The NCRC AD case collection is one of the largest in the world, and has been used for identification of many genes involved in AD pathogenesis, including the filaggrin discovery.
Alan IrvineConsultant Dermatologist, Professor
Alan graduated in Medicine from Queen’s University Belfast (QUB) in 1991. In 1998, he was awarded a research doctorate (MD) in Human Genetics, also from QUB. He completed Dermatology Training in Belfast in July 1999, followed by fellowships in Great Ormond Street Children’s Hospital, and Children’s Memorial Hospital Chicago, where he was a Fulbright Scholar.
He was appointed Consultant Dermatologist (Attending Physician) in Our Lady’s Children’s Hospital and St. James’s Hospital, Dublin, Ireland in October 2002. The OLCHC department provides specialist clinics in severe atopic dermatitis, vascular malformations, laser treatments, and genetic skin diseases with more than 10 000 secondary and tertiary paediatric attendances per annum. His adult clinics provide a service for complex atopic dermatitis and genodermatoses.
He is Professor in Dermatology, Trinity College Dublin. His research interests are in epithelial genetics, disease mechanisms in, and therapy of, atopic dermatitis. His work on the genetics of atopic dermatitis with long term collaborative partner Irwin McLean has helped refocus attention on the role of the skin barrier in the pathogenesis of this disease and of allergic disease in general. He is funded by the National Children’s Research Centre and the Wellcome Trust, and has attracted approximately €11M funding to date.
Alan IrvineConsultant Dermatologist, Professor
Role:
Janna is an experienced epithelial biologist with expertise in skin equivalent cultures and genetic analysis of skin disease. Her work currently involves using skin equivalents to study skin barrier function in atopic dermatitis. Janna also is running projects studying the role of miRNA in Atopic Dermatitis
Dr. Maeve McAleer
Position: Consultant Dermatologist
Role:
Maeve is a consultant dermatologist who has recently completed her PhD on skin barrier function in Atopic Dermatitis at NCRC.
Dr Veronika Dvorakova
Position: Clinical Fellow/MD student
Role:
Veronika is studying the genetic basis and therapeutic approaches to vascular anomalies and overgrowth syndromes
The NCRC AD case collection is one of the largest in the world, and has been used for identification of many genes involved in AD pathogenesis, including the filaggrin discovery.
We have long standing research programs examining skin barrier function in atopic dermatitis. We use non-invasive techniques such as Raman spectroscopy and tape stripping to gain mechanistic and functional insights into AD pathogenesis.
We provide care for a large cohort of patients with vascular anomalies and overgrowth syndromes. We collaborate with investigators in Belgium on gene identification and with companies developing novel therapies.
For the last two decades we have worked on identification of causal genetic mutations in children with genetic skin disorders.
The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.
| Pigors M, Common JEA, Wong XFCC, Malik S, Scott CA, Tabarra N, Liany H, Liu J, Limviphuvadh V, Maurer-Stroh S, Tang MB, Lench N, Margolis DJ, van Heel DA, Mein CA, Novak N, Baurecht H, Weidinger S, McLean WHI, Irvine AD, O'Toole EA, Simpson MA, Kelsell DP, 2018 May 29, Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and additional risk genes. J Invest Dermatol, DOI: 10.1016/j.jid.2018.05.013 |
| Gerbens LAA, Apfelbacher CJ, Irvine AD, Barbarot S, de Booij RJ, Boyce AE, Deleuran M, Eichenfield LF, Hof MH, Middelkamp-Hup MA, Roberts A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Williamson PR, Flohr C, Spuls PI, international TREAT Registry Taskforce., 2018 May 15, TREatment of ATopic eczema (TREAT) Registry Taskforce: An international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo- and systemic therapy registries. Br J Dermatol, DOI: 10.1111/bjd.16714 |
| Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG, 2018 May 5, The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients. Br J Dermatol, DOI: 10.1111/bjd.16722 |
| Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, O'Neill L, Rosala-Hallas A, Sach T, Spowart C, Taams L, Walker C, Wan M, Webb N, Williamson P, Flohr C, TREAT Trial Investigators., 2018 May 4, A randomised controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate versus ciclosporin in the treatment of severe atopic eczema in children: The TREatment of severe Atopic eczema Trial (TREAT). Br J Dermatol, DOI: 10.1111/bjd.16717 |
