Alan Irvine


Alan Irvine

Consultant Dermatologist, Professor

Alan graduated in Medicine from Queen’s University Belfast (QUB) in 1991. In 1998, he was awarded a research doctorate (MD) in Human Genetics, also from QUB. He completed Dermatology Training in Belfast in July 1999, followed by fellowships in Great Ormond Street Children’s Hospital, and Children’s Memorial Hospital Chicago, where he was a Fulbright Scholar.

He was appointed Consultant Dermatologist (Attending Physician) in Children’s Health Ireland at Crumlin (CHI at Crumlin) and St. James’s Hospital, Dublin, Ireland in October 2002. The CHI at Crumlin department provides specialist clinics in severe atopic dermatitis, vascular malformations, laser treatments, and genetic skin diseases with more than 10 000 secondary and tertiary paediatric attendances per annum. His adult clinics provide a service for complex atopic dermatitis and genodermatoses.

He is Professor in Dermatology, Trinity College Dublin. His research interests are in epithelial genetics, disease mechanisms in, and therapy of, atopic dermatitis. His work on the genetics of atopic dermatitis with long term collaborative partner Irwin McLean has helped refocus attention on the role of the skin barrier in the pathogenesis of this disease and of allergic disease in general. He is funded by the National Children’s Research Centre and the Wellcome Trust, and has attracted approximately €11M funding to date.

Alan Irvine

Consultant Dermatologist, Professor

Dr. Janna Nousbeck
Position: Post-Doctoral Researcher

Role:
Janna is an experienced epithelial biologist with expertise in skin equivalent cultures and genetic analysis of skin disease. Her work currently involves using skin equivalents to study skin barrier function in atopic dermatitis. Janna also is running projects studying the role of miRNA in Atopic Dermatitis

Dr. Maeve McAleer
Position: Consultant Dermatologist

Role:
Maeve is a consultant dermatologist who has recently completed her PhD on skin barrier function in Atopic Dermatitis at NCRC.

Dr Veronika Dvorakova
Position: Clinical Fellow/MD student

Role:
Veronika is studying the genetic basis and therapeutic approaches to vascular anomalies and overgrowth syndromes

Identification of Genes for Childhood Atopic Dermatitis

The NCRC AD case collection is one of the largest in the world, and has been used for identification of many genes involved in AD pathogenesis, including the filaggrin discovery.

Skin Barrier function in Atopic Dermatitis

We have long standing research programs examining skin barrier function in atopic dermatitis. We use non-invasive techniques such as Raman spectroscopy and tape stripping to gain mechanistic and functional insights into AD pathogenesis.

Overgrowth Syndrome and Vascular Anomalies

We provide care for a large cohort of patients with vascular anomalies and overgrowth syndromes. We collaborate with investigators in Belgium on gene identification and with companies developing novel therapies.

