Alan Irvine


Alan Irvine

Consultant Dermatologist, Professor

Alan graduated in Medicine from Queen’s University Belfast (QUB) in 1991. In 1998, he was awarded a research doctorate (MD) in Human Genetics, also from QUB. He completed Dermatology Training in Belfast in July 1999, followed by fellowships in Great Ormond Street Children’s Hospital, and Children’s Memorial Hospital Chicago, where he was a Fulbright Scholar.

He was appointed Consultant Dermatologist (Attending Physician) in Our Lady’s Children’s Hospital and St. James’s Hospital, Dublin, Ireland in October 2002. The OLCHC department provides specialist clinics in severe atopic dermatitis, vascular malformations, laser treatments, and genetic skin diseases with more than 10 000 secondary and tertiary paediatric attendances per annum. His adult clinics provide a service for complex atopic dermatitis and genodermatoses.

He is Professor in Dermatology, Trinity College Dublin. His research interests are in epithelial genetics, disease mechanisms in, and therapy of, atopic dermatitis. His work on the genetics of atopic dermatitis with long term collaborative partner Irwin McLean has helped refocus attention on the role of the skin barrier in the pathogenesis of this disease and of allergic disease in general. He is funded by the National Children’s Research Centre and the Wellcome Trust, and has attracted approximately €11M funding to date.

Alan Irvine

Consultant Dermatologist, Professor

Dr. Janna Nousbeck
Position: Post-Doctoral Researcher

Role:
Janna is an experienced epithelial biologist with expertise in skin equivalent cultures and genetic analysis of skin disease. Her work currently involves using skin equivalents to study skin barrier function in atopic dermatitis. Janna also is running projects studying the role of miRNA in Atopic Dermatitis

Dr. Maeve McAleer
Position: Consultant Dermatologist

Role:
Maeve is a consultant dermatologist who has recently completed her PhD on skin barrier function in Atopic Dermatitis at NCRC.

Dr Veronika Dvorakova
Position: Clinical Fellow/MD student

Role:
Veronika is studying the genetic basis and therapeutic approaches to vascular anomalies and overgrowth syndromes

Angela Scullion
Position: Senior Clinical Trials Research Co-Ordinator
Angela.scullion@ncrc.ie

Role:
Angela is Senior Research Co-Ordinator within the Children’s Clinical Research Unit on the campus of Children’s Health Ireland at Crumlin, focussing on paediatric clinical trials in Dermatology, Allergy and Cardiology.

Identification of Genes for Childhood Atopic Dermatitis

The NCRC AD case collection is one of the largest in the world, and has been used for identification of many genes involved in AD pathogenesis, including the filaggrin discovery.

Skin Barrier function in Atopic Dermatitis

We have long standing research programs examining skin barrier function in atopic dermatitis. We use non-invasive techniques such as Raman spectroscopy and tape stripping to gain mechanistic and functional insights into AD pathogenesis.

Overgrowth Syndrome and Vascular Anomalies

We provide care for a large cohort of patients with vascular anomalies and overgrowth syndromes. We collaborate with investigators in Belgium on gene identification and with companies developing novel therapies.