| McAleer MA, Jakasa I, Raj N, O'Donnell CPF, Lane ME, Rawlings AV, Voegeli R, McLean WHI, Kezic S, Irvine AD, 2018 Apr 25, Early life regional and temporal variation in filaggrin-derived natural moisturising factor, filaggrin processing enzyme activity, corneocyte phenotypes and plasmin activity: Implications for atopic dermatitis. Br J Dermatol, DOI: 10.1111/bjd.16691 |
| Dvorakova V, Rea D, O'Regan GM, Irvine AD, 2018 Mar 26, Generalized lymphatic anomaly successfully treated with long-term, low-dose sirolimus. Pediatr Dermatol, DOI: 10.1111/pde.13494 |
| Hawkes CP, Murray DM, Kenny LC, Kiely M, O'B Hourihane J, Irvine AD, Wu Z, Argon Y, Reitz RE, McPhaul MJ, Grimberg A, 2018, Correlation of Insulin-Like Growth Factor-I and -II Concentrations at Birth Measured by Mass Spectrometry and Growth from Birth to Two Months. Horm Res Paediatr, DOI: 10.1159/000486035 |
| Lynch SA, Crushell E, Lambert DM, Byrne N, Gorman K, King MD, Green A, O'Sullivan S, Browne F, Hughes J, Knerr I, Monavari AA, Cotter M, McConnell VPM, Kerr B, Jones SA, Keenan C, Murphy N, Cody D, Ennis S, Turner J, Irvine AD, Casey J, 2018 Apr, Catalogue of inherited disorders found among the Irish Traveller population. J Med Genet, DOI: 10.1136/jmedgenet-2017-104974 |
| Geoghegan JA, Irvine AD, Foster TJ, 2018 Jun, Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends Microbiol, DOI: 10.1016/j.tim.2017.11.008 |
| Hennessy Á, Ní Chaoimh C, McCarthy EK, Kingston C, Irvine AD, Hourihane JO, Kenny LC, Murray DM, Kiely M, 2018 Mar, Variation in iodine food composition data has a major impact on estimates of iodine intake in young children. Eur J Clin Nutr, DOI: 10.1038/s41430-017-0030-9 |
| Paller AS, Czarnowicki T, Renert-Yuval Y, Holland K, Huynh T, Sadlier M, McAleer MA, Tran G, Geddes GC, Irvine AD, Guttman-Yassky E, 2018 Mar, The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2017.10.026 |
| McCarthy EK, Kiely ME, Hannon G, Ahearne C, Kenny LC, Hourihane JO, Irvine AD, Murray DM, 2017 Sep, Microcytosis is associated with low cognitive outcomes in healthy 2-year-olds in a high-resource setting. Br J Nutr, DOI: 10.1017/S0007114517001945 |
| Drucker AM, Eyerich K, de Bruin-Weller MS, Thyssen JP, Spuls PI, Irvine AD, Girolomoni G, Dhar S, Flohr C, Murrell DF, Paller AS, Guttman-Yassky E, 2018 Mar, Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement. Br J Dermatol, DOI: 10.1111/bjd.15928 |
| Simpson EL, Bruin-Weller M, Flohr C, Ardern-Jones MR, Barbarot S, Deleuran M, Bieber T, Vestergaard C, Brown SJ, Cork MJ, Drucker AM, Eichenfield LF, Foelster-Holst R, Guttman-Yassky E, Nosbaum A, Reynolds NJ, Silverberg JI, Schmitt J, Seyger MMB, Spuls PI, Stalder JF, Su JC, Takaoka R, Traidl-Hoffmann C, Thyssen JP, van der Schaft J, Wollenberg A, Irvine AD, Paller AS, 2017 Oct, When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2017.06.042 |
| Dvorakova V, O'Regan GM, Irvine AD, 2017 Sep, Methotrexate for Severe Childhood Atopic Dermatitis: Clinical Experience in a Tertiary Center. Pediatr Dermatol, DOI: 10.1111/pde.13209 |
| Spuls PI, Gerbens LAA, Apfelbacher CJ, Wall D, Arents BWM, Barbarot S, Roberts A, Deleuran M, Middelkamp-Hup MA, Vestergaard C, Weidinger S, Schmitt J, Irvine AD, Flohr C, 2017 Sep, The International TREatment of ATopic Eczema (TREAT) Registry Taskforce: An Initiative to Harmonize Data Collection across National Atopic Eczema Photo- and Systemic Therapy Registries. J Invest Dermatol, DOI: 10.1016/j.jid.2017.05.014 |
| McCarthy EK, Ní Chaoimh C, Kenny LC, Hourihane JO, Irvine AD, Murray DM, Kiely ME, 2018 Jan, Iron status, body size, and growth in the first 2 years of life. Matern Child Nutr, DOI: 10.1111/mcn.12458 |
| Murad A, O'Regan G, Watson R, McDermott M, O'Sullivan M, Irvine AD, 2017 Apr 10, Erythema elevatum diutinum in a healthy child. Clin Exp Dermatol, DOI: 10.1111/ced.13083 |
| Fleury OM, McAleer MA, Feuillie C, Formosa-Dague C, Sansevere E, Bennett DE, Towell AM, McLean WHI, Kezic S, Robinson DA, Fallon PG, Foster TJ, Dufrêne YF, Irvine AD, Geoghegan JA, 2017 Jun, Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis. Infect Immun, DOI: 10.1128/IAI.00994-16 |
| Gerbens LA, Boyce AE, Wall D, Barbarot S, de Booij RJ, Deleuran M, Middelkamp-Hup MA, Roberts A, Vestergaard C, Weidinger S, Apfelbacher CJ, Irvine AD, Schmitt J, Williamson PR, Spuls PI, Flohr C, 2017 Feb 27, TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema registries. Trials, DOI: 10.1186/s13063-016-1765-7 |