Identification of Single Gene Genetic Skin Disorders

For the last two decades we have worked on identification of causal genetic mutations in children with genetic skin disorders.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Xing C, Kanchwala M, Rios J, Hyatt T, Wang RC, Tran A, Dougherty I, Tovar A, Purnadi C, Kumar MG, Berk D, Shinawi M, Irvine AD, Toledo-Bahena M, Agim NG, Glass DA 2nd, 2021 Jun 3, Biallelic variants in RNU12 cause CDAGS syndrome. Hum Mutat, DOI: 10.1002/humu.24239
Stefanovic N, Irvine AD, Flohr C, 2021 May 21, The Role of the Environment and Exposome in Atopic Dermatitis. Curr Treat Options Allergy, DOI: 10.1007/s40521-021-00289-9
Deleuran M, Marcoux D, De Bruin-Weller MS, Irvine AD, Baselga E, Ahn K, Castro AP, Bansal A, Chao J, Bégo-Le-Bagousse G, Rossi AB, 2021 May 27, Dupilumab Provides Significant Clinical Benefit in a Phase 3 Trial in Adolescents with Uncontrolled Atopic Dermatitis Irrespective of Prior Systemic Immunosuppressant Use. Acta Derm Venereol, DOI: 10.2340/00015555-3848
Guttman-Yassky E, Teixeira HD, Simpson EL, Papp KA, Pangan AL, Blauvelt A, Thaçi D, Chu CY, Hong HC, Katoh N, Paller AS, Calimlim B, Gu Y, Hu X, Liu M, Yang Y, Liu J, Tenorio AR, Chu AD, Irvine AD, 2021 Jun 5, Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials. Lancet, DOI: 10.1016/S0140-6736(21)00588-2
Fagan N, Meah N, York K, Bokhari L, Fletcher G, Chen G, Tobin DJ, Messenger A, Irvine AD, Sinclair R, Wall D, 2021 Jan-Feb, Shedding light on therapeutics in alopecia and their relevance to COVID-19. Clin Dermatol, DOI: 10.1016/j.clindermatol.2020.12.015
Miyano T, Irvine AD, Tanaka RJ, 2021 Apr 24, A mathematical model to identify optimal combinations of drug targets for dupilumab poor responders in atopic dermatitis. Allergy, DOI: 10.1111/all.14870
Luger T, Paller AS, Irvine AD, Sidbury R, Eichenfield LF, Werfel T, Bieber T, 2021 Apr 8, Topical therapy of atopic dermatitis with a focus on pimecrolimus. J Eur Acad Dermatol Venereol, DOI: 10.1111/jdv.17272
Doherty AM, Colleran GC, Durcan L, Irvine AD, Barrett E, 2021 Mar 13, A pilot study of burnout and long covid in senior specialist doctors. Ir J Med Sci, DOI: 10.1007/s11845-021-02594-3
Wall D, Meah N, York K, Bhoyrul B, Bokhari L, Abraham LS, Adams R, Bergfeld W, Betz RC, Blume-Peytavi U, Callender V, Campbell C, Chambers J, Chen G, Chitreddy V, Cotsarelis G, Craiglow B, Dhurat R, Dlova N, Donovan J, Duque-Estrada B, Eisman S, Ellison A, Farrant P, Barberá JF, Gadzhigoroeva A, Grimalt R, Harries M, Hordinsky M, Irvine AD, Jolliffe V, Jones L, King B, Lee WS, Lortkipanidze N, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Ovcharenko Y, Piraccini BM, Pirmez R, Rakowska A, Reygagne P, Riley M, Rudnicka L, Saceda Corralo D, Shapiro J, Sharma P, Silyuk T, Kaiumov S, Tobin DJ, Tosti A, Vañó-Galván S, Vogt A, Wade M, Yip L, Zlotogorski A, Zhou C, Sinclair R, 2021 Apr 1, A Global eDelphi Exercise to Identify Core Domains and Domain Items for the Development of a Global Registry of Alopecia Areata Disease Severity and Treatment Safety (GRASS). JAMA Dermatol, DOI: 10.1001/jamadermatol.2020.5839
Mulick AR, Mansfield KE, Silverwood RJ, Budu-Aggrey A, Roberts A, Custovic A, Pearce N, Irvine AD, Smeeth L, Abuabara K, Langan SM, 2021 Mar 2, Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort. Br J Dermatol, DOI: 10.1111/bjd.19885
Forde K, Resta N, Ranieri C, Rea D, Kubassova O, Hinton M, Andrews KA, Semple R, Irvine AD, Dvorakova V, 2021 Feb 27, Clinical experience with the AKT1 inhibitor miransertib in two children with PIK3CA-related overgrowth syndrome. Orphanet J Rare Dis, DOI: 10.1186/s13023-021-01745-0
McCarthy EK, Murray DM, Hourihane JOB, Kenny LC, Irvine AD, Kiely ME, 2021 Apr 6, Behavioral consequences at 5 y of neonatal iron deficiency in a low-risk maternal-infant cohort. Am J Clin Nutr, DOI: 10.1093/ajcn/nqaa367
