Andrew Hogan

Andrew Hogan

Principal Investigator

Dr Andrew Hogan is a lecturer in Immunology at Maynooth University & Principal Investigator of the Childhood Obesity Immunology Research Group based in the NCRC and Maynooth University. Previously he was a UCD Newman Scholar in Obesity and Diabetes and NCRC Research Fellow. In 2012, Dr Hogan, along with Prof O’Shea & Prof Declan Cody, established the Childhood Obesity Consortium with the support of the NCRC. The goal of the consortium is to investigate the impact of childhood obesity on the immune system, and to investigate the potential of early intervention in halting the progression to co-morbid disease.

Andrew Hogan

Principal Investigator

Dr Laura Tobin
Position: Group Coordinator

Laura is a senior coordinator with the research group, overseeing the management of the team.

Ms Nicole Wood
Position: Research Scientist

Nicole is a research scientist with the group based in the NCRC labs.

Ms Aisling O’Brien
Position: PhD candidate

Aisling is a 3rd year PhD candidate with the group. Her project investigates MAIT cell metabolism in obesity

Dr Arimin Mat
Position: Endocrine SpR and PhD candidate

Mat is an Endocrine SpR and 3rd year PhD candidate with the group. His project investigates myeloid driven inflammation in T2DM

Dr Karen Whelan
Position: Child Psychiatrist & PhD candidate

Karen is a Child Psychiatrist & PhD candidate, co-supervised with Prof Louise Gallagher & Dr Jane McGrath.

Ms Marta Pisarska
Position: PhD candidate

Marta is a PhD candidate with the group. Her project investigates the impact of childhood obesity on innate immune cell function and metabolism, and their modulation by Metformin and Glucagon like peptide-1

Investigating the impact of childhood obesity on innate immune cell function and metabolism, and their modulation by Metformin and Glucagon like peptide-1

Currently there is no protocol for the targeting inflammation in childhood obesity, allowing the development of co-morbid diseases to go unchecked into adulthood. We aim to investigate the impact of the anti-diabetic agent metformin (in vivo) and the weight loss and immunomodulatory agent Glucagon Like Peptide-1 (in vitro) on obesity driven inflammation in children. This will generate an expanded evidence base for potential therapeutic use in childhood obesity.

Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders

Second generation antipsychotics (SGAs) are widely used to manage symptoms of psychosis and irritability in autism spectrum disorder (ASD). Previously considered to have lower side-effects, the safety of SGAs is under review due to associated cardiometabolic dysregulation in some patients. We hypothesize that there is a subgroup of children and adolescents with ASD and early onset psychosis (EOP) who have pro-inflammatory immune profiles prior to starting SGA medication. Secondly, we hypothesise that this subgroup is at increased risk of developing the cardiometabolic

