Orla KilleenConsultant Adolescent and Paediatric Rheumatologist Associate Clinical Professor UCD
Dr Orla Killeen graduated from University College Ireland, Galway (NUIG) in 1996. She trained in General Paediatrics in Our Lady’s Children’s Hospital, Crumlin, and in Temple Street University Hospital, Dublin, before sub-specialising in Paediatric Rheumatology. She undertook her paediatric rheumatology training at Great Ormond Street Children’s Hospital, London, and went on to complete a Barbara Ansell Fellowship in Paediatric Rheumatology in the Royal Hospital for Sick Children, Glasgow. She was appointed as Ireland’s first Paediatric Rheumatologist in 2004, and has been based at Our Lady’s Children’s Hospital, Crumlin, and St Vincent’s University Hospital, Dublin, since July 2006. She established the National Centre for Paediatric Rheumatology (NCPR) in 2006, providing care for patients with rheumatic and musculoskeletal disorders both on a local and national level. Her areas of interest include care of the Young person/Adolescent Rheumatology focusing in particular on Transition as well as juvenile idiopathic arthritis (JIA), Down’s Arthritis, juvenile dermatomyositis (JDM) and Auto-Inflammatory Syndromes.
Orla KilleenConsultant Adolescent and Paediatric Rheumatologist Associate Clinical Professor UCD
Down’s Arthritis (DA) is rarely recognised at onset, and remains under-diagnosed. As a direct consequence, children with DA can present with significant joint damage and disability at diagnosis. This MD project was upgraded to a PhD study in 2015. Initially focused on evaluating the clinical and pathological features of Arthritis in children with Down syndrome, further studies that seek to define the disease in terms of it’s genetic, immunological and histopathological origins are ongoing.
Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory condition primarily affecting children, and has an estimated prevalence of 1 per 106 (OMIM 259680). It is characterized by relapsing episodes of localized bone inflammation. We are currently undertaking whole exome sequencing to identify genetic variants associated with CRMO. This data may inform a personalized therapeutic approach based on target therapies leading to reduced inflammatory load and bone damage.
This study is investigating the resilience resources and mechanisms in families of children with chronic pain due to Juvenile Idiopathic Arthritis (JIA).
The incidence of Juvenile-onset Systemic Lupus Erythematosus (JSLE) in the UK is unknown. Furthermore, we do not know how children and young people present and when and where they access care. This study aims to determine the incidence of JSLE and begin to understand how and where we look after children and young people with JSLE in the UK and Ireland.
The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.
| Lythgoe H, Smith EMD, Killeen OG, Murphy R, Pilkington C, Pain CE, Beresford MW, in association with the British Paediatric Surveillance Unit, 2022 Oct 6, Prospective epidemiological study of juvenile-onset systemic lupus erythematosus in the UK and Republic of Ireland. Rheumatology (Oxford), DOI: 10.1093/rheumatology/keac064 |
| O'Leary D, Wilson AG, MacDermott EJ, Lowry C, Killeen OG, 2021 Mar 25, Variability in phenotype and response to treatment in chronic nonbacterial osteomyelitis; the Irish experience of a national cohort. Pediatr Rheumatol Online J, DOI: 10.1186/s12969-021-00530-4 |
| O'Leary D, Killeen OG, Wilson AG, 2021 Mar 17, Genetics of chronic nonbacterial osteomyelitis in the irish population: no significant association with rare FBLIM1 variants. Pediatr Rheumatol Online J, DOI: 10.1186/s12969-021-00533-1 |
| Kelleher KJ, Russell J, Killeen OG, Leahy TR, 2020 Aug 26, Treatment-recalcitrant laryngeal sarcoidosis responsive to sirolimus. BMJ Case Rep, DOI: 10.1136/bcr-2020-235372 |
| O'Leary D, O'Connor C, Nertney L, MacDermott EJ, Mullane D, Franklin O, Killeen OG, 2019 Nov 4, Juvenile systemic lupus erythematosus presenting as pancarditis. Pediatr Rheumatol Online J, DOI: 10.1186/s12969-019-0372-z |
