Owen Smith


Owen Smith

Consultant Paediatric Haematologist, Professor

Professor of Paediatric and Adolescent Medicine, UCD; Consultant Paediatric Haematologist, Our Lady’s Children’s Hospital, Crumlin; Chief Academic Lead to the Children’s Hospital Group; Hon. Regius Professor of Physic [1637], TCD

Professor Owen Smith CBE is a principal investigator at the National Children’s Research Centre, Crumlin and Systems Biology Ireland, University College Dublin. His two main areas of research have focused on evidence-based randomised peer-reviewed haemato-oncology clinical trials with a focus on clinical questions within all domains of paediatric and adolescent blood and cancer and the elucidation of the relationship between the protein C activation pathway and systemic inflammatory response sepsis syndromes.

One of Professor Smiths’ major contributions to Irish medicine has been through the promotion of clinical research as evidenced by; a significant expansion of clinical paediatric scholarship with excellent research outputs, a strengthening of national and international academic collaborations, and the nurturing, education, and career development of the present generation of Irish consultant paediatric haematologists. In addition, Professor Smith’s has a strong record of championing significant national developments in child and adolescent health in this country over the two decades.

In 2015 Professor Smith conferred honorary Commander in the Most Excellent Order of the British Empire (CBE) for his life-long work on cancer in children and adolescents by Queen Elizabeth, on the advice of the Foreign and Commonwealth Office.