| Ní Chaoimh C, McCarthy EK, Hourihane JO, Kenny LC, Irvine AD, Murray DM, Kiely ME, 2018 Mar, Low vitamin D deficiency in Irish toddlers despite northerly latitude and a high prevalence of inadequate intakes. Eur J Nutr, DOI: 10.1007/s00394-016-1368-9 |
| Kiely M, O'Donovan SM, Kenny LC, Hourihane JO, Irvine AD, Murray DM, 2017 Mar, Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland. J Steroid Biochem Mol Biol, DOI: 10.1016/j.jsbmb.2016.12.006 |
| McCarthy EK, Kenny LC, Hourihane JOB, Irvine AD, Murray DM, Kiely ME, 2017 Jun, Impact of maternal, antenatal and birth-associated factors on iron stores at birth: data from a prospective maternal-infant birth cohort. Eur J Clin Nutr, DOI: 10.1038/ejcn.2016.255 |
| Storan ER, Irvine AD, 2017 Jan, Access to Genetic Diagnostics for Genodermatoses: Who Should Get Tested? Why? Who Pays? Pediatr Dermatol, DOI: 10.1111/pde.13041 |
| Domínguez-Hüttinger E, Christodoulides P, Miyauchi K, Irvine AD, Okada-Hatakeyama M, Kubo M, Tanaka RJ, 2017 Jun, Mathematical modeling of atopic dermatitis reveals "double-switch" mechanisms underlying 4 common disease phenotypes. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2016.10.026 |
| Samuelov L, Li Q, Bochner R, Najor NA, Albrecht L, Malchin N, Goldsmith T, Grafi-Cohen M, Vodo D, Fainberg G, Meilik B, Goldberg I, Warshauer E, Rogers T, Edie S, Ishida-Yamamoto A, Burzenski L, Erez N, Murray SA, Irvine AD, Shultz L, Green KJ, Uitto J, Sprecher E, Sarig O, 2017 May, SVEP1 plays a crucial role in epidermal differentiation. Exp Dermatol, DOI: 10.1111/exd.13256 |
| Nousbeck J, Irvine AD, 2016 Dec, Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis. J Invest Dermatol, DOI: 10.1016/j.jid.2016.08.020 |
| Hawkes CP, Zemel BS, Kiely M, Irvine AD, Kenny LC, O'B Hourihane J, Murray DM, 2016, Body Composition within the First 3 Months: Optimized Correction for Length and Correlation with BMI at 2 Years. Horm Res Paediatr, DOI: 10.1159/000448659 |
| Lovgren ML, McAleer MA, Irvine AD, Wilson NJ, Tavadia S, Schwartz ME, Cole C, Sandilands A, Smith FJD, Zamiri M, 2017 May, Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening. Br J Dermatol, DOI: 10.1111/bjd.14973 |
| Mahil SK, Twelves S, Farkas K, Setta-Kaffetzi N, Burden AD, Gach JE, Irvine AD, Képíró L, Mockenhaupt M, Oon HH, Pinner J, Ranki A, Seyger MM, Soler-Palacin P, Storan ER, Tan ES, Valeyrie-Allanore L, Young HS, Trembath RC, Choon SE, Szell M, Bata-Csorgo Z, Smith CH, Di Meglio P, Barker JN, Capon F, 2016 Nov, AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production. J Invest Dermatol, DOI: 10.1016/j.jid.2016.06.618 |
| Kennedy EA, Connolly J, Hourihane JO, Fallon PG, McLean WHI, Murray D, Jo JH, Segre JA, Kong HH, Irvine AD, 2017 Jan, Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2016.07.029 |
| Chaoimh CN, Murray DM, Kenny LC, Irvine AD, Hourihane JO, Kiely M, 2016 Nov, Cord blood leptin and gains in body weight and fat mass during infancy. Eur J Endocrinol, DOI: 10.1530/EJE-16-0431 |
| Soblet J, Kangas J, Nätynki M, Mendola A, Helaers R, Uebelhoer M, Kaakinen M, Cordisco M, Dompmartin A, Enjolras O, Holden S, Irvine AD, Kangesu L, Léauté-Labrèze C, Lanoel A, Lokmic Z, Maas S, McAleer MA, Penington A, Rieu P, Syed S, van der Vleuten C, Watson R, Fishman SJ, Mulliken JB, Eklund L, Limaye N, Boon LM, Vikkula M, 2017 Jan, Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations. J Invest Dermatol, DOI: 10.1016/j.jid.2016.07.034 |
| McCarthy EK, Ní Chaoimh C, Hourihane JO, Kenny LC, Irvine AD, Murray DM, Kiely M, 2017 Jul, Iron intakes and status of 2-year-old children in the Cork BASELINE Birth Cohort Study. Matern Child Nutr, DOI: 10.1111/mcn.12320 |
| Kelleher MM, Dunn-Galvin A, Gray C, Murray DM, Kiely M, Kenny L, McLean WHI, Irvine AD, Hourihane JO, 2016 Apr, Skin barrier impairment at birth predicts food allergy at 2 years of age. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.12.1312 |
| Strid J, McLean WH, Irvine AD, 2016 Mar, Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation? J Invest Dermatol, DOI: 10.1016/j.jid.2015.12.025 |
| Dvorakova V, Watson RM, Terron-Kwiatkowski A, Andrew N, Irvine AD, 2016 Jul, Congenital reticular ichthyosiform erythroderma. Clin Exp Dermatol, DOI: 10.1111/ced.12795 |
| Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, Curtin JA, Bønnelykke K, Tian C, Takahashi A, Esparza-Gordillo J, Alves AC, Thyssen JP, den Dekker HT, Ferreira MA, Altmaier E, Sleiman PM, Xiao FL, Gonzalez JR, Marenholz I, Kalb B, Yanes MP, Xu CJ, Carstensen L, Groen-Blokhuis MM, Venturini C, Pennell CE, Barton SJ, Levin AM, Curjuric I, Bustamante M, Kreiner-Møller E, Lockett GA, Bacelis J, Bunyavanich S, Myers RA, Matanovic A, Kumar A, Tung JY, Hirota T, Kubo M, McArdle WL, Henderson AJ, Kemp JP, Zheng J, Smith GD, Rüschendorf F, Bauerfeind A, Lee-Kirsch MA, Arnold A, Homuth G, Schmidt CO, Mangold E, Cichon S, Keil T, Rodríguez E, Peters A, Franke A, Lieb W, Novak N, Fölster-Holst R, Horikoshi M, Pekkanen J, Sebert S, Husemoen LL, Grarup N, de Jongste JC, Rivadeneira F, Hofman A, Jaddoe VW, Pasmans SG, Elbert NJ, Uitterlinden AG, Marks GB, Thompson PJ, Matheson MC, Robertson CF, Australian Asthma Genetics Consortium (AAGC)., Ried JS, Li J, Zuo XB, Zheng XD, Yin XY, Sun LD, McAleer MA, O'Regan GM, Fahy CM, Campbell LE, Macek M, Kurek M, Hu D, Eng C, Postma DS, Feenstra B, Geller F, Hottenga JJ, Middeldorp CM, Hysi P, Bataille V, Spector T, Tiesler CM, Thiering E, Pahukasahasram B, Yang JJ, Imboden M, Huntsman S, Vilor-Tejedor N, Relton CL, Myhre R, Nystad W, Custovic A, Weiss ST, Meyers DA, Söderhäll C, Melén E, Ober C, Raby BA, Simpson A, Jacobsson B, Holloway JW, Bisgaard H, Sunyer J, Hensch NMP, Williams LK, Godfrey KM, Wang CA, Boomsma DI, Melbye M, Koppelman GH, Jarvis D, McLean WI, Irvine AD, Zhang XJ, Hakonarson H, Gieger C, Burchard EG, Martin NG, Duijts L, Linneberg A, Jarvelin MR, Noethen MM, Lau S, Hübner N, Lee YA, Tamari M, Hinds DA, Glass D, Brown SJ, Heinrich J, Evans DM, Weidinger S, 2015 Dec, Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet, DOI: 10.1038/ng.3424 |
| Wedgeworth E, Glover M, Irvine AD, Neri I, Baselga E, Clayton TH, Beattie PE, Bjerre JV, Burrows NP, Foelster-Holst R, Hedelund L, Hernandez-Martin A, Audrain H, Bhate K, Brown SJ, Baryschpolec S, Darne S, Durack A, Dvorakova V, Gach J, Goldstraw N, Goodyear H, Grabczynska S, Greenblatt D, Halpern J, Hearn RM, Hoey S, Hughes B, Jayaraj R, Johansson EK, Lam M, Leech S, O'Regan GM, Morrison D, Porter W, Ramesh R, Schill T, Shaw L, Taylor AE, Taylor R, Thomson J, Tiffin P, Tsakok M, Janmohamed SR, Laguda B, McPherson T, Oranje AP, Patrizi A, Ravenscroft JC, Shahidullah H, Solman L, Svensson A, Wahlgren CF, Hoeger PH, Flohr C, 2016 Mar, Propranolol in the treatment of infantile haemangiomas: lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce survey. Br J Dermatol, DOI: 10.1111/bjd.14233 |
| Mercier S, Küry S, Salort-Campana E, Magot A, Agbim U, Besnard T, Bodak N, Bou-Hanna C, Bréhéret F, Brunelle P, Caillon F, Chabrol B, Cormier-Daire V, David A, Eymard B, Faivre L, Figarella-Branger D, Fleurence E, Ganapathi M, Gherardi R, Goldenberg A, Hamel A, Igual J, Irvine AD, Israël-Biet D, Kannengiesser C, Laboisse C, Le Caignec C, Mahé JY, Mallet S, MacGowan S, McAleer MA, McLean I, Méni C, Munnich A, Mussini JM, Nagy PL, Odel J, O'Regan GM, Péréon Y, Perrier J, Piard J, Puzenat E, Sampson JB, Smith F, Soufir N, Tanji K, Thauvin C, Ulane C, Watson RM, Khumalo NP, Mayosi BM, Barbarot S, Bézieau S, 2015 Oct 15, Expanding the clinical spectrum of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis due to FAM111B mutations. Orphanet J Rare Dis, DOI: 10.1186/s13023-015-0352-4 |
| Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, 2016 Feb, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.06.045 |
| Schmitt J, Schwarz K, Baurecht H, Hotze M, Fölster-Holst R, Rodríguez E, Lee YAE, Franke A, Degenhardt F, Lieb W, Gieger C, Kabesch M, Nöthen MM, Irvine AD, McLean WHI, Deckert S, Stephan V, Schwarz P, Aringer M, Novak N, Weidinger S, 2016 Jan, Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.06.029 |
| Chen YC, Auer-Grumbach M, Matsukawa S, Zitzelsberger M, Themistocleous AC, Strom TM, Samara C, Moore AW, Cho LT, Young GT, Weiss C, Schabhüttl M, Stucka R, Schmid AB, Parman Y, Graul-Neumann L, Heinritz W, Passarge E, Watson RM, Hertz JM, Moog U, Baumgartner M, Valente EM, Pereira D, Restrepo CM, Katona I, Dusl M, Stendel C, Wieland T, Stafford F, Reimann F, von Au K, Finke C, Willems PJ, Nahorski MS, Shaikh SS, Carvalho OP, Nicholas AK, Karbani G, McAleer MA, Cilio MR, McHugh JC, Murphy SM, Irvine AD, Jensen UB, Windhager R, Weis J, Bergmann C, Rautenstrauss B, Baets J, De Jonghe P, Reilly MM, Kropatsch R, Kurth I, Chrast R, Michiue T, Bennett DL, Woods CG, Senderek J, 2015 Aug, Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception. Nat Genet, DOI: 10.1038/ng0815-962b |
