We are looking at how reactive oxygen species released by human intestinal cells help protect the gut by disabling bacteria and interfering with their ability to cause infection
Billy BourkeProfessor of Paediatrics
Professor Bourke qualified in Medicine from University College Dublin (UCD) in 1988, and received his MD from UCD in 1995. He trained in The Mater Hospital, Dublin, Our Lady’s Children’s Hospital, Crumlin, and The Rotunda, before pursuing a Fellowship in Paediatric Gastroenterology in The Hospital for Sick Children/University of Toronto. He was appointed Consultant Paediatric Gastroenterologist in Our Lady’s Children’s Hospital, Crumlin in 1997.
Professor Bourke’s main laboratory research interest is in infectious diarrhoeal diseases of childhood, and his group focuses particularly on Campylobacter jejuni, a major human intestinal pathogen and the most common cause of bacterial gastroenteritis. Together with a group of close collaborators that includes Professor Ulla Knaus, Dr Marguerite Clyne, and Dr Tadhg O’Croinin at UCD, and the National Children’s Research Centre, Professor Bourke has developed an internationally competitive infection biology research programme that has close collaborative ties with leading national and international scientists in the area of Campylobacter pathogenesis.
Professor Bourke also has an established track record in clinical epidemiology research on digestive diseases of childhood. Together with Dr Marion Rowland, a clinical epidemiologist recognised internationally for her work on the epidemiology of H. pylori, he has a major research interest in the epidemiology of cystic fibrosis-associated liver disease. These studies, funded by grants from the Health Research Board and the National Children’s Research Centre, have focussed on understanding the population incidence and risk factors for the development of liver disease, and its complications among Irish children with cystic fibrosis.
Professor Bourke also collaborates closely with Dr Séamus Hussey, who has set up the DOCHAS project, an ambitious translational research programme that aims to define the epidemiology and biology of Crohn’s disease and ulcerative colitis in Irish children.
Billy BourkeProfessor of Paediatrics
We are looking at how reactive oxygen species released by human intestinal cells help protect the gut by disabling bacteria and interfering with their ability to cause infection
This study combines research on paediatric specimen with animal studies to understand the redox-initiated progression from chronic inflammation to fibrotic strictures in Crohn’s disease.
This is a long-term project that has been determine the incidence, severity and outcome of liver disease in Irish children with cystic fibrosis
The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.
| Ryan N, Cooper S, Dominik A, Quinn S, Broderick A, Bourke B, Hussey S, 2023 Aug, Outcomes of Tofacitinib Use in an Irish Pediatric Cohort. JPGN Rep, DOI: 10.1097/PG9.0000000000000332 |
| Rowland M, Drummond J, Connolly L, Daly E, McCormick PA, Bourke B, Cystic Fibrosis Registry of Ireland, Cystic Fibrosis Liver Disease Research Study Group, 2023 Nov, The natural history of cystic fibrosis liver disease a prospective cohort study. J Cyst Fibros, DOI: 10.1016/j.jcf.2023.07.002 |
