Afif EL-Khuffash


Afif EL-Khuffash

Consultant Neonatologist & Associate Professor

Prof EL-Khuffash is a Consultant Neonatologist at the Rotunda Hospital in Dublin, Ireland. His primary clinical and research area of expertise is the assessment heart function in term and preterm neonates. He is the lead for neonatal echocardiography and heart function assessment in the neonatal intensive care unit in the Rotunda Hospital.

Prof EL-Khuffash completed a fellowship in neonatal cardiology in Our Lady’s Children’s Hospital, Crumlin. He has explored the use of novel technology in monitoring the cardiovascular function of preterm and sick term infants and was part devising the only neonatal echo training course in Canada. He co-devised the world’s first echo teaching website and mobile device app. Recently, Prof EL-Khuffash has assumed a leadership role at a European level in devising training guidelines for echocardiography by the Neonatologist. He is the lead editor of the Haemodynamic Module in the NOTE project, offering a new international online Masters level educational programme in neonatal medicine as collaboration between the European Society for Neonatology (ESN) and the Faculty of Health Sciences at the University of Southampton.

Prof EL-Khuffash graduated from Trinity College, Dublin in 2002 and enrolled in the Royal College of Physicians of Ireland paediatric specialist training scheme in 2005. He completed a Doctor of Medicine (MD) degree in University College, Dublin in 2008 and his neonatal specialty training in Toronto, Canada (2009-2011). Following this, he was appointed as a consultant Neonatologist and Assistant Professor of Paediatrics at the University of Toronto in January of 2011. He obtained a diploma in clinical epidemiology during his time in Toronto.

He is the recipient of several national and international research awards, with international peer reviewed publications and keynote presentations and the lead for cardiovascular research, supervising several post graduate PhD candidates.

Afif EL-Khuffash

Consultant Neonatologist & Associate Professor

Dr Adam James
Position: MD Student

Dr Colm Breatnach
Position: PhD Student

Dr Aisling Smith
Position: PhD Student

Dr Neidin Bussmann
Position: MD Student

Dr Lyudmyla Zakharchenko
Position: MD Student

The MINT Study

The Use of Milrinone in Neonates with Persistent Pulmonary Hypertension of the Newborn: A Randomised Controlled Trial Pilot Study (MINT 1)

PDA RCT

The purpose of this pilot study is to assess the feasibility of performing the trial and to obtain preliminary data to calculate a sample size for a definitive multi-centre trial of early PDA treatment using a PDAsc. We aim to recruit a total of 60 infants with a high-risk PDA over a two-year period.



The list of publications below is automatically derived from MEDLINE/PubMed. As a result, there may be incorrect or missing publications.