| Berki DM, Liu L, Choon SE, David Burden A, Griffiths CEM, Navarini AA, Tan ES, Irvine AD, Ranki A, Ogo T, Petrof G, Mahil SK, Duckworth M, Allen MH, Vito P, Trembath RC, McGrath J, Smith CH, Capon F, Barker JN, 2015 Dec, Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris. J Invest Dermatol, DOI: 10.1038/jid.2015.288 |
| O'Donovan SM, O'B Hourihane J, Murray DM, Kenny LC, Khashan AS, Chaoimh CN, Irvine AD, Kiely M, 2016 Jan, Neonatal adiposity increases the risk of atopic dermatitis during the first year of life. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.05.035 |
| O'Rafferty C, O'Regan GM, Irvine AD, Smith OP, 2015 Oct, Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon. Br J Haematol, DOI: 10.1111/bjh.13557 |
| O'Rafferty C, O'Regan GM, Irvine AD, Smith OP, 2015 Oct, Kasabach-Merritt syndrome, kaposiform haemangioendothelioma and platelet blockade. Br J Haematol, DOI: 10.1111/bjh.13558 |
| McAleer MA, Pohler E, Smith FJ, Wilson NJ, Cole C, MacGowan S, Koetsier JL, Godsel LM, Harmon RM, Gruber R, Crumrine D, Elias PM, McDermott M, Butler K, Broderick A, Sarig O, Sprecher E, Green KJ, McLean WH, Irvine AD, 2015 Nov, Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.05.002 |
| Riethmuller C, McAleer MA, Koppes SA, Abdayem R, Franz J, Haftek M, Campbell LE, MacCallum SF, McLean WHI, Irvine AD, Kezic S, 2015 Dec, Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.04.042 |
| Chen YC, Auer-Grumbach M, Matsukawa S, Zitzelsberger M, Themistocleous AC, Strom TM, Samara C, Moore AW, Cho LT, Young GT, Weiss C, Schabhüttl M, Stucka R, Schmid AB, Parman Y, Graul-Neumann L, Heinritz W, Passarge E, Watson RM, Hertz JM, Moog U, Baumgartner M, Valente EM, Pereira D, Restrepo CM, Katona I, Dusl M, Stendel C, Wieland T, Stafford F, Reimann F, von Au K, Finke C, Willems PJ, Nahorski MS, Shaikh SS, Carvalho OP, Nicholas AK, Karbani G, McAleer MA, Cilio MR, McHugh JC, Murphy SM, Irvine AD, Jensen UB, Windhager R, Weis J, Bergmann C, Rautenstrauss B, Baets J, De Jonghe P, Reilly MM, Kropatsch R, Kurth I, Chrast R, Michiue T, Bennett DL, Woods CG, Senderek J, 2015 Jul, Transcriptional regulator PRDM12 is essential for human pain perception. Nat Genet, DOI: 10.1038/ng.3308 |
| Quinn N, MacMahon J, Irvine AD, Lowry C, 2015 Feb, Sweet syndrome revealing systemic lupus erythematosus. Ir Med J, DOI: 10.1038/ng.3308 |
| Purcell C, Cant A, Irvine AD, 2015 Sep 5, DOCK8 primary immunodeficiency syndrome. Lancet, DOI: 10.1016/S0140-6736(14)62039-0 |
| O'Donovan SM, Murray DM, Hourihane JO, Kenny LC, Irvine AD, Kiely M, 2015 Oct, Adherence with early infant feeding and complementary feeding guidelines in the Cork BASELINE Birth Cohort Study. Public Health Nutr, DOI: 10.1017/S136898001500018X |
| Higgins E, Al Shehri T, McAleer MA, Conlon N, Feighery C, Lilic D, Irvine AD, 2015 Feb, Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2014.12.1867 |
| Kelleher M, Dunn-Galvin A, Hourihane JO, Murray D, Campbell LE, McLean WH, Irvine AD, 2015 Apr, Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2014.12.013 |
| Baurecht H, Hotze M, Brand S, Büning C, Cormican P, Corvin A, Ellinghaus D, Ellinghaus E, Esparza-Gordillo J, Fölster-Holst R, Franke A, Gieger C, Hubner N, Illig T, Irvine AD, Kabesch M, Lee YA, Lieb W, Marenholz I, McLean WH, Morris DW, Mrowietz U, Nair R, Nöthen MM, Novak N, O'Regan GM, Psoriasis Association Genetics Extension., Schreiber S, Smith C, Strauch K, Stuart PE, Trembath R, Tsoi LC, Weichenthal M, Barker J, Elder JT, Weidinger S, Cordell HJ, Brown SJ, 2015 Jan 8, Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet, DOI: 10.1016/j.ajhg.2014.12.004 |
| Hussain S, Berki DM, Choon SE, Burden AD, Allen MH, Arostegui JI, Chaves A, Duckworth M, Irvine AD, Mockenhaupt M, Navarini AA, Seyger MM, Soler-Palacin P, Prins C, Valeyrie-Allanore L, Vicente MA, Trembath RC, Smith CH, Barker JN, Capon F, 2015 Apr, IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2014.09.043 |
| Gallagher A, Hourihane JO, Kenny LC, Irvine AD, Khashan AS, 2014 Dec, A longitudinal study of skin barrier function in pregnancy and the postnatal period. Obstet Med, DOI: 10.1177/1753495X14547428 |
| O'Donovan SM, Murray DM, Hourihane JO, Kenny LC, Irvine AD, Kiely M, 2015 Jun, Cohort profile: The Cork BASELINE Birth Cohort Study: Babies after SCOPE: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints. Int J Epidemiol, DOI: 10.1093/ije/dyu157 |