Identification of Single Gene Genetic Skin Disorders

For the last two decades we have worked on identification of causal genetic mutations in children with genetic skin disorders.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Lenehan SM, Boylan GB, Livingstone V, Fogarty L, Twomey DM, Nikolovski J, Irvine AD, Kiely M, Kenny LC, Ob Hourihane J, Murray DM, 2019 Sep 13, The impact of short-term predominate breastfeeding on cognitive outcome at 5 years. Acta Paediatr, DOI: 10.1111/apa.15014
Thyssen JP, Jakasa I, Riethmüller C, Schön MP, Braun A, Haftek M, Fallon PG, Wróblewski J, Jakubowski H, Eckhart L, Declercq W, Koppes S, Engebretsen KA, Bonefeld C, Irvine AD, Keita-Alassane S, Simon M, Kawasaki H, Kubo A, Amagai M, Matsui T, Kezic S, 2019 Aug 31, Filaggrin expression and processing deficiencies impair corneocyte surface texture and stiffness in mice. J Invest Dermatol, DOI: 10.1016/j.jid.2019.07.716
Bosma AL, Spuls PI, Garcia-Doval I, Naldi L, Prieto-Merino D, Tesch F, Apfelbacher CJ, Arents BWM, Barbarot S, Baselga E, Deleuran M, Eichenfield LF, Gerbens LAA, Irvine AD, Manca A, Mendes-Bastos P, Middelkamp-Hup MA, Roberts A, Seneschal J, Svensson Å, Thyssen JP, Torres T, Vermeulen FM, Vestergaard C, von Kobyletzki LB, Wall D, Weidinger S, Schmitt J, Flohr C, 2019 Aug 24, TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema. Br J Dermatol, DOI: 10.1111/bjd.18452
Revencu N, Fastre E, Ravoet M, Helaers R, Brouillard P, Bisdorff-Bresson A, Chung CWT, Gerard M, Dvorakova V, Irvine AD, Boon LM, Vikkula M, 2019 Jul 12, RASA1 mosaic mutations in patients with capillary malformation-arteriovenous malformation. J Med Genet, DOI: 10.1136/jmedgenet-2019-106024
Stefanovic N, Flohr C, Irvine AD, 2019 Jun 13, The exposome in atopic dermatitis. Allergy, DOI: 10.1111/all.13946
Chasseuil E, McGrath JA, Seo A, Balguerie X, Bodak N, Chasseuil H, Denis-Musquer M, Goldenberg A, Goussot R, Irvine AD, Khumalo NP, King MC, Küry S, Lipsker D, Mallet S, Mayosi BM, Nanda A, Puzenat E, Salort-Campana E, Sidbury R, Shimamura A, Bézieau S, Mercier S, Barbarot S, 2019 Apr 10, Dermatological manifestations of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP): a case series of 28 patients. Br J Dermatol, DOI: 10.1111/bjd.17996
Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG, 2019 Apr 2, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy, DOI: 10.1111/all.13801
Leshem YA, Bissonnette R, Paul C, Silverberg JI, Irvine AD, Paller AS, Cork MJ, Guttman-Yassky E, 2019 May, Optimization of placebo use in clinical trials with systemic treatments for atopic dermatitis: an International Eczema Council survey-based position statement. J Eur Acad Dermatol Venereol, DOI: 10.1111/jdv.15480
Irvine AD, Mina-Osorio P, 2019 Feb 13, Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide. Br J Dermatol, DOI: 10.1111/bjd.17766
Hawkes CP, Grimberg A, Kenny LC, Kiely M, Hourihane JOB, Irvine AD, McPhaul MJ, Caulfield MP, Zemel BS, Murray DM, 2019 Apr, The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months. Pediatr Res, DOI: 10.1038/s41390-019-0331-x
Vermeulen FM, Gerbens LAA, Bosma AL, Apfelbacher CJ, Irvine AD, Arents BWM, Barbarot S, Deleuran M, Eichenfield LF, Manca A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Middelkamp-Hup MA, Spuls PI, Flohr C, International TREAT Registry Taskforce., 2019 Sep, TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries. Br J Dermatol, DOI: 10.1111/bjd.17715
Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M, 2019 Mar, Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2019.01.003
Harkins CP, Holden MTG, Irvine AD, 2019 Mar, Antimicrobial resistance in atopic dermatitis: Need for an urgent rethink. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2018.11.027
Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD, 2019 Jan, The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.11.015
