Jaythoon Hassan


Jaythoon Hassan

Senior Clinical Scientist

Jaythoon is a Senior Clinical Scientist in the National Virus Reference Laboratory (NVRL) which is located in UCD. She obtained a PhD in Immunology from Trinity College Dublin and is a Fellow of the Royal College of Pathologists. Jaythoon previously held Research Fellowship posts in The Dept. of Immunology, St. James’s Hospital and The Children’s Research Centre at Our Lady’s Hospital for Sick Children, Crumlin where her research centred on neonatal immunity. Since joining the NVRL in 2005, Jaythoon’s scientific interests have focused on host-pathogen interactions with particular emphasis on the research- diagnostic interface of immunity to viral infections.

Current active areas of research include an understanding of immunity due to  vaccine or natural exposure for eg. immunity to mumps as mumps outbreaks continue to occur in highly vaccinated populations; monitoring of  immune responses to EBV and CMV in the immunosuppressed host employing paediatric kidney transplant recipients and adult liver transplant recipients as models; biomarkers for detection of recency in HIV infection. Jaythoon aims to translate these findings towards development and innovation of diagnostic assays to improve laboratory based algorithms. She works in close collaboration with colleagues in the HSE Health Protection Surveillance Centre; the Children’s University Hospital, Temple Street; St. Vincent’s University Hospital and Trinity College Dublin to facilitate these studies.

Jaythoon Hassan

Senior Clinical Scientist

Anna Connell
Position: Postdoctoral Researcher
anna.connell@ucd.ie

Role:
The research project I’m undertaking aims to investigate the antibody response and novel immune signatures to mumps using clinical samples from a number of well-characterised cohorts.

Staging of HIV infections utilising commonly used HIV serological assays

It is critical that we are able to measure and monitor HIV incidence to understand transmission patterns, to provide a rational basis for targeting prevention efforts, to evaluate interventions to reduce transmissions and to predict the burden of HIV infection in different demographic and risk populations.

Use of host-protein immune response assays to distinguish between bacterial and viral infections.

Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate antibiotic misuse and patient management. A recent study identified circulating host immune response proteins that can discriminate viral from bacterial infection. This approach has the potential to utilise the host’s immune response to infection rather than direct pathogen detection.

Investigation of Biomarkers which Predict the Risk of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients.