| Nason GJ, Baker JF, Seoighe D, Irvine AD, McDermott M, Orr D, Capra M, Kelly PM, 2014 May, Congenital-infantile fibrosarcoma of the foot--avoidance of amputation. Ir Med J, DOI: 10.1093/ije/dyu157 |
| Kiely C, Devaney D, Fischer J, Lenane P, Irvine AD, 2014 Jul-Aug, Ichthyosis prematurity syndrome: a case report and review of known mutations. Pediatr Dermatol, DOI: 10.1111/pde.12320 |
| Cole C, Kroboth K, Schurch NJ, Sandilands A, Sherstnev A, O'Regan GM, Watson RM, McLean WH, Barton GJ, Irvine AD, Brown SJ, 2014 Jul, Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2014.04.021 |
| Courtney DG, Atkinson SD, Allen EH, Moore JE, Walsh CP, Pedrioli DM, MacEwen CJ, Pellegrini G, Maurizi E, Serafini C, Fantacci M, Liao H, Irvine AD, McLean WH, Moore CB, 2014 May 6, siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy. Invest Ophthalmol Vis Sci, DOI: 10.1167/iovs.13-12957 |
| Salinas CF, Irvine AD, Itin PH, Di Giovanna JJ, Schneider H, Clarke AJ, McGovern LS, Fete M, 2014 Oct, Second International Conference on a classification of ectodermal dysplasias: development of a multiaxis model. Am J Med Genet A, DOI: 10.1002/ajmg.a.36507 |
| Irvine AD, 2014 Mar, Commentary: Methotrexate and ciclosporin in the treatment of severe eczema in children. Br J Dermatol, DOI: 10.1111/bjd.12821 |
| Irvine AD, 2014 Feb, Crossing barriers; restoring barriers? Filaggrin protein replacement takes a bow. J Invest Dermatol, DOI: 10.1038/jid.2013.506 |
| Thawer-Esmail F, Jakasa I, Todd G, Wen Y, Brown SJ, Kroboth K, Campbell LE, O'Regan GM, McLean WH, Irvine AD, Kezic S, Sandilands A, 2014 Jan, South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2013.09.053 |
| Conte MI, Pescatore A, Paciolla M, Esposito E, Miano MG, Lioi MB, McAleer MA, Giardino G, Pignata C, Irvine AD, Scheuerle AE, Royer G, Hadj-Rabia S, Bodemer C, Bonnefont JP, Munnich A, Smahi A, Steffann J, Fusco F, Ursini MV, 2014 Feb, Insight into IKBKG/NEMO locus: report of new mutations and complex genomic rearrangements leading to incontinentia pigmenti disease. Hum Mutat, DOI: 10.1002/humu.22483 |
| Wall D, McMenamin M, O'Mahony D, Irvine AD, 2013 Nov 21, Kaposi sarcoma in an patient with atopic dermatitis treated with ciclosporin. BMJ Case Rep, DOI: 10.1136/bcr-2013-202171 |
| Fahy CM, Fortune A, Quinn F, McMenamin ME, Browne PV, Langabeer S, McCarron S, Hayden P, Marren P, Ni Chonghaile M, Irvine AD, Vandenberghe E, Barnes L, 2014 Feb, Development of mycosis fungoides after bone marrow transplantation for chronic myeloid leukaemia: transmission from an allogeneic donor. Br J Dermatol, DOI: 10.1111/bjd.12647 |
| Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG, 2013 Nov, Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2013.08.046 |
| Revencu N, Boon LM, Mendola A, Cordisco MR, Dubois J, Clapuyt P, Hammer F, Amor DJ, Irvine AD, Baselga E, Dompmartin A, Syed S, Martin-Santiago A, Ades L, Collins F, Smith J, Sandaradura S, Barrio VR, Burrows PE, Blei F, Cozzolino M, Brunetti-Pierri N, Vicente A, Abramowicz M, Désir J, Vilain C, Chung WK, Wilson A, Gardiner CA, Dwight Y, Lord DJ, Fishman L, Cytrynbaum C, Chamlin S, Ghali F, Gilaberte Y, Joss S, Boente Mdel C, Léauté-Labrèze C, Delrue MA, Bayliss S, Martorell L, González-Enseñat MA, Mazereeuw-Hautier J, O'Donnell B, Bessis D, Pyeritz RE, Salhi A, Tan OT, Wargon O, Mulliken JB, Vikkula M, 2013 Dec, RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation. Hum Mutat, DOI: 10.1002/humu.22431 |
| Flohr C, Irvine AD, 2013 Sep, Systemic therapies for severe atopic dermatitis in children and adults. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2013.03.016 |
| Samuelov L, Sarig O, Harmon RM, Rapaport D, Ishida-Yamamoto A, Isakov O, Koetsier JL, Gat A, Goldberg I, Bergman R, Spiegel R, Eytan O, Geller S, Peleg S, Shomron N, Goh CSM, Wilson NJ, Smith FJD, Pohler E, Simpson MA, McLean WHI, Irvine AD, Horowitz M, McGrath JA, Green KJ, Sprecher E, 2013 Oct, Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. Nat Genet, DOI: 10.1038/ng.2739 |
| Higgins E, Capra M, Schwartz ME, Smith FJ, McLean WH, Irvine AD, 2013 Dec, Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma. Br J Dermatol, DOI: 10.1111/bjd.12574 |
| Foley C, Moran B, McMenamin M, McDermott R, Ormond P, Irvine AD, 2014 Jan, Spontaneous regression of cutaneous metastases of squamous cell carcinoma. QJM, DOI: 10.1093/qjmed/hct162 |