| Stenke E, Stallard L, Cooper S, Dominik A, Pilkington A, Sugrue S, O'Sullivan M, McDermott M, Quinn S, Broderick A, Bourke B, Hussey S, 2023 May 1, Mucosal Atrophy Predicts Poorer Outcomes in Pediatric Ulcerative Colitis-A National Inception Cohort Study. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000003746 |
| Marek-Yagel D, Stenke E, Pode-Shakked B, Dunne C, Crushell E, Bryce-Smith A, McDermott M, O'Sullivan MJ, Veber A, Krishnamurthy M, Wells JM, Anikster Y, Bourke B, 2023 May, Nonsense mutation in the novel PERCC1 gene as a genetic cause of congenital diarrhea and enteropathy. Hum Genet, DOI: 10.1007/s00439-022-02486-1 |
| Rowland M, McNally P, Fitzpatrick E, Bourke B, 2022 Jul, Transient elastography lacks precision in children. Pediatr Res, DOI: 10.1038/s41390-021-01694-1 |
| Sasame A, Stokes D, Bourke B, Connolly L, Fitzpatrick E, Rowland M, 2022 Mar, The impact of liver disease on mortality in cystic fibrosis-A systematic review. J Cyst Fibros, DOI: 10.1016/j.jcf.2021.07.014 |
| Rowland M, McGee A, McNally P, Bourke B, 2022 Jan 1, Performance Characteristics, Intra- and Inter-Operator Agreement of Transient Elastography in Pediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000003254 |
| Sasame A, Connolly L, Fitzpatrick E, Stokes D, Bourke B, Rowland M, 2020, The impact of liver disease on mortality in cystic fibrosis - a systematic review protocol. HRB Open Res, DOI: 10.12688/hrbopenres.13065.3 |
| Stenke E, Aviello G, Singh A, Martin S, Winter D, Sweeney B, McDermott M, Bourke B, Hussey S, Knaus UG, 2020 Oct, NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation. Redox Biol, DOI: 10.1016/j.redox.2020.101752 |
| Sandys N, Loomes C, Keane A, Hussey S, Broderick A, McDermott M, O'Sullivan M, Bourke B, 2020 Oct, Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0000000000002879 |
| Rowland M, McGee A, Broderick A, Drumm B, Connolly L, Daly LE, Drummond J, Fitzpatrick E, Linnane B, McCormick PA, McNally P, Rainford L, Bourke B, Cystic Fibrosis Registry of Ireland, Cystic Fibrosis Liver Disease Research Group, 2020 Oct, Repeatability of transient elastography in children. Pediatr Res, DOI: 10.1038/s41390-020-0916-4 |
| Aviello G, Singh AK, O'Neill S, Conroy E, Gallagher W, D'Agostino G, Walker AW, Bourke B, Scholz D, Knaus UG, 2019 Nov, Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects. Mucosal Immunol, DOI: 10.1038/s41385-019-0205-x |
| Collins A, Mannion R, Broderick A, Hussey S, Devins M, Bourke B, 2019, Gabapentin for the treatment of pain manifestations in children with severe neurological impairment: a single-centre retrospective review. BMJ Paediatr Open, DOI: 10.1136/bmjpo-2019-000467 |
| Stenke E, Bourke B, Knaus UG, 2019, Correction to: NADPH Oxidases in Inflammatory Bowel Disease. Methods Mol Biol, DOI: 10.1007/978-1-4939-9424-3_39 |
| Stenke E, Bourke B, Knaus UG, 2019, NAPDH Oxidases in Inflammatory Bowel Disease. Methods Mol Biol, DOI: 10.1007/978-1-4939-9424-3_38 |
| Dolan B, Burkitt-Gray L, Shovelin S, Bourke B, Drumm B, Rowland M, Clyne M, 2018 Mar, The use of stool specimens reveals Helicobacter pylori strain diversity in a cohort of adolescents and their family members in a developed country. Int J Med Microbiol, DOI: 10.1016/j.ijmm.2017.11.005 |
| Stenke E, Bourke B, Knaus U, 2017, Crohn's Strictures-Moving Away from the Knife. Front Pediatr, DOI: 10.3389/fped.2017.00141 |
| Clyne M, Duggan G, Dunne C, Dolan B, Alvarez L, Bourke B, 2017, Erratum to: Assays to Study the Interaction of Campylobacter jejuni with the Mucosal Surface. Methods Mol Biol, DOI: 10.1007/978-1-4939-6536-6_22 |
