Aideen Long


Aideen Long

Professor in Molecular Medicine

Aideen Long is Professor in Molecular Medicine at Trinity College Dublin, the University of Dublin and Director of the Trinity Translational Medicine Institute. She completed a B.Sc. in Biochemistry at UCD and graduated with a PhD in Biotechnology from DCU. She joined the Department of Clinical Medicine in 2005 where she was appointed Senior Lecturer in Molecular Medicine. Prior to joining Trinity she held the post of Senior Lecturer in Biochemistry at the Royal College of Surgeons in Ireland. She was Dean of Graduate Studies at Trinity from 2013 to 2016. Aideen Long has been an active member of the Irish Society for Immunology and was elected president of the society in 2007. She served in this post until September 2013 during which time she was actively engaged in promoting Irish immunology both at home and abroad.

Aideen Long

Professor in Molecular Medicine

Characterisation of the migratory/inflammatory properties of gut-homing T cells in paediatric patients with inflammatory bowel disease

Inflammatory bowel disease (IBD) is an inflammatory condition affecting the gastrointestinal tract. It is caused when white blood cells called “T cells” that secrete small proteins called ‘cytokines’ invade the gut, causing redness, swelling and pain (inflammation). A recently developed, effective way of reducing inflammation is by using antibodies to either block the action of the cytokines or the movement of the T cells into the tissue. While this approach works well for some patients, it is not effective for all. We aim to find a way to predict and monitor the patient response to therapies that are designed to block T cell migration into the gut.