Paller AS, Spergel JM, Mina-Osorio P, Irvine AD, 2019 Jan, The atopic march and atopic multimorbidity: Many trajectories, many pathways. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.11.006
Clowry J, Irvine AD, McLoughlin RM, 2019 Jan, Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis? J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.08.038
McCarthy EK, Murray DM, Malvisi L, Kenny LC, O'B Hourihane J, Irvine AD, Kiely ME, 2018 Oct 1, Antenatal Vitamin D Status Is Not Associated with Standard Neurodevelopmental Assessments at Age 5 Years in a Well-Characterized Prospective Maternal-Infant Cohort. J Nutr, DOI: 10.1093/jn/nxy150
McAleer MA, Jakasa I, Hurault G, Sarvari P, McLean WHI, Tanaka RJ, Kezic S, Irvine AD, 2019 Mar, Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesis. Br J Dermatol, DOI: 10.1111/bjd.17088
Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF, 2018 Aug 14, Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels. MBio, DOI: 10.1128/mBio.01184-18
Hennessy Á, Hourihane JO, Malvisi L, Irvine AD, Kenny LC, Murray DM, Kiely ME, 2018 Nov, Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE Birth Cohort Study. Allergy, DOI: 10.1111/all.13590
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, Cooper HL, Irvine AD, Oon HH, Kingo K, Köks S, Mrowietz U, Puig L, Reynolds N, Tan ES, Tanew A, Torz K, Trattner H, Valentine M, Wahie S, Warren RB, Wright A, Bata-Csörgő Z, Szell M, Griffiths CEM, Burden AD, Choon SE, Smith CH, Barker JN, Navarini AA, Capon F, 2019 Mar, Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.06.038
Simpson EL, Reynolds NJ, Flohr C, Paller AS, Silverberg JI, Cork MJ, Guttman-Yassky E, Irvine AD, 2018 Aug, Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'". J Am Acad Dermatol, DOI: 10.1016/j.jaad.2018.03.048
Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD, 2018 Jun 21, Atopic dermatitis. Nat Rev Dis Primers, DOI: 10.1038/s41572-018-0001-z
Pigors M, Common JEA, Wong XFCC, Malik S, Scott CA, Tabarra N, Liany H, Liu J, Limviphuvadh V, Maurer-Stroh S, Tang MBY, Lench N, Margolis DJ, van Heel DA, Mein CA, Novak N, Baurecht H, Weidinger S, McLean WHI, Irvine AD, O'Toole EA, Simpson MA, Kelsell DP, 2018 Dec, Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes. J Invest Dermatol, DOI: 10.1016/j.jid.2018.05.013
Gerbens LAA, Apfelbacher CJ, Irvine AD, Barbarot S, de Booij RJ, Boyce AE, Deleuran M, Eichenfield LF, Hof MH, Middelkamp-Hup MA, Roberts A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Williamson PR, Flohr C, Spuls PI, international TREAT Registry Taskforce., 2019 Apr, TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo- and systemic therapy registries. Br J Dermatol, DOI: 10.1111/bjd.16714
Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG, 2018 Oct, The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis. Br J Dermatol, DOI: 10.1111/bjd.16722
Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, O'Neill L, Rosala-Hallas A, Sach T, Spowart C, Taams L, Walker C, Wan M, Webb N, Williamson P, Flohr C, TREAT Trial Investigators., 2018 Dec, A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT). Br J Dermatol, DOI: 10.1111/bjd.16717
McAleer MA, Jakasa I, Raj N, O'Donnell CPF, Lane ME, Rawlings AV, Voegeli R, McLean WHI, Kezic S, Irvine AD, 2018 Aug, Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis. Br J Dermatol, DOI: 10.1111/bjd.16691
Dvorakova V, Rea D, O'Regan GM, Irvine AD, 2018 Jul, Generalized lymphatic anomaly successfully treated with long-term, low-dose sirolimus. Pediatr Dermatol, DOI: 10.1111/pde.13494
Hawkes CP, Murray DM, Kenny LC, Kiely M, O'B Hourihane J, Irvine AD, Wu Z, Argon Y, Reitz RE, McPhaul MJ, Grimberg A, 2018, Correlation of Insulin-Like Growth Factor-I and -II Concentrations at Birth Measured by Mass Spectrometry and Growth from Birth to Two Months. Horm Res Paediatr, DOI: 10.1159/000486035