Hotz A, Kopp J, Bourrat E, Oji V, Komlosi K, Giehl K, Bouadjar B, Bygum A, Tantcheva-Poor I, Hellström Pigg M, Has C, Yang Z, Irvine AD, Betz RC, Zambruno G, Tadini G, Süßmuth K, Gruber R, Schmuth M, Mazereeuw-Hautier J, Jonca N, Guez S, Brena M, Hernandez-Martin A, van den Akker P, Bolling MC, Hannula-Jouppi K, Zimmer AD, Alter S, Vahlquist A, Fischer J, 2021 Jan 9, Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients. Genes (Basel), DOI: 10.3390/genes12010080
Towell AM, Feuillie C, Vitry P, Da Costa TM, Mathelié-Guinlet M, Kezic S, Fleury OM, McAleer MA, Dufrêne YF, Irvine AD, Geoghegan JA, 2021 Jan 5, Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.2014444118
McAleer MA, Jakasa I, Stefanovic N, McLean WHI, Kezic S, Irvine AD, 2020 Dec 2, Topical corticosteroids normalize both skin and systemic inflammatory markers in infant atopic dermatitis. Br J Dermatol, DOI: 10.1111/bjd.19703
Siegels D, Heratizadeh A, Abraham S, Binnmyr J, Brockow K, Irvine AD, Halken S, Mortz CG, Flohr C, Schmid-Grendelmeier P, Van der Poel LA, Muraro A, Weidinger S, Werfel T, Schmitt J, European Academy of Allergy, Clinical Immunology Atopic Dermatitis Guideline group., 2021 Apr, Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis. Allergy, DOI: 10.1111/all.14631
Delles C, Dayan CM, Dominiczak AF, Donnelly SC, Irvine AD, 2021 Feb 18, Announcing the first AoP webinar: 'Can evidence-based medicine survive in a pandemic?' QJM, DOI: 10.1093/qjmed/hcaa287
Boggs JME, Irvine AD, 2021 Jan, PLACK syndrome resulting from a novel homozygous variant in CAST. Pediatr Dermatol, DOI: 10.1111/pde.14383
Haftek M, McAleer MA, Jakasa I, McLean WI, Kezic S, Irvine AD, 2020, Changes in nano-mechanical properties of human epidermal cornified cells in children with atopic dermatitis. Wellcome Open Res, DOI: 10.12688/wellcomeopenres.15729.2
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Asz-Sigall D, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee WS, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair RD, 2021 Jun, The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2020.09.028
Alsaleemi A, O'Connor C, Irvine AD, Leahy TR, 2020 Nov, Topical cidofovir for the treatment of recalcitrant viral warts and molluscum contagiosum in Jacobsen syndrome. Pediatr Dermatol, DOI: 10.1111/pde.14355
Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ, 2020 Sep 1, The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metab, DOI: 10.1016/j.cmet.2020.07.016
Onoufriadis A, Cabezas A, Ng JCF, Canales J, Costas MJ, Ribeiro JM, Rodrigues JR, McAleer MA, Castelo-Soccio L, Simpson MA, Fraternali F, Irvine AD, Cameselle JC, McGrath JA, 2021 May, Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations. Br J Dermatol, DOI: 10.1111/bjd.19481
Langan SM, Irvine AD, Weidinger S, 2020 Aug 1, Atopic dermatitis. Lancet, DOI: 10.1016/S0140-6736(20)31286-1
Cunningham L, Dvorakova V, Browne F, Irvine AD, 2021 Mar, High-dose bilastine for the treatment of BASCULE syndrome. Clin Exp Dermatol, DOI: 10.1111/ced.14377
Freeman EE, McMahon DE, Hruza GJ, Irvine AD, Spuls PI, Smith CH, Mahil SK, Castelo-Soccio L, Cordoro KM, Lara-Corrales I, Naik HB, Alhusayen R, Ingram JR, Feldman SR, Balogh EA, Kappelman MD, Wall D, Meah N, Sinclair R, Beylot-Barry M, Fitzgerald M, French LE, Lim HW, Griffiths CEM, Flohr C, 2020 Sep, International collaboration and rapid harmonization across dermatologic COVID-19 registries. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2020.06.050
Nousbeck J, McAleer MA, Hurault G, Kenny E, Harte K, Kezic S, Tanaka RJ, Irvine AD, 2021 Mar, MicroRNA analysis of childhood atopic dermatitis reveals a role for miR-451a. Br J Dermatol, DOI: 10.1111/bjd.19254
Mahil SK, Yiu ZZN, Mason KJ, Dand N, Coker B, Wall D, Fletcher G, Bosma A, Capon F, Iversen L, Langan SM, Di Meglio P, Musters AH, Prieto-Merino D, Tsakok T, Warren RB, Flohr C, Spuls PI, Griffiths CEM, Barker J, Irvine AD, Smith CH, Secure-AD and PsoProtect study groups., 2020 Aug, Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic. Br J Dermatol, DOI: 10.1111/bjd.19161
