Maureen J. O’Sullivan


Maureen J. O’Sullivan

Consultant Paediatric Pathologist, Professor

Professor O’Sullivan is a consultant paediatric pathologist working at OLCHC, which houses the national paediatric oncology-haematology unit. Her specific interest is in paediatric solid tumours and, in the research setting, the genetics, epigenetics and biology of these tumours. Professor O’Sullivan’s group particularly focuses on sarcomas and paediatric renal tumours. They have characterised several novel chromosomal translocations and studied the biological impact these have on cell biology. The work has benefits in terms of diagnosis, prognosis, biological understanding and novel therapeutic development for these rare cancers, which are all too often neglected despite their aggressive behaviour.

Maureen J. O’Sullivan

Consultant Paediatric Pathologist, Professor

Dr Antonio Lazaro Cabeza
Position: Post-doctoral Researcher

Role:
Antonio has been a post-doctoral researcher in Professor O’Sullivan’s group since 2015, having completed his PhD at the University of Madrid.

Dr Colin Kenny
Position: Post-doctoral Researcher
ckenny7@tcd.ie

Role:
Colin completed his PhD with Professor O’Sullivan’s group is now a post-doctoral researcher in the group

The role of transcription factors in sarcomagenesis

Professor O’Sullivan’s group identified and characterised in 2012 the then only known genetic mutation recurrently seen in Clear Cell Sarcoma of Kidney (CCSK), and have been working on the biologic implications of that mutation (YWHAE-NUTM2 fusion) since then, with very exciting results. Recently, one further mutation was identified in CCSK – this is within the BCOR gene which has a role in epigenetic regulation of gene transcription. Professor O’Sullivan’s group have now studied a very large cohort of cases of CCSK collected from international sources to total 159 tumours for these two genetic mutations. Their findings show distinct subsets of CCSK with the BCOR and YWHAE alterations. They have adopted several technical approaches specifically to investigate the epigenetic effect of BCOR ITD in cells. Their studies on YWHAE-NUTM2 are already advanced and they will be uniquely positioned to draw comparisons between the molecular mechanisms in their contributions to CCSK oncogenesis.

An Exploration of Novel Therapeutic Targets in Malignant Rhabdoid Tumour

Malignant rhabdoid tumour (MRT), one of the most aggressive human cancers, afflicts very young children and has extremely poor outcomes. Despite its highly malignant nature, MRT bears mutations in just one gene known as SMARCB1. This gene encodes a protein that is important in the organization of the DNA (the genetic blueprint) within the cell thereby having a major influence on which genes are actively expressed within that cell. We have a number of aims, including working out what cell type rhabdoid tumour arises from, as this is not known and can be important in choosing best treatment. The DNA within a cell is arranged into a structure called chromatin and the precise arrangement is quite dynamic and highly regulated. SMARCB1 is a subunit of a multiprotein complex involved in this regulation of chromatin’s organisation. Therefore, we aimed to work out what exactly happens in terms of DNA organisation when SMARCB1 is inactivated (as occurs in the MRT tumour cell setting) and how this contributes to the cancer developing, but then also to establish what happens when we put SMARCB1 back into the tumour cells that are missing it. Revealing the changes in the chromatin that follow on from loss of, and reintroduction of, SMARCB1 would allow for the identification of vulnerabilities in the MRT cancer cell that could be targeted in new treatments for MRT.



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Wu MK, Vujanic GM, Fahiminiya S, Watanabe N, Thorner PS, O'Sullivan MJ, Fabian MR, Foulkes WD, 2018 Jan, Anaplastic sarcomas of the kidney are characterized by DICER1 mutations. Mod Pathol, DOI: 10.1038/modpathol.2017.100
Ma CA, Xi L, Cauff B, DeZure A, Freeman AF, Hambleton S, Kleiner G, Leahy TR, O'Sullivan M, Makiya M, O'Regan G, Pittaluga S, Niemela J, Stoddard J, Rosenzweig SD, Raffeld M, Klion AD, Milner JD, 2017 Feb 2, Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea. Blood, DOI: 10.1182/blood-2016-09-737817
O'Sullivan M, 2016 Nov, Pediatric soft tissue tumor pathology: A happy morpho-molecular union. Semin Diagn Pathol, DOI: 10.1053/j.semdp.2016.08.008
MacMahon JM, O'Sullivan MJ, McDermott M, Quinn F, Morris T, Green AJ, Betts DR, O'Connell SM, 2017, Early Bilateral Gonadoblastoma in a Young Child with Mosaicism for Turner Syndrome and Trisomy 18 with Y Chromosome. Horm Res Paediatr, DOI: 10.1159/000448172
Chagtai T, Zill C, Dainese L, Wegert J, Savola S, Popov S, Mifsud W, Vujanić G, Sebire N, Le Bouc Y, Ambros PF, Kager L, O'Sullivan MJ, Blaise A, Bergeron C, Mengelbier LH, Gisselsson D, Kool M, Tytgat GA, van den Heuvel-Eibrink MM, Graf N, van Tinteren H, Coulomb A, Gessler M, Williams RD, Pritchard-Jones K, 2016 Sep 10, Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study. J Clin Oncol, DOI: 10.1200/JCO.2015.66.0001
Wu MK, Cotter MB, Pears J, McDermott MB, Fabian MR, Foulkes WD, O'Sullivan MJ, 2016 Jul, Tumor progression in DICER1-mutated cystic nephroma-witnessing the genesis of anaplastic sarcoma of the kidney. Hum Pathol, DOI: 10.1016/j.humpath.2016.03.002
Kenny C, Bausenwein S, Lazaro A, Furtwängler R, Gooskens SL, van den Heuvel Eibrink M, Vokuhl C, Leuschner I, Graf N, Gessler M, O'Sullivan MJ, 2016 Apr, Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story. J Pathol, DOI: 10.1002/path.4693
Karlsson J, Valind A, Jansson C, O'Sullivan MJ, Holmquist Mengelbier L, Gisselsson D, 2016 Mar 8, Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression. Oncotarget, DOI: 10.18632/oncotarget.7152
Foley RW, Aworanti OM, Gorman L, McGovern B, O'Sullivan M, Smith OP, Twomey E, Gillick J, 2016 Apr, Unusual childhood presentations of abdominal non-Hodgkin's lymphoma. Pediatr Int, DOI: 10.1111/ped.12807
Gooskens SL, Kenny C, Lazaro A, O'Meara E, van Tinteren H, Spreafico F, Vujanic G, Leuschner I, Coulomb-L'Herminé A, Perotti D, de Camargo B, Bergeron C, Acha García T, Tanaka M, Pieters R, Pritchard-Jones K, Graf N, van den Heuvel-Eibrink MM, O'Sullivan MJ, 2016 Feb, The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney. Genes Chromosomes Cancer, DOI: 10.1002/gcc.22320
Kelly LC, Lázaro A, O'Sullivan MJ, 2015 Jul 22, What Do We Know about the Role of miRNAs in Pediatric Sarcoma? Int J Mol Sci, DOI: 10.3390/ijms160716593
McGovern E, McNally P, O'Sullivan M, Phelan E, Sumner K, Best DH, McMahon CJ, 2016 Apr, Infantile pulmonary capillary haemangiomatosis: a lethal form of pulmonary hypertension. Cardiol Young, DOI: 10.1017/S1047951115001006
Wegert J, Ishaque N, Vardapour R, Geörg C, Gu Z, Bieg M, Ziegler B, Bausenwein S, Nourkami N, Ludwig N, Keller A, Grimm C, Kneitz S, Williams RD, Chagtai T, Pritchard-Jones K, van Sluis P, Volckmann R, Koster J, Versteeg R, Acha T, O'Sullivan MJ, Bode PK, Niggli F, Tytgat GA, van Tinteren H, van den Heuvel-Eibrink MM, Meese E, Vokuhl C, Leuschner I, Graf N, Eils R, Pfister SM, Kool M, Gessler M, 2015 Feb 9, Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell, DOI: 10.1016/j.ccell.2015.01.002