Lynch SA, Crushell E, Lambert DM, Byrne N, Gorman K, King MD, Green A, O'Sullivan S, Browne F, Hughes J, Knerr I, Monavari AA, Cotter M, McConnell VPM, Kerr B, Jones SA, Keenan C, Murphy N, Cody D, Ennis S, Turner J, Irvine AD, Casey J, 2018 Apr, Catalogue of inherited disorders found among the Irish Traveller population. J Med Genet, DOI: 10.1136/jmedgenet-2017-104974
Geoghegan JA, Irvine AD, Foster TJ, 2018 Jun, Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends Microbiol, DOI: 10.1016/j.tim.2017.11.008
Hennessy Á, Ní Chaoimh C, McCarthy EK, Kingston C, Irvine AD, Hourihane JO, Kenny LC, Murray DM, Kiely M, 2018 Mar, Variation in iodine food composition data has a major impact on estimates of iodine intake in young children. Eur J Clin Nutr, DOI: 10.1038/s41430-017-0030-9
Paller AS, Czarnowicki T, Renert-Yuval Y, Holland K, Huynh T, Sadlier M, McAleer MA, Tran G, Geddes GC, Irvine AD, Guttman-Yassky E, 2018 Mar, The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2017.10.026
McCarthy EK, Kiely ME, Hannon G, Ahearne C, Kenny LC, Hourihane JO, Irvine AD, Murray DM, 2017 Sep, Microcytosis is associated with low cognitive outcomes in healthy 2-year-olds in a high-resource setting. Br J Nutr, DOI: 10.1017/S0007114517001945
Drucker AM, Eyerich K, de Bruin-Weller MS, Thyssen JP, Spuls PI, Irvine AD, Girolomoni G, Dhar S, Flohr C, Murrell DF, Paller AS, Guttman-Yassky E, 2018 Mar, Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement. Br J Dermatol, DOI: 10.1111/bjd.15928
Simpson EL, Bruin-Weller M, Flohr C, Ardern-Jones MR, Barbarot S, Deleuran M, Bieber T, Vestergaard C, Brown SJ, Cork MJ, Drucker AM, Eichenfield LF, Foelster-Holst R, Guttman-Yassky E, Nosbaum A, Reynolds NJ, Silverberg JI, Schmitt J, Seyger MMB, Spuls PI, Stalder JF, Su JC, Takaoka R, Traidl-Hoffmann C, Thyssen JP, van der Schaft J, Wollenberg A, Irvine AD, Paller AS, 2017 Oct, When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2017.06.042
Dvorakova V, O'Regan GM, Irvine AD, 2017 Sep, Methotrexate for Severe Childhood Atopic Dermatitis: Clinical Experience in a Tertiary Center. Pediatr Dermatol, DOI: 10.1111/pde.13209
Spuls PI, Gerbens LAA, Apfelbacher CJ, Wall D, Arents BWM, Barbarot S, Roberts A, Deleuran M, Middelkamp-Hup MA, Vestergaard C, Weidinger S, Schmitt J, Irvine AD, Flohr C, 2017 Sep, The International TREatment of ATopic Eczema (TREAT) Registry Taskforce: An Initiative to Harmonize Data Collection across National Atopic Eczema Photo- and Systemic Therapy Registries. J Invest Dermatol, DOI: 10.1016/j.jid.2017.05.014
McCarthy EK, Ní Chaoimh C, Kenny LC, Hourihane JO, Irvine AD, Murray DM, Kiely ME, 2018 Jan, Iron status, body size, and growth in the first 2 years of life. Matern Child Nutr, DOI: 10.1111/mcn.12458
Murad A, O'Regan G, Watson R, McDermott M, O'Sullivan M, Irvine AD, 2017 Jun, Erythema elevatum diutinum in a healthy child. Clin Exp Dermatol, DOI: 10.1111/ced.13083
Fleury OM, McAleer MA, Feuillie C, Formosa-Dague C, Sansevere E, Bennett DE, Towell AM, McLean WHI, Kezic S, Robinson DA, Fallon PG, Foster TJ, Dufrêne YF, Irvine AD, Geoghegan JA, 2017 Jun, Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis. Infect Immun, DOI: 10.1128/IAI.00994-16
Gerbens LA, Boyce AE, Wall D, Barbarot S, de Booij RJ, Deleuran M, Middelkamp-Hup MA, Roberts A, Vestergaard C, Weidinger S, Apfelbacher CJ, Irvine AD, Schmitt J, Williamson PR, Spuls PI, Flohr C, 2017 Feb 27, TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema registries. Trials, DOI: 10.1186/s13063-016-1765-7
Ní Chaoimh C, McCarthy EK, Hourihane JO, Kenny LC, Irvine AD, Murray DM, Kiely ME, 2018 Mar, Low vitamin D deficiency in Irish toddlers despite northerly latitude and a high prevalence of inadequate intakes. Eur J Nutr, DOI: 10.1007/s00394-016-1368-9
