The NCRC AD case collection is one of the largest in the world, and has been used for identification of many genes involved in AD pathogenesis, including the filaggrin discovery.
Alan IrvineConsultant Dermatologist, Professor
Alan graduated in Medicine from Queen’s University Belfast (QUB) in 1991. In 1998, he was awarded a research doctorate (MD) in Human Genetics, also from QUB. He completed Dermatology Training in Belfast in July 1999, followed by fellowships in Great Ormond Street Children’s Hospital, and Children’s Memorial Hospital Chicago, where he was a Fulbright Scholar.
He was appointed Consultant Dermatologist (Attending Physician) in Children’s Health Ireland at Crumlin (CHI at Crumlin) and St. James’s Hospital, Dublin, Ireland in October 2002. The CHI at Crumlin department provides specialist clinics in severe atopic dermatitis, vascular malformations, laser treatments, and genetic skin diseases with more than 10 000 secondary and tertiary paediatric attendances per annum. His adult clinics provide a service for complex atopic dermatitis and genodermatoses.
He is Professor in Dermatology, Trinity College Dublin. His research interests are in epithelial genetics, disease mechanisms in, and therapy of, atopic dermatitis. His work on the genetics of atopic dermatitis with long term collaborative partner Irwin McLean has helped refocus attention on the role of the skin barrier in the pathogenesis of this disease and of allergic disease in general. He is funded by the National Children’s Research Centre and the Wellcome Trust, and has attracted approximately €11M funding to date.
Alan IrvineConsultant Dermatologist, Professor
Role:
Janna is an experienced epithelial biologist with expertise in skin equivalent cultures and genetic analysis of skin disease. Her work currently involves using skin equivalents to study skin barrier function in atopic dermatitis. Janna also is running projects studying the role of miRNA in Atopic Dermatitis
Dr. Maeve McAleer
Position: Consultant Dermatologist
Role:
Maeve is a consultant dermatologist who has recently completed her PhD on skin barrier function in Atopic Dermatitis at NCRC.
Dr Veronika Dvorakova
Position: Clinical Fellow/MD student
Role:
Veronika is studying the genetic basis and therapeutic approaches to vascular anomalies and overgrowth syndromes
The NCRC AD case collection is one of the largest in the world, and has been used for identification of many genes involved in AD pathogenesis, including the filaggrin discovery.
We have long standing research programs examining skin barrier function in atopic dermatitis. We use non-invasive techniques such as Raman spectroscopy and tape stripping to gain mechanistic and functional insights into AD pathogenesis.
We provide care for a large cohort of patients with vascular anomalies and overgrowth syndromes. We collaborate with investigators in Belgium on gene identification and with companies developing novel therapies.
For the last two decades we have worked on identification of causal genetic mutations in children with genetic skin disorders.
The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.
| Wall D, Meah N, York K, Bhoyrul B, Bokhari L, Abraham LS, Adams R, Bergfeld W, Betz RC, Blume-Peytavi U, Callender V, Campbell C, Chambers J, Chen G, Chitreddy V, Cotsarelis G, Craiglow B, Dhurat R, Dlova N, Donovan J, Duque-Estrada B, Eisman S, Ellison A, Farrant P, Barberá JF, Gadzhigoroeva A, Grimalt R, Harries M, Hordinsky M, Irvine AD, Jolliffe V, Jones L, King B, Lee WS, Lortkipanidze N, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Ovcharenko Y, Piraccini BM, Pirmez R, Rakowska A, Reygagne P, Riley M, Rudnicka L, Saceda Corralo D, Shapiro J, Sharma P, Silyuk T, Kaiumov S, Tobin DJ, Tosti A, Vañó-Galván S, Vogt A, Wade M, Yip L, Zlotogorski A, Zhou C, Sinclair R, 2021 Mar 3, A Global eDelphi Exercise to Identify Core Domains and Domain Items for the Development of a Global Registry of Alopecia Areata Disease Severity and Treatment Safety (GRASS). JAMA Dermatol, DOI: 10.1001/jamadermatol.2020.5839 |
