N, Kavanagh P, Hemeryck L, Kieran J, Barry M, Walsh PT, Lucitt M, 2018 Nov, Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals. J Cardiovasc Pharmacol Ther, DOI: 10.1177/1074248418776261 |
| McDonnell CJ, Soule EE, Walsh PT, O'Donnell JS, Preston RJS, 2018 Mar, The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease. Semin Thromb Hemost, DOI: 10.1055/s-0037-1608910 |
| Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG, 2017 Jul 15, IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. J Immunol, DOI: 10.4049/jimmunol.1602185 |
| Walsh PT, Fallon PG, 2018 Apr, The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases. Ann N Y Acad Sci, DOI: 10.1111/nyas.13280 |
| Sweeney CM, Russell SE, Malara A, Kelly G, Hughes R, Tobin AM, Adamzik K, Walsh PT, Kirby B, 2016 Mar, Human ß-Defensin 3 and Its Mouse Ortholog Murine ß-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice. J Invest Dermatol, DOI: 10.1016/j.jid.2015.12.011 |
| Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT, 2016 Sep, IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation. Mucosal Immunol, DOI: 10.1038/mi.2015.134 |
| Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH, 2016 Jan 15, Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia. J Immunol, DOI: 10.4049/jimmunol.1501820 |
| Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ, 2015 Aug 13, Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury. Blood, DOI: 10.1182/blood-2015-03-632877 |
| Walsh PT, McCreless E, Pedersen AB, 2013 Sep, Faecal avoidance and selective foraging: do wild mice have the luxury to avoid faeces? Anim Behav, DOI: 10.1016/j.anbehav.2013.06.011 |
| Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2013 Sep 15, Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by γδ T cells. J Immunol, DOI: 10.4049/jimmunol.1300828 |
| Podolin PL, Foley JP, Carpenter DC, Bolognese BJ, Logan GA, Long E 3rd, Harrison OJ, Walsh PT, 2013 Mar 1, T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice. Am J Physiol Lung Cell Mol Physiol, DOI: 10.1152/ajplung.00152.2012 |
| Russell SE, Moore AC, Fallon PG, Walsh PT, 2012, Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice. PLoS One, DOI: 10.1371/journal.pone.0047748 |
| Russell SE, Walsh PT, 2012, Sterile inflammation - do innate lymphoid cell subsets play a role? Front Immunol, DOI: 10.3389/fimmu.2012.00246 |
| Carey JB, Pearson FE, Vrdoljak A, McGrath MG, Crean AM, Walsh PT, Doody T, O'Mahony C, Hill AV, Moore AC, 2011, Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice. PLoS One, DOI: 10.1371/journal.pone.0022442 |
| Masters SL, Walsh PT, 2010 Mar 9, Release of the mitochondrial endosymbiont helps explain sterile inflammation. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1000366107 |
| Stefanska AM, Walsh PT, 2009 Apr, Chronic obstructive pulmonary disease: evidence for an autoimmune component. Cell Mol Immunol, DOI: 10.1038/cmi.2009.11 |
| Harrison OJ, Foley J, Bolognese BJ, Long E 3rd, Podolin PL, Walsh PT, 2008 Nov 16, Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett, DOI: 10.1016/j.imlet.2008.07.011 |
| Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA, 2008 Aug 1, Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol, DOI: 10.4049/jimmunol.181.3.1692 |
| Turka LA, Walsh PT, 2008 Jan 1, IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci, DOI: 10.2741/2773 |
| LaRosa DF, Gelman AE, Rahman AH, Zhang J, Turka LA, Walsh PT, 2007 Feb 15, CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett, DOI: 10.1016/j.imlet.2006.12.007 |
| Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA, 2006 Nov, The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity, DOI: 10.1016/j.immuni.2006.08.023 |
| Buckler JL, Walsh PT, Porrett PM, Choi Y, Turka LA, 2006 Oct 1, Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol, DOI: 10.4049/jimmunol.177.7.4262 |
| King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA, Choi Y, 2006 Sep, TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med, DOI: 10.1038/nm1449 |
| Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA, 2006 Sep, PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest, DOI: 10.1172/JCI28057 |
| Taylor DK, Walsh PT, LaRosa DF, Zhang J, Burchill MA, Farrar MA, Turka LA, 2006 Aug 15, Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol, DOI: 10.4049/jimmunol.177.4.2216 |
| Walsh PT, Benoit BM, Wysocka M, Dalton NM, Turka LA, Rook AH, 2006 Mar, A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. J Invest Dermatol, DOI: 10.1038/sj.jid.5700121 |
| Walsh PT, Taylor DK, Turka LA, 2004 Nov, Tregs and transplantation tolerance. J Clin Invest, DOI: 10.1172/JCI23238 |
| Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA, 2004 May 1, Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol, DOI: 10.4049/jimmunol.172.9.5287 |
| Walsh PT, Strom TB, Turka LA, 2004 Feb, Routes to transplant tolerance versus rejection; the role of cytokines. Immunity, DOI: 10.1016/s1074-7613(04)00024-x |
| Smith LM, Walsh PT, Rüdiger T, Cotter TG, Mc Carthy TV, Marx A, O'Connor R, 2004 Jan 15, EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res, DOI: 10.1016/j.yexcr.2003.08.021 |
| Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA, 2003 Dec 1, TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol, DOI: 10.4049/jimmunol.171.11.5751 |
| Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y, 2003 Sep, TRAF6 is a critical factor for dendritic cell maturation and development. Immunity, DOI: 10.1016/s1074-7613(03)00230-9 |
| Chiffoleau E, Walsh PT, Turka L, 2003 Jun, Apoptosis and transplantation tolerance. Immunol Rev, DOI: 10.1034/j.1600-065x.2003.00037.x |
| Walsh PT, Smith LM, O'Connor R, 2002 Dec, Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes. Immunology, DOI: 10.1046/j.1365-2567.2002.01525.x |
| Walsh PT, O'Connor R, 2000 Apr, The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis. Eur J Immunol, DOI: 10.1002/(SICI)1521-4141(200004)30:4<1010::AID-IMMU1010>3.0.CO;2-C |
| Payne MP, Walsh PT, 1994 Jan-Feb, Structure-activity relationships for skin sensitization potential: development of structural alerts for use in knowledge-based toxicity prediction systems. J Chem Inf Comput Sci, DOI: 10.1021/ci00017a019 |
Patrick Walsh