Kiely M, O'Donovan SM, Kenny LC, Hourihane JO, Irvine AD, Murray DM, 2017 Mar, Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland. J Steroid Biochem Mol Biol, DOI: 10.1016/j.jsbmb.2016.12.006
McCarthy EK, Kenny LC, Hourihane JOB, Irvine AD, Murray DM, Kiely ME, 2017 Jun, Impact of maternal, antenatal and birth-associated factors on iron stores at birth: data from a prospective maternal-infant birth cohort. Eur J Clin Nutr, DOI: 10.1038/ejcn.2016.255
Storan ER, Irvine AD, 2017 Jan, Access to Genetic Diagnostics for Genodermatoses: Who Should Get Tested? Why? Who Pays? Pediatr Dermatol, DOI: 10.1111/pde.13041
Domínguez-Hüttinger E, Christodoulides P, Miyauchi K, Irvine AD, Okada-Hatakeyama M, Kubo M, Tanaka RJ, 2017 Jun, Mathematical modeling of atopic dermatitis reveals "double-switch" mechanisms underlying 4 common disease phenotypes. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2016.10.026
Samuelov L, Li Q, Bochner R, Najor NA, Albrecht L, Malchin N, Goldsmith T, Grafi-Cohen M, Vodo D, Fainberg G, Meilik B, Goldberg I, Warshauer E, Rogers T, Edie S, Ishida-Yamamoto A, Burzenski L, Erez N, Murray SA, Irvine AD, Shultz L, Green KJ, Uitto J, Sprecher E, Sarig O, 2017 May, SVEP1 plays a crucial role in epidermal differentiation. Exp Dermatol, DOI: 10.1111/exd.13256
Nousbeck J, Irvine AD, 2016 Dec, Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis. J Invest Dermatol, DOI: 10.1016/j.jid.2016.08.020
Hawkes CP, Zemel BS, Kiely M, Irvine AD, Kenny LC, O'B Hourihane J, Murray DM, 2016, Body Composition within the First 3 Months: Optimized Correction for Length and Correlation with BMI at 2 Years. Horm Res Paediatr, DOI: 10.1159/000448659
Lovgren ML, McAleer MA, Irvine AD, Wilson NJ, Tavadia S, Schwartz ME, Cole C, Sandilands A, Smith FJD, Zamiri M, 2017 May, Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening. Br J Dermatol, DOI: 10.1111/bjd.14973
Mahil SK, Twelves S, Farkas K, Setta-Kaffetzi N, Burden AD, Gach JE, Irvine AD, Képíró L, Mockenhaupt M, Oon HH, Pinner J, Ranki A, Seyger MMB, Soler-Palacin P, Storan ER, Tan ES, Valeyrie-Allanore L, Young HS, Trembath RC, Choon SE, Szell M, Bata-Csorgo Z, Smith CH, Di Meglio P, Barker JN, Capon F, 2016 Nov, AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production. J Invest Dermatol, DOI: 10.1016/j.jid.2016.06.618
Kennedy EA, Connolly J, Hourihane JO, Fallon PG, McLean WHI, Murray D, Jo JH, Segre JA, Kong HH, Irvine AD, 2017 Jan, Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2016.07.029
Chaoimh CN, Murray DM, Kenny LC, Irvine AD, Hourihane JO, Kiely M, 2016 Nov, Cord blood leptin and gains in body weight and fat mass during infancy. Eur J Endocrinol, DOI: 10.1530/EJE-16-0431
Soblet J, Kangas J, Nätynki M, Mendola A, Helaers R, Uebelhoer M, Kaakinen M, Cordisco M, Dompmartin A, Enjolras O, Holden S, Irvine AD, Kangesu L, Léauté-Labrèze C, Lanoel A, Lokmic Z, Maas S, McAleer MA, Penington A, Rieu P, Syed S, van der Vleuten C, Watson R, Fishman SJ, Mulliken JB, Eklund L, Limaye N, Boon LM, Vikkula M, 2017 Jan, Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations. J Invest Dermatol, DOI: 10.1016/j.jid.2016.07.034
McCarthy EK, Ní Chaoimh C, Hourihane JO, Kenny LC, Irvine AD, Murray DM, Kiely M, 2017 Jul, Iron intakes and status of 2-year-old children in the Cork BASELINE Birth Cohort Study. Matern Child Nutr, DOI: 10.1111/mcn.12320
Kelleher MM, Dunn-Galvin A, Gray C, Murray DM, Kiely M, Kenny L, McLean WHI, Irvine AD, Hourihane JO, 2016 Apr, Skin barrier impairment at birth predicts food allergy at 2 years of age. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2015.12.1312
Strid J, McLean WHI, Irvine AD, 2016 Mar, Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation? J Invest Dermatol, DOI: 10.1016/j.jid.2015.12.025