Owen Smith

Consultant Paediatric Haematologist, Professor



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Tummala H, Dokal AD, Walne A, Ellison A, Cardoso S, Amirthasigamanipillai S, Kirwan M, Browne I, Sidhu JK, Rajeeve V, Rio-Machin A, Seraihi AA, Duncombe AS, Jenner M, Smith OP, Enright H, Norton A, Aksu T, Özbek NY, Pontikos N, Cutillas P, Dokal I, Vulliamy T, 2018 Jul 24, Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1803275115
Malone A, Smith OP, 2017 Oct, Nelarabine toxicity in children and adolescents with relapsed/refractory T-ALL/T-LBL: can we avoid throwing the baby out with the bathwater? Br J Haematol, DOI: 10.1111/bjh.14875
Gleeson EM, McDonnell CJ, Soule EE, Willis Fox O, Rushe H, Rehill A, Smith OP, O'Donnell JS, Preston RJS, 2017 Nov, A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective protease-activated receptor 1 signaling. J Thromb Haemost, DOI: 10.1111/jth.13807
Malone A, Wlodarski M, Nolan B, Smyth L, Smith OP, 2017 Apr, Transient myeloproliferative disorder in an infant with PTPN11 mutation. Br J Haematol, DOI: 10.1111/bjh.14517
O'Rafferty C, O'Brien M, Smyth E, Keane S, Robinson H, Lynam P, O'Marcaigh A, Smith OP, 2016 May, Administration of G-CSF from day +6 post-allogeneic hematopoietic stem cell transplantation in children and adolescents accelerates neutrophil engraftment but does not appear to have an impact on cost savings. Pediatr Transplant, DOI: 10.1111/petr.12670
Cseh AM, Niemeyer CM, Yoshimi A, Catala A, Frühwald MC, Hasle H, van den Heuvel-Eibrink MM, Lauten M, De Moerloose B, Smith OP, Bernig T, Gruhn B, Kulozik AE, Metzler M, Olcay L, Suttorp M, Furlan I, Strahm B, Flotho C, 2016 Mar, Therapy with low-dose azacitidine for MDS in children and young adults: a retrospective analysis of the EWOG-MDS study group. Br J Haematol, DOI: 10.1111/bjh.13915
Wlodarski MW, Hirabayashi S, Pastor V, Starý J, Hasle H, Masetti R, Dworzak M, Schmugge M, van den Heuvel-Eibrink M, Ussowicz M, De Moerloose B, Catala A, Smith OP, Sedlacek P, Lankester AC, Zecca M, Bordon V, Matthes-Martin S, Abrahamsson J, Kühl JS, Sykora KW, Albert MH, Przychodzien B, Maciejewski JP, Schwarz S, Göhring G, Schlegelberger B, Cseh A, Noellke P, Yoshimi A, Locatelli F, Baumann I, Strahm B, Niemeyer CM, EWOG-MDS., 2016 Mar 17, Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents. Blood, DOI: 10.1182/blood-2015-09-669937
Foley RW, Aworanti OM, Gorman L, McGovern B, O'Sullivan M, Smith OP, Twomey E, Gillick J, 2016 Apr, Unusual childhood presentations of abdominal non-Hodgkin's lymphoma. Pediatr Int, DOI: 10.1111/ped.12807
Piccin A, Murphy C, Eakins E, Kunde J, Corvetta D, Di Pierro A, Negri G, Guido M, Sainati L, Mc Mahon C, Smith OP, Murphy W, 2015, Circulating microparticles, protein C, free protein S and endothelial vascular markers in children with sickle cell anaemia. J Extracell Vesicles, DOI: 10.3402/jev.v4.28414
O'Regan N, Gegenbauer K, O'Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O'Donnell JS, 2016 Mar 3, A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood, DOI: 10.1182/blood-2015-07-654921
Zwaan CM, Kolb EA, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R, De Bont ES, De Moerloose B, Dworzak M, Gibson BE, Hasle H, Leverger G, Locatelli F, Ragu C, Ribeiro RC, Rizzari C, Rubnitz JE, Smith OP, Sung L, Tomizawa D, van den Heuvel-Eibrink MM, Creutzig U, Kaspers GJ, 2015 Sep 20, Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia. J Clin Oncol, DOI: 10.1200/JCO.2015.62.8289
O'Rafferty C, O'Regan GM, Irvine AD, Smith OP, 2015 Oct, Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon. Br J Haematol, DOI: 10.1111/bjh.13557
O'Rafferty C, O'Regan GM, Irvine AD, Smith OP, 2015 Oct, Kasabach-Merritt syndrome, kaposiform haemangioendothelioma and platelet blockade. Br J Haematol, DOI: 10.1111/bjh.13558
Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ, 2015 Aug 13, Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury. Blood, DOI: 10.1182/blood-2015-03-632877