Paller AS, Guttman-Yassky E, Irvine AD, Baselga E, de Bruin-Weller M, Jayawardena S, Zhang A, Mina-Osorio P, Rizova E, Ozturk ZE, 2020 Mar 24, Protocol for a prospective, observational, longitudinal study in paediatric patients with moderate-to-severe atopic dermatitis (PEDISTAD): study objectives, design and methodology. BMJ Open, DOI: 10.1136/bmjopen-2019-033507
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee WS, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair R, 2020 Jul, The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2020.03.004
Vermeulen FM, Gerbens LAA, Schmitt J, Deleuran M, Irvine AD, Logan K, Ouwerkerk W, Vestergaard C, Flohr C, Spuls PI, international TREAT Registry Taskforce., 2020 Dec, The European TREatment of ATopic eczema (TREAT) Registry Taskforce survey: prescribing practices in Europe for phototherapy and systemic therapy in adult patients with moderate-to-severe atopic eczema. Br J Dermatol, DOI: 10.1111/bjd.18959
Ní Chaoimh C, Nico C, Puppels GJ, Caspers PJ, Wong XFCC, Common JE, Irvine AD, Hourihane JO, 2020 May, In vivo Raman spectroscopy discriminates between FLG loss-of-function carriers vs wild-type in day 1-4 neonates. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2020.01.022
Blakeway H, Van-de-Velde V, Allen VB, Kravvas G, Palla L, Page MJ, Flohr C, Weller RB, Irvine AD, McPherson T, Roberts A, Williams HC, Reynolds N, Brown SJ, Paternoster L, Langan SM, (on behalf of UK TREND Eczema Network)., 2020 Sep, What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review. Br J Dermatol, DOI: 10.1111/bjd.18778
Alexander H, Paller AS, Traidl-Hoffmann C, Beck LA, De Benedetto A, Dhar S, Girolomoni G, Irvine AD, Spuls P, Su J, Thyssen JP, Vestergaard C, Werfel T, Wollenberg A, Deleuran M, Flohr C, 2020 Jun, The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group. Br J Dermatol, DOI: 10.1111/bjd.18643
Drislane C, Irvine AD, 2020 Jan, The role of filaggrin in atopic dermatitis and allergic disease. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2019.10.008
Lenehan SM, Boylan GB, Livingstone V, Fogarty L, Twomey DM, Nikolovski J, Irvine AD, Kiely M, Kenny LC, Hourihane JOB, Murray DM, 2020 May, The impact of short-term predominate breastfeeding on cognitive outcome at 5 years. Acta Paediatr, DOI: 10.1111/apa.15014
Thyssen JP, Jakasa I, Riethmüller C, Schön MP, Braun A, Haftek M, Fallon PG, Wróblewski J, Jakubowski H, Eckhart L, Declercq W, Koppes S, Engebretsen KA, Bonefeld C, Irvine AD, Keita-Alassane S, Simon M, Kawasaki H, Kubo A, Amagai M, Matsui T, Kezic S, 2020 Mar, Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice. J Invest Dermatol, DOI: 10.1016/j.jid.2019.07.716
Bosma AL, Spuls PI, Garcia-Doval I, Naldi L, Prieto-Merino D, Tesch F, Apfelbacher CJ, Arents BWM, Barbarot S, Baselga E, Deleuran M, Eichenfield LF, Gerbens LAA, Irvine AD, Manca A, Mendes-Bastos P, Middelkamp-Hup MA, Roberts A, Seneschal J, Svensson Å, Thyssen JP, Torres T, Vermeulen FM, Vestergaard C, von Kobyletzki LB, Wall D, Weidinger S, Schmitt J, Flohr C, 2020 Jun, TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema. Br J Dermatol, DOI: 10.1111/bjd.18452
Revencu N, Fastre E, Ravoet M, Helaers R, Brouillard P, Bisdorff-Bresson A, Chung CWT, Gerard M, Dvorakova V, Irvine AD, Boon LM, Vikkula M, 2020 Jan, RASA1 mosaic mutations in patients with capillary malformation-arteriovenous malformation. J Med Genet, DOI: 10.1136/jmedgenet-2019-106024
Stefanovic N, Flohr C, Irvine AD, 2020 Jan, The exposome in atopic dermatitis. Allergy, DOI: 10.1111/all.13946
Chasseuil E, McGrath JA, Seo A, Balguerie X, Bodak N, Chasseuil H, Denis-Musquer M, Goldenberg A, Goussot R, Irvine AD, Khumalo NP, King MC, Küry S, Lipsker D, Mallet S, Mayosi BM, Nanda A, Puzenat E, Salort-Campana E, Sidbury R, Shimamura A, Bézieau S, Mercier S, Barbarot S, 2019 Oct, Dermatological manifestations of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP): a case series of 28 patients. Br J Dermatol, DOI: 10.1111/bjd.17996
Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG, 2019 Oct, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy, DOI: 10.1111/all.13801
Leshem YA, Bissonnette R, Paul C, Silverberg JI, Irvine AD, Paller AS, Cork MJ, Guttman-Yassky E, 2019 May, Optimization of placebo use in clinical trials with systemic treatments for atopic dermatitis: an International Eczema Council survey-based position statement. J Eur Acad Dermatol Venereol, DOI: 10.1111/jdv.15480
Irvine AD, Mina-Osorio P, 2019 Nov, Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide. Br J Dermatol, DOI: 10.1111/bjd.17766
Hawkes CP, Grimberg A, Kenny LC, Kiely M, Hourihane JOB, Irvine AD, McPhaul MJ, Caulfield MP, Zemel BS, Murray DM, 2019 Apr, The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months. Pediatr Res, DOI: 10.1038/s41390-019-0331-x
Vermeulen FM, Gerbens LAA, Bosma AL, Apfelbacher CJ, Irvine AD, Arents BWM, Barbarot S, Deleuran M, Eichenfield LF, Manca A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Middelkamp-Hup MA, Spuls PI, Flohr C, International TREAT Registry Taskforce., 2019 Sep, TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries. Br J Dermatol, DOI: 10.1111/bjd.17715
Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M, 2019 Mar, Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2019.01.003
Harkins CP, Holden MTG, Irvine AD, 2019 Mar, Antimicrobial resistance in atopic dermatitis: Need for an urgent rethink. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2018.11.027
Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD, 2019 Jan, The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.11.015
Paller AS, Spergel JM, Mina-Osorio P, Irvine AD, 2019 Jan, The atopic march and atopic multimorbidity: Many trajectories, many pathways. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.11.006
Clowry J, Irvine AD, McLoughlin RM, 2019 Jan, Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis? J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.08.038
McCarthy EK, Murray DM, Malvisi L, Kenny LC, O'B Hourihane J, Irvine AD, Kiely ME, 2018 Oct 1, Antenatal Vitamin D Status Is Not Associated with Standard Neurodevelopmental Assessments at Age 5 Years in a Well-Characterized Prospective Maternal-Infant Cohort. J Nutr, DOI: 10.1093/jn/nxy150
McAleer MA, Jakasa I, Hurault G, Sarvari P, McLean WHI, Tanaka RJ, Kezic S, Irvine AD, 2019 Mar, Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesis. Br J Dermatol, DOI: 10.1111/bjd.17088
Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF, 2018 Aug 14, Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels. mBio, DOI: 10.1128/mBio.01184-18
Hennessy Á, Hourihane JO, Malvisi L, Irvine AD, Kenny LC, Murray DM, Kiely ME, 2018 Nov, Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE Birth Cohort Study. Allergy, DOI: 10.1111/all.13590
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, Cooper HL, Irvine AD, Oon HH, Kingo K, Köks S, Mrowietz U, Puig L, Reynolds N, Tan ES, Tanew A, Torz K, Trattner H, Valentine M, Wahie S, Warren RB, Wright A, Bata-Csörgő Z, Szell M, Griffiths CEM, Burden AD, Choon SE, Smith CH, Barker JN, Navarini AA, Capon F, 2019 Mar, Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.06.038
Simpson EL, Reynolds NJ, Flohr C, Paller AS, Silverberg JI, Cork MJ, Guttman-Yassky E, Irvine AD, 2018 Aug, Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'". J Am Acad Dermatol, DOI: 10.1016/j.jaad.2018.03.048
Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD, 2018 Jun 21, Atopic dermatitis. Nat Rev Dis Primers, DOI: 10.1038/s41572-018-0001-z
Pigors M, Common JEA, Wong XFCC, Malik S, Scott CA, Tabarra N, Liany H, Liu J, Limviphuvadh V, Maurer-Stroh S, Tang MBY, Lench N, Margolis DJ, van Heel DA, Mein CA, Novak N, Baurecht H, Weidinger S, McLean WHI, Irvine AD, O'Toole EA, Simpson MA, Kelsell DP, 2018 Dec, Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes. J Invest Dermatol, DOI: 10.1016/j.jid.2018.05.013