O'Meara E, Stack D, Phelan S, McDonagh N, Kelly L, Sciot R, Debiec-Rychter M, Morris T, Cochrane D, Sorensen P, O'Sullivan MJ, 2014 Dec, Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child. Genes Chromosomes Cancer, DOI: 10.1002/gcc.22208
Harvey H, Piskareva O, Creevey L, Alcock LC, Buckley PG, O'Sullivan MJ, Segura MF, Gallego S, Stallings RL, Bray IM, 2015 Apr 1, Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f. Int J Cancer, DOI: 10.1002/ijc.29144
Uwineza A, Gill H, Buckley P, Owens C, Capra M, O'Sullivan C, McDermott M, Brett F, Farrell M, Pears J, O'Sullivan MJ, 2014 Sep, Rhabdoid tumor: the Irish experience 1986-2013. Cancer Genet, DOI: 10.1016/j.cancergen.2014.05.015
Lynn M, Shah N, Conroy J, Ennis S, Morris T, Betts D, O'Sullivan M, 2014 Mar, A study of alveolar rhabdomyosarcoma copy number alterations by single nucleotide polymorphism analysis. Appl Immunohistochem Mol Morphol, DOI: 10.1097/PDM.0000000000000030
Karlsson J, Holmquist Mengelbier L, Ciornei CD, Naranjo A, O'Sullivan MJ, Gisselsson D, 2014 May, Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin. Genes Chromosomes Cancer, DOI: 10.1002/gcc.22149
Nason GJ, Baker JF, O'Toole P, Walsh A, Lui DF, O'Neill F, O'Sullivan M, Kelly PM, 2013 Dec, Fibroma of the peroneus longus tendon sheath in a child: a case report. J Orthop Surg (Hong Kong), DOI: 10.1177/230949901302100326
McHugh J, Storey L, Bacon L, O'Marcaigh A, O'Sullivan M, Smith O, 2013 Oct, Paediatric follicular lymphoma. Br J Haematol, DOI: 10.1111/bjh.12493
Fam HK, Walton C, Mitra SA, Chowdhury M, Osborne N, Choi K, Sun G, Wong PC, O'Sullivan MJ, Turashvili G, Aparicio S, Triche TJ, Bond M, Pallen CJ, Boerkoel CF, 2013 Oct, TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells. Mol Cancer Res, DOI: 10.1158/1541-7786.MCR-12-0575
Kelly L, Bryan K, Kim SY, Janeway KA, Killian JK, Schildhaus HU, Miettinen M, Helman L, Meltzer PS, van de Rijn M, Debiec-Rychter M, O'Sullivan M, NIH Pediatric and Wild-Type GIST Clinic., 2013, Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST]. PLoS One, DOI: 10.1371/journal.pone.0064102
Lynn M, Wang Y, Slater J, Shah N, Conroy J, Ennis S, Morris T, Betts DR, Fletcher JA, O'Sullivan MJ, 2013 Jun, High-resolution genome-wide copy-number analyses identify localized copy-number alterations in Ewing sarcoma. Diagn Mol Pathol, DOI: 10.1097/PDM.0b013e31827a47f9
Killian JK, Kim SY, Miettinen M, Smith C, Merino M, Tsokos M, Quezado M, Smith WI Jr, Jahromi MS, Xekouki P, Szarek E, Walker RL, Lasota J, Raffeld M, Klotzle B, Wang Z, Jones L, Zhu Y, Wang Y, Waterfall JJ, O'Sullivan MJ, Bibikova M, Pacak K, Stratakis C, Janeway KA, Schiffman JD, Fan JB, Helman L, Meltzer PS, 2013 Jun, Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. Cancer Discov, DOI: 10.1158/2159-8290.CD-13-0092
Watson JA, Bryan K, Williams R, Popov S, Vujanic G, Coulomb A, Boccon-Gibod L, Graf N, Pritchard-Jones K, O'Sullivan M, 2013, miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema. PLoS One, DOI: 10.1371/journal.pone.0053417
Oudijk L, Gaal J, Korpershoek E, van Nederveen FH, Kelly L, Schiavon G, Verweij J, Mathijssen RH, den Bakker MA, Oldenburg RA, van Loon RL, O'Sullivan MJ, de Krijger RR, Dinjens WN, 2013 Mar, SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors. Mod Pathol, DOI: 10.1038/modpathol.2012.186
Tareen F, McDowell DT, O'Sullivan M, Mortell A, 2013 Jun, Urachal carcinoid--a new presentation. Eur J Pediatr Surg, DOI: 10.1055/s-0032-1324797
Conlon N, Teoh CW, Pears J, O'Sullivan M, 2012 Sep 7, Bilateral botryoid nephroblastoma: a rare cause of renal failure. BMJ Case Rep, DOI: 10.1136/bcr.02.2012.5854
O'Meara E, Stack D, Lee CH, Garvin AJ, Morris T, Argani P, Han JS, Karlsson J, Gisselson D, Leuschner I, Gessler M, Graf N, Fletcher JA, O'Sullivan MJ, 2012 May, Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. J Pathol, DOI: 10.1002/path.3985
Howley S, Stack D, Morris T, McDermott M, Capra M, Betts D, O'Sullivan MJ, 2012 Feb, Ectomesenchymoma with t(1;12)(p32;p13) evolving from embryonal rhabdomyosarcoma shows no rearrangement of ETV6. Hum Pathol, DOI: 10.1016/j.humpath.2011.03.010
Lockwood WW, Stack D, Morris T, Grehan D, O'Keane C, Stewart GL, Cumiskey J, Lam WL, Squire JA, Thomas DM, O'Sullivan MJ, 2011 May, Cyclin E1 is amplified and overexpressed in osteosarcoma. J Mol Diagn, DOI: 10.1016/j.jmoldx.2010.11.020
Rizkalla H, Wildgrove H, Quinn F, Capra M, O'Sullivan MJ, 2011, Congenital fibrosarcoma of the ileum: case report with molecular confirmation and literature review. Fetal Pediatr Pathol, DOI: 10.3109/15513815.2010.547554
Teo M, Crotty P, O'Sullivan M, French CA, Walshe JM, 2011 Apr 20, NUT midline carcinoma in a young woman. J Clin Oncol, DOI: 10.1200/JCO.2010.32.7486
Hayes BD, O'Sullivan MJ, 2011 Jul-Aug, Intranodal hybrid benign nerve sheath tumor. Pediatr Dev Pathol, DOI: 10.2350/10-06-0843-CR.1
Janeway KA, Kim SY, Lodish M, Nosé V, Rustin P, Gaal J, Dahia PL, Liegl B, Ball ER, Raygada M, Lai AH, Kelly L, Hornick JL, NIH Pediatric and Wild-Type GIST Clinic., O'Sullivan M, de Krijger RR, Dinjens WN, Demetri GD, Antonescu CR, Fletcher JA, Helman L, Stratakis CA, 2011 Jan 4, Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1009199108
Curry S, Ibrahim F, Grehan D, McDermott M, Capra M, Betts D, O'Sullivan M, 2011 May-Jun, Rhabdomyosarcoma-associated renal cell carcinoma: a link with constitutional Tp53 mutation. Pediatr Dev Pathol, DOI: 10.2350/10-07-0871-CR.1
Mulligan L, Nosherwan A, Hayes R, Pears J, McDermott M, O'Sullivan M, 2011 May-Jun, Wilms tumor arising in extracoelomic paravertebral soft tissues. Pediatr Dev Pathol, DOI: 10.2350/10-05-0840-CR.1
Gaal J, Stratakis CA, Carney JA, Ball ER, Korpershoek E, Lodish MB, Levy I, Xekouki P, van Nederveen FH, den Bakker MA, O'Sullivan M, Dinjens WN, de Krijger RR, 2011 Jan, SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors. Mod Pathol, DOI: 10.1038/modpathol.2010.185
Machado I, Alberghini M, Giner F, Corrigan M, O'Sullivan M, Noguera R, Pellin A, Bertoni F, Llombart-Bosch A, 2010 Jul, Histopathological characterization of small cell osteosarcoma with immunohistochemistry and molecular genetic support. A study of 10 cases. Histopathology, DOI: 10.1111/j.1365-2559.2010.03589.x
Foley NH, Bray IM, Tivnan A, Bryan K, Murphy DM, Buckley PG, Ryan J, O'Meara A, O'Sullivan M, Stallings RL, 2010 Apr 21, MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Mol Cancer, DOI: 10.1186/1476-4598-9-83
Sargent J, O'Marcaigh A, Smith O, Butler K, Gavin P, O'Sullivan M, 2010 Apr, Candida albicans-associated necrotizing vasculitis producing life-threatening gastrointestinal hemorrhage. Hum Pathol, DOI: 10.1016/j.humpath.2009.09.015
Bray I, Bryan K, Prenter S, Buckley PG, Foley NH, Murphy DM, Alcock L, Mestdagh P, Vandesompele J, Speleman F, London WB, McGrady PW, Higgins DG, O'Meara A, O'Sullivan M, Stallings RL, 2009 Nov 16, Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival. PLoS One, DOI: 10.1371/journal.pone.0007850