| Weidinger S, Willis-Owen SA, Kamatani Y, Baurecht H, Morar N, Liang L, Edser P, Street T, Rodriguez E, O'Regan GM, Beattie P, Fölster-Holst R, Franke A, Novak N, Fahy CM, Winge MC, Kabesch M, Illig T, Heath S, Söderhäll C, Melén E, Pershagen G, Kere J, Bradley M, Lieden A, Nordenskjold M, Harper JI, McLean WH, Brown SJ, Cookson WO, Lathrop GM, Irvine AD, Moffatt MF, 2013 Dec 1, A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet, DOI: 10.1093/hmg/ddt317 |
| Langan SM, Irvine AD, 2013 Jul, Childhood eczema and the importance of the physical environment. J Invest Dermatol, DOI: 10.1038/jid.2013.128 |
| Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I, Hübner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U, Hotze M, Prokisch H, Heim K, Herder C, Hirota T, Tamari M, Kubo M, Takahashi A, Nakamura Y, Tsoi LC, Stuart P, Elder JT, Sun L, Zuo X, Yang S, Zhang X, Hoffmann P, Nöthen MM, Fölster-Holst R, Winkelmann J, Illig T, Boehm BO, Duerr RH, Büning C, Brand S, Glas J, McAleer MA, Fahy CM, Kabesch M, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S, 2013 Jul, High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet, DOI: 10.1038/ng.2642 |
| Asai Y, Greenwood C, Hull PR, Alizadehfar R, Ben-Shoshan M, Brown SJ, Campbell L, Michel DL, Bussières J, Rousseau F, Fujiwara TM, Morgan K, Irvine AD, McLean WH, Clarke A, 2013 Jul, Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2013.03.043 |
| Foley CC, McMenamin M, Gordon KD, Irvine AD, 2013 Dec, An unusual case of genital swelling. Clin Exp Dermatol, DOI: 10.1111/ced.12131 |
| Kelleher MM, O'Carroll M, Gallagher A, Murray DM, Dunn Galvin A, Irvine AD, Hourihane JO, 2013 Nov-Dec, Newborn transepidermal water loss values: a reference dataset. Pediatr Dermatol, DOI: 10.1111/pde.12106 |
| McAleer MA, Irvine AD, 2013 Feb, The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2012.12.668 |
| McLean WH, Irvine AD, 2013 Feb, Old King coal - molecular mechanisms underlying an ancient treatment for atopic eczema. J Clin Invest, DOI: 10.1172/JCI67438 |
| McLean WH, Irvine AD, 2012 Nov 15, Heritable filaggrin disorders: the paradigm of atopic dermatitis. J Invest Dermatol, DOI: 10.1038/skinbio.2012.6 |
| Irwin McLean WH, Irvine AD, 2012 Nov, Heritable Filaggrin Disorders: The Paradigm of Atopic Dermatitis. J Invest Dermatol, DOI: 10.1038/skinbio.2012.6 |
| Pohler E, Mamai O, Hirst J, Zamiri M, Horn H, Nomura T, Irvine AD, Moran B, Wilson NJ, Smith FJ, Goh CS, Sandilands A, Cole C, Barton GJ, Evans AT, Shimizu H, Akiyama M, Suehiro M, Konohana I, Shboul M, Teissier S, Boussofara L, Denguezli M, Saad A, Gribaa M, Dopping-Hepenstal PJ, McGrath JA, Brown SJ, Goudie DR, Reversade B, Munro CS, McLean WH, 2012 Nov, Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma. Nat Genet, DOI: 10.1038/ng.2444 |
| Hackett BC, Phelan E, Ryan A, Kenny L, Murphy M, Irvine AD, Watson RM, 2013 Nov-Dec, Use of systemic corticosteroids in management of a large congenital haemangioma of the scalp. Pediatr Dermatol, DOI: 10.1111/j.1525-1470.2012.01795.x |
| Crushell E, O'Leary D, Irvine AD, O'Shea A, Mayne PD, Reardon W, 2012 Sep, Methylenetetrahydrofolate reductase (MTHFR) deficiency presenting as a rash. Am J Med Genet A, DOI: 10.1002/ajmg.a.35479 |
| McAleer MA, Flohr C, Irvine AD, 2012 Jul 23, Management of difficult and severe eczema in childhood. BMJ, DOI: 10.1002/ajmg.a.35479 |
| Irvine AD, 2012 Jul, Double trouble: homozygous dominant mutations and hair loss in pachyonychia congenita. J Invest Dermatol, DOI: 10.1038/jid.2012.121 |
| Krawczyk J, McDermott M, Irvine AD, O'Marcaigh A, Storey L, Smith O, 2012 May, Skin involvement in Down syndrome transient abnormal myelopoiesis. Br J Haematol, DOI: 10.1111/j.1365-2141.2012.09079.x |
| Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD, 2012 Apr, Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2011.12.989 |
| Sandilands A, Brown SJ, Goh CS, Pohler E, Wilson NJ, Campbell LE, Miyamoto K, Kubo A, Irvine AD, Thawer-Esmail F, Munro CS, McLean WH, Kudoh J, Amagai M, Matsui T, 2012 May, Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin. J Invest Dermatol, DOI: 10.1038/jid.2011.479 |
| Liao H, Irvine AD, Macewen CJ, Weed KH, Porter L, Corden LD, Gibson AB, Moore JE, Smith FJ, McLean WH, Moore CB, 2011, Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy. PLoS One, DOI: 10.1371/journal.pone.0028582 |
| Brown SJ, Kroboth K, Sandilands A, Campbell LE, Pohler E, Kezic S, Cordell HJ, McLean WH, Irvine AD, 2012 Jan, Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. J Invest Dermatol, DOI: 10.1038/jid.2011.342 |