Immunosuppressive therapies significantly reduce the risk of graft rejection in organ transplantation but increase the susceptibility of recipients to infections. Infections with viral pathogens, in particular CMV, occur frequently and increase the recipient's risk of graft failure. This study aims to evaluate the risk factors for progression to CMV disease occurring in these patients.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Ní Gabhann-Dromgoole J, de Chaumont C, Shahnazaryan D, Smith S, Malone C, Hassan J, De Gascun CF, Jefferies CA, Murphy CC, 2019, Systemic IL-1β production as a consequence of corneal HSV-1 infection-contribution to the development of herpes simplex keratitis. Int J Ophthalmol, DOI: 10.18240/ijo.2019.09.19
Robinson E, Moran J, O'Donnell K, Hassan J, Tuite H, Ennis O, Cooney F, Nugent E, Preston L, O'Dea S, Doyle S, Keating S, Connell J, De Gascun C, Igoe D, 2019 Jan, Integration of a recent infection testing algorithm into HIV surveillance in Ireland: improving HIV knowledge to target prevention. Epidemiol Infect, DOI: 10.1017/S0950268819000244
Hassan J, Moran J, Murphy G, Mason O, Connell J, De Gascun C, 2019 Oct, Discrimination between recent and non-recent HIV infections using routine diagnostic serological assays. Med Microbiol Immunol, DOI: 10.1007/s00430-019-00590-0
Shannon S, Brennan D, Hanna D, Younger Z, Hassan J, Breslin G, 2018 Apr 20, The Effect of a School-Based Intervention on Physical Activity and Well-Being: a Non-Randomised Controlled Trial with Children of Low Socio-Economic Status. Sports Med Open, DOI: 10.1186/s40798-018-0129-0
Hassan J, Dean J, De Gascun CF, Riordan M, Sweeney C, Connell J, Awan A, 2018 Jun, Plasma EBV microRNAs in paediatric renal transplant recipients. J Nephrol, DOI: 10.1007/s40620-017-0462-2
Hassan J, Browne K, De Gascun C, 2016 Nov, HIV-1 in Monocytes and Macrophages: An Overlooked Reservoir? Viral Immunol, DOI: 10.1089/vim.2016.0091
Hassan J, O'Neill D, Honari B, De Gascun C, Connell J, Keogan M, Hickey D, 2016 Feb, Cytomegalovirus Infection in Ireland: Seroprevalence, HLA Class I Alleles, and Implications. Medicine (Baltimore), DOI: 10.1097/MD.0000000000002735
Kenny L, O'Kelly E, Connell J, De Gascun C, Hassan J, 2016 Jan, Mumps outbreaks in a highly vaccinated population: Investigation of a neutralization titre against the current circulating wildtype genotype G5 mumps virus. J Clin Virol, DOI: 10.1016/j.jcv.2015.11.023
O' Riordan B, Carr MJ, Connell J, Dunford L, Hall WW, Hassan J, 2014 Aug, Seroepidemiology and phylogenetic characterisation of measles virus in Ireland, 2004-2013. J Clin Virol, DOI: 10.1016/j.jcv.2014.05.010
Hassan J, Carr M, Connell J, De Gascun C, 2014 May 22, Letter to the Editor: smoking and older age associated with mumps in an outbreak in a group of highly-vaccinated individuals attending a youth club party, The Netherlands, 2012. Euro Surveill, DOI: 10.2807/1560-7917.es2014.19.20.20807
Moran J, Dean J, De Oliveira A, O'Connell M, Riordan M, Connell J, Awan A, Hall WW, Hassan J, 2013 Dec, Increased levels of PD-1 expression on CD8 T cells in patients post-renal transplant irrespective of chronic high EBV viral load. Pediatr Transplant, DOI: 10.1111/petr.12156
Hassan J, Herbert M, Smith L, Connell J, 2013 Aug, Towards improving the retrospective diagnosis of congenital cytomegalovirus infection in dried blood spots. Viral Immunol, DOI: 10.1089/vim.2013.0027
Crowley A, Connell J, Schaffer K, Hall W, Hassan J, 2012 Dec, Is there diagnostic value in detection of immunoglobulin g antibodies to the epstein-barr virus early antigen? Biores Open Access, DOI: 10.1089/biores.2012.0274
Fitzpatrick G, Ward M, Ennis O, Johnson H, Cotter S, Carr MJ, O Riordan B, Waters A, Hassan J, Connell J, Hall W, Clarke A, Murphy H, Fitzgerald M, 2012 Dec 6, Use of a geographic information system to map cases of measles in real-time during an outbreak in Dublin, Ireland, 2011. Euro Surveill, DOI: 10.2807/ese.17.49.20330-en
Hassan J, Dean J, Moss E, Carr MJ, Hall WW, Connell J, 2012 Apr, Seroepidemiology of the recent mumps virus outbreaks in Ireland. J Clin Virol, DOI: 10.1016/j.jcv.2011.12.022