| Scanlan E, Ardill L, Whelan MV, Shortt C, Nally JE, Bourke B, Ó Cróinín T, 2017 Apr, Relaxation of DNA supercoiling leads to increased invasion of epithelial cells and protein secretion by Campylobacter jejuni. Mol Microbiol, DOI: 10.1111/mmi.13614 |
| Clyne M, Duggan G, Dunne C, Dolan B, Alvarez L, Bourke B, 2017, Assays to Study the Interaction of Campylobacter jejuni with the Mucosal Surface. Methods Mol Biol, DOI: 10.1007/978-1-4939-6536-6_12 |
| Clyne M, Duggan G, Naughton J, Bourke B, 2017, Methods to Assess the Direct Interaction of C. jejuni with Mucins. Methods Mol Biol, DOI: 10.1007/978-1-4939-6536-6_10 |
| Shortt C, Scanlan E, Hilliard A, Cotroneo CE, Bourke B, Ó Cróinín T, 2016 Sep 13, DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus. mBio, DOI: 10.1128/mBio.01227-16 |
| Alvarez LA, Kovačič L, Rodríguez J, Gosemann JH, Kubica M, Pircalabioru GG, Friedmacher F, Cean A, Ghişe A, Sărăndan MB, Puri P, Daff S, Plettner E, von Kriegsheim A, Bourke B, Knaus UG, 2016 Sep 13, NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.1605443113 |
| Pircalabioru G, Aviello G, Kubica M, Zhdanov A, Paclet MH, Brennan L, Hertzberger R, Papkovsky D, Bourke B, Knaus UG, 2016 May 11, Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection. Cell Host Microbe, DOI: 10.1016/j.chom.2016.04.007 |
| Hayes P, Dhillon S, O'Neill K, Thoeni C, Hui KY, Elkadri A, Guo CH, Kovacic L, Aviello G, Alvarez LA, Griffiths AM, Snapper SB, Brant SR, Doroshow JH, Silverberg MS, Peter I, McGovern DP, Cho J, Brumell JH, Uhlig HH, Bourke B, Muise AA, Knaus UG, 2015 Sep 1, Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol, DOI: 10.1016/j.jcmgh.2015.06.005 |
| Casey JP, Slattery S, Cotter M, Monavari AA, Knerr I, Hughes J, Treacy EP, Devaney D, McDermott M, Laffan E, Wong D, Lynch SA, Bourke B, Crushell E, 2015 Nov, Clinical and genetic characterisation of infantile liver failure syndrome type 1, due to recessive mutations in LARS. J Inherit Metab Dis, DOI: 10.1007/s10545-015-9849-1 |
| Bourke B, Hussey S, 2015 Mar, Chronic infections of the small intestine. Curr Opin Gastroenterol, DOI: 10.1097/MOG.0000000000000153 |
| Bourke B, 2015 Feb, Outcomes of children after esophagogastroduodenoscopy for chronic abdominal pain. Clin Gastroenterol Hepatol, DOI: 10.1016/j.cgh.2014.08.007 |
| Rowland M, Gallagher C, Gallagher CG, Laoide RÓ, Canny G, Broderick AM, Drummond J, Greally P, Slattery D, Daly L, McElvaney NG, Bourke B, 2015 Jan, Outcome in patients with cystic fibrosis liver disease. J Cyst Fibros, DOI: 10.1016/j.jcf.2014.05.013 |
| Naughton J, Duggan G, Bourke B, Clyne M, 2014 Jan-Feb, Interaction of microbes with mucus and mucins: recent developments. Gut Microbes, DOI: 10.4161/gmic.26680 |
| Alvarez LA, Bourke B, Pircalabioru G, Georgiev AY, Knaus UG, Daff S, Corcionivoschi N, 2013, Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity. PLoS One, DOI: 10.1371/journal.pone.0075534 |
| Naughton JA, Mariño K, Dolan B, Reid C, Gough R, Gallagher ME, Kilcoyne M, Gerlach JQ, Joshi L, Rudd P, Carrington S, Bourke B, Clyne M, 2013 Aug, Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins. Infect Immun, DOI: 10.1128/IAI.00415-13 |
| Crowley E, Bourke B, Hussey S, 2013 Feb, How to use Helicobacter pylori testing in paediatric practice. Arch Dis Child Educ Pract Ed, DOI: 10.1136/archdischild-2012-301642 |
| Alemka A, Corcionivoschi N, Bourke B, 2012, Defense and adaptation: the complex inter-relationship between Campylobacter jejuni and mucus. Front Cell Infect Microbiol, DOI: 10.3389/fcimb.2012.00015 |
| Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B, 2012 Jul 19, Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe, DOI: 10.1016/j.chom.2012.05.018 |
| Casey JP, McGettigan P, Lynam-Lennon N, McDermott M, Regan R, Conroy J, Bourke B, O'Sullivan J, Crushell E, Lynch S, Ennis S, 2012 Jul, Identification of a mutation in LARS as a novel cause of infantile hepatopathy. Mol Genet Metab, DOI: 10.1016/j.ymgme.2012.04.017 |
| Blackburn C, McDermott M, Bourke B, 2012 Feb, Clinical presentation of and outcome for solitary rectal ulcer syndrome in children. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0b013e31823014c0 |
| Rowland M, Bourke B, 2011 Nov, Liver disease in cystic fibrosis. Curr Opin Pulm Med, DOI: 10.1097/MCP.0b013e32834b7f51 |
| Rowland M, Gallagher CG, O'Laoide R, Canny G, Broderick A, Hayes R, Greally P, Slattery D, Daly L, Durie P, Bourke B, 2011 Jan, Outcome in cystic fibrosis liver disease. Am J Gastroenterol, DOI: 10.1038/ajg.2010.316 |
| Piccin A, Cortelazzo S, Rovigatti U, Bourke B, Smith OP, 2010 Aug, Immunosuppressive treatments in Crohn's disease induce myelodysplasia and leukaemia. Am J Hematol, DOI: 10.1002/ajh.21755 |
| Alemka A, Whelan S, Gough R, Clyne M, Gallagher ME, Carrington SD, Bourke B, 2010 Aug, Purified chicken intestinal mucin attenuates Campylobacter jejuni pathogenicity in vitro. J Med Microbiol, DOI: 10.1099/jmm.0.019315-0 |
| Pawlikowska L, Strautnieks S, Jankowska I, Czubkowski P, Emerick K, Antoniou A, Wanty C, Fischler B, Jacquemin E, Wali S, Blanchard S, Nielsen IM, Bourke B, McQuaid S, Lacaille F, Byrne JA, van Eerde AM, Kolho KL, Klomp L, Houwen R, Bacchetti P, Lobritto S, Hupertz V, McClean P, Mieli-Vergani G, Shneider B, Nemeth A, Sokal E, Freimer NB, Knisely AS, Rosenthal P, Whitington PF, Pawlowska J, Thompson RJ, Bull LN, 2010 Jul, Differences in presentation and progression between severe FIC1 and BSEP deficiencies. J Hepatol, DOI: 10.1016/j.jhep.2010.01.034 |
| Alemka A, Clyne M, Shanahan F, Tompkins T, Corcionivoschi N, Bourke B, 2010 Jun, Probiotic colonization of the adherent mucus layer of HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties. Infect Immun, DOI: 10.1128/IAI.01249-09 |
| Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M Jr, Rowland M, Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemková D, Hannah WB, Phillips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM, Durie PR, Knowles MR, Gene Modifier Study Group, 2009 Sep 9, Genetic modifiers of liver disease in cystic fibrosis. JAMA, DOI: 10.1001/jama.2009.1295 |
| Rowland M, Fleming P, Bourke B, 2010 Feb, Looking in the mouth for Crohn's disease. Inflamm Bowel Dis, DOI: 10.1002/ibd.20983 |
| Hussey S, Bourke B, Broderick A, Phelan E, McDermott M, 2008 Jul, Cryptogenic, multifocal, ulcerous, and stenosing enteritis as a manifestation of enterocolic venopathy. J Pediatr Gastroenterol Nutr, DOI: 10.1097/MPG.0b013e3181661ad1 |
| Fitzpatrick E, Bourke B, Drumm B, Rowland M, 2008 Apr, The incidence of cyclic vomiting syndrome in children: population-based study. Am J Gastroenterol, DOI: 10.1111/j.1572-0241.2007.01668.x |
| Cróinín TO, McCormack A, van Vliet AH, Kusters JG, Bourke B, 2007 Jul, Random mutagenesis to identify novel Helicobacter mustelae virulence factors. FEMS Immunol Med Microbiol, DOI: 10.1111/j.1574-695X.2006.00207.x |