| Mulick AR, Mansfield KE, Silverwood RJ, Buddu-Aggrey A, Roberts A, Custovic A, Pearce N, Irvine AD, Smeeth L, Abuabara K, Langan SM, 2021 Mar 2, Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort. Br J Dermatol, DOI: 10.1111/bjd.19885 |
| Forde K, Resta N, Ranieri C, Rea D, Kubassova O, Hinton M, Andrews KA, Semple R, Irvine AD, Dvorakova V, 2021 Feb 27, Clinical experience with the AKT1 inhibitor miransertib in two children with PIK3CA-related overgrowth syndrome. Orphanet J Rare Dis, DOI: 10.1186/s13023-021-01745-0 |
| McCarthy EK, Murray DM, Hourihane JOB, Kenny LC, Irvine AD, Kiely ME, 2021 Jan 29, Behavioral consequences at 5 y of neonatal iron deficiency in a low-risk maternal-infant cohort. Am J Clin Nutr, DOI: 10.1093/ajcn/nqaa367 |
| Hotz A, Kopp J, Bourrat E, Oji V, Komlosi K, Giehl K, Bouadjar B, Bygum A, Tantcheva-Poor I, Hellström Pigg M, Has C, Yang Z, Irvine AD, Betz RC, Zambruno G, Tadini G, Süßmuth K, Gruber R, Schmuth M, Mazereeuw-Hautier J, Jonca N, Guez S, Brena M, Hernandez-Martin A, van den Akker P, Bolling MC, Hannula-Jouppi K, Zimmer AD, Alter S, Vahlquist A, Fischer J, 2021 Jan 9, Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients. Genes (Basel), DOI: 10.3390/genes12010080 |
| Towell AM, Feuillie C, Vitry P, Da Costa TM, Mathelié-Guinlet M, Kezic S, Fleury OM, McAleer MA, Dufrêne YF, Irvine AD, Geoghegan JA, 2021 Jan 5, Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis. Proc Natl Acad Sci U S A, DOI: 10.1073/pnas.2014444118 |
| McAleer MA, Jakasa I, Stefanovic N, McLean WHI, Kezic S, Irvine AD, 2020 Dec 2, Topical Corticosteroids Normalize both Skin and Systemic Inflammatory Markers in Infant Atopic Dermatitis. Br J Dermatol, DOI: 10.1111/bjd.19703 |
| Siegels D, Heratizadeh A, Abraham S, Binnmyr J, Brockow K, Irvine AD, Halken S, Mortz CG, Flohr C, Schmid-Grendelmeier P, Van der Poel LA, Muraro A, Weidinger S, Werfel T, Schmitt J, European Academy of Allergy, Clinical Immunology Atopic Dermatitis Guideline group., 2020 Oct 19, Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis. Allergy, DOI: 10.1111/all.14631 |
| Delles C, Dayan CM, Dominiczak AF, Donnelly SC, Irvine AD, 2021 Feb 18, Announcing the first AoP webinar: 'Can evidence-based medicine survive in a pandemic?' QJM, DOI: 10.1093/qjmed/hcaa287 |
| Boggs JME, Irvine AD, 2021 Jan, PLACK syndrome resulting from a novel homozygous variant in CAST. Pediatr Dermatol, DOI: 10.1111/pde.14383 |
| Haftek M, McAleer MA, Jakasa I, McLean WI, Kezic S, Irvine AD, 2020, Changes in nano-mechanical properties of human epidermal cornified cells in children with atopic dermatitis. Wellcome Open Res, DOI: 10.12688/wellcomeopenres.15729.2 |
| Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee WS, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair RD, 2020 Sep 11, The Alopecia Areata Consensus of Experts (ACE) Study PART II: Results of an International Expert Opinion on Diagnosis and Laboratory Evaluation for Alopecia Areata. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2020.09.028 |
| Alsaleemi A, O'Connor C, Irvine AD, Leahy TR, 2020 Nov, Topical cidofovir for the treatment of recalcitrant viral warts and molluscum contagiosum in Jacobsen syndrome. Pediatr Dermatol, DOI: 10.1111/pde.14355 |
| Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ, 2020 Sep 1, The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell Metab, DOI: 10.1016/j.cmet.2020.07.016 |
| Onoufriadis A, Cabezas A, Ng JCF, Canales J, Costas MJ, Ribeiro JM, Rodrigues JR, McAleer MA, Castelo-Soccio L, Simpson MA, Fraternali F, Irvine AD, Cameselle JC, McGrath JA, 2020 Aug 13, Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations. Br J Dermatol, DOI: 10.1111/bjd.19481 |
| Langan SM, Irvine AD, Weidinger S, 2020 Aug 1, Atopic dermatitis. Lancet, DOI: 10.1016/S0140-6736(20)31286-1 |
| Cunningham L, Dvorakova V, Browne F, Irvine AD, 2021 Mar, High-dose bilastine for the treatment of BASCULE syndrome. Clin Exp Dermatol, DOI: 10.1111/ced.14377 |