Schaffer K, Hassan J, Staines A, Coughlan S, Holder P, Tuite G, McCormick AP, Traynor O, Hall WW, Connell J, 2011 Dec, Surveillance of Epstein-Barr virus loads in adult liver transplantation: associations with age, sex, posttransplant times, and transplant indications. Liver Transpl, DOI: 10.1002/lt.22406
Moran J, Carr M, Waters A, Boyle S, Riordan M, Connell J, Awan A, Hall W, Hassan J, 2011 Aug 15, Epstein-barr virus gene expression, human leukocyte antigen alleles and chronic high viral loads in pediatric renal transplant patients. Transplantation, DOI: 10.1097/TP.0b013e3182247bf2
Waters A, Hassan J, De Gascun C, Kissoon G, Knowles S, Molloy E, Connell J, Hall WW, 2010 Nov, Human cytomegalovirus UL144 is associated with viremia and infant development sequelae in congenital infection. J Clin Microbiol, DOI: 10.1128/JCM.01133-10
Carr MJ, Moss E, Waters A, Dean J, Jin L, Coughlan S, Connell J, Hall WW, Hassan J, 2010 Sep, Molecular epidemiological evaluation of the recent resurgence in mumps virus infections in Ireland. J Clin Microbiol, DOI: 10.1128/JCM.00434-10
Treacy A, Carr MJ, Dunford L, Palacios G, Cannon GA, O'Grady A, Moran J, Hassan J, Loy A, Connell J, Devaney D, Kelehan P, Hall WW, 2010 Feb, First report of sudden death due to myocarditis caused by adenovirus serotype 3. J Clin Microbiol, DOI: 10.1128/JCM.00815-09
Schaffer K, Moran J, Duffy M, McCormick AP, Hall WW, Hassan J, 2009 Oct, Kinetics of host immune responses and cytomegalovirus resistance in a liver transplant patient. Liver Transpl, DOI: 10.1002/lt.21832
Carr MJ, Conway A, Waters A, Moran J, Hassan J, Hall WW, Connell J, 2009 Jan, Molecular epidemiology of circulating measles virus in Ireland 2002-2007. J Med Virol, DOI: 10.1002/jmv.21365
Hassan J, Irwin F, Dooley S, Connell J, 2008 Dec, Mycoplasma pneumoniae infection in a pediatric population: analysis of soluble immune markers as risk factors for asthma. Hum Immunol, DOI: 10.1016/j.humimm.2008.09.003
Reid F, Hassan J, Irwin F, Waters A, Hall W, Connell J, 2008 Feb, Epidemiologic and diagnostic evaluation of a recent mumps outbreak using oral fluid samples. J Clin Virol, DOI: 10.1016/j.jcv.2007.10.009
Roe B, Coughlan S, Hassan J, Grogan A, Farrell G, Norris S, Bergin C, Hall WW, 2007 Oct 1, Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV. J Infect Dis, DOI: 10.1086/520935
Hassan J, Connell J, 2007 Aug, Translational mini-review series on infectious disease: congenital cytomegalovirus infection: 50 years on. Clin Exp Immunol, DOI: 10.1111/j.1365-2249.2007.03454.x
Hassan J, Dooley S, Hall W, 2007 Mar, Immunological response to cytomegalovirus in congenitally infected neonates. Clin Exp Immunol, DOI: 10.1111/j.1365-2249.2007.03302.x
O'Neill RM, Hassan J, Reen DJ, 2003 May 1, IL-7-regulated homeostatic maintenance of recent thymic emigrants in association with caspase-mediated cell proliferation and apoptotic cell death. J Immunol, DOI: 10.4049/jimmunol.170.9.4524
Jaleco S, Kinet S, Hassan J, Dardalhon V, Swainson L, Reen D, Taylor N, 2002 Dec 15, IL-7 and CD4+ T-cell proliferation. Blood, DOI: 10.1182/blood-2002-06-1760
Hassan J, Reen DJ, 2002 Mar, IL-7 and homeostasis of recent thymic emigrants. Trends Immunol, DOI: 10.1016/s1471-4906(01)02173-1
Hassan J, Reen DJ, 2001 Aug 15, Human recent thymic emigrants--identification, expansion, and survival characteristics. J Immunol, DOI: 10.4049/jimmunol.167.4.1970
Hassan J, Reen DJ, 1998 Oct, IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. Eur J Immunol, DOI: 10.1002/(SICI)1521-4141(199810)28:10<3057::AID-IMMU3057>3.0.CO;2-Z
Hassan J, Rainsford E, Reen DJ, 1997 Dec, Linkage of protein kinase C-beta activation and intracellular interleukin-2 accumulation in human naive CD4 T cells. Immunology, DOI: 10.1046/j.1365-2567.1997.00375.x
Hassan J, Reen DJ, 1997 Mar, Cord blood CD4+ CD45RA+ T cells achieve a lower magnitude of activation when compared with their adult counterparts. Immunology, DOI: 10.1111/j.1365-2567.1997.00397.x
