Judith Coppinger


Judith Coppinger

Senior Lecturer

Judith obtained a PhD from the RCSI in 2004, before undertaking postdoctoral training at the Scripps Research Institute, San Diego in new folding mechanisms in Cystic Fibrosis (CF). In 2011, she joined the University of California, San Diego as a faculty member before receiving an SFI award and returning to Ireland. In 2013, she became a a Principal investigator at the University College Dublin, where she set up a basic/translational research program focused on identifying new therapies and biomarkers in CF. Judith’s research areas include:

  • Examining exosomes as biomarkers of therapy and disease progression in Cystic Fibrosis.
  • Examining the therapeutic restoration of CFTR using kinase inhibitors in Cystic Fibrosis lung cells00

Judith now joins the RCSI and National Children’s Research Center as a Principal Investigator and Senior Lecturer in the Dept. of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland.

Judith Coppinger

Senior Lecturer

Dr Anne Trappe
Position: Postdoctoral Researcher
annetrappe@rcsi.ie

Role:
Deciphering the functional and clinical properties of exosomes in Cystic Fibrosis

Role of Exosomes in CF Airway Pathogenesis (RECAP)

Examining both the biomarker potential and functionality of exosomes from CF patient lung cells

Examining the therapeutic restoration of CFTR using kinase inhibitors in Cystic Fibrosis lung cells

Dissection of the PI3K/Akt/mTOR signalling pathway as a therapeutic target in Cystic Fibrosis.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Trappe A, Donnelly SC, McNally P, Coppinger JA, 2021 Mar 12, Role of extracellular vesicles in chronic lung disease. Thorax, DOI: 10.1136/thoraxjnl-2020-216370
Useckaite Z, Ward MP, Trappe A, Reilly R, Lennon J, Davage H, Matallanas D, Cassidy H, Dillon ET, Brennan K, Doyle SL, Carter S, Donnelly S, Linnane B, McKone EF, McNally P, Coppinger JA, 2020 Jun, Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis. Thorax, DOI: 10.1136/thoraxjnl-2019-214027
Shields S, Conroy E, O'Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O'Connor D, McCann A, Gallagher WM, Coppinger JA, 2019 May 3, Correction: BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer. Oncotarget, DOI: 10.18632/oncotarget.26920
Shields S, Conroy E, O'Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O'Connor D, McCann A, Gallagher WM, Coppinger JA, 2018 Mar 20, BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer. Oncotarget, DOI: 10.18632/oncotarget.24590
Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA, 2017 Aug 9, Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis. Sci Rep, DOI: 10.1038/s41598-017-06588-z
Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C, 2014, Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One, DOI: 10.1371/journal.pone.0113765
Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH, 2015 Aug, Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol, DOI: 10.1007/s12035-014-8881-8
Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA, 2015 Jan, Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics, DOI: 10.1074/mcp.M114.037697
Choi S, Kelber J, Jiang X, Strnadel J, Fujimura K, Pasillas M, Coppinger J, Klemke R, 2014 Feb 1, Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem, DOI: 10.1016/j.ab.2013.10.025
Coppinger JA, Hutt DM, Razvi A, Koulov AV, Pankow S, Yates JR 3rd, Balch WE, 2012, A chaperone trap contributes to the onset of cystic fibrosis. PLoS One, DOI: 10.1371/journal.pone.0037682
Jang CY, Coppinger JA, Yates JR 3rd, Fang G, 2011 Apr 29, Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2011.04.004
Jang CY, Coppinger JA, Yates JR 3rd, Fang G, 2010 Mar 5, Phospho-regulation of DDA3 function in mitosis. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2010.01.115
Koulov AV, LaPointe P, Lu B, Razvi A, Coppinger J, Dong MQ, Matteson J, Laister R, Arrowsmith C, Yates JR 3rd, Balch WE, 2010 Mar 15, Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. Mol Biol Cell, DOI: 10.1091/mbc.e09-12-1017
Minamide LS, Maiti S, Boyle JA, Davis RC, Coppinger JA, Bao Y, Huang TY, Yates J, Bokoch GM, Bamburg JR, 2010 Feb 19, Isolation and characterization of cytoplasmic cofilin-actin rods. J Biol Chem, DOI: 10.1074/jbc.M109.063768
Liu GH, Guan T, Datta K, Coppinger J, Yates J 3rd, Gerace L, 2009 Nov, Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol Cell Biol, DOI: 10.1128/MCB.00684-09
Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G, 2009 May 1, Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci, DOI: 10.1242/jcs.044321
Zhu H, Coppinger JA, Jang CY, Yates JR 3rd, Fang G, 2008 Dec 1, FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. J Cell Biol, DOI: 10.1083/jcb.200807046
Steiniger SC, Coppinger JA, Krüger JA, Yates J 3rd, Janda KD, 2008 Dec, Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. Stem Cells, DOI: 10.1634/stemcells.2008-0397
Zhao WM, Coppinger JA, Seki A, Cheng XL, Yates JR 3rd, Fang G, 2008 Sep 9, RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.0709227105
Seki A, Coppinger JA, Jang CY, Yates JR, Fang G, 2008 Jun 20, Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science, DOI: 10.1126/science.1157425
Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd, Fang G, 2008 Apr 21, DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol, DOI: 10.1083/jcb.200711032
Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G, 2008 Apr 7, Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol, DOI: 10.1083/jcb.200712027
Coppinger JA, Maguire PB, 2007, Insights into the platelet releasate. Curr Pharm Des, DOI: 10.2174/138161207781662885
Coppinger JA, O'Connor R, Wynne K, Flanagan M, Sullivan M, Maguire PB, Fitzgerald DJ, Cagney G, 2007 Jun 1, Moderation of the platelet releasate response by aspirin. Blood, DOI: 10.1182/blood-2006-07-038539
Coppinger J, Fitzgerald DJ, Maguire PB, 2007, Isolation of the platelet releasate. Methods Mol Biol, DOI: 10.1385/1-59745-214-9:307
Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR 3rd, Balch WE, 2006 Nov 17, Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell, DOI: 10.1016/j.cell.2006.09.043
McRedmond JP, Park SD, Reilly DF, Coppinger JA, Maguire PB, Shields DC, Fitzgerald DJ, 2004 Feb, Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics, DOI: 10.1074/mcp.M300063-MCP200
Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB, 2004 Mar 15, Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, DOI: 10.1182/blood-2003-08-2804
du Laney TV, Cherry RS, Coppinger JA, Truskey GA, 1992 Nov-Dec, Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. Biotechnol Prog, DOI: 10.1021/bp00018a600

Funding Agency:Science Foundation of Ireland
Project Title:Characterising Hsp90 signalling in Cystic Fibrosis
Start Date/End Date:2013-2017
Funding Agency:National Children’s Research Centre Fund
Project Title:Dissecting the role of exosomes in Cystic Fibrosis
Start Date/End Date:2017-2020
Name:Professor Jonathan Lin
DepartmentPathology
Institution:University of California San Diego
Country:USA
Name:Professor William Balch
DepartmentCell Biology
Institution:The Scripps Research Institute
Country:USA
Name: Professor Deborah Penque
DepartmentGenetics
Institution:National Institute of Health, Lisbon
Country:Portugal
Name:Professor Christian Behl
Institution:University of Mainz
Country:Germany
Name: Professor Stephen Keely
DepartmentMolecular Medicine
Institution:Royal College of Surgeons in Ireland
Country:Ireland
Name:Professor Paul McNally
Institution:Our Lady’s Children’s Hospital
Country: Ireland