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

McCarthy C, O'Donnell CP, Kelly NEW, O'Shea D, Hogan AE, 2021 May, COVID-19 severity and obesity: are MAIT cells a factor? Lancet Respir Med, DOI: 10.1016/S2213-2600(21)00140-5
O'Neill C, Cassidy FC, O'Shea D, Hogan AE, 2021 Mar 30, Mucosal Associated Invariant T Cells in Cancer-Friend or Foe? Cancers (Basel), DOI: 10.3390/cancers13071582
Hams E, Roberts J, Bermingham R, Hogan AE, O'Shea D, O'Neill L, Fallon PG, 2020, Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity. Front Immunol, DOI: 10.3389/fimmu.2020.01966
Pisarska MM, Dunne MR, O'Shea D, Hogan AE, 2020 Aug, Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases? Eur J Immunol, DOI: 10.1002/eji.202048645
Brien AO, Kedia-Mehta N, Tobin L, Veerapen N, Besra GS, Shea DO, Hogan AE, 2020 Nov, Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity. Cell Mol Immunol, DOI: 10.1038/s41423-020-0375-1
Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT, 2019 Sep 5, Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nat Commun, DOI: 10.1038/s41467-019-11944-w
Melo AM, O'Brien AM, Phelan JJ, Kennedy SA, Wood NAW, Veerapen N, Besra GS, Clarke NE, Foley EK, Ravi A, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, Conroy MJ, Hogan AE, O'Sullivan J, Dunne MR, 2019, Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma. Front Immunol, DOI: 10.3389/fimmu.2019.01580
O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE, 2019 Jun 15, Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses. J Immunol, DOI: 10.4049/jimmunol.1801600
O'Shea D, Hogan AE, 2019 Apr 23, Dysregulation of Natural Killer Cells in Obesity. Cancers (Basel), DOI: 10.3390/cancers11040573
Brennan K, O'Leary BD, Mc Laughlin D, Kinlen D, Molloy EJ, Cody D, Paran S, McAuliffe FM, Hogan AE, Doyle SL, 2019 Jul, Nucleic acid cytokine responses in obese children and infants of obese mothers. Cytokine, DOI: 10.1016/j.cyto.2019.03.015
Brennan K, O'Leary BD, Mc Laughlin D, Breen EP, Connolly E, Ali N, O'Driscoll DN, Ozaki E, Mahony R, Mulfaul K, Ryan AM, Ni Chianain A, McHugh A, Molloy EJ, Hogan AE, Paran S, McAuliffe FM, Doyle SL, 2018 Aug 15, Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation. J Immunol, DOI: 10.4049/jimmunol.1700956
Tobin LM, Mavinkurve M, Carolan E, Kinlen D, O'Brien EC, Little MA, Finlay DK, Cody D, Hogan AE, O'Shea D, 2017 Dec 21, NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI Insight, DOI: 10.1172/jci.insight.94939
Khan F, Mat A, Hogan AE, Kent BD, Eigenheer S, Corrigan MA, O'Shea D, Butler MW, 2017 Dec 1, Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM, DOI: 10.1093/qjmed/hcx125
Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L, 2017 Feb 21, Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity, DOI: 10.1016/j.immuni.2017.01.008
Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M, 2016 Sep 13, iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab, DOI: 10.1016/j.cmet.2016.08.003
Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG, 2016 Feb, The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism. FASEB J, DOI: 10.1096/fj.15-277822
Gaoatswe G, Kent BD, Corrigan MA, Nolan G, Hogan AE, McNicholas WT, O'Shea D, 2015 Oct 1, Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. Sleep, DOI: 10.5665/sleep.5062
Carolan E, Tobin LM, Mangan BA, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter DC, Doherty DG, Lynch L, O'Shea D, Hogan AE, 2015 Jun 15, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol, DOI: 10.4049/jimmunol.1402945
Woods CP, Corrigan M, Gathercole L, Taylor A, Hughes B, Gaoatswe G, Manolopoulos K, Hogan AE, O'Connell J, Stewart PM, Tomlinson JW, O'Shea D, Sherlock M, 2015 Apr, Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT). J Clin Endocrinol Metab, DOI: 10.1210/jc.2014-4120
Ip BC, Hogan AE, Nikolajczyk BS, 2015 Feb, Lymphocyte roles in metabolic dysfunction: of men and mice. Trends Endocrinol Metab, DOI: 10.1016/j.tem.2014.12.001
Yang S, Wang B, Humphries F, Hogan AE, O'Shea D, Moynagh PN, 2014 Dec 18, The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance. Immunity, DOI: 10.1016/j.immuni.2014.11.013
Carolan E, Hogan AE, Corrigan M, Gaotswe G, O'Connell J, Foley N, O'Neill LA, Cody D, O'Shea D, 2014 Mar, The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression. J Clin Endocrinol Metab, DOI: 10.1210/jc.2013-3529
Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O'Connell J, O'Shea D, 2014 Apr, Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia, DOI: 10.1007/s00125-013-3145-0
Zeng SG, Ghnewa YG, O'Reilly VP, Lyons VG, Atzberger A, Hogan AE, Exley MA, Doherty DG, 2013 Aug 15, Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro. J Immunol, DOI: 10.4049/jimmunol.1202223
Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG, 2013 Jul 1, Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells. J Immunol, DOI: 10.4049/jimmunol.1300121
O'Shea D, Corrigan M, Dunne MR, Jackson R, Woods C, Gaoatswe G, Moynagh PN, O'Connell J, Hogan AE, 2013 Nov, Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection. Int J Obes (Lond), DOI: 10.1038/ijo.2013.16
Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, 2012 Sep 21, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity, DOI: 10.1016/j.immuni.2012.06.016
Farah N, Hogan AE, O'Connor N, Kennelly MM, O'Shea D, Turner MJ, 2012 Oct, Correlation between maternal inflammatory markers and fetomaternal adiposity. Cytokine, DOI: 10.1016/j.cyto.2012.05.024
O'Reilly V, Zeng SG, Bricard G, Atzberger A, Hogan AE, Jackson J, Feighery C, Porcelli SA, Doherty DG, 2011, Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells. PLoS One, DOI: 10.1371/journal.pone.0028648
Michielsen AJ, Hogan AE, Marry J, Tosetto M, Cox F, Hyland JM, Sheahan KD, O'Donoghue DP, Mulcahy HE, Ryan EJ, O'Sullivan JN, 2011, Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer. PLoS One, DOI: 10.1371/journal.pone.0027944
Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D, 2011 Nov, Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia, DOI: 10.1007/s00125-011-2232-3
Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D, 2011 Sep, Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol, DOI: 10.1016/j.clim.2011.01.011
Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, 2011 Aug, Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide. Clin Immunol, DOI: 10.1016/j.clim.2011.03.016
Kenna T, O'Brien M, Hogan AE, Exley MA, Porcelli SA, Hegarty JE, O'Farrelly C, Doherty DG, 2007 Apr, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver. Cancer Immunol Immunother, DOI: 10.1007/s00262-006-0215-x

Funding Agency:National Children's Research Centre
Project Title:Investigating the impact of childhood obesity on innate immune cell function and metabolism, and their modulation by Metformin and Glucagon like peptide-1
Start Date/End Date:March 2017/February 2020
Funding Agency:NCRC
Project Title:Project Title: Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorder
Start Date/End Date:Jan 2018/Jan 2021
Name:Professor Donal O’Shea
DepartmentEndocrinology & Obesity Immunology
Institution:St Vincent’s HealthCare Group
Name: Professor Declan Cody
DepartmentDept. of Endocrinology
Institution:Our Ladies Children’s Hospital Crumlin
Name:Dr Helen Heneghan
Institution:St Vincent’s HealthCare Group
Name:Professor Paul Moynagh
DepartmentInstitute of Immunology
Institution:Maynooth University
Name:Professor Lydia Lynch
DepartmentBiochemistry & Immunology
Institution:Trinity College Dublin
Name:Professor David Finlay
DepartmentBiochemistry & Immunology
Institution:Trinity College Dublin
Name:Professor Louise Gallagher
Institution:Trinity College Dublin