Hassan J, Reen DJ, 1996 Apr, Reduced primary antigen-specific T-cell precursor frequencies in neonates is associated with deficient interleukin-2 production. Immunology, DOI: 10.1046/j.1365-2567.1996.476587.x
Hassan J, Yanni G, Hegarty V, Feighery C, Bresnihan B, Whelan A, 1996 Mar, Increased numbers of CD5+ B cells and T cell receptor (TCR) gamma delta+ T cells are associated with younger age of onset in rheumatoid arthritis (RA). Clin Exp Immunol, DOI: 10.1111/j.1365-2249.1996.tb08287.x
Hassan J, O'Neill S, O'Neill LA, Pattison U, Reen DJ, 1995 Oct, Signalling via CD28 of human naive neonatal T lymphocytes. Clin Exp Immunol, DOI: 10.1111/j.1365-2249.1995.tb06655.x
Wang Y, Puri P, Hassan J, Miyakita H, Reen DJ, 1995 Aug, Abnormal innervation and altered nerve growth factor messenger ribonucleic acid expression in ureteropelvic junction obstruction. J Urol, DOI: 10.1097/00005392-199508000-00091
Hassan J, Reen DJ, 1994 Jun, Interleukin-1 augments the diminished interleukin-2 mRNA expression and proliferative response of neonatal T lymphocytes to anti-CD2 antibodies. Scand J Immunol, DOI: 10.1111/j.1365-3083.1994.tb03418.x
Hassan J, Feighery C, Bresnihan B, Keogan M, Fitzgerald MX, Whelan A, 1994 Jan, Serum IgA and IgG subclasses during treatment for acute respiratory exacerbation in cystic fibrosis: analysis of patients colonised with mucoid or non-mucoid strains of pseudomonas aeruginosa. Immunol Invest, DOI: 10.3109/08820139409063428
Hassan J, Feighery C, Bresnihan B, Whelan A, 1992 Sep, Prevalence of anti-Fab antibodies in patients with autoimmune and infectious diseases. Clin Exp Immunol, DOI: 10.1111/j.1365-2249.1992.tb06974.x
Hassan J, Whelan A, Bresnihan B, Feighery C, 1991, Induction of IgM and IgM-rheumatoid factor synthesis in vitro by indomethacin. Rheumatol Int, DOI: 10.1007/bf02274885
Hassan J, Feighery C, Bresnihan B, Whelan A, 1991, Effect of gold therapy on CD5+ B-cells and TCR gamma delta+ T-cells in patients with rheumatoid arthritis. Rheumatol Int, DOI: 10.1007/bf00332557
Coffey M, Hassan J, Feighery C, Fitzgerald M, Bresnihan B, 1989 Jul, Rheumatoid factors in cystic fibrosis: associations with disease manifestations and recurrent bacterial infections. Clin Exp Immunol, DOI: 10.1007/bf00332557
Hassan J, Feighery C, Bresnihan B, Whelan A, 1989 Jun, Expression and regulation of the HLA-DR antigen on circulating monocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum, DOI: 10.1002/anr.1780320605
Soden M, Hassan J, Scott DL, Hanly JG, Moriarty M, Whelan A, Feighery C, Bresnihan B, 1989 May, Lymphoid irradiation in intractable rheumatoid arthritis. Long-term followup of patients treated with 750 rads or 2,000 rads. Arthritis Rheum, DOI: 10.1002/anr.1780320503
Hassan J, Feighery C, Bresnihan B, Whelan A, 1987 Oct, Characterization and quantification of solubilised HLA-DR antigens from circulating human monocytes using an immunoblotting procedure. Tissue Antigens, DOI: 10.1111/j.1399-0039.1987.tb01616.x

Funding Agency:Temple Street Foundation
Project Title:Dynamic Expression of Circulating MicroRNAs in Paediatric Renal Transplant Recipients
Start Date/End Date:01/01/2017 - 01/01/2019
Total Awarded:€250,091
Role:Co-Principal Investigator
Funding Agency:SFI
Project Title:Cell EXPLORERS- National Expansion for a Sustainable Public Engagement Model
Start Date/End Date:01/01/2017 - 01/01/2019
Total Awarded:€181,332
Role:Collaborator
Funding Agency:UCD Seed funding
Project Title:HIV-1 in Peripheral Blood Monocytes: Investigation into their contribution to the overall pool of HIV-1 replication and latency.
Start Date/End Date:01/06/2015 - 31/12/2016
Total Awarded:€9,212
Role:Principal Investigator
Name:Professor Clair Gardiner
DepartmentSchool of Biochemistry and Immunology
Institution:Trinity College Dublin
Country:Ireland
Name:Dr. Steven Rubin
DepartmentCenters for Biologics Evaluation and Research
Institution:FDA US Food and Drug Administration
Country:United States of America
Name:Dr. Gary Murphy
DepartmentNational Infection Service
Institution:Public Health England
Country:United Kingdom