| Freeman EE, McMahon DE, Hruza GJ, Irvine AD, Spuls PI, Smith CH, Mahil SK, Castelo-Soccio L, Cordoro KM, Lara-Corrales I, Naik HB, Alhusayen R, Ingram JR, Feldman SR, Balogh EA, Kappelman MD, Wall D, Meah N, Sinclair R, Beylot-Barry M, Fitzgerald M, French LE, Lim HW, Griffiths CEM, Flohr C, 2020 Sep, International collaboration and rapid harmonization across dermatologic COVID-19 registries. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2020.06.050 |
| Nousbeck J, McAleer MA, Hurault G, Kenny E, Harte K, Kezic S, Tanaka RJ, Irvine AD, 2021 Mar, MicroRNA analysis of childhood atopic dermatitis reveals a role for miR-451a. Br J Dermatol, DOI: 10.1111/bjd.19254 |
| Mahil SK, Yiu ZZN, Mason KJ, Dand N, Coker B, Wall D, Fletcher G, Bosma A, Capon F, Iversen L, Langan SM, Di Meglio P, Musters AH, Prieto-Merino D, Tsakok T, Warren RB, Flohr C, Spuls PI, Griffiths CEM, Barker J, Irvine AD, Smith CH, Secure-AD and PsoProtect study groups., 2020 Aug, Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic. Br J Dermatol, DOI: 10.1111/bjd.19161 |
| Paller AS, Guttman-Yassky E, Irvine AD, Baselga E, de Bruin-Weller M, Jayawardena S, Zhang A, Mina-Osorio P, Rizova E, Ozturk ZE, 2020 Mar 24, Protocol for a prospective, observational, longitudinal study in paediatric patients with moderate-to-severe atopic dermatitis (PEDISTAD): study objectives, design and methodology. BMJ Open, DOI: 10.1136/bmjopen-2019-033507 |
| Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee WS, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair R, 2020 Jul, The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol, DOI: 10.1016/j.jaad.2020.03.004 |
| Vermeulen FM, Gerbens LAA, Schmitt J, Deleuran M, Irvine AD, Logan K, Ouwerkerk W, Vestergaard C, Flohr C, Spuls PI, international TREAT Registry Taskforce., 2020 Dec, The European TREatment of ATopic eczema (TREAT) Registry Taskforce survey: prescribing practices in Europe for phototherapy and systemic therapy in adult patients with moderate-to-severe atopic eczema. Br J Dermatol, DOI: 10.1111/bjd.18959 |
| Ní Chaoimh C, Nico C, Puppels GJ, Caspers PJ, Wong XFCC, Common JE, Irvine AD, Hourihane JO, 2020 May, In vivo Raman spectroscopy discriminates between FLG loss-of-function carriers vs wild-type in day 1-4 neonates. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2020.01.022 |
| Blakeway H, Van-de-Velde V, Allen VB, Kravvas G, Palla L, Page MJ, Flohr C, Weller RB, Irvine AD, McPherson T, Roberts A, Williams HC, Reynolds N, Brown SJ, Paternoster L, Langan SM, (on behalf of UK TREND Eczema Network)., 2020 Sep, What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review. Br J Dermatol, DOI: 10.1111/bjd.18778 |
| Alexander H, Paller AS, Traidl-Hoffmann C, Beck LA, De Benedetto A, Dhar S, Girolomoni G, Irvine AD, Spuls P, Su J, Thyssen JP, Vestergaard C, Werfel T, Wollenberg A, Deleuran M, Flohr C, 2020 Jun, The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group. Br J Dermatol, DOI: 10.1111/bjd.18643 |
| Drislane C, Irvine AD, 2020 Jan, The role of filaggrin in atopic dermatitis and allergic disease. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2019.10.008 |
| Lenehan SM, Boylan GB, Livingstone V, Fogarty L, Twomey DM, Nikolovski J, Irvine AD, Kiely M, Kenny LC, Hourihane JOB, Murray DM, 2020 May, The impact of short-term predominate breastfeeding on cognitive outcome at 5 years. Acta Paediatr, DOI: 10.1111/apa.15014 |
| Thyssen JP, Jakasa I, Riethmüller C, Schön MP, Braun A, Haftek M, Fallon PG, Wróblewski J, Jakubowski H, Eckhart L, Declercq W, Koppes S, Engebretsen KA, Bonefeld C, Irvine AD, Keita-Alassane S, Simon M, Kawasaki H, Kubo A, Amagai M, Matsui T, Kezic S, 2020 Mar, Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice. J Invest Dermatol, DOI: 10.1016/j.jid.2019.07.716 |