The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

Conroy MJ, Maher SG, Melo AM, Doyle SL, Foley E, Reynolds JV, Long A, Lysaght J, 2018, Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients. Front Immunol, DOI: 10.3389/fimmu.2018.01867
Brennan R, Haap-Hoff A, Gu L, Gautier V, Long A, Schröder M, 2018 Sep, Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3. Eur J Cell Biol, DOI: 10.1016/j.ejcb.2018.08.001
Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS, 2018 Jul, RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Sci OA, DOI: 10.4155/fsoa-2018-0022
Duggan SP, Garry C, Behan FM, Phipps S, Kudo H, Kirca M, Zaheer A, McGarrigle S, Reynolds JV, Goldin R, Kalloger SE, Schaeffer DF, Long A, Strid J, Kelleher D, 2018, siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth. Cell Mol Gastroenterol Hepatol, DOI: 10.1016/j.jcmgh.2018.01.012
Dunne PJ, Maher CO, Freeley M, Dunne K, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG, 2018, CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection. Front Immunol, DOI: 10.3389/fimmu.2018.00940
Prichard DO, Byrne AM, Murphy JO, Reynolds JV, O'Sullivan J, Feighery R, Doyle B, Eldin OS, Finn SP, Maguire A, Duff D, Kelleher DP, Long A, 2017 Dec, Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-αv trafficking. J Cell Mol Med, DOI: 10.1111/jcmm.13271
Duff D, Long A, 2017 Jul, Roles for RACK1 in cancer cell migration and invasion. Cell Signal, DOI: 10.1016/j.cellsig.2017.03.005
Sharma R, Quilty F, Gilmer JF, Long A, Byrne AM, 2017 Jan 3, Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism. Oncotarget, DOI: 10.18632/oncotarget.13514
Gavin J, Quilty F, Majer F, Gilsenan G, Byrne AM, Long A, Radics G, Gilmer JF, 2016 Nov 1, A fluorescent analogue of tauroursodeoxycholic acid reduces ER stress and is cytoprotective. Bioorg Med Chem Lett, DOI: 10.1016/j.bmcl.2016.06.059
Molloy B, Freeley M, Long A, McManus R, 2015, Candidate Gene Knockdown in Celiac Disease. Methods Mol Biol, DOI: 10.1007/978-1-4939-2839-2_14
Byrne AM, Bekiaris S, Duggan G, Prichard D, Kirca M, Finn S, Reynolds JV, Kelleher D, Long A, 2015 Nov 3, Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion. Br J Cancer, DOI: 10.1038/bjc.2015.350
Freeley M, Derrick E, Dempsey E, Hoff A, Davies A, Leake D, Vermeulen A, Kelleher D, Long A, 2015 Sep, RNAi Screening with Self-Delivering, Synthetic siRNAs for Identification of Genes That Regulate Primary Human T Cell Migration. J Biomol Screen, DOI: 10.1177/1087057115588288
Long A, Freeley M, 2014 Dec, Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration. Biochem Soc Trans, DOI: 10.1042/BST20140204
Ong ST, Freeley M, Skubis-Zegadło J, Fazil MH, Kelleher D, Fresser F, Baier G, Verma NK, Long A, 2014 Jul 11, Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration. J Biol Chem, DOI: 10.1074/jbc.M113.545863
Májer F, Sharma R, Mullins C, Keogh L, Phipps S, Duggan S, Kelleher D, Keely S, Long A, Radics G, Wang J, Gilmer JF, 2014 Jan 1, New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid. Bioorg Med Chem, DOI: 10.1016/j.bmc.2013.11.029
Freeley M, Long A, 2013 Oct 15, Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection. Biochem J, DOI: 10.1042/BJ20130950
Freeley M, Long A, 2013 Oct 31, The two hit hypothesis: an improved method for siRNA-mediated gene silencing in stimulated primary human T cells. J Immunol Methods, DOI: 10.1016/j.jim.2013.08.005
Fahey S, Dempsey E, Long A, 2014 Jan, The role of chemokines in acute and chronic hepatitis C infection. Cell Mol Immunol, DOI: 10.1038/cmi.2013.37
Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA, 2013 Aug 1, RACK1 to the future--a historical perspective. Cell Commun Signal, DOI: 10.1186/1478-811X-11-53
Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, 2013 May 21, Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes. FEBS Lett, DOI: 10.1016/j.febslet.2013.03.041
Byrne G, Freeley M, Feighery C, Whelan A, Long A, 2013 Apr, Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease. Clin Immunol, DOI: 10.1016/j.clim.2013.01.007
Freeley M, Long A, 2012, Regulating the Regulator: Phosphorylation of PKC θ in T Cells. Front Immunol, DOI: 10.3389/fimmu.2012.00227
Verma NK, Dempsey E, Long A, Davies A, Barry SP, Fallon PG, Volkov Y, Kelleher D, 2012 Aug 3, Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling. J Biol Chem, DOI: 10.1074/jbc.M112.376616
Freeley M, O'Dowd F, Paul T, Kashanin D, Davies A, Kelleher D, Long A, 2012 Jun 15, L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes. J Immunol, DOI: 10.4049/jimmunol.1103242
Májer F, Salomon JJ, Sharma R, Etzbach SV, Najib MN, Keaveny R, Long A, Wang J, Ehrhardt C, Gilmer JF, 2012 Mar 1, New fluorescent bile acids: synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid. Bioorg Med Chem, DOI: 10.1016/j.bmc.2012.01.002
Byrne AM, Sharma R, Duggan G, Kelleher D, Long A, 2012 May, Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells. Glycobiology, DOI: 10.1093/glycob/cwr190
Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A, 2012 Jan, Hepatitis C virus--T-cell responses and viral escape mutations. Eur J Immunol, DOI: 10.1002/eji.201141593
Fitzmaurice K, Petrovic D, Ramamurthy N, Simmons R, Merani S, Gaudieri S, Sims S, Dempsey E, Freitas E, Lea S, McKiernan S, Norris S, Long A, Kelleher D, Klenerman P, 2011 Nov, Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection. Gut, DOI: 10.1136/gut.2010.228403
Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A, 2011 Jun, Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. Hepatology, DOI: 10.1002/hep.24327