| Irvine AD, McLean WH, Leung DY, 2011 Oct 6, Filaggrin mutations associated with skin and allergic diseases. N Engl J Med, DOI: 10.1056/NEJMra1011040 |
| Hawkes CP, Hourihane JO, Kenny LC, Irvine AD, Kiely M, Murray DM, 2011 Sep, Gender- and gestational age-specific body fat percentage at birth. Pediatrics, DOI: 10.1542/peds.2010-3856 |
| Bracken J, Robinson I, Snow A, Watson R, Irvine AD, Rea D, Phelan E, 2011 Sep, PHACE syndrome: MRI of intracerebral vascular anomalies and clinical findings in a series of 12 patients. Pediatr Radiol, DOI: 10.1007/s00247-011-2142-z |
Please visit PubMed for more information on Alan Irvine's publications
| Name: | Professor Irwin McLean |
| Department | Human Genetics |
| Institution: | University of Dundee |
| Country: | UK |
| Name: | Dr Sanja Kezic |
| Department | Toxicology |
| Institution: | Academic Medicine Centre Amsterdam |
| Country: | Netherlands |
| Name: | Professor Stephan Weidinger |
| Department | Dermatology |
| Institution: | Kiel |
| Country: | Germany |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| PRiTI | Clinical, immunologic and microbiologic characterisation of early onset atopic eczema: A study to identify factors in disease initiation, severity, flare and resolution. | Non-Interventional Study | NCRC | Academic - Investigator Led |
| TREAT | A randomised clinical trial to assess the treatment safety and efficacy of oral methotrexate (MTX) vs ciclosporin (CyA) in the treatment of severe recalcitrant atopic eczema (AE) in children | Clinical Trial | King’s College London and Guy’s and St. Thomas’ NHS Foundation Trust | Academic - Investigator Led |
| APPLES | A prospective paediatric study to assess the long-term safety of tacrolimus ointment for the treatment of atopic dermatitis. | Non-Interventional Clinical Trial | Astellas Pharma | Industry Sponsored |
| EASE | Double-blind, Randomised, Vehicle-controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis Bullosa | Clinical Trial | Amryt | Industry Sponsored |
| Inflazome CAPS | MCC950 and derivatives in CAPS patients | Non-Interventional Study | Inflazome Ltd / Trinity College Dublin | Academic - Investigator Led |
| BADBIR | British Association of Dermatologists Biologic Interventions Register | Non-Interventional Study | University of Manchester | Academic - Collaborative Group |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| Eczema & Food Allergy | Identification of Major Susceptibility Genes for Eczema and Food Allergy | Non-Interventional Clinical Trial | NCRC, Wellcome Trust | Academic - Investigator Led |
| Whole Exome Sequencing | Whole exome screening and next generation sequencing | Non-Interventional Study | NCRC and University of Dundee | Academic - Investigator Led |
| Regional Filaggrin | A Study to Investigate Regional Filaggrin Expression | Non-Interventional Study | NCRC | Academic - Investigator Led |
| DS107E-05 | A prospective, randomised, vehicle-controlled, double-blind, exploratory clinical trial to assess the efficacy and steroid sparing potential of DGLA cream topically applied to early childhood patients with moderate to severe atopic dermatitis | Clinical Trial | Afimmune | Industry Sponsored |
| Overgrowth genetics projects | Clinical and molecular characterization of PIK3Kinase related Overgrowth Syndromes | Non-Interventional Study | NCRC and Cambridge University | Academic - Investigator Led |
| Vascular malformation projects | Clinical and molecular characterization of hyperkeratotic vascular malformations | Non-Interventional Study | NCRC and Université catholique de Louvain | Academic - Investigator Led |
Alan is a former Section Editor of the Journal of Investigative Dermatology and an Associate Editor of Allergy, and was the Lead Editor of the 3rd Edition of Harper’s Textbook of Pediatric Dermatology (2011). He is an Honorary Professor in the School of Life Sciences, University of Dundee. In 2016 he was awarded a DSc from Queens University Belfast in recognition of his skin barrier research.
Alan’s international awards include: 2006/2007 Paul Gerson Unna Prize from the German Dermatology Society, 2013 Jerry Dolovich Memorial Lecture (AAAAI), 2015 Dr Sydney Watson Smith Lecture (Royal College of Physicians of Edinburgh), 2016 RW Goltz Memorial Lecture (University of Minnesota).
Other positions and responsibilities: