Jonathan Bond


Jonathan Bond

UCD Brendan McGonnell Professor of Paediatric Molecular Haemato-oncology

Jonathan is a medical graduate of Trinity College and trained as a haematologist in Ireland. After completing his clinical attachments at OLCHC, he moved to London to do laboratory research at UCL Institute of Child Health. He went on to do a PhD in Molecular Haematology at Imperial College/ MRC Clinical Sciences Centre (now the LMS), followed by a post-doctoral fellowship at the Hôpital Necker-Enfants Malades in Paris. The main theme of his work has been the investigation of how gene regulation is subverted in leukaemia.

Jonathan returned to Ireland in 2018 to lead a new collaborative paediatric leukaemia research program between OLCHC and Systems Biology Ireland at UCD. More is known about the molecular biology of childhood leukaemia than ever before, and huge amounts of genetic, transcriptional and epigenetic information continue to be generated. It’s important that these data are interrogated intelligently, and it’s incumbent on clinicians and biologists to help drive this analysis. Jonathan’s group will use systems biology approaches to investigate gene and protein networks in paediatric leukaemia, with particular reference to normal haematopoiesis. The ultimate hope is to find more precise and effective cures for children and adolescents with these diseases.

Jonathan Bond

UCD Brendan McGonnell Professor of Paediatric Molecular Haemato-oncology

Dr James Smith
Position: Postdoctoral Researcher
james.smith@ucd.ie

Role:
James is investigating the molecular effects of epigenetic mutations in childhood and adolescent leukaemia.

Thomas Lefeivre
Position: PhD Student
thomas.lefeivre1@ucdconnect.ie

Role:
Thomas is using a combination of computational biology and laboratory experiments to investigate the functional interaction between different mutations in childhood and adolescent leukaemia.

Using systems biology to improve the treatment of childhood leukaemia

We will use systems biology analysis to investigate the mechanisms of oncogenesis and treatment resistance in paediatric leukaemias. These approaches initially involve computational modelling of the complex interdependent genes and protein networks that are crucial for leukaemia cell survival. We predict that these analyses will identify hidden ‘Achilles’ heels’ which can be targeted to help kill the leukaemia cells, and this will be tested in cell line models and primary patient samples. Ultimately, we hope that the combination of these analyses will help us find more precise and effective cures for children with blood cancers.



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Bond J, Labis E, Marceau-Renaut A, Duployez N, Labopin M, Hypolite G, Michel G, Ducassou S, Boutroux H, Nelken B, Bertrand Y, Baruchel A, Petit A, Asnafi V, Leverger G, Preudhomme C, Macintyre E, Lapillonne H, 2018 Aug, Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia. Leukemia, DOI: 10.1038/s41375-018-0187-9
Bond J, Tran Quang C, Hypolite G, Belhocine M, Bergon A, Cordonnier G, Ghysdael J, Macintyre E, Boissel N, Spicuglia S, Asnafi V, 2018 Mar, Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome. Mol Cancer Res, DOI: 10.1158/1541-7786.MCR-17-0442
Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, Cieslak A, Trinquand A, Pastoret C, Belhocine M, Spicuglia S, Lheritier V, Leprêtre S, Thomas X, Huguet F, Ifrah N, Dombret H, Macintyre E, Boissel N, Asnafi V, 2017 Aug 10, Early Response-Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study. J Clin Oncol, DOI: 10.1200/JCO.2016.71.8585
Bond J, Touzart A, Nadal N, Trinquand A, Thouvenin S, Da Cruz V, Bonté PE, Radford-Weiss I, Garnier N, Stéphan JL, Macintyre E, 2018 May, Early thymic precursor-like lymphomatous presentation of the ETV6-NCOA2 translocation. Br J Haematol, DOI: 10.1111/bjh.14579
Cordonnier G, Mandoli A, Radhouane A, Hypolite G, Lhermitte L, Belhocine M, Asnafi V, Macintyre E, Martens JHA, Fumagalli S, Bond J, 2017 Jun, CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis. Leukemia, DOI: 10.1038/leu.2017.53
Bond J, Domaschenz R, Roman-Trufero M, Sabbattini P, Ferreiros-Vidal I, Gerrard G, Asnafi V, Macintyre E, Merkenschlager M, Dillon N, 2016 Oct 4, Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia. Oncotarget, DOI: 10.18632/oncotarget.11688
Bond J, Marchand T, Touzart A, Cieslak A, Trinquand A, Sutton L, Radford-Weiss I, Lhermitte L, Spicuglia S, Dombret H, Macintyre E, Ifrah N, Hamel JF, Asnafi V, 2016 Jun, An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. Haematologica, DOI: 10.3324/haematol.2015.141218
Bond J, Touzart A, Cieslak A, Trinquand A, Marchand T, Escoffre M, Contet A, Muller M, Schmitt C, Fest T, Asnafi V, Macintyre E, 2016 Aug, NAP1L1-MLLT10 is a rare recurrent translocation that is associated with HOXA activation and poor treatment response in T-cell acute lymphoblastic leukaemia. Br J Haematol, DOI: 10.1111/bjh.13772
Bond J, Bergon A, Durand A, Tigaud I, Thomas X, Asnafi V, Spicuglia S, Macintyre E, 2014 Nov 6, Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL. Blood, DOI: 10.1182/blood-2014-04-567636
Cieslak A, Le Noir S, Trinquand A, Lhermitte L, Franchini DM, Villarese P, Gon S, Bond J, Simonin M, Vanhille L, Reimann C, Verhoeyen E, Larghero J, Six E, Spicuglia S, André-Schmutz I, Langerak A, Nadel B, Macintyre E, Payet-Bornet D, Asnafi V, 2014 Aug 25, RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement. J Exp Med, DOI: 10.1084/jem.20132585
Trinquand A, Tanguy-Schmidt A, Ben Abdelali R, Lambert J, Beldjord K, Lengliné E, De Gunzburg N, Payet-Bornet D, Lhermitte L, Mossafa H, Lhéritier V, Bond J, Huguet F, Buzyn A, Leguay T, Cahn JY, Thomas X, Chalandon Y, Delannoy A, Bonmati C, Maury S, Nadel B, Macintyre E, Ifrah N, Dombret H, Asnafi V, 2013 Dec 1, Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. J Clin Oncol, DOI: 10.1200/JCO.2012.48.5292
Goodyer M, Sargent J, Bond J, McMahon C, Dunne B, Smith O, 2013 Oct, Allogeneic stem cell transplantation as immunotherapy for X-linked lymphoproliferative disease-associated cerebral T-cell lymphoma. Br J Haematol, DOI: 10.1111/bjh.12454
Bond J, Hough R, Moppett J, Vora A, Mitchell C, Goulden N, 2013 Apr, 'Stroke-like syndrome' caused by intrathecal methotrexate in patients treated during the UKALL 2003 trial. Leukemia, DOI: 10.1038/leu.2012.328
Bond J, Adams S, Richards S, Vora A, Mitchell C, Goulden N, 2011 Sep 1, Polymorphism in the PAI-1 (SERPINE1) gene and the risk of osteonecrosis in children with acute lymphoblastic leukemia. Blood, DOI: 10.1182/blood-2011-05-355206
Beel K, Cotter MM, Blatny J, Bond J, Lucas G, Green F, Vanduppen V, Leung DW, Rooney S, Smith OP, Rosen MK, Vandenberghe P, 2009 Jan, A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. Br J Haematol, DOI: 10.1111/j.1365-2141.2008.07416.x
Enright H, Bond J, 2008 Apr, Chronic leukemias. Dis Mon, DOI: 10.1016/j.disamonth.2007.12.005
Bond J, Shahdadpuri R, Mc Mahon C, O'marcaigh A, Cotter M, Smith O, 2007 Oct 15, Successful treatment of acute Epstein-Barr virus infection associated with X-linked lymphoproliferative disorder with rituximab. Pediatr Blood Cancer, DOI: 10.1002/pbc.21081