Niemeyer CM, Loh ML, Cseh A, Cooper T, Dvorak CC, Chan R, Xicoy B, Germing U, Kojima S, Manabe A, Dworzak M, De Moerloose B, Starý J, Smith OP, Masetti R, Catala A, Bergstraesser E, Ussowicz M, Fabri O, Baruchel A, Cavé H, Zwaan M, Locatelli F, Hasle H, van den Heuvel-Eibrink MM, Flotho C, Yoshimi A, 2015 Jan, Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia. Haematologica, DOI: 10.3324/haematol.2014.109892
Piccin A, O' Marcaigh A, Mc Mahon C, Murphy C, Okafor I, Marcheselli L, Casey W, Claffey L, Smith OP, 2014 Jul, Non-activated plasma-derived PC improves amputation rate of children undergoing sepsis. Thromb Res, DOI: 10.1016/j.thromres.2014.04.019
Creutzig U, Zimmermann M, Dworzak MN, Gibson B, Tamminga R, Abrahamsson J, Ha SY, Hasle H, Maschan A, Bertrand Y, Leverger G, von Neuhoff C, Razzouk B, Rizzari C, Smisek P, Smith OP, Stark B, Reinhardt D, Kaspers GL, 2014 Sep, The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01. Haematologica, DOI: 10.3324/haematol.2014.104182
Langabeer SE, Smith OP, McMahon C, 2014 Mar, The JAK2 V617F mutation in pediatric myeloproliferative neoplasms: how and when? Pediatr Hematol Oncol, DOI: 10.3109/08880018.2013.869288
Elder PT, Cairns C, Dick A, McCallion WA, McCarthy A, Smith OP, Macartney C, 2014 Jul, A severe bleeding diathesis in a 6-year-old girl secondary to a composite diagnosis of splenic hemangiomatosis and small bowel lymphangiomatosis. J Pediatr Hematol Oncol, DOI: 10.1097/MPH.0000000000000012
Leahy TR, Smith OP, Bacon CL, Storey L, Lynam P, Gavin PJ, Butler KM, O'Marcaigh AS, 2013 Oct, Does vaccine dose predict response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study. Pediatr Blood Cancer, DOI: 10.1002/pbc.24589
Krawczyk J, Maguire S, Sandys N, Kelly J, Ryan C, O'Marcaigh A, Storey L, Rooney S, Phillips C, Smith OP, 2013 Sep, In search of Pinkel's children: unravelling the biological heterogeneity of childhood acute lymphoblastic leukaemia by genotype and treatment molecular response. Ir J Med Sci, DOI: 10.1007/s11845-012-0892-8
Krawczyk J, Haslam K, Lynam P, Kelly J, Storey L, O'Marcaigh A, Langabeer SE, Smith OP, 2013 Feb, No prognostic impact of P2RY8-CRLF2 fusion in intermediate cytogenetic risk childhood B-cell acute lymphoblastic leukaemia. Br J Haematol, DOI: 10.1111/bjh.12130
Gleeson M, O'Marcaigh A, Cotter M, Brosnahan D, Vulliamy T, Smith OP, 2012 Dec, Retinal vasculopathy in autosomal dominant dyskeratosis congenita due to TINF2 mutation. Br J Haematol, DOI: 10.1111/bjh.12088
Rao U, Piccin A, Malone A, O'Hanlon K, Breatnach F, O'Meara A, McDermott M, Butler K, O'Sullivan N, Russell J, O'Marcaigh A, Smith OP, 2013 Jun, Utility of bronchoalveolar lavage in the diagnosis of pulmonary infection in children with haematological malignancies. Ir J Med Sci, DOI: 10.1007/s11845-012-0852-3
Smith OP, 2012 Mar, Foreword for Burkitt lymphoma special issue. Br J Haematol, DOI: 10.1111/j.1365-2141.2012.09041.x
Alkindi S, Smith OP, Enright H, 2011 Aug, Successful Use of Alternative Anticoagulants in the Management of Heparin-induced Thrombocytopenia with Thrombotic Complications: Report of 5 cases and review of literature. Sultan Qaboos Univ Med J, DOI: 10.1111/j.1365-2141.2012.09041.x
Keohane C, Bacon CL, Moran B, Irvine AD, Smith OP, 2011 Feb, Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by cidofovir. Pediatr Transplant, DOI: 10.1111/j.1399-3046.2010.01387.x
Curry S, Bacon CL, Robinson I, Capra M, Smith OP, 2010 Nov, Leukaemic alveolar rhabdomyosarcoma. Br J Haematol, DOI: 10.1111/j.1365-2141.2010.08338.x
Langabeer SE, Owen CJ, McCarron SL, Fitzgibbon J, Smith OP, O'Marcaigh A, Browne P, 2010 Dec, A novel RUNX1 mutation in a kindred with familial platelet disorder with propensity to acute myeloid leukaemia: male predominance of affected individuals. Eur J Haematol, DOI: 10.1111/j.1600-0609.2010.01513.x
Malone A, Langabeer S, O'Marcaigh A, Storey L, Bacon CL, Smith OP, 2010 Oct, A doctor(s) dilemma: ETV6-ABL1 positive acute lymphoblastic leukaemia. Br J Haematol, DOI: 10.1111/j.1365-2141.2010.08323.x
Piccin A, Cortelazzo S, Rovigatti U, Bourke B, Smith OP, 2010 Aug, Immunosuppressive treatments in Crohn's disease induce myelodysplasia and leukaemia. Am J Hematol, DOI: 10.1002/ajh.21755
Bruneau JC, O'Marcaigh A, Smith OP, 2010 Sep, Gemtuzumab ozogamicin (Mylotarg) upregulates tissue factor expression but not secretion of inflammatory cytokines TNF-alpha or IL-8. Leuk Res, DOI: 10.1016/j.leukres.2010.04.008
Sargent JT, Smith OP, 2010 May, Haematological emergencies managing hypercalcaemia in adults and children with haematological disorders. Br J Haematol, DOI: 10.1111/j.1365-2141.2010.08173.x
Kelly K, Storey L, O' Sullivan M, Butler K, McDermott M, Corbally M, McMahon C, Smith OP, O' Marcaigh A, 2010 Mar, Esophageal strictures during treatment for acute lymphoblastic leukemia. J Pediatr Hematol Oncol, DOI: 10.1097/MPH.0b013e3181ced25c
Bruneau JC, O'Marcaigh A, Smith OP, 2010 Jan, Pro-inflammatory and pro-coagulant properties of 6-thioguanine and 6-mercaptopurine: implications for their potential role in the development of sinusoidal obstruction syndrome. Leuk Lymphoma, DOI: 10.3109/10428190903370353
Smith OP, 2009 Mar, Thrombotic complications in children with cancer. Vnitr Lek, DOI: 10.3109/10428190903370353
Beel K, Cotter MM, Blatny J, Bond J, Lucas G, Green F, Vanduppen V, Leung DW, Rooney S, Smith OP, Rosen MK, Vandenberghe P, 2009 Jan, A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. Br J Haematol, DOI: 10.1111/j.1365-2141.2008.07416.x
Kelly K, McMahon C, Langabeer S, Eliwan H, O'Marcaigh A, Smith OP, 2008 Nov 15, Congenital JAK2V617F polycythemia vera: where does the genotype-phenotype diversity end? Blood, DOI: 10.1182/blood-2008-08-175620
Piccin A, Fleming P, Eakins E, McGovern E, Smith OP, McMahon C, 2008 Apr-May, Sickle cell disease and dental treatment. J Ir Dent Assoc, DOI: 10.1182/blood-2008-08-175620
Piccin A, Russell JD, Fleming P, Butler K, McDermott M, Smith OP, O'Marcaigh A, 2008 Feb, Invasive rhino-maxillary mucormycosis diagnosed before HSCT. Pediatr Blood Cancer, DOI: 10.1002/pbc.20994
Jabbour HN, Sales KJ, Smith OP, Battersby S, Boddy SC, 2006 Jun 27, Prostaglandin receptors are mediators of vascular function in endometrial pathologies. Mol Cell Endocrinol, DOI: 10.1016/j.mce.2006.03.025
Cotter M, Connell T, Colhoun E, Smith OP, McMahon C, 2005 Feb, Carbonic anhydrase II deficiency: a rare autosomal recessive disorder of osteopetrosis, renal tubular acidosis, and cerebral calcification. J Pediatr Hematol Oncol, DOI: 10.1016/j.mce.2006.03.025
Cotter M, Gulmann C, Jeffers M, Smith OP, 2004 Aug, Increased bone marrow angiogenesis in children with severe chronic neutropenia treated with granulocyte colony-stimulating factor. J Pediatr Hematol Oncol, DOI: 10.1016/j.mce.2006.03.025
Laffan M, O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy D, Smith OP, 2003 Jun, Analysis and results of the recombinant factor VIIa extended-use registry. Blood Coagul Fibrinolysis, DOI: 10.1016/j.mce.2006.03.025
Cotter M, Rooney S, O'Marcaigh A, Smith OP, 2003 Aug, Successful use of gemtuzumab ozogamicin in a child with relapsed CD33-positive acute lymphoblastic leukaemia. Br J Haematol, DOI: 10.1016/j.mce.2006.03.025
Zwaan CM, Reinhardt D, Jürgens H, Huismans DR, Hählen K, Smith OP, Biondi A, van Wering ER, Feingold J, Kaspers GJ, 2003 Feb, Gemtuzumab ozogamicin in pediatric CD33-positive acute lymphoblastic leukemia: first clinical experiences and relation with cellular sensitivity to single agent calicheamicin. Leukemia, DOI: 10.1038/sj.leu.2402749
Pulè MA, Gullmann C, Dennis D, McMahon C, Jeffers M, Smith OP, 2002 Sep, Increased angiogenesis in bone marrow of children with acute lymphoblastic leukaemia has no prognostic significance. Br J Haematol, DOI: 10.1038/sj.leu.2402749
McMahon C, Callaghan CO, O'Brien D, Smith OP, 2001 Jul-Sep, The increasing prevalence of childhood sickle-cell disease in Ireland. Ir J Med Sci, DOI: 10.1038/sj.leu.2402749
Smith OP, 2002 Apr, Shwachman-Diamond syndrome. Semin Hematol, DOI: 10.1038/sj.leu.2402749
Philpott N, Kelleher BP, Smith OP, O'Broin SD, 2001 Feb, High serum folates and the simplification of red cell folate analysis. Clin Lab Haematol, DOI: 10.1038/sj.leu.2402749
McMahon C, Will A, Hu P, Shah GN, Sly WS, Smith OP, 2001 Apr 1, Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome. Blood, DOI: 10.1038/sj.leu.2402749