El-Khuffash A, McNamara PJ, Breatnach C, Bussmann N, Smith A, Feeney O, Tully E, Griffin J, de Boode WP, Cleary B, Franklin O, Dempsey E, 2018, The use of milrinone in neonates with persistent pulmonary hypertension of the newborn - a randomised controlled trial pilot study (MINT 1): study protocol and review of literature. Matern Health Neonatol Perinatol, DOI: 10.1186/s40748-018-0093-1
Walsh N, Breathnach C, El-Khuffash A, Franklin O, Corcoran JD, 2018 May 10, The utility of routine echocardiography in newborn infants with a persistent oxygen requirement Ir Med J, DOI: 10.1186/s40748-018-0093-1
Bussmann N, El-Khuffash A, Breatnach CR, McCallion N, Franklin O, Singh GK, Levy PT, 2018 Nov 19, Left ventricular diastolic function influences right ventricular - Pulmonary vascular coupling in premature infants. Early Hum Dev, DOI: 10.1016/j.earlhumdev.2018.11.006
Dwyer L, Smith A, McDermott R, Breatnach C, El-Khuffash A, Corcoran JD, 2018 Aug 13, Staff Attitudes towards Patient Safety Culture and Working Conditions in an Irish Tertiary Neonatal Unit Ir Med J, DOI: 10.1016/j.earlhumdev.2018.11.006
Smith A, Tamgumus S, Lawless S, Penrose P, EL-Khuffash A, Boyle MA, 2018 Sep 10, Tentacles For Tinies: The Many Arms of the Crocheted Octopus Ir Med J, DOI: 10.1016/j.earlhumdev.2018.11.006
de Boode WP, Roehr CC, El-Khuffash A, 2018 Oct, Comprehensive state-of-the-art overview of neonatologist performed echocardiography: Steps towards standardization of the use of echocardiography in neonatal intensive care. Pediatr Res, DOI: 10.1038/s41390-018-0118-5
Singh Y, Roehr CC, Tissot C, Rogerson S, Gupta S, Bohlin K, Breindahl M, El-Khuffash A, de Boode W, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Education, training, and accreditation of Neonatologist Performed Echocardiography in Europe-framework for practice. Pediatr Res, DOI: 10.1038/s41390-018-0078-9
Groves AM, Singh Y, Dempsey E, Molnar Z, Austin T, El-Khuffash A, de Boode WP, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Introduction to neonatologist-performed echocardiography. Pediatr Res, DOI: 10.1038/s41390-018-0076-y
de Boode WP, van der Lee R, Eriksen BH, Nestaas E, Dempsey E, Singh Y, Austin T, El-Khuffash A, European Special Interest Group “Neonatologist-Performed Echocardiography” (NPE)., 2018 Jul, The role of Neonatologist Performed Echocardiography in the assessment and management of neonatal shock. Pediatr Res, DOI: 10.1038/s41390-018-0081-1
Nestaas E, Schubert U, de Boode WP, El-Khuffash A, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Tissue Doppler velocity imaging and event timings in neonates: a guide to image acquisition, measurement, interpretation, and reference values. Pediatr Res, DOI: 10.1038/s41390-018-0079-8
de Boode WP, Singh Y, Molnar Z, Schubert U, Savoia M, Sehgal A, Levy P, McNamara P, El-Khuffash A, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Application of Neonatologist Performed Echocardiography in the assessment and management of persistent pulmonary hypertension of the newborn. Pediatr Res, DOI: 10.1038/s41390-018-0082-0
El-Khuffash A, Schubert U, Levy PT, Nestaas E, de Boode WP, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Deformation imaging and rotational mechanics in neonates: a guide to image acquisition, measurement, interpretation, and reference values. Pediatr Res, DOI: 10.1038/s41390-018-0080-2
van Laere D, van Overmeire B, Gupta S, El Khuffash A, Savoia M, McNamara PJ, Schwarz CE, de Boode WP, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Application of NPE in the assessment of a patent ductus arteriosus. Pediatr Res, DOI: 10.1038/s41390-018-0077-x