| Bosma AL, Spuls PI, Garcia-Doval I, Naldi L, Prieto-Merino D, Tesch F, Apfelbacher CJ, Arents BWM, Barbarot S, Baselga E, Deleuran M, Eichenfield LF, Gerbens LAA, Irvine AD, Manca A, Mendes-Bastos P, Middelkamp-Hup MA, Roberts A, Seneschal J, Svensson Å, Thyssen JP, Torres T, Vermeulen FM, Vestergaard C, von Kobyletzki LB, Wall D, Weidinger S, Schmitt J, Flohr C, 2020 Jun, TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema. Br J Dermatol, DOI: 10.1111/bjd.18452 |
| Revencu N, Fastre E, Ravoet M, Helaers R, Brouillard P, Bisdorff-Bresson A, Chung CWT, Gerard M, Dvorakova V, Irvine AD, Boon LM, Vikkula M, 2020 Jan, RASA1 mosaic mutations in patients with capillary malformation-arteriovenous malformation. J Med Genet, DOI: 10.1136/jmedgenet-2019-106024 |
| Stefanovic N, Flohr C, Irvine AD, 2020 Jan, The exposome in atopic dermatitis. Allergy, DOI: 10.1111/all.13946 |
| Chasseuil E, McGrath JA, Seo A, Balguerie X, Bodak N, Chasseuil H, Denis-Musquer M, Goldenberg A, Goussot R, Irvine AD, Khumalo NP, King MC, Küry S, Lipsker D, Mallet S, Mayosi BM, Nanda A, Puzenat E, Salort-Campana E, Sidbury R, Shimamura A, Bézieau S, Mercier S, Barbarot S, 2019 Oct, Dermatological manifestations of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP): a case series of 28 patients. Br J Dermatol, DOI: 10.1111/bjd.17996 |
| Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG, 2019 Oct, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy, DOI: 10.1111/all.13801 |
| Leshem YA, Bissonnette R, Paul C, Silverberg JI, Irvine AD, Paller AS, Cork MJ, Guttman-Yassky E, 2019 May, Optimization of placebo use in clinical trials with systemic treatments for atopic dermatitis: an International Eczema Council survey-based position statement. J Eur Acad Dermatol Venereol, DOI: 10.1111/jdv.15480 |
| Irvine AD, Mina-Osorio P, 2019 Nov, Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide. Br J Dermatol, DOI: 10.1111/bjd.17766 |
| Hawkes CP, Grimberg A, Kenny LC, Kiely M, Hourihane JOB, Irvine AD, McPhaul MJ, Caulfield MP, Zemel BS, Murray DM, 2019 Apr, The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months. Pediatr Res, DOI: 10.1038/s41390-019-0331-x |
| Vermeulen FM, Gerbens LAA, Bosma AL, Apfelbacher CJ, Irvine AD, Arents BWM, Barbarot S, Deleuran M, Eichenfield LF, Manca A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Middelkamp-Hup MA, Spuls PI, Flohr C, International TREAT Registry Taskforce., 2019 Sep, TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries. Br J Dermatol, DOI: 10.1111/bjd.17715 |
| Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M, 2019 Mar, Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2019.01.003 |
| Harkins CP, Holden MTG, Irvine AD, 2019 Mar, Antimicrobial resistance in atopic dermatitis: Need for an urgent rethink. Ann Allergy Asthma Immunol, DOI: 10.1016/j.anai.2018.11.027 |
| Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD, 2019 Jan, The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.11.015 |
| Paller AS, Spergel JM, Mina-Osorio P, Irvine AD, 2019 Jan, The atopic march and atopic multimorbidity: Many trajectories, many pathways. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.11.006 |
| Clowry J, Irvine AD, McLoughlin RM, 2019 Jan, Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis? J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.08.038 |
| McCarthy EK, Murray DM, Malvisi L, Kenny LC, O'B Hourihane J, Irvine AD, Kiely ME, 2018 Oct 1, Antenatal Vitamin D Status Is Not Associated with Standard Neurodevelopmental Assessments at Age 5 Years in a Well-Characterized Prospective Maternal-Infant Cohort. J Nutr, DOI: 10.1093/jn/nxy150 |
| McAleer MA, Jakasa I, Hurault G, Sarvari P, McLean WHI, Tanaka RJ, Kezic S, Irvine AD, 2019 Mar, Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesis. Br J Dermatol, DOI: 10.1111/bjd.17088 |
| Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF, 2018 Aug 14, Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels. mBio, DOI: 10.1128/mBio.01184-18 |
| Hennessy Á, Hourihane JO, Malvisi L, Irvine AD, Kenny LC, Murray DM, Kiely ME, 2018 Nov, Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE Birth Cohort Study. Allergy, DOI: 10.1111/all.13590 |
| Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, Cooper HL, Irvine AD, Oon HH, Kingo K, Köks S, Mrowietz U, Puig L, Reynolds N, Tan ES, Tanew A, Torz K, Trattner H, Valentine M, Wahie S, Warren RB, Wright A, Bata-Csörgő Z, Szell M, Griffiths CEM, Burden AD, Choon SE, Smith CH, Barker JN, Navarini AA, Capon F, 2019 Mar, Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol, DOI: 10.1016/j.jaci.2018.06.038 |
| Simpson EL, Reynolds NJ, Flohr C, Paller AS, Silverberg JI, Cork MJ, Guttman-Yassky E, Irvine AD, 2018 Aug, Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'". J Am Acad Dermatol, DOI: 10.1016/j.jaad.2018.03.048 |
| Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD, 2018 Jun 21, Atopic dermatitis. Nat Rev Dis Primers, DOI: 10.1038/s41572-018-0001-z |
| Pigors M, Common JEA, Wong XFCC, Malik S, Scott CA, Tabarra N, Liany H, Liu J, Limviphuvadh V, Maurer-Stroh S, Tang MBY, Lench N, Margolis DJ, van Heel DA, Mein CA, Novak N, Baurecht H, Weidinger S, McLean WHI, Irvine AD, O'Toole EA, Simpson MA, Kelsell DP, 2018 Dec, Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes. J Invest Dermatol, DOI: 10.1016/j.jid.2018.05.013 |
| Gerbens LAA, Apfelbacher CJ, Irvine AD, Barbarot S, de Booij RJ, Boyce AE, Deleuran M, Eichenfield LF, Hof MH, Middelkamp-Hup MA, Roberts A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Williamson PR, Flohr C, Spuls PI, international TREAT Registry Taskforce., 2019 Apr, TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo- and systemic therapy registries. Br J Dermatol, DOI: 10.1111/bjd.16714 |
| Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG, 2018 Oct, The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis. Br J Dermatol, DOI: 10.1111/bjd.16722 |
| Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, O'Neill L, Rosala-Hallas A, Sach T, Spowart C, Taams L, Walker C, Wan M, Webb N, Williamson P, Flohr C, TREAT Trial Investigators., 2018 Dec, A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT). Br J Dermatol, DOI: 10.1111/bjd.16717 |
| McAleer MA, Jakasa I, Raj N, O'Donnell CPF, Lane ME, Rawlings AV, Voegeli R, McLean WHI, Kezic S, Irvine AD, 2018 Aug, Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis. Br J Dermatol, DOI: 10.1111/bjd.16691 |
| Dvorakova V, Rea D, O'Regan GM, Irvine AD, 2018 Jul, Generalized lymphatic anomaly successfully treated with long-term, low-dose sirolimus. Pediatr Dermatol, DOI: 10.1111/pde.13494 |
| Hawkes CP, Murray DM, Kenny LC, Kiely M, O'B Hourihane J, Irvine AD, Wu Z, Argon Y, Reitz RE, McPhaul MJ, Grimberg A, 2018, Correlation of Insulin-Like Growth Factor-I and -II Concentrations at Birth Measured by Mass Spectrometry and Growth from Birth to Two Months. Horm Res Paediatr, DOI: 10.1159/000486035 |
| Lynch SA, Crushell E, Lambert DM, Byrne N, Gorman K, King MD, Green A, O'Sullivan S, Browne F, Hughes J, Knerr I, Monavari AA, Cotter M, McConnell VPM, Kerr B, Jones SA, Keenan C, Murphy N, Cody D, Ennis S, Turner J, Irvine AD, Casey J, 2018 Apr, Catalogue of inherited disorders found among the Irish Traveller population. J Med Genet, DOI: 10.1136/jmedgenet-2017-104974 |
| Geoghegan JA, Irvine AD, Foster TJ, 2018 Jun, Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends Microbiol, DOI: 10.1016/j.tim.2017.11.008 |
Please visit PubMed for more information on Alan Irvine's publications
| Name: | Professor Irwin McLean |
| Department | Human Genetics |
| Institution: | University of Dundee |
| Country: | UK |
| Name: | Dr Sanja Kezic |
| Department | Toxicology |
| Institution: | Academic Medicine Centre Amsterdam |
| Country: | Netherlands |
| Name: | Professor Stephan Weidinger |
| Department | Dermatology |
| Institution: | Kiel |
| Country: | Germany |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| TREAT | A randomised clinical trial to assess the treatment safety and efficacy of oral methotrexate (MTX) vs ciclosporin (CyA) in the treatment of severe recalcitrant atopic eczema (AE) in children | Clinical Trial | King’s College London and Guy’s and St. Thomas’ NHS Foundation Trust | Academic - Investigator Led |