O'Broin SD, Kelleher BP, McPartlin J, O'Gorman P, Browne M, White B, Smith OP, 2000 Jun, Optimization of routine plasma homocysteine monitoring. Blood Coagul Fibrinolysis, DOI: 10.1038/sj.leu.2402749
Smith OP, Cox J, 1999 Nov, Historical review. Inherited bone marrow failure: the men behind the empty space. Br J Haematol, DOI: 10.1038/sj.leu.2402749
White B, Martin M, Kelleher S, Browne P, McCann SR, Smith OP, 1999 Jul, Successful use of recombinant FVIIa (Novoseven) in the management of pulmonary haemorrhage secondary to Aspergillus infection in a patient with leukaemia and acquired FVII deficiency. Br J Haematol, DOI: 10.1038/sj.leu.2402749
Vulliamy TJ, Knight SW, Heiss NS, Smith OP, Poustka A, Dokal I, Mason PJ, 1999 Aug 15, Dyskeratosis congenita caused by a 3' deletion: germline and somatic mosaicism in a female carrier. Blood, DOI: 10.1038/sj.leu.2402749
Schulman S, Wallensten R, White B, Smith OP, 1999 Mar, Efficacy of a high purity, chemically treated and nanofiltered factor IX concentrate for continuous infusion in haemophilia patients undergoing surgery. Haemophilia, DOI: 10.1038/sj.leu.2402749
Smith OP, White B, Vaughan D, Rafferty M, Claffey L, Lyons B, Casey W, 1997 Nov 29, Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet, DOI: 10.1038/sj.leu.2402749
Smith OP, Hann IM, Chessells JM, Reeves BR, Milla P, 1996 Aug, Haematological abnormalities in Shwachman-Diamond syndrome. Br J Haematol, DOI: 10.1038/sj.leu.2402749
Smith OP, Chan MY, Evans J, Veys P, 1995 Nov, Shwachman-Diamond syndrome and matched unrelated donor BMT. Bone Marrow Transplant, DOI: 10.1038/sj.leu.2402749
Smith OP, Reeves BR, Kempski HM, Evans JP, 1995 Sep, Kostmann's disease, recombinant HuG-CSF, monosomy 7 and MDS/AML. Br J Haematol, DOI: 10.1038/sj.leu.2402749
Smith OP, Hann IM, Cox H, Novelli V, 1995 Aug, Visceral leishmaniasis: rapid response to AmBisome treatment. Arch Dis Child, DOI: 10.1038/sj.leu.2402749
Smith OP, Hann IM, Woodward CE, Brockington M, 1995 Jun, Pearson's marrow/pancreas syndrome: haematological features associated with deletion and duplication of mitochondrial DNA. Br J Haematol, DOI: 10.1038/sj.leu.2402749
Smith OP, Hoffbrand AV, Buckley C, 1994 May 26, Fludarabine and psoriasis. N Engl J Med, DOI: 10.1056/NEJM199405263302118
Smith OP, Gale R, Hamon M, McWhinney P, Prentice HG, 1994 Jan, Amphotericin B-induced nephrogenic diabetes insipidus: resolution with its liposomal counterpart. Bone Marrow Transplant, DOI: 10.1056/NEJM199405263302118
Hamon MD, Gale RF, Macdonald ID, Smith OP, Collis CH, Skeggs DB, Gandhi L, Prentice HG, 1993 Sep, Incidence of cataracts after single fraction total body irradiation: the role of steroids and graft versus host disease. Bone Marrow Transplant, DOI: 10.1056/NEJM199405263302118
McWhinney PH, Kibbler CC, Hamon MD, Smith OP, Gandhi L, Berger LA, Walesby RK, Hoffbrand AV, Prentice HG, 1993 Sep, Progress in the diagnosis and management of aspergillosis in bone marrow transplantation: 13 years' experience. Clin Infect Dis, DOI: 10.1056/NEJM199405263302118
Hamon MD, Prentice HG, Gottlieb DJ, Macdonald ID, Cunningham JM, Smith OP, Gilmore M, Gandhi L, Collis C, 1993 May, Immunotherapy with interleukin 2 after ABMT in AML. Bone Marrow Transplant, DOI: 10.1056/NEJM199405263302118
Gale R, Smith OP, Wood M, Mehta AB, 1992 Oct 31, Splenic lymphoma with villous lymphocytes complicated by autoimmune haemolytic anaemia. Lancet, DOI: 10.1056/NEJM199405263302118
Whelan JS, Davis CL, Rule S, Ranson M, Smith OP, Mehta AB, Catovsky D, Rohatiner AZ, Lister TA, 1991 Jul, Fludarabine phosphate for the treatment of low grade lymphoid malignancy. Br J Cancer, DOI: 10.1056/NEJM199405263302118
Smith OP, Prentice HG, Hazlehurst G, Brozovic B, Hoffbrand AV, Mehta AB, 1991, Blood product support in patients undergoing chemotherapy and autologous or allogeneic bone marrow transplantation for haematological malignancies. Clin Lab Haematol, DOI: 10.1056/NEJM199405263302118
Madden GJ, Smith OP, 1990 Oct, Lingual cellulitis causing upper airway obstruction. Br J Oral Maxillofac Surg, DOI: 10.1056/NEJM199405263302118
Smith OP, Mehta AB, 1990 Sep 29, Fludarabine monophosphate for prolymphocytic leukaemia. Lancet, DOI: 10.1056/NEJM199405263302118