| Byrne CM, Clyne M, Bourke B, 2007 Feb, Campylobacter jejuni adhere to and invade chicken intestinal epithelial cells in vitro. Microbiology (Reading), DOI: 10.1099/mic.0.2006/000711-0 |
| Bourke B, Broderick A, Bohane T, 2006 Dec, Peutz-Jeghers syndrome and management recommendations. Clin Gastroenterol Hepatol, DOI: 10.1016/j.cgh.2006.09.028 |
| Bourke B, 2002 Jan, Campylobacter infection: small bowel and colon. Curr Opin Gastroenterol, DOI: 10.1097/00001574-200201000-00002 |
| Rowland M, Broderick A, Bourke B, 2006 Jul, Behavioral and nutritional treatment to improve energy intake and growth in toddlers and preschool-aged children with cystic fibrosis. Pediatrics, DOI: 10.1542/peds.2006-0641 |
| Rowland M, Daly L, Vaughan M, Higgins A, Bourke B, Drumm B, 2006 Jan, Age-specific incidence of Helicobacter pylori. Gastroenterology, DOI: 10.1053/j.gastro.2005.11.004 |
| Hashim A, Mulcahy G, Bourke B, Clyne M, 2006 Jan, Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells. Infect Immun, DOI: 10.1128/IAI.74.1.99-107.2006 |
| Harty S, Fleming P, Rowland M, Crushell E, McDermott M, Drumm B, Bourke B, 2005 Sep, A prospective study of the oral manifestations of Crohn's disease. Clin Gastroenterol Hepatol, DOI: 10.1016/s1542-3565(05)00424-6 |
| Rowland M, Bourke B, Drumm B, 2005 Sep, Do the Rome criteria help the doctor or the patient? J Pediatr Gastroenterol Nutr, DOI: 10.1097/01.scs.0000180296.19978.75 |
| Bourke B, 2005 Jul, Will treatment of Helicobacter pylori infection in childhood alter the risk of developing gastric cancer? Can J Gastroenterol, DOI: 10.1155/2005/732369 |
| Bourke B, Ceponis P, Chiba N, Czinn S, Ferraro R, Fischbach L, Gold B, Hyunh H, Jacobson K, Jones NL, Koletzko S, Lebel S, Moayyedi P, Ridell R, Sherman P, van Zanten S, Beck I, Best L, Boland M, Bursey F, Chaun H, Cooper G, Craig B, Creuzenet C, Critch J, Govender K, Hassall E, Kaplan A, Keelan M, Noad G, Robertson M, Smith L, Stein M, Taylor D, Walters T, Persaud R, Whitaker S, Woodland R, Canadian Helicobacter Study Group, 2005 Jul, Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation. Can J Gastroenterol, DOI: 10.1155/2005/732369 |
| Hashim A, Clyne M, Mulcahy G, Akiyoshi D, Chalmers R, Bourke B, 2004 Oct, Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes. Infect Immun, DOI: 10.1128/IAI.72.10.6125-6131.2004 |
Please visit PubMed for more information on Billy Bourke's publications
| Funding Agency: | The Health Research Board (HRA 214-PHR-662) |
| Project Title: | The Natural History of Cystic Fibrosis Liver Disease- Refining the Phenotype |
| Start Date/End Date: | 2014-2017 |
| Total Awarded: | €325,169 |
| Role: | Co Applicant |
| Funding Agency: | The Children’s Medical and Research Foundation Project Grant. |
| Project Title: | Reactive oxygen species targeting the bacterial phosphotyrosine network as defence strategy against mucosal pathogens |
| Start Date/End Date: | 2012-2017 |
| Total Awarded: | €1,024,000 |
| Name: | Professor Ulla Knaus |
| Department | Medicine and Medical Science |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Dr Marion Rowland |
| Department | Medicine and Medical Science |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Dr Marguerite Clyne |
| Department | Medicine and Medical Science |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Dr Tadhg O’Croinin |
| Department | Biological Science |
| Institution: | UCD |
| Country: | Ireland |
| Name: | Dr Séamus Hussey |
| Department | Medicine and Medical Science |
| Institution: | UCD |
| Country: | Ireland |