| Foley C, Floudas A, Canavan M, Biniecka M, MacDermott EJ, Veale DJ, Mullan RH, Killeen OG, Fearon U, 2020 Apr, Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome-Associated Arthritis. Arthritis Rheumatol, DOI: 10.1002/art.41150 |
| Foley CM, Deely DA, MacDermott EJ, Killeen OG, 2019, Arthropathy of Down syndrome: an under-diagnosed inflammatory joint disease that warrants a name change. RMD Open, DOI: 10.1136/rmdopen-2018-000890 |
| Ramanan AV, Hampson LV, Lythgoe H, Jones AP, Hardwick B, Hind H, Jacobs B, Vasileiou D, Wadsworth I, Ambrose N, Davidson J, Ferguson PJ, Herlin T, Kavirayani A, Killeen OG, Compeyrot-Lacassagne S, Laxer RM, Roderick M, Swart JF, Hedrich CM, Beresford MW, 2019, Defining consensus opinion to develop randomised controlled trials in rare diseases using Bayesian design: An example of a proposed trial of adalimumab versus pamidronate for children with CNO/CRMO. PLoS One, DOI: 10.1371/journal.pone.0215739 |
| Foley C, Killeen OG, 2019 May, Musculoskeletal anomalies in children with Down syndrome: an observational study. Arch Dis Child, DOI: 10.1136/archdischild-2018-315751 |
| Batthish M, Costigan C, Killeen OG, 2009 Jan, Raynaud's phenomenon as a presenting feature of hypothyroidism in an 11-year-old girl. J Rheumatol, DOI: 10.3899/jrheum.080678 |
| Gardner-Medwin JM, Killeen OG, Ryder CA, Bradshaw K, Johnson K, 2006 Nov, Magnetic resonance imaging identifies features in clinically unaffected knees predicting extension of arthritis in children with monoarthritis. J Rheumatol, DOI: 10.3899/jrheum.080678 |
| Killeen OG, Gardner-Medwin JM, 2006 Jun, In juvenile idiopathic arthritis, is folate supplementation effective against methotrexate toxicity at the expense of methotrexate's efficacy? Arch Dis Child, DOI: 10.1136/adc.2006.094219 |
| Killeen OG, Burke C, Devaney D, Clarke TA, 2004 Sep, The value of the perinatal and neonatal autopsy. Ir Med J, DOI: 10.1136/adc.2006.094219 |
| Killeen OG, Kelehan P, Reardon W, 2002 Jan, Double vagina with sex reversal, congenital diaphragmatic hernia, pulmonary and cardiac malformations--another case of Meacham syndrome. Clin Dysmorphol, DOI: 10.1097/00019605-200201000-00005 |
| Funding Agency: | NCRC |
| Project Title: | Whole exome mapping of genetic variants linked with the development of chronic recurrent multifocal osteomyelitis |
| Start Date/End Date: | 2017 - 2018 |
| Funding Agency: | NCRC; Arthritis Ireland & AbbVie Pharmaceuticals (Newman Fellowship in Down’s Arthropathy) |
| Project Title: | Down’s Arthropathy (DA): Clinical Features and Biomarkers of Arthritis in Children with Trisomy 21 |
| Start Date/End Date: | 2012- ongoing |
| Funding Agency: | Barbara Ansell Clinical Fellowship |
| Project Title: | The early identification of disease progression and relapse in Juvenile Idiopathic Arthritis (JIA) |
| Funding Agency: | AbbVie Pharmaceuticals Ireland & Arthritis Ireland |
| Project Title: | Self-management needs of children with JIA in Ireland: a qualitative survey of families |
| Name: | Dr Emma Jane Mac Dermott |
| Department | Rheumatology |
| Institution: | Children's Health Ireland, Crumlin |
| Country: | Ireland |
| Name: | Professor Gerry Wilson |
| Department | School of Medicine |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Professor Ursula Fearon |
| Department | Department of Medicine |
| Institution: | Trinity College Dublin |
| Country: | Ireland |
| Name: | Dr Michael McDermott |
| Department | Experimental Rheumatology |
| Institution: | Leeds Institute of Rheumatic and Musculoskeletal Medicine |
| Country: | United Kingdom |
| Name: | Dr Sophia Saetes and Professor Brian McGuire |
| Department | Department of Psychology |
| Institution: | NUI Galway |
| Country: | Ireland |
| Name: | Cillian Condon |
| Department | Trinity Centre for Health Science |
| Institution: | TCD |
| Country: | Ireland |
| Name: | Professor Michael Beresford |
| Department | Department of Women’s and Children’s Health, Institute of Translational Medicine |
| Institution: | University of Liverpool |
| Country: | United Kingdom |