    Professor Smith has a strong record of championing significant national developments in child and adolescent health in this country over the two decades. For example, he was:

    • Project director for the creation of National Centre for Hereditary Coagulation Disorders [1997 – 2001 / St. James’s Hospital]
    • Project director of the National Paediatric Haematology-Oncology Programme [2002 – 2007 / Our Lady’s Children’s Hospital, Crumlin]
    • Member of the National Paediatric Hospital Development Board [2009]
    • Member of the Dolphin Review Group [on the National Children’s Hospital [2012]
    • Special Advisor to the Children’s Hospital Group Board [2014 – 2017]
    • Chairman of the National Genetic and Genomic Medicine Network Strategy Group [2015]
    • Member of the Cancer Strategy 2017-2025 advising on child, adolescent and young adult cancers [2015-2016]
    • Currently Chief Academic Lead of the Paediatric Academic Health Sciences Network of the Children’s Hospital Group

    The co-author of more than 350 research original articles, letters, books, book chapters and papers, Professor Smith is a Fellow of the Royal College of Paediatrics and Child Health, Royal College of Pathologists, Royal College of Physicians of Dublin, Royal College of Physicians London, Royal College of Physicians Glasgow, and Royal College of Physicians Edinburgh. He is a member of numerous associations and societies, including; the Medical Research Council Childhood Leukaemia Working Party, Children’s Oncology Group [USA], the International Berlin Frankfurt Munster Study Group for Childhood Leukaemia, the United Kingdom Children’s Cancer Group, European Working Group on paediatric aplastic anaemia and myelodysplastic syndromes. He is an international advocate for children and adolescents with rare diseases and for expanded access to expensive drugs

    Professor Smith has received numerous awards throughout his career that have included; Presidents Prize of the Dublin University Biological Association in 1984 and 1985, Postgraduate Travelling Scholarship in Medicine, Sheppard Memorial Prize in Medicine and the Sir John Banks Medical in Medicine from Trinity College in 1991. He was the recipient of the Junior Chamber Ireland’s National Outstanding Young Person of the Year Award in the area of Scientific Development in 1998 and he delivered the 41st Graves Lecture and the 31st St Luke’s Lecture to the Royal Academy of Medicine in Ireland in 2001 and 2006 respectively. He was admitted to Honorary Fellowship of Trinity College Dublin in 2009 and was awarded Honorary Professorship title of Regius Professor of Physic (1637) in the School of Medicine, Trinity College Dublin in 2014.

    In 2015 Professor Smith conferred honorary Commander in the Most Excellent Order of the British Empire (CBE) for his life-long work on cancer in children and adolescents by Queen Elizabeth, on the advice of the Foreign and Commonwealth Office.