Please visit PubMed for more information on Alan Irvine's publications

Name:Professor Irwin McLean
DepartmentHuman Genetics
Institution:University of Dundee
Country:UK
Name:Dr Sanja Kezic
DepartmentToxicology
Institution:Academic Medicine Centre Amsterdam
Country:Netherlands
Name:Professor Stephan Weidinger
DepartmentDermatology
Institution:Kiel
Country:Germany

Current Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
PRiTIClinical, immunologic and microbiologic characterisation of early onset atopic eczema: A study to identify factors in disease initiation, severity, flare and resolution.Non-Interventional StudyNCRCAcademic - Investigator Led
TREATA randomised clinical trial to assess the treatment safety and efficacy of oral methotrexate (MTX) vs ciclosporin (CyA) in the treatment of severe recalcitrant atopic eczema (AE) in childrenClinical TrialKing’s College London and Guy’s and St. Thomas’ NHS Foundation TrustAcademic - Investigator Led
APPLESA prospective paediatric study to assess the long-term safety of tacrolimus ointment for the treatment of atopic dermatitis.Non-Interventional Clinical TrialAstellas PharmaIndustry Sponsored
EASEDouble-blind, Randomised, Vehicle-controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis BullosaClinical TrialAmrytIndustry Sponsored
BADBIRBritish Association of Dermatologists Biologic Interventions RegisterNon-Interventional StudyUniversity of ManchesterAcademic - Collaborative Group

Previous Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
Eczema & Food AllergyIdentification of Major Susceptibility Genes for Eczema and Food AllergyNon-Interventional Clinical TrialNCRC, Wellcome TrustAcademic - Investigator Led
Whole Exome SequencingWhole exome screening and next generation sequencingNon-Interventional StudyNCRC and University of DundeeAcademic - Investigator Led
Regional FilaggrinA Study to Investigate Regional Filaggrin ExpressionNon-Interventional StudyNCRCAcademic - Investigator Led
DS107E-05A prospective, randomised, vehicle-controlled, double-blind, exploratory clinical trial to assess the efficacy and steroid sparing potential of DGLA cream topically applied to early childhood patients with moderate to severe atopic dermatitisClinical TrialAfimmuneIndustry Sponsored
Overgrowth genetics projectsClinical and molecular characterization of PIK3Kinase related Overgrowth SyndromesNon-Interventional StudyNCRC and Cambridge UniversityAcademic - Investigator Led
Vascular malformation projectsClinical and molecular characterization of hyperkeratotic vascular malformationsNon-Interventional StudyNCRC and Université catholique de LouvainAcademic - Investigator Led
Inflazome CAPSMCC950 and derivatives in CAPS patientsNon-Interventional StudyInflazome Ltd / Trinity College DublinAcademic - Investigator Led

    Alan is a former Section Editor of the Journal of Investigative Dermatology and an Associate Editor of Allergy, and was the Lead Editor of the 3rd Edition of Harper’s Textbook of Pediatric Dermatology (2011). He is an Honorary Professor in the School of Life Sciences, University of Dundee. In 2016 he was awarded a DSc from Queens University Belfast in recognition of his skin barrier research.

    Alan’s international awards include: 2006/2007 Paul Gerson Unna Prize from the German Dermatology Society, 2013 Jerry Dolovich Memorial Lecture (AAAAI), 2015 Dr Sydney Watson Smith Lecture (Royal College of Physicians of Edinburgh), 2016 RW Goltz Memorial Lecture (University of Minnesota).

    Other positions and responsibilities:

    • Director of the International Eczema Council
    • Member of the UK TREND collaborative initiative led by the British Association of Dermatology on translational research
    • Executive Committee member of the international TREAT initiative for Registries in Atopic Dermatitis (https://treat-registry-taskforce.org )
    • Medical Director of the Irish Skin Foundation’s Skin registry programme.
    • Scientific Committee Member Debra Ireland
    • Principal Investigator INFANT SFI Centre