Examining both the biomarker potential and functionality of exosomes from CF patient lung cells
Judith CoppingerSenior Lecturer
Judith obtained a PhD from the RCSI in 2004, before undertaking postdoctoral training at the Scripps Research Institute, San Diego in new folding mechanisms in Cystic Fibrosis (CF). In 2011, she joined the University of California, San Diego as a faculty member before receiving an SFI award and returning to Ireland. In 2013, she became a a Principal investigator at the University College Dublin, where she set up a basic/translational research program focused on identifying new therapies and biomarkers in CF. Judith’s research areas include:
Judith now joins the RCSI and National Children’s Research Center as a Principal Investigator and Senior Lecturer in the Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland.
Judith CoppingerSenior Lecturer
Dr Anne Trappe
Position: Postdoctoral Researcher
annetrappe@rcsi.ie
Role:
Deciphering the functional and clinical properties of exosomes in Cystic Fibrosis
Examining both the biomarker potential and functionality of exosomes from CF patient lung cells
Dissection of the PI3K/Akt/mTOR signalling pathway as a therapeutic target in Cystic Fibrosis.
The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.
| Trappe A, Donnelly SC, McNally P, Coppinger JA, 2021 Mar 12, Role of extracellular vesicles in chronic lung disease. Thorax, DOI: 10.1136/thoraxjnl-2020-216370 |
| Useckaite Z, Ward MP, Trappe A, Reilly R, Lennon J, Davage H, Matallanas D, Cassidy H, Dillon ET, Brennan K, Doyle SL, Carter S, Donnelly S, Linnane B, McKone EF, McNally P, Coppinger JA, 2020 Jun, Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis. Thorax, DOI: 10.1136/thoraxjnl-2019-214027 |
| Shields S, Conroy E, O'Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O'Connor D, McCann A, Gallagher WM, Coppinger JA, 2019 May 3, Correction: BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer. Oncotarget, DOI: 10.18632/oncotarget.26920 |
| Shields S, Conroy E, O'Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O'Connor D, McCann A, Gallagher WM, Coppinger JA, 2018 Mar 20, BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer. Oncotarget, DOI: 10.18632/oncotarget.24590 |
| Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA, 2017 Aug 9, Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis. Sci Rep, DOI: 10.1038/s41598-017-06588-z |
| Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C, 2014, Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One, DOI: 10.1371/journal.pone.0113765 |
| Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH, 2015 Aug, Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol, DOI: 10.1007/s12035-014-8881-8 |
| Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA, 2015 Jan, Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics, DOI: 10.1074/mcp.M114.037697 |
| Choi S, Kelber J, Jiang X, Strnadel J, Fujimura K, Pasillas M, Coppinger J, Klemke R, 2014 Feb 1, Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem, DOI: 10.1016/j.ab.2013.10.025 |
| Coppinger JA, Hutt DM, Razvi A, Koulov AV, Pankow S, Yates JR 3rd, Balch WE, 2012, A chaperone trap contributes to the onset of cystic fibrosis. PLoS One, DOI: 10.1371/journal.pone.0037682 |
| Jang CY, Coppinger JA, Yates JR 3rd, Fang G, 2011 Apr 29, Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2011.04.004 |
| Jang CY, Coppinger JA, Yates JR 3rd, Fang G, 2010 Mar 5, Phospho-regulation of DDA3 function in mitosis. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2010.01.115 |
| Koulov AV, LaPointe P, Lu B, Razvi A, Coppinger J, Dong MQ, Matteson J, Laister R, Arrowsmith C, Yates JR 3rd, Balch WE, 2010 Mar 15, Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. Mol Biol Cell, DOI: 10.1091/mbc.e09-12-1017 |
| Minamide LS, Maiti S, Boyle JA, Davis RC, Coppinger JA, Bao Y, Huang TY, Yates J, Bokoch GM, Bamburg JR, 2010 Feb 19, Isolation and characterization of cytoplasmic cofilin-actin rods. J Biol Chem, DOI: 10.1074/jbc.M109.063768 |
| Liu GH, Guan T, Datta K, Coppinger J, Yates J 3rd, Gerace L, 2009 Nov, Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol Cell Biol, DOI: 10.1128/MCB.00684-09 |
| Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G, 2009 May 1, Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci, DOI: 10.1242/jcs.044321 |
| Zhu H, Coppinger JA, Jang CY, Yates JR 3rd, Fang G, 2008 Dec 1, FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. J Cell Biol, DOI: 10.1083/jcb.200807046 |
| Steiniger SC, Coppinger JA, Krüger JA, Yates J 3rd, Janda KD, 2008 Dec, Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. Stem Cells, DOI: 10.1634/stemcells.2008-0397 |
| Zhao WM, Coppinger JA, Seki A, Cheng XL, Yates JR 3rd, Fang G, 2008 Sep 9, RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.0709227105 |
| Seki A, Coppinger JA, Jang CY, Yates JR, Fang G, 2008 Jun 20, Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science, DOI: 10.1126/science.1157425 |
| Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd, Fang G, 2008 Apr 21, DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol, DOI: 10.1083/jcb.200711032 |
| Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G, 2008 Apr 7, Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol, DOI: 10.1083/jcb.200712027 |
| Coppinger JA, Maguire PB, 2007, Insights into the platelet releasate. Curr Pharm Des, DOI: 10.2174/138161207781662885 |
| Coppinger JA, O'Connor R, Wynne K, Flanagan M, Sullivan M, Maguire PB, Fitzgerald DJ, Cagney G, 2007 Jun 1, Moderation of the platelet releasate response by aspirin. Blood, DOI: 10.1182/blood-2006-07-038539 |
| Coppinger J, Fitzgerald DJ, Maguire PB, 2007, Isolation of the platelet releasate. Methods Mol Biol, DOI: 10.1385/1-59745-214-9:307 |
| Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR 3rd, Balch WE, 2006 Nov 17, Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell, DOI: 10.1016/j.cell.2006.09.043 |
| McRedmond JP, Park SD, Reilly DF, Coppinger JA, Maguire PB, Shields DC, Fitzgerald DJ, 2004 Feb, Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics, DOI: 10.1074/mcp.M300063-MCP200 |
| Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB, 2004 Mar 15, Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, DOI: 10.1182/blood-2003-08-2804 |
| du Laney TV, Cherry RS, Coppinger JA, Truskey GA, 1992 Nov-Dec, Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. Biotechnol Prog, DOI: 10.1021/bp00018a600 |
| Funding Agency: | Science Foundation of Ireland |
| Project Title: | Characterising Hsp90 signalling in Cystic Fibrosis |
| Start Date/End Date: | 2013-2017 |
| Funding Agency: | National Children’s Research Centre Fund |
| Project Title: | Dissecting the role of exosomes in Cystic Fibrosis |
| Start Date/End Date: | 2017-2020 |
| Name: | Professor Jonathan Lin |
| Department | Pathology |
| Institution: | University of California San Diego |
| Country: | USA |
| Name: | Professor William Balch |
| Department | Cell Biology |
| Institution: | The Scripps Research Institute |
| Country: | USA |
| Name: | Professor Deborah Penque |
| Department | Genetics |
| Institution: | National Institute of Health, Lisbon |
| Country: | Portugal |
| Name: | Professor Christian Behl |
| Institution: | University of Mainz |
| Country: | Germany |
| Name: | Professor Stephen Keely |
| Department | Molecular Medicine |
| Institution: | Royal College of Surgeons in Ireland |
| Country: | Ireland |
| Name: | Professor Paul McNally |
| Institution: | Our Lady’s Children’s Hospital |
| Country: | Ireland |