Patrick Walsh

Patrick Walsh

Assistant Professor in Paediatric Immunology

Having earned a PhD in biochemistry at UCC in 2001, Professor Walsh conducted his postdoctoral research in the laboratory of Professor Laurence Turka at the University of Pennsylvania. In 2006, he accepted a position as principal scientist in R&D at GlaxoSmithKline in Philadelphia, before returning to Ireland as a senior scientist and programme manager at the Immunology Research Centre at TCD in 2008. In January 2011, he joined the NCRC as a lecturer in Paediatric Immunology and Principal Investigator on the Paediatric Research in Translational Immunology (PRiTI) programme, which coincided with his receipt of a Science Foundation Ireland President of Ireland Young Researcher award in 2011.

The research conducted by Professor Walsh’s group investigates the mechanisms which control immunity and tolerance, particularly in the context of autoimmune and inflammatory disease conditions. They take a translational research approach, using both preclinical models, and patient samples, to investigate novel mechanisms implicated in the pathogenesis of diseases such as psoriasis and inflammatory bowel disease, with the goal of identifying novel targets for therapeutic intervention. Professor Walsh’s laboratory is located at the National Children’s Research Centre at Our Lady’s Children’s Hospital, Crumlin, allowing close collaboration with paediatric clinician scientists to facilitate these studies. He also collaborates with colleagues in the pharmaceutical drug development industry.

Current areas of investigation include the role of novel Interleukin-1 family members in inflammation and autoimmune disease, as well as understanding the mechanisms through which interleukin-2 acts in the maintenance of immune tolerance. His aim is to translate his groups findings towards the development of improved therapeutics for autoimmune and inflammatory disease in patients.

Patrick Walsh

Assistant Professor in Paediatric Immunology

Dr. Eirini Giannoudaki
Position: Postdoctoral Fellow

Postdoctoral researcher supported by HRB

Dr. Yasmina Hernandez Santana
Position: Postdoctoral Fellow

Postdoctoral researcher supported by the NCRC

Gemma Leon
Position: PhD student

Irish Research Council Employment-Based Postgraduate Scholar

Emma O’Connor
Position: PhD student

Scott fellowship (co-supervised with Professor Richard Porter, School of Biochemistry & Immunology, TCD.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

O'Connor EB, Muñoz-Wolf N, Leon G, Lavelle EC, Mills KHG, Walsh PT, Porter RK, 2020, UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation. PLoS One, DOI: 10.1371/journal.pone.0239713
Leon G, Hussey S, Walsh PT, 2020 Aug 29, The Diverse Roles of the IL-36 Family in Gastrointestinal Inflammation and Resolution. Inflamm Bowel Dis, DOI: 10.1093/ibd/izaa232
Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT, 2019 Sep 5, Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nat Commun, DOI: 10.1038/s41467-019-11944-w
Hernandez-Santana YE, Giannoudaki E, Leon G, Lucitt MB, Walsh PT, 2019 Sep, Current perspectives on the interleukin-1 family as targets for inflammatory disease. Eur J Immunol, DOI: 10.1002/eji.201848056
Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG, 2019 Oct, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy, DOI: 10.1111/all.13801
Boland AJ, Gangadharan N, Kavanagh P, Hemeryck L, Kieran J, Barry M, Walsh PT, Lucitt M, 2018 Nov, Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals. J Cardiovasc Pharmacol Ther, DOI: 10.1177/1074248418776261
McDonnell CJ, Soule EE, Walsh PT, O'Donnell JS, Preston RJS, 2018 Mar, The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease. Semin Thromb Hemost, DOI: 10.1055/s-0037-1608910
Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG, 2017 Jul 15, IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. J Immunol, DOI: 10.4049/jimmunol.1602185
Walsh PT, Fallon PG, 2018 Apr, The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases. Ann N Y Acad Sci, DOI: 10.1111/nyas.13280
Sweeney CM, Russell SE, Malara A, Kelly G, Hughes R, Tobin AM, Adamzik K, Walsh PT, Kirby B, 2016 Mar, Human ß-Defensin 3 and Its Mouse Ortholog Murine ß-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice. J Invest Dermatol, DOI: 10.1016/j.jid.2015.12.011
Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT, 2016 Sep, IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation. Mucosal Immunol, DOI: 10.1038/mi.2015.134
Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH, 2016 Jan 15, Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia. J Immunol, DOI: 10.4049/jimmunol.1501820
Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ, 2015 Aug 13, Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury. Blood, DOI: 10.1182/blood-2015-03-632877
Walsh PT, McCreless E, Pedersen AB, 2013 Sep, Faecal avoidance and selective foraging: do wild mice have the luxury to avoid faeces? Anim Behav, DOI: 10.1016/j.anbehav.2013.06.011
Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, Fallon PG, Walsh PT, 2013 Sep 15, Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by γδ T cells. J Immunol, DOI: 10.4049/jimmunol.1300828
Podolin PL, Foley JP, Carpenter DC, Bolognese BJ, Logan GA, Long E 3rd, Harrison OJ, Walsh PT, 2013 Mar 1, T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice. Am J Physiol Lung Cell Mol Physiol, DOI: 10.1152/ajplung.00152.2012
Russell SE, Moore AC, Fallon PG, Walsh PT, 2012, Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice. PLoS One, DOI: 10.1371/journal.pone.0047748
Russell SE, Walsh PT, 2012, Sterile inflammation - do innate lymphoid cell subsets play a role? Front Immunol, DOI: 10.3389/fimmu.2012.00246
Carey JB, Pearson FE, Vrdoljak A, McGrath MG, Crean AM, Walsh PT, Doody T, O'Mahony C, Hill AV, Moore AC, 2011, Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice. PLoS One, DOI: 10.1371/journal.pone.0022442
Masters SL, Walsh PT, 2010 Mar 9, Release of the mitochondrial endosymbiont helps explain sterile inflammation. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1000366107
Stefanska AM, Walsh PT, 2009 Apr, Chronic obstructive pulmonary disease: evidence for an autoimmune component. Cell Mol Immunol, DOI: 10.1038/cmi.2009.11
Harrison OJ, Foley J, Bolognese BJ, Long E 3rd, Podolin PL, Walsh PT, 2008 Nov 16, Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett, DOI: 10.1016/j.imlet.2008.07.011
Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA, 2008 Aug 1, Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol, DOI: 10.4049/jimmunol.181.3.1692
Turka LA, Walsh PT, 2008 Jan 1, IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci, DOI: 10.2741/2773
LaRosa DF, Gelman AE, Rahman AH, Zhang J, Turka LA, Walsh PT, 2007 Feb 15, CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett, DOI: 10.1016/j.imlet.2006.12.007
Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA, 2006 Nov, The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity, DOI: 10.1016/j.immuni.2006.08.023
Buckler JL, Walsh PT, Porrett PM, Choi Y, Turka LA, 2006 Oct 1, Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol, DOI: 10.4049/jimmunol.177.7.4262
King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA, Choi Y, 2006 Sep, TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med, DOI: 10.1038/nm1449
Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA, 2006 Sep, PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest, DOI: 10.1172/JCI28057
Taylor DK, Walsh PT, LaRosa DF, Zhang J, Burchill MA, Farrar MA, Turka LA, 2006 Aug 15, Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol, DOI: 10.4049/jimmunol.177.4.2216
Walsh PT, Benoit BM, Wysocka M, Dalton NM, Turka LA, Rook AH, 2006 Mar, A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. J Invest Dermatol, DOI: 10.1038/sj.jid.5700121
Walsh PT, Taylor DK, Turka LA, 2004 Nov, Tregs and transplantation tolerance. J Clin Invest, DOI: 10.1172/JCI23238
Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA, 2004 May 1, Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol, DOI: 10.4049/jimmunol.172.9.5287
Walsh PT, Strom TB, Turka LA, 2004 Feb, Routes to transplant tolerance versus rejection; the role of cytokines. Immunity, DOI: 10.1016/s1074-7613(04)00024-x
Smith LM, Walsh PT, Rüdiger T, Cotter TG, Mc Carthy TV, Marx A, O'Connor R, 2004 Jan 15, EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res, DOI: 10.1016/j.yexcr.2003.08.021
Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA, 2003 Dec 1, TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol, DOI: 10.4049/jimmunol.171.11.5751
Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y, 2003 Sep, TRAF6 is a critical factor for dendritic cell maturation and development. Immunity, DOI: 10.1016/s1074-7613(03)00230-9
Chiffoleau E, Walsh PT, Turka L, 2003 Jun, Apoptosis and transplantation tolerance. Immunol Rev, DOI: 10.1034/j.1600-065x.2003.00037.x
Walsh PT, Smith LM, O'Connor R, 2002 Dec, Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes. Immunology, DOI: 10.1046/j.1365-2567.2002.01525.x
Walsh PT, O'Connor R, 2000 Apr, The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis. Eur J Immunol, DOI: 10.1002/(SICI)1521-4141(200004)30:4<1010::AID-IMMU1010>3.0.CO;2-C
Payne MP, Walsh PT, 1994 Jan-Feb, Structure-activity relationships for skin sensitization potential: development of structural alerts for use in knowledge-based toxicity prediction systems. J Chem Inf Comput Sci, DOI: 10.1021/ci00017a019

Funding Agency:National Children’s Research Foundation
Start Date/End Date:Jan 2017-Dec 2019
Funding Agency:Health Research Board
Start Date/End Date:March 2016-Feb 2019
Funding Agency:Irish Research Council
Start Date/End Date:Oct 2016-Sept 2020
Funding Agency:Broad Biomedical Research Program @ Crohn’s Colitis Foundation
Start Date/End Date:March 2016-April 2017
Name:Dr. Devon Taylor
Institution:Medimmune LLC
Name:Professor Padraic Fallon
DepartmentClinical Medicine
Institution:Trinity College Dublin
Name:Dr. Séamus Hussey
Name:Dr. Roger Preston
DepartmentMolecular and Cellular Therapeutics
Institution:Royal College of Surgeons
Name:Dr. Silvia Melgar
Institution:University College Cork