de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA, 2011 Mar 29, The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. Nat Commun, DOI: 10.1038/ncomms1243
Sharma R, Prichard D, Majer F, Byrne AM, Kelleher D, Long A, Gilmer JF, 2011 Jan 13, Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators. J Med Chem, DOI: 10.1021/jm100860s
Freeley M, Kelleher D, Long A, 2011 May, Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites. Cell Signal, DOI: 10.1016/j.cellsig.2010.10.013
Verma NK, Dempsey E, Freeley M, Botting CH, Long A, Kelleher D, Volkov Y, 2011 Jun, Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells. J Cell Physiol, DOI: 10.1002/jcp.22478
Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C, Johnston JA, 2010 Nov 5, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11. FEBS Lett, DOI: 10.1016/j.febslet.2010.10.007
Sharma R, Majer F, Peta VK, Wang J, Keaveney R, Kelleher D, Long A, Gilmer JF, 2010 Sep 15, Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A). Bioorg Med Chem, DOI: 10.1016/j.bmc.2010.07.030
Kozak K, Bakos G, Hoff A, Bennett E, Dunican D, Davies A, Kelleher D, Long A, Csucs G, 2010 Aug, Workflow-based software environment for large-scale biological experiments. J Biomol Screen, DOI: 10.1177/1087057110377354
Freeley M, Bakos G, Davies A, Kelleher D, Long A, Dunican DJ, 2010 Jun, A high-content analysis toolbox permits dissection of diverse signaling pathways for T lymphocyte polarization. J Biomol Screen, DOI: 10.1177/1087057110369703
Verma NK, Davies AM, Long A, Kelleher D, Volkov Y, 2010 Jun, STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL. Cell Mol Biol Lett, DOI: 10.2478/s11658-010-0008-2
Duggan SP, Behan FM, Kirca M, Smith S, Reynolds JV, Long A, Kelleher D, 2010 May, An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels. Carcinogenesis, DOI: 10.1093/carcin/bgq036
Byrne AM, Foran E, Sharma R, Davies A, Mahon C, O'Sullivan J, O'Donoghue D, Kelleher D, Long A, 2010 Apr, Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells. Carcinogenesis, DOI: 10.1093/carcin/bgq011
Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE, 2009 Aug, Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods, DOI: 10.1038/nmeth.1351
Looby E, Abdel-Latif MM, Athié-Morales V, Duggan S, Long A, Kelleher D, 2009 Jun 17, Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells. BMC Cancer, DOI: 10.1186/1471-2407-9-190
Lawler K, O'Sullivan G, Long A, Kenny D, 2009 Jun, Shear stress induces internalization of E-cadherin and invasiveness in metastatic oesophageal cancer cells by a Src-dependent pathway. Cancer Sci, DOI: 10.1111/j.1349-7006.2009.01160.x
Verma NK, Dourlat J, Davies AM, Long A, Liu WQ, Garbay C, Kelleher D, Volkov Y, 2009 May 1, STAT3-stathmin interactions control microtubule dynamics in migrating T-cells. J Biol Chem, DOI: 10.1074/jbc.M807761200
Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A, 2007 Dec, Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells. Cell Signal, DOI: 10.1016/j.cellsig.2007.07.020
Lawler K, Foran E, O'Sullivan G, Long A, Kenny D, 2006 Oct, Mobility and invasiveness of metastatic esophageal cancer are potentiated by shear stress in a ROCK- and Ras-dependent manner. Am J Physiol Cell Physiol, DOI: 10.1152/ajpcell.00626.2005
Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G, 2006 Apr 7, Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science, DOI: 10.1126/science.1122000
Volkov Y, Long A, Freeley M, Golden-Mason L, O'Farrelly C, Murphy A, Kelleher D, 2006 Feb, The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. Gastroenterology, DOI: 10.1053/j.gastro.2005.10.047
El Din El Homasany BS, Volkov Y, Takahashi M, Ono Y, Keryer G, Delouvée A, Looby E, Long A, Kelleher D, 2005 Dec 15, The scaffolding protein CG-NAP/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells. J Immunol, DOI: 10.4049/jimmunol.175.12.7811
Foran E, McWilliam P, Kelleher D, Croke DT, Long A, 2006 Apr 15, The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells. Int J Cancer, DOI: 10.1002/ijc.21593
Shah SA, Looby E, Volkov Y, Long A, Kelleher D, 2005 Sep, Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines. Eur J Cancer, DOI: 10.1016/j.ejca.2005.06.015
O'Toole D, Abdel-Latif MM, Long A, Windle HJ, Murphy AM, Bowie A, O'Neill LA, Weir DG, Kelleher D, 2005 Oct 15, Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury? J Cell Biochem, DOI: 10.1002/jcb.20539
Freeley M, Volkov Y, Kelleher D, Long A, 2005 Aug 26, Stimulus-induced phosphorylation of PKC theta at the C-terminal hydrophobic-motif in human T lymphocytes. Biochem Biophys Res Commun, DOI: 10.1016/j.bbrc.2005.06.136
Fanning A, Volkov Y, Freeley M, Kelleher D, Long A, 2005 Apr, CD44 cross-linking induces protein kinase C-regulated migration of human T lymphocytes. Int Immunol, DOI: 10.1093/intimm/dxh225
Long A, Mitchell S, Kashanin D, Williams V, Prina Mello A, Shvets I, Kelleher D, Volkov Y, 2004 Dec, A multidisciplinary approach to the study of T cell migration. Ann N Y Acad Sci, DOI: 10.1196/annals.1322.035
Looby E, Long A, Kelleher D, Volkov Y, 2005 May 10, Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. Int J Cancer, DOI: 10.1002/ijc.20803
Murphy JF, Lennon F, Steele C, Kelleher D, Fitzgerald D, Long AC, 2005 Mar, Engagement of CD44 modulates cyclooxygenase induction, VEGF generation, and proliferation in human vascular endothelial cells. FASEB J, DOI: 10.1096/fj.03-1376fje

Funding Agency:National Children's Research Centre
Project Title:Characterisation of the migratory/inflammatory properties of gut-homing T cells in paediatric patients with inflammatory bowel disease
Start Date/End Date:1
Total Awarded:€49,885
Role:Principal Investigator