Levy P, Tissot C, Horsberg Eriksen B, Nestaas E, Rogerson S, McNamara PJ, El-Khuffash A, de Boode WP, European Special Interest Group “Neonatologist Performed Echocardiography” (NPE)., 2018 Jul, Application of Neonatologist Performed Echocardiography in the Assessment and Management of Neonatal Heart Failure unrelated to Congenital Heart Disease. Pediatr Res, DOI: 10.1038/s41390-018-0075-z
Mashally S, Nield LE, McNamara PJ, Martins FF, El-Khuffash A, Jain A, Weisz DE, 2018 Nov, Late oral acetaminophen versus immediate surgical ligation in preterm infants with persistent large patent ductus arteriosus. J Thorac Cardiovasc Surg, DOI: 10.1016/j.jtcvs.2018.05.098
Bussmann N, Breatnach C, Levy PT, McCallion N, Franklin O, El-Khuffash A, 2018 Sep, Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study. J Perinatol, DOI: 10.1038/s41372-018-0147-2
Levy PT, El Khuffash A, Woo KV, Singh GK, 2018 Aug, Right Ventricular-Pulmonary Vascular Interactions: An Emerging Role for Pulmonary Artery Acceleration Time by Echocardiography in Adults and Children. J Am Soc Echocardiogr, DOI: 10.1016/j.echo.2018.04.004
Jain A, Mohamed A, Kavanagh B, Shah PS, Kuipers BCW, El-Khuffash A, Mertens L, Jankov RP, McNamara PJ, 2018 Sep, Cardiopulmonary Adaptation During First Day of Life in Human Neonates. J Pediatr, DOI: 10.1016/j.jpeds.2018.04.051
Papadhima I, Louis D, Purna J, Deshpande P, Diambomba Y, Lee S, Shah P, Weisz D, El-Khuffash A, McNamara PJ, Mertens L, Jain A, 2018 Aug, Targeted neonatal echocardiography (TNE) consult service in a large tertiary perinatal center in Canada. J Perinatol, DOI: 10.1038/s41372-018-0130-y
Smith A, McNamara PJ, El-Khuffash AF, 2018 Aug, Non-pharmacological management of a hemodynamically significant patent ductus arteriosus. Semin Fetal Neonatal Med, DOI: 10.1016/j.siny.2018.03.008
Monteith C, Malone FD, El-Khuffash A, Kent E, 2018 Apr, Reply to letter to the editor entitled "Non-Invasive cardiac output monitoring (NICOM®) can predict the evolution of uteroplacental disease-results of the prospective HANDLE study". Eur J Obstet Gynecol Reprod Biol, DOI: 10.1016/j.ejogrb.2017.12.040
Martin T, Smith A, Breatnach CR, Kent E, Shanahan I, Boyle M, Levy PT, Franklin O, El-Khuffash A, 2018 Feb, Infants Born with Down Syndrome: Burden of Disease in the Early Neonatal Period. J Pediatr, DOI: 10.1016/j.jpeds.2017.09.046
Dempsey EM, El-Khuffash AF, 2018 Jan, Objective cardiovascular assessment in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/archdischild-2017-313837
Reynolds A, Slattery S, Byrne S, Neary E, Müllers S, Kent E, Malone FD, El-Khuffash A, McGarvey C, Hayes BC, 2017 Nov 13, Timing of administration of antenatal magnesium sulfate and umbilical cord blood magnesium levels in preterm babies. J Matern Fetal Neonatal Med, DOI: 10.1080/14767058.2017.1398724
Breatnach CR, Monteith C, McSweeney L, Tully EC, Malone FD, Kent E, Doherty A, Franklin O, El-Khuffash A, 2018, The Impact of Maternal Gestational Hypertension and the Use of Anti-Hypertensives on Neonatal Myocardial Performance. Neonatology, DOI: 10.1159/000480396
Smith A, Breatnach CR, James AT, Franklin O, El-Khuffash A, 2018 Apr, Incidental Findings on Routine Targeted Neonatal Echocardiography Performed in Preterm Neonates Younger Than 29 Weeks' Gestation. J Ultrasound Med, DOI: 10.1002/jum.14422
El-Khuffash AF, 2017 Nov, Early career investigator highlight-November. Pediatr Res, DOI: 10.1038/pr.2017.189
Breatnach CR, Levy PT, Franklin O, El-Khuffash A, 2017 Oct, Strain Rate and Its Positive Force-Frequency Relationship: Further Evidence from a Premature Infant Cohort. J Am Soc Echocardiogr, DOI: 10.1016/j.echo.2017.07.008
Fink D, El-Khuffash A, McNamara PJ, Nitzan I, Hammerman C, 2018 Jan, Tale of Two Patent Ductus Arteriosus Severity Scores: Similarities and Differences. Am J Perinatol, DOI: 10.1055/s-0037-1605576