O'Sullivan MJ, 2009 Oct, Gastrointestinal stromal tumors. Pediatr Surg Int, DOI: 10.1007/s00383-009-2477-9
Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ, 2009 Jul, Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet, DOI: 10.1038/ng.392
Shahdadpuri R, O'Meara A, O'Sullivan M, Reardon W, 2008 Jul, Low-grade fibromyxoid sarcoma: yet another malignancy associated with Kabuki syndrome. Clin Dysmorphol, DOI: 10.1097/MCD.0b013e3282f5f4e3
Zhang L, Anglesio MS, O'Sullivan M, Zhang F, Yang G, Sarao R, Mai PN, Cronin S, Hara H, Melnyk N, Li L, Wada T, Liu PP, Farrar J, Arceci RJ, Sorensen PH, Penninger JM, 2007 Sep, The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med, DOI: 10.1038/nm1621
Ng TL, O'Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE, 2007 Sep, Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV. J Mol Diagn, DOI: 10.2353/jmoldx.2007.070009
O'Sullivan MJ, McCabe A, Gillett P, Penman ID, MacKinlay GA, Pritchard J, 2005 Nov-Dec, Multiple gastric stromal tumors in a child without syndromic association lacks common KIT or PDGFRalpha mutations. Pediatr Dev Pathol, DOI: 10.1007/s10024-005-0083-y
O'Sullivan M, Budhraja V, Sadovsky Y, Pfeifer JD, 2005 Jun, Tumor heterogeneity affects the precision of microarray analysis. Diagn Mol Pathol, DOI: 10.1007/s10024-005-0083-y
Murphy A, Stallings RL, Howard J, O'Sullivan M, Hayes R, Breatnach F, McDermott MB, 2005 Jan 15, Primary desmoplastic small round cell tumor of bone: report of a case with cytogenetic confirmation. Cancer Genet Cytogenet, DOI: 10.1016/j.cancergencyto.2004.05.003
Plowman SJ, Williamson DJ, O'Sullivan MJ, Doig J, Ritchie AM, Harrison DJ, Melton DW, Arends MJ, Hooper ML, Patek CE, 2003 Dec, While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Mol Cell Biol, DOI: 10.1016/j.cancergencyto.2004.05.003
O'Sullivan MJ, Pfeifer JD, Dehner LP, 2003 Mar, Lack of SYT-SSX fusion transcripts in malignant peripheral nerve sheath tumors on RT-PCR analysis of 34 archival cases, by Tamborini E., et al. Lab Invest, DOI: 10.1016/j.cancergencyto.2004.05.003
Miles CG, Slight J, Spraggon L, O'Sullivan M, Patek C, Hastie ND, 2003 Apr, Mice lacking the 68-amino-acid, mammal-specific N-terminal extension of WT1 develop normally and are fertile. Mol Cell Biol, DOI: 10.1016/j.cancergencyto.2004.05.003
O'Sullivan MJ, Sirgi KE, Dehner LP, 2002 Jul, Low-grade fibrosarcoma (hyalinizing spindle cell tumor with giant rosettes) with pulmonary metastases at presentation: case report and review of the literature. Int J Surg Pathol, DOI: 10.1177/106689690201000310
Hill DA, O'Sullivan MJ, Zhu X, Vollmer RT, Humphrey PA, Dehner LP, Pfeifer JD, 2002 Aug, Practical application of molecular genetic testing as an aid to the surgical pathologic diagnosis of sarcomas: a prospective study. Am J Surg Pathol, DOI: 10.1177/106689690201000310
O'Sullivan MJ, Humphrey PA, Dehner LP, Pfeifer JD, 2002 Aug, t(X;18) reverse transcriptase-polymerase chain reaction demonstrating a variant transcript. J Mol Diagn, DOI: 10.1016/S1525-1578(10)60700-3
Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW, 2002 Jul 15, Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene. Cancer Res, DOI: 10.1016/S1525-1578(10)60700-3
O'Sullivan MJ, Dehner LP, Humphrey PA, Pfeifer JD, 2002 Jul, Transcripts, transcripts, everywhere. Adv Anat Pathol, DOI: 10.1016/S1525-1578(10)60700-3

Funding Agency:Health Research Board – Clinician Scientist Award
Project Title:The role of transcription factors in sarcomagenesis with an emphasis on clear cell sarcoma of kidney and undifferentiated sarcoma
Start Date/End Date:December 2012 – May 31st, 2018
Funding Agency:The National Children’s Research Centre
Project Title:Characterization of novel chromosomal translocations in sarcomas with emphasis on t (17;19) and t (10; 17) as initial investigations.
Start Date/End Date:August 2008 – January 2011
Funding Agency:The National Children’s Research Centre
Project Title:An exploration of biological targets for novel therapeutics in rhabdoid tumours
Funding Agency:The National Children’s Research Centre
Project Title:Pathogenesis of Clear Cell Sarcoma of Kidney-establishing the relative roles of BCOR and 14-3-3e-NUTM2
Start Date/End Date: 03/04/2017- ongoing
Name:Professor Ivo Leuschner
DepartmentPathology, Division of Paediatric Pathology
Institution:Christian-Albrechts University Kiel,
Country:Germany
Name:Dr. Christian Vokuhl
DepartmentPathology
Institution:Christian-Albrechts University, Kiel
Country:Germany
Name:Professor Manfred Gessler
DepartmentTheodor-Boveri-Institute/Biocenter
Institution:Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, Wuerzburg University, 97074 Wuerzburg
Country:Germany
Name:Professor Norbert Graf
DepartmentPaediatric Oncology and Hematology,
Institution:Saarland University Hospital, Homburg
Country:Germany
Name:Professor Adrian Bracken
DepartmentGenetics
Institution:Smurfit Institute, Trinity College, Dublin
Country:Ireland
Name:Dr. Gerard Cagney
DepartmentConway Institute
Institution:University College Dublin
Country:Ireland