Please visit PubMed for more information on Alan Irvine's publications

Name:Professor Irwin McLean
DepartmentHuman Genetics
Institution:University of Dundee
Country:UK
Name:Dr Sanja Kezic
DepartmentToxicology
Institution:Academic Medicine Centre Amsterdam
Country:Netherlands
Name:Professor Stephan Weidinger
DepartmentDermatology
Institution:Kiel
Country:Germany

Current Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
TREATA randomised clinical trial to assess the treatment safety and efficacy of oral methotrexate (MTX) vs ciclosporin (CyA) in the treatment of severe recalcitrant atopic eczema (AE) in childrenClinical TrialKing’s College London and Guy’s and St. Thomas’ NHS Foundation TrustAcademic - Investigator Led
EASEDouble-blind, Randomised, Vehicle-controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis BullosaClinical TrialAmrytIndustry Sponsored
BADBIRBritish Association of Dermatologists Biologic Interventions RegisterNon-Interventional StudyUniversity of ManchesterAcademic - Collaborative Group
AD Real WorldA Real World Evaluation to Describe Resource Use for the Management of Moderate to Severe Atopic Dermatitis in Secondary Care for Children and Adolescents Aged 6 to 17 in the Republic of IrelandNon-Interventional StudySanofiIndustry Sponsored
VADUnderstanding T-Cell Immunity in Atopic Dermatitis Patients: Relevance to Staphylococcal Aureus Vaccine DesignNon-Interventional Study
MEASURE ADGlobal Cross-Sectional Burden-of- Illness Study in Adolescent and Adult Patients with Atopic Dermatitis.Non-Interventional StudyAbbVieIndustry Sponsored
EPIK-P1Retrospective Chart Review Study of Patients with PIK3CA- Related Overgrowth Spectrum (PROS) who have received alpelisib as part of a compassionate use program.Non-Interventional StudyNovartisIndustry Sponsored

Previous Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
Eczema & Food AllergyIdentification of Major Susceptibility Genes for Eczema and Food AllergyNon-Interventional Clinical Trial
Whole Exome SequencingWhole exome screening and next generation sequencingNon-Interventional StudyUniversity of DundeeAcademic-Investigator Led
Regional FilaggrinA Study to Investigate Regional Filaggrin ExpressionNon-Interventional Study
DS107E-05A prospective, randomised, vehicle-controlled, double-blind, exploratory clinical trial to assess the efficacy and steroid sparing potential of DGLA cream topically applied to early childhood patients with moderate to severe atopic dermatitisClinical TrialAfimmuneIndustry Sponsored
Overgrowth genetics projectsClinical and molecular characterization of PIK3Kinase related Overgrowth SyndromesNon-Interventional StudyCambridge UniversityAcademic-Investigator Led
Vascular malformation projectsClinical and molecular characterization of hyperkeratotic vascular malformationsNon-Interventional StudyUniversité Catholique de LouvainAcademic-Investigator Led
Inflazome CAPSMCC950 and derivatives in CAPS patientsNon-Interventional StudyInflazome Ltd / Trinity College DublinAcademic - Investigator Led
PRiTIClinical, immunologic and microbiologic characterisation of early onset atopic eczema: A study to identify factors in disease initiation, severity, flare and resolution.Non-Interventional Study
APPLESA prospective paediatric study to assess the long-term safety of tacrolimus ointment for the treatment of atopic dermatitis.Non-Interventional Clinical TrialAstellas PharmaIndustry Sponsored
ARQ-092A Phase 1/2 Study of ARQ 092 in Patients With Overgrowth Diseases and Vascular Anomalies With Genetic Alterations of the PI3K/AKT PathwayClinical TrialArquleIndustry Sponsored

    Alan is a former Section Editor of the Journal of Investigative Dermatology and an Associate Editor of Allergy, and was the Lead Editor of the 3rd Edition of Harper’s Textbook of Pediatric Dermatology (2011). He is an Honorary Professor in the School of Life Sciences, University of Dundee. In 2016 he was awarded a DSc from Queens University Belfast in recognition of his skin barrier research.

    Alan’s international awards include: 2006/2007 Paul Gerson Unna Prize from the German Dermatology Society, 2013 Jerry Dolovich Memorial Lecture (AAAAI), 2015 Dr Sydney Watson Smith Lecture (Royal College of Physicians of Edinburgh), 2016 RW Goltz Memorial Lecture (University of Minnesota).

    Other positions and responsibilities:

    • Director of the International Eczema Council
    • Member of the UK TREND collaborative initiative led by the British Association of Dermatology on translational research
    • Executive Committee member of the international TREAT initiative for Registries in Atopic Dermatitis (https://treat-registry-taskforce.org )
    • Medical Director of the Irish Skin Foundation’s Skin registry programme.
    • Scientific Committee Member Debra Ireland
    • Principal Investigator INFANT SFI Centre