Monteith C, McSweeney L, Breatnach CR, Doherty A, Shirren L, Tully EC, Dicker P, Malone FD, El-Khuffash A, Kent E, 2017 Sep, Non-invasive cardiac output monitoring (NICOM®) can predict the evolution of uteroplacental disease-Results of the prospective HANDLE study. Eur J Obstet Gynecol Reprod Biol, DOI: 10.1016/j.ejogrb.2017.07.018
Forman E, Breatnach CR, Ryan S, Semberova J, Miletin J, Foran A, El-Khuffash A, 2017 Nov, Noninvasive continuous cardiac output and cerebral perfusion monitoring in term infants with neonatal encephalopathy: assessment of feasibility and reliability. Pediatr Res, DOI: 10.1038/pr.2017.154
El-Khuffash A, McNamara PJ, 2017 Jun, Hemodynamic Assessment and Monitoring of Premature Infants. Clin Perinatol, DOI: 10.1016/j.clp.2017.02.001
Levy PT, El-Khuffash A, Patel MD, Breatnach CR, James AT, Sanchez AA, Abuchabe C, Rogal SR, Holland MR, McNamara PJ, Jain A, Franklin O, Mertens L, Hamvas A, Singh GK, 2017 Jul, Maturational Patterns of Systolic Ventricular Deformation Mechanics by Two-Dimensional Speckle-Tracking Echocardiography in Preterm Infants over the First Year of Age. J Am Soc Echocardiogr, DOI: 10.1016/j.echo.2017.03.003
Doherty A, El-Khuffash A, Monteith C, McSweeney L, Breatnach C, Kent E, Tully E, Malone F, Thornton P, 2017 Apr 1, Comparison of bioreactance and echocardiographic non-invasive cardiac output monitoring and myocardial function assessment in primagravida women. Br J Anaesth, DOI: 10.1093/bja/aex045
Breatnach CR, El-Khuffash A, James A, McCallion N, Franklin O, 2017 May, Serial measures of cardiac performance using tissue Doppler imaging velocity in preterm infants <29weeks gestations. Early Hum Dev, DOI: 10.1016/j.earlhumdev.2017.03.012
Nielsen M, Sheikh N, Fitzgerald E, Meehan M, LeBlanc D, Eogan M, El-Khuffash A, Drew RJ, 2017 Jun, Screening for early-onset invasive group B Streptococcal disease in neonates in an Irish hospital (2001-2014): a retrospective audit. Infect Dis (Lond), DOI: 10.1080/23744235.2017.1285045
Breatnach CR, Franklin O, James AT, McCallion N, El-Khuffash A, 2017 Sep, The impact of a hyperdynamic left ventricle on right ventricular function measurements in preterm infants with a patent ductus arteriosus. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/archdischild-2016-311189
Weisz DE, McNamara PJ, El-Khuffash A, 2017 Feb, Cardiac biomarkers and haemodynamically significant patent ductus arteriosus in preterm infants. Early Hum Dev, DOI: 10.1016/j.earlhumdev.2016.12.007
Levy PT, El-Khuffash A, 2017 Mar, Pulmonary arterial hypertension after ibuprofen treatment in the first week of life? J Pediatr, DOI: 10.1016/j.jpeds.2016.11.047
Breatnach CR, Forman E, Foran A, Monteith C, McSweeney L, Malone F, McCallion N, Franklin O, El-Khuffash A, 2017 Feb, Left ventricular rotational mechanics in infants with hypoxic ischemic encephalopathy and preterm infants at 36 weeks postmenstrual age: A comparison with healthy term controls. Echocardiography, DOI: 10.1111/echo.13421
Jain A, El-Khuffash AF, Kuipers BCW, Mohamed A, Connelly KA, McNamara PJ, Jankov RP, Mertens L, 2017 Mar, Left Ventricular Function in Healthy Term Neonates During the Transitional Period. J Pediatr, DOI: 10.1016/j.jpeds.2016.11.003
Breatnach CR, Levy PT, James AT, Franklin O, El-Khuffash A, 2016, Novel Echocardiography Methods in the Functional Assessment of the Newborn Heart. Neonatology, DOI: 10.1159/000445779
Breatnach CR, Franklin O, McCallion N, El-Khuffash A, 2017 Jan, The Effect of a Significant Patent Ductus Arteriosus on Doppler Flow Patterns of Preductal Vessels: An Assessment of the Brachiocephalic Artery. J Pediatr, DOI: 10.1016/j.jpeds.2016.09.029
de Boode WP, Singh Y, Gupta S, Austin T, Bohlin K, Dempsey E, Groves A, Eriksen BH, van Laere D, Molnar Z, Nestaas E, Rogerson S, Schubert U, Tissot C, van der Lee R, van Overmeire B, El-Khuffash A, 2016 Oct, Recommendations for neonatologist performed echocardiography in Europe: Consensus Statement endorsed by European Society for Paediatric Research (ESPR) and European Society for Neonatology (ESN). Pediatr Res, DOI: 10.1038/pr.2016.126
Ting JY, Resende M, More K, Nicholls D, Weisz DE, El-Khuffash A, Jain A, McNamara PJ, 2016 Aug, Predictors of respiratory instability in neonates undergoing patient ductus arteriosus ligation after the introduction of targeted milrinone treatment. J Thorac Cardiovasc Surg, DOI: 10.1016/j.jtcvs.2016.03.085
El-Khuffash A, Weisz DE, McNamara PJ, 2016 Sep, Reflections of the changes in patent ductus arteriosus management during the last 10 years. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/archdischild-2014-306214
Weisz DE, Martins FF, Nield LE, El-Khuffash A, Jain A, McNamara PJ, 2016 Aug, Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent hemodynamically significant patent ductus arteriosus. J Perinatol, DOI: 10.1038/jp.2016.60
Breatnach CR, Flanagan F, James A, Corcoran JD, Franklin O, El-Khuffash A, 2015 Oct, The Use of Inhaled Nitric Oxide in a Tertiary Neonatal Intensive Care Unit. Ir Med J, DOI: 10.1038/jp.2016.60
James AT, Corcoran JD, Franklin O, El-Khuffash AF, 2016 Jan, Clinical utility of right ventricular fractional area change in preterm infants. Early Hum Dev, DOI: 10.1016/j.earlhumdev.2015.10.015
James AT, Corcoran JD, Breatnach CR, Franklin O, Mertens L, El-Khuffash A, 2016, Longitudinal Assessment of Left and Right Myocardial Function in Preterm Infants Using Strain and Strain Rate Imaging. Neonatology, DOI: 10.1159/000440940
El-Khuffash A, James AT, Corcoran JD, Dicker P, Franklin O, Elsayed YN, Ting JY, Sehgal A, Malikiwi A, Harabor A, Soraisham AS, McNamara PJ, 2015 Dec, A Patent Ductus Arteriosus Severity Score Predicts Chronic Lung Disease or Death before Discharge. J Pediatr, DOI: 10.1016/j.jpeds.2015.09.028
James AT, Corcoran JD, Hayes B, Franklin O, El-Khuffash A, 2015 Nov, The effect of antenatal magnesium sulfate on left ventricular afterload and myocardial function measured using deformation and rotational mechanics imaging. J Perinatol, DOI: 10.1038/jp.2015.104
James A, Corcoran JD, Mertens L, Franklin O, El-Khuffash A, 2015 Jul, Left Ventricular Rotational Mechanics in Preterm Infants Less Than 29 Weeks' Gestation over the First Week after Birth. J Am Soc Echocardiogr, DOI: 10.1016/j.echo.2015.02.015
EL-Khuffash A, James AT, Cleary A, Semberova J, Franklin O, Miletin J, 2015 May, Late medical therapy of patent ductus arteriosus using intravenous paracetamol. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/archdischild-2014-307930
James AT, Corcoran JD, McNamara PJ, Franklin O, El-Khuffash AF, 2016 Jan, The effect of milrinone on right and left ventricular function when used as a rescue therapy for term infants with pulmonary hypertension. Cardiol Young, DOI: 10.1017/S1047951114002698
James AT, Corcoran JD, Jain A, McNamara PJ, Mertens L, Franklin O, El-Khuffash AF, 2014 Dec, Assessment of myocardial performance in preterm infants less than 29 weeks gestation during the transitional period. Early Hum Dev, DOI: 10.1016/j.earlhumdev.2014.09.004
James AT, Bee C, Corcoran JD, McNamara PJ, Franklin O, El-Khuffash AF, 2015 Apr, Treatment of premature infants with pulmonary hypertension and right ventricular dysfunction with milrinone: a case series. J Perinatol, DOI: 10.1038/jp.2014.208
Butler GC, Al-Assaf N, Tarrant A, Ryan S, El-Khuffash A, 2014 Sep, Using lateral radiographs to determine umbilical venous catheter tip position in neonates. Ir Med J, DOI: 10.1038/jp.2014.208
Weisz DE, Jain A, Ting J, McNamara PJ, El-Khuffash A, 2014, Non-invasive cardiac output monitoring in preterm infants undergoing patent ductus arteriosus ligation: a comparison with echocardiography. Neonatology, DOI: 10.1159/000365278
Jain A, Mohamed A, El-Khuffash A, Connelly KA, Dallaire F, Jankov RP, McNamara PJ, Mertens L, 2014 Dec, A comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and z scores. J Am Soc Echocardiogr, DOI: 10.1016/j.echo.2014.08.018
Finan E, Sehgal A, Khuffash AE, McNamara PJ, 2014 Oct, Targeted neonatal echocardiography services: need for standardized training and quality assurance. J Ultrasound Med, DOI: 10.7863/ultra.33.10.1833
Doherty A, Carvalho JC, Drewlo S, El-Khuffash A, Downey K, Dodds M, Kingdom J, 2014 Aug, Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia. J Obstet Gynaecol Can, DOI: 10.1016/S1701-2163(15)30511-9
El-Khuffash A, Jain A, Corcoran D, Shah PS, Hooper CW, Brown N, Poole SD, Shelton EL, Milne GL, Reese J, McNamara PJ, 2014 Sep, Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr Res, DOI: 10.1038/pr.2014.82
El-Khuffash AF, Jain A, Weisz D, Mertens L, McNamara PJ, 2014 Jul, Assessment and treatment of post patent ductus arteriosus ligation syndrome. J Pediatr, DOI: 10.1016/j.jpeds.2014.03.048
Saleemi MS, El-Khuffash A, Franklin O, Corcoran JD, 2014 Jul, Serial changes in myocardial function in preterm infants over a four week period: the effect of gestational age at birth. Early Hum Dev, DOI: 10.1016/j.earlhumdev.2014.04.012
Leslie AT, Jain A, El-Khuffash A, Keyzers M, Rogerson S, McNamara PJ, 2013 Nov, Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants. J Perinatol, DOI: 10.1038/jp.2013.85
EL-Khuffash A, McNamara PJ, Lapointe A, Jain A, 2013, Adrenal function in preterm infants undergoing patent ductus arteriosus ligation. Neonatology, DOI: 10.1159/000350017
El-Khuffash A, Herbozo C, Jain A, Lapointe A, McNamara PJ, 2013 Sep, Targeted neonatal echocardiography (TnECHO) service in a Canadian neonatal intensive care unit: a 4-year experience. J Perinatol, DOI: 10.1038/jp.2013.42
Saleemi MS, Bruton K, El-Khuffash A, Kirkham C, Franklin O, Corcoran JD, 2013 Sep, Myocardial assessment using tissue doppler imaging in preterm very low-birth weight infants before and after red blood cell transfusion. J Perinatol, DOI: 10.1038/jp.2013.39
El-Khuffash AF, Jain A, McNamara PJ, 2013 Jun, Ligation of the patent ductus arteriosus in preterm infants: understanding the physiology. J Pediatr, DOI: 10.1016/j.jpeds.2012.12.094
El-Khuffash AF, Jain A, Dragulescu A, McNamara PJ, Mertens L, 2012 Oct, Acute changes in myocardial systolic function in preterm infants undergoing patent ductus arteriosus ligation: a tissue Doppler and myocardial deformation study. J Am Soc Echocardiogr, DOI: 10.1016/j.echo.2012.07.016
Chierichetti M, Engelberts D, El-Khuffash A, Babyn P, Post M, Kavanagh BP, 2012 Jun, Continuous negative abdominal distension augments recruitment of atelectatic lung. Crit Care Med, DOI: 10.1097/CCM.0b013e318246bd6a
El-Khuffash AF, Mertens L, 2012 May, Early treatment of the patent ductus arteriosus: do we know what we are doing?. Pediatr Crit Care Med, DOI: 10.1097/PCC.0b013e31822f0fa1
Weisz DE, Jain A, McNamara PJ, EL-Khuffash A, 2012, Non-invasive cardiac output monitoring in neonates using bioreactance: a comparison with echocardiography. Neonatology, DOI: 10.1159/000337295
El-Khuffash A, Unger S, 2012 May, The concept of milk kinship in Islam: issues raised when offering preterm infants of Muslim families donor human milk. J Hum Lact, DOI: 10.1177/0890334411434803
Jain A, McNamara PJ, Ng E, El-Khuffash A, 2012 Feb, The use of targeted neonatal echocardiography to confirm placement of peripherally inserted central catheters in neonates. Am J Perinatol, DOI: 10.1055/s-0031-1295649
Jain A, Sahni M, El-Khuffash A, Khadawardi E, Sehgal A, McNamara PJ, 2012 Apr, Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. J Pediatr, DOI: 10.1016/j.jpeds.2011.09.027
El-Khuffash A, Kieran E, Palmer K, Molloy E, 2011 Mar, Neonatal respiratory extracorporeal membrane oxygenation (ECMO) referrals. Ir Med J, DOI: 10.1016/j.jpeds.2011.09.027
El-Khuffash AF, McNamara PJ, 2011 Jun, The patent ductus arteriosus ligation decision. J Pediatr, DOI: 10.1016/j.jpeds.2010.12.047
El-Khuffash AF, Slevin M, McNamara PJ, Molloy EJ, 2011 Mar, Troponin T, N-terminal pro natriuretic peptide and a patent ductus arteriosus scoring system predict death before discharge or neurodevelopmental outcome at 2 years in preterm infants. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2010.185967
El-Khuffash AF, McNamara PJ, 2011 Feb, Neonatologist-performed functional echocardiography in the neonatal intensive care unit. Semin Fetal Neonatal Med, DOI: 10.1016/j.siny.2010.05.001
El-Khuffash A, Molloy E, 2009, The Use of N-Terminal-Pro-BNP in Preterm Infants. Int J Pediatr, DOI: 10.1155/2009/175216
El-Khuffash A, Molloy EJ, 2009, Incidental finding of endocarditis in a preterm neonate. BMJ Case Rep, DOI: 10.1136/bcr.2006.106625
Molloy EJ, El-Khuffash A, Bieda A, Jelinek MM, Baley J, 2009 Jan, Elevated iron indices in preterm infants: association with male gender. Am J Perinatol, DOI: 10.1055/s-0028-1090588
El-Khuffash AF, Molloy EJ, 2008 Sep, Influence of a patent ductus arteriosus on cardiac troponin T levels in preterm infants. J Pediatr, DOI: 10.1016/j.jpeds.2008.04.014
Walsh SA, Yao N, El-Khuffash A, Twomey A, Molloy EJ, 2008 Feb, Efficacy of intravenous immunoglobulin in the management of haemolytic disease of the newborn. Ir Med J, DOI: 10.1016/j.jpeds.2008.04.014
O'Rourke DJ, El-Khuffash A, Moody C, Walsh K, Molloy EJ, 2008 May, Patent ductus arteriosus evaluation by serial echocardiography in preterm infants. Acta Paediatr, DOI: 10.1111/j.1651-2227.2008.00745.x
El-Khuffash A, Davis PG, Walsh K, Molloy EJ, 2008 Jul, Cardiac troponin T and N-terminal-pro-B type natriuretic peptide reflect myocardial function in preterm infants. J Perinatol, DOI: 10.1038/jp.2008.21
El-Khuffash A, Barry D, Walsh K, Davis PG, Molloy EJ, 2008 Nov, Biochemical markers may identify preterm infants with a patent ductus arteriosus at high risk of death or severe intraventricular haemorrhage. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2007.133140
Morris I, McCallion N, El-Khuffash A, Molloy EJ, 2008 Jul, Serum albumin and mortality in very low birth weight infants. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2007.131375
El-Khuffash AF, Molloy EJ, 2008, Serum troponin in neonatal intensive care. Neonatology, DOI: 10.1159/000112540
El-Khuffash A, Higgins M, Walsh K, Molloy EJ, 2008, Quantitative assessment of the degree of ductal steal using celiac artery blood flow to left ventricular output ratio in preterm infants. Neonatology, DOI: 10.1159/000110869
El-Khuffash AF, Amoruso M, Culliton M, Molloy EJ, 2007 Sep, N-terminal pro-B-type natriuretic peptide as a marker of ductal haemodynamic significance in preterm infants: a prospective observational study. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2007.119701
El-Khuffash AF, Molloy EJ, Walsh K, 2008, Left atrial appendage mimicking an intra-cardiac vegetation in preterm neonates. Neonatology, DOI: 10.1159/000107353
El-Khuffash A, Molloy EJ, 2007 Jul, Are B-type natriuretic peptide (BNP) and N-terminal-pro-BNP useful in neonates? Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2006.106039
El-Khuffash A, Molloy EJ, 2007 Mar, Incidental finding of endocarditis in a preterm neonate. Arch Dis Child Fetal Neonatal Ed, DOI: 10.1136/adc.2006.106625
Beamish J, O'Connell MJ, El Khuffash A, Duff DF, McMahon CJ, 2006 Nov, Calcified occlusion of the right coronary artery in Kawasaki disease: evidence of myocardial ischaemia using cardiac technetium-99m-tetrofosmin perfusion single-photon emission computed tomography. Arch Dis Child, DOI: 10.1136/adc.2006.099630

Funding Agency:The Rotunda Foundation
Project Title:Epidural Related Maternal Fever: an epoch study assessing Interleukin 6 and serum levobupivacaine levels in labouring women undergoing epidural analgesia.
Total Awarded:€44,889
Role:Co - PI
Funding Agency:National Children’s Research Centre
Project Title:Post-Operative Myocardial Performance and Pulmonary Hypertension in Infants with Down Syndrome: The Role of Inflammation.
Total Awarded:€145,250
Role:PI
Funding Agency:National Children’s Research Centre
Project Title:A Randomised Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score.
Total Awarded:€4,385
Role:PI
Funding Agency:National Children’s Research Centre
Project Title:Assessment of Cardiac Function in Preterm and Term Infants with Twin to Twin Transfusion Syndrome Using Novel Echocardiography Techniques.
Total Awarded:€6,550
Role:PI
Funding Agency:Health Research Board / National Children’s Hospital Foundation
Project Title:Longitudinal Assessment of Cardiac Function in Infants with Downs Syndrome Using Novel Echocardiography Techniques.
Total Awarded:€298,381
Role:PI
Funding Agency:The Rotunda Hospital Foundation
Project Title:Assessment of Cardiac Function in Preterm and Term Infants with Twin to Twin Transfusion Syndrome Using Novel Echocardiography Techniques
Total Awarded:€26,500
Role:Co-PI
Funding Agency:Temple Street Children’s Hospital Foundation
Project Title:A Randomised Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score
Total Awarded:€108,600
Role:PI
Funding Agency:Friends of the Rotunda
Project Title:Assessment of Cardiac Function in Preterm and Term Infants with Twin to Twin Transfusion Syndrome Using Novel Echocardiography Techniques
Total Awarded:€23,534
Role:PI
Funding Agency:Health Research Board
Project Title:The Use of Milrinone in Neonates with Persistent Pulmonary Hypertension of the Newborn: A Randomized Controlled Trial Feasibility Study (MINT 1).
Total Awarded:€176,527
Role:PI
Funding Agency:Friends of the Rotunda
Project Title:The Use of Targeted Neonatal Echocardiography to Predict Short Term Clinical Sequelae Associated with a Patent Ductus Arteriosus.
Total Awarded:€10,000
Role:Co-PI
Funding Agency:MRCG/HRB/Friends of the Rotunda
Project Title:The HANDLE Study: haemodynamic assessment in pregnancy & neonatal echocardiography assessment.
Total Awarded:€188,125
Role:Co-PI
Funding Agency:William S. Fenwick Award and the Edie Steinberg Scholarship Fund - University of Toronto
Project Title:Establishing Reference Ranges of Myocardial Function in Preterm Infants Using Tissue Doppler Imaging and Speckle Tracking Techniques.
Total Awarded:CAD $9,900
Role:PI
Funding Agency:Educational Grant, Ikaria
Project Title:Targeted Neonatal Echocardiography Teaching Application for smart phones and tablet PCs.
Total Awarded:CAD $35,000
Role:PI
Funding Agency:Hospital for Sick Children
Project Title:The use of NICOM in assessing the hemodynamic state of premature infants.
Total Awarded:CAD $3,000
Role:PI
Funding Agency:The Physicians’ Services Incorporated Foundation
Project Title:The use of echocardiographic and biochemical markers to predict low cardiac output following patent ductus arteriosus ligation in preterm infants.
Total Awarded:CAD $