Madeline Murphy


Madeline Murphy

Conway Fellow/ Lecturer

Dr Madeline Murphy is a Conway Fellow and Principal Investigator in the School of Medicine, UCD. She leads a translational medical research group within the Conway Institute, with a keen interest in translating her research findings towards development of innovative diagnostics and therapeutics.  Her major research interest is to understand the biology that leads to scarring and illness. Her current research focus is to understand the biology of scarring that leads to narrowed airways resulting in breathing difficulties for babies and children. Her long-term goal is to use this understanding of disease biology to create new treatments. She also investigates breast cancer and diabetic kidney disease.

 

Madeline Murphy

Conway Fellow/ Lecturer

Emma Dorris
Position: Research Scientist
emma.dorris@ucd.ie

Role:
Dr. Emma Dorris will lead the experimental process for this project.

Investigation into prevention of fibrotic scar formation as treatment for subglottic stenosis

Premature babies and sick children that have difficulty breathing may have a small tube placed into their airways to help them breathe. The risk of damage to the airway with this treatment is usually very low. However, for some children scarring of the airway can occur just below the vocal chords (subglottis). This can cause the airway to narrow (stenosis). The exact cause of the scarring (fibrosis) is not yet known. The most severe cases can have 70-100% narrowing of the airway. Current treatment requires surgery to (a) insert a tracheostomy tube below the narrow area to help breathing (b) expand the airway with the baby’s own cartilage or (c) resection of the narrow portion. This research is focusing on understanding the biology that leads to the scarring. The long-term goal is to use our understanding of the pathophysiology to create a new treatment to prevent this fibrosis and ultimately stop the narrowing of the airways.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Elster N, Toomey S, Fan Y, Cremona M, Morgan C, Weiner Gorzel K, Bhreathnach U, Milewska M, Murphy M, Madden S, Naidoo J, Fay J, Kay E, Carr A, Kennedy S, Furney S, Mezynski J, Breathhnach O, Morris P, Grogan L, Hill A, Kennedy S, Crown J, Gallagher W, Hennessy B, Eustace A, 2018, Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer. Ther Adv Med Oncol, DOI: 10.1177/1758835918778297
Brown J, Hux K, Hey M, Murphy M, 2017, Exploring cognitive support use and preference by college students with TBI: A mixed-methods study. NeuroRehabilitation, DOI: 10.3233/NRE-162065
McAdam SAM, Eléouët MP, Best M, Brodribb TJ, Murphy MC, Cook SD, Dalmais M, Dimitriou T, Gélinas-Marion A, Gill WM, Hegarty M, Hofer JMI, Maconochie M, McAdam EL, McGuiness P, Nichols DS, Ross JJ, Sussmilch FC, Urquhart S, 2017 Sep, Linking Auxin with Photosynthetic Rate via Leaf Venation. Plant Physiol, DOI: 10.1104/pp.17.00535
Bhreathnach U, Griffin B, Brennan E, Ewart L, Higgins D, Murphy M, 2017 Apr, Profibrotic IHG-1 complexes with renal disease associated HSPA5 and TRAP1 in mitochondria. Biochim Biophys Acta Mol Basis Dis, DOI: 10.1016/j.bbadis.2017.01.015
Griffin B, Murphy M, 2015 Nov, A Friend in Need: Activated Protein C Stabilizes YB-1 during Renal Ischemia Reperfusion Injury. J Am Soc Nephrol, DOI: 10.1681/ASN.2015040351
Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M, McCann A, Furlong F, 2015 May, Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. Cancer Med, DOI: 10.1002/cam4.409
Docherty NG, Murphy M, Martin F, Brennan EP, Godson C, 2014 Sep, Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-β1-associated profibrotic responses in diabetic kidney disease. Exp Physiol, DOI: 10.1113/expphysiol.2014.078774
Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C, Murphy M, 2014 Dec, IHG-1 increases mitochondrial fusion and bioenergetic function. Diabetes, DOI: 10.2337/db13-1256
Higgins DF, Murphy M, 2014 May, Epigenetic unsilencing reverses renal fibrosis. J Am Soc Nephrol, DOI: 10.1681/ASN.2014010006
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M, 2013 Aug, IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses. Biochim Biophys Acta, DOI: 10.1016/j.bbamcr.2013.03.027
Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C, GENIE Consortium., 2013 Mar, Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1. J Am Soc Nephrol, DOI: 10.1681/ASN.2012060550
Murphy M, Hickey F, Godson C, 2013 Jan, IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease. Curr Opin Nephrol Hypertens, DOI: 10.1097/MNH.0b013e32835b54b0
Kelly NA, Murphy M, Giles S, Russell JD, 2012 Nov, Subglottic injury: a clinically relevant animal model. Laryngoscope, DOI: 10.1002/lary.23515
Hickey FB, Corcoran JB, Docherty NG, Griffin B, Bhreathnach U, Furlong F, Martin F, Godson C, Murphy M, 2011 Aug, IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α. J Am Soc Nephrol, DOI: 10.1681/ASN.2010111154
Börgeson E, Docherty NG, Murphy M, Rodgers K, Ryan A, O'Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C, 2011 Sep, Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis. FASEB J, DOI: 10.1096/fj.11-185017
Rowan F, Docherty NG, Murphy M, Murphy TB, Coffey JC, O'Connell PR, 2010 Nov, Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis. Ann Surg, DOI: 10.1097/SLA.0b013e3181fdc54c
Rowan F, Docherty NG, Murphy M, Murphy B, Calvin Coffey J, O'Connell PR, 2010 Nov, Desulfovibrio bacterial species are increased in ulcerative colitis. Dis Colon Rectum, DOI: 10.1007/DCR.0b013e3181f1e620
Brennan EP, Ehrich M, O'Donovan H, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA, 2010 Jul 1, DNA methylation profiling in cell models of diabetic nephropathy. Epigenetics, DOI: 10.4161/epi.5.5.12077
McKnight AJ, Patterson CC, Pettigrew KA, Savage DA, Kilner J, Murphy M, Sadlier D, Maxwell AP, Warren 3/U.K. Genetics of Kidneys in Diabetes (GoKinD) Study Group., 2010 May, A GREM1 gene variant associates with diabetic nephropathy. J Am Soc Nephrol, DOI: 10.1681/ASN.2009070773
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, McKnight AJ, van den Boom D, Maxwell AP, Savage DA, 2009 Apr 1, Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines. Epigenetics, DOI: 10.4161/epi.4.3.8793
Ryan A, Murphy M, Godson C, Hickey FB, 2009 Dec, Diabetes mellitus and apoptosis: inflammatory cells. Apoptosis, DOI: 10.1007/s10495-009-0340-z
Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, O'Connell PR, 2009 May, Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts. Br J Surg, DOI: 10.1002/bjs.6577
Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, Godson C, 2008 Oct, Regulation and consequences of differential gene expression in diabetic kidney disease. Biochem Soc Trans, DOI: 10.1042/BST0360941
Murphy M, Docherty NG, Griffin B, Howlin J, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady HR, Furlong F, Godson C, Martin F, 2008 Sep, IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis. J Am Soc Nephrol, DOI: 10.1681/ASN.2007101080
Furlong F, Crean J, Thornton L, O'Leary R, Murphy M, Martin F, 2007 Jun, Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose. Am J Physiol Renal Physiol, DOI: 10.1152/ajprenal.00342.2006
Lambe T, Finlay D, Murphy M, Martin F, 2006 May, Differential expression of connexin 43 in mouse mammary cells. Cell Biol Int, DOI: 10.1016/j.cellbi.2006.02.008
Roxburgh SA, Murphy M, Pollock CA, Brazil DP, 2006, Recapitulation of embryological programmes in renal fibrosis--the importance of epithelial cell plasticity and developmental genes. Nephron Physiol, DOI: 10.1159/000092453
Healy DA, Daly PJ, Docherty NG, Murphy M, Fitzpatrick JM, Watson RW, 2006 Mar, Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury. J Am Soc Nephrol, DOI: 10.1681/ASN.2005090980
Docherty NG, O'Sullivan OE, Healy DA, Murphy M, O'neill AJ, Fitzpatrick JM, Watson RW, 2006 May, TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation. Am J Physiol Renal Physiol, DOI: 10.1152/ajprenal.00406.2005
Kirwan RP, Leonard MO, Murphy M, Clark AF, O'Brien CJ, 2005 Dec, Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells. Glia, DOI: 10.1002/glia.20247
McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, DeLucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T, 2005 Jul 21, Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron, DOI: 10.1016/j.neuron.2005.06.030
Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, Brady HR, 2005 Jun, Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy. Am J Kidney Dis, DOI: 10.1053/j.ajkd.2005.03.014
Crean JK, Furlong F, Finlay D, Mitchell D, Murphy M, Conway B, Brady HR, Godson C, Martin F, 2004 Oct, Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization. FASEB J, DOI: 10.1096/fj.04-1546fje
Conway BR, Maxwell AP, Savage DA, Patterson CC, Doran PP, Murphy M, Brady HR, Fogarty DG, 2004 Apr, Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes. Diabetes, DOI: 10.2337/diabetes.53.4.1162
Fair T, Murphy M, Rizos D, Moss C, Martin F, Boland MP, Lonergan P, 2004 Feb, Analysis of differential maternal mRNA expression in developmentally competent and incompetent bovine two-cell embryos. Mol Reprod Dev, DOI: 10.1002/mrd.10385
Fair T, Gutierrez-Adan A, Murphy M, Rizos D, Martin F, Boland MP, Lonergan P, 2004 Feb, Search for the bovine homolog of the murine ped gene and characterization of its messenger RNA expression during bovine preimplantation development. Biol Reprod, DOI: 10.1095/biolreprod.103.022137
Sax JK, Stoddard A, Murphy ME, Chodosh L, El-Deiry WS, 2003 Jul-Aug, Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line. Cancer Biol Ther, DOI: 10.4161/cbt.2.4.477
Dolan V, Murphy M, Alarcon P, Brady HR, Hensey C, 2003 Aug, Gremlin - a putative pathogenic player in progressive renal disease. Expert Opin Ther Targets, DOI: 10.1517/14728222.7.4.523
Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS, 2002 Nov, BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol, DOI: 10.1038/ncb866
Lappin DW, McMahon R, Murphy M, Brady HR, 2002, Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy. Nephrol Dial Transplant, DOI: 10.1093/ndt/17.suppl_9.65
Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR, 2002 Nov 15, The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem, DOI: 10.1074/jbc.M203715200
Murphy M, McMahon R, Lappin DW, Brady HR, 2002, Gremlins: is this what renal fibrogenesis has come to? Exp Nephrol, DOI: 10.1159/000063698
Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, Godson C, Martin F, Brady HR, 2002 Mar 22, High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. J Biol Chem, DOI: 10.1074/jbc.M109172200
Murphy ME, Kariwa H, Mizutani T, Tanabe H, Yoshimatsu K, Arikawa J, Takashima I, 2001 Jun, Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus. J Vet Med Sci, DOI: 10.1292/jvms.63.637
Murphy M, Harte T, McInerney J, Smith TJ, 2000 Oct 17, Molecular cloning of an Atlantic salmon nucleoside diphosphate kinase cDNA and its pattern of expression during embryogenesis. Gene, DOI: 10.1016/s0378-1119(00)00374-7
Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, Brady HR, 1999 Feb 26, Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem, DOI: 10.1074/jbc.274.9.5830
Marshall JD, Aste-Amézaga M, Chehimi SS, Murphy M, Olsen H, Trinchieri G, 1999 Jan, Regulation of human IL-18 mRNA expression. Clin Immunol, DOI: 10.1006/clim.1998.4633
van den Bos C, Silverstetter S, Murphy M, Connolly T, 1998 Sep, p21(cip1) rescues human mesenchymal stem cells from apoptosis induced by low-density culture. Cell Tissue Res, DOI: 10.1007/s004410051138
Cheng T, Erickson-Miller CL, Li C, Cardier J, Wang Y, Dempsey J, Mogle M, Barbera E, Murphy MJ Jr, Dai W, 1995 Jul, HIMeg-1, a cell line derived from a CML patient, is capable of monocytic and megakaryocytic differentiation. Leukemia, DOI: 10.1007/s004410051138
Murphy MC, Zampelas A, Puddicombe SM, Furlonger NP, Morgan LM, Williams CM, 1993 Nov, Pretranslational regulation of the expression of the lipoprotein lipase (EC 3.1.1.34) gene by dietary fatty acids in the rat. Br J Nutr, DOI: 10.1079/bjn19930168

Funding Agency:NCRC
Project Title:Investigation into prevention of fibrotic scar formation as treatment for subglottic stenosis
Start Date/End Date:3 years (2019-2022)
Total Awarded:€269,275
Role:Principal Investigator
Name:John Russell
Position:Consultant Paediatric Otolaryngologist
Role:Co-Principal Investigator
DepartmentEar Nose & Throat Department ENT
Institution:Children's Health Ireland at Crumlin
Country:Ireland