| EASE | Double-blind, Randomised, Vehicle-controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis Bullosa | Clinical Trial | Amryt | Industry Sponsored |
| BADBIR | British Association of Dermatologists Biologic Interventions Register | Non-Interventional Study | University of Manchester | Academic - Collaborative Group |
| AD Real World | A Real World Evaluation to Describe Resource Use for the Management of Moderate to Severe Atopic Dermatitis in Secondary Care for Children and Adolescents Aged 6 to 17 in the Republic of Ireland | Non-Interventional Study | Sanofi | Industry Sponsored |
| VAD | Understanding T-Cell Immunity in Atopic Dermatitis Patients: Relevance to Staphylococcal Aureus Vaccine Design | Non-Interventional Study | ||
| MEASURE AD | Global Cross-Sectional Burden-of- Illness Study in Adolescent and Adult Patients with Atopic Dermatitis. | Non-Interventional Study | AbbVie | Industry Sponsored |
| EPIK-P1 | Retrospective Chart Review Study of Patients with PIK3CA- Related Overgrowth Spectrum (PROS) who have received alpelisib as part of a compassionate use program. | Non-Interventional Study | Novartis | Industry Sponsored |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| Eczema & Food Allergy | Identification of Major Susceptibility Genes for Eczema and Food Allergy | Non-Interventional Clinical Trial | ||
| Whole Exome Sequencing | Whole exome screening and next generation sequencing | Non-Interventional Study | University of Dundee | Academic-Investigator Led |
| Regional Filaggrin | A Study to Investigate Regional Filaggrin Expression | Non-Interventional Study | ||
| DS107E-05 | A prospective, randomised, vehicle-controlled, double-blind, exploratory clinical trial to assess the efficacy and steroid sparing potential of DGLA cream topically applied to early childhood patients with moderate to severe atopic dermatitis | Clinical Trial | Afimmune | Industry Sponsored |
| Overgrowth genetics projects | Clinical and molecular characterization of PIK3Kinase related Overgrowth Syndromes | Non-Interventional Study | Cambridge University | Academic-Investigator Led |
| Vascular malformation projects | Clinical and molecular characterization of hyperkeratotic vascular malformations | Non-Interventional Study | Université Catholique de Louvain | Academic-Investigator Led |
| Inflazome CAPS | MCC950 and derivatives in CAPS patients | Non-Interventional Study | Inflazome Ltd / Trinity College Dublin | Academic - Investigator Led |
| PRiTI | Clinical, immunologic and microbiologic characterisation of early onset atopic eczema: A study to identify factors in disease initiation, severity, flare and resolution. | Non-Interventional Study | ||
| APPLES | A prospective paediatric study to assess the long-term safety of tacrolimus ointment for the treatment of atopic dermatitis. | Non-Interventional Clinical Trial | Astellas Pharma | Industry Sponsored |
| ARQ-092 | A Phase 1/2 Study of ARQ 092 in Patients With Overgrowth Diseases and Vascular Anomalies With Genetic Alterations of the PI3K/AKT Pathway | Clinical Trial | Arqule | Industry Sponsored |
Alan is a former Section Editor of the Journal of Investigative Dermatology and an Associate Editor of Allergy, and was the Lead Editor of the 3rd Edition of Harper’s Textbook of Pediatric Dermatology (2011). He is an Honorary Professor in the School of Life Sciences, University of Dundee. In 2016 he was awarded a DSc from Queens University Belfast in recognition of his skin barrier research.
Alan’s international awards include: 2006/2007 Paul Gerson Unna Prize from the German Dermatology Society, 2013 Jerry Dolovich Memorial Lecture (AAAAI), 2015 Dr Sydney Watson Smith Lecture (Royal College of Physicians of Edinburgh), 2016 RW Goltz Memorial Lecture (University of Minnesota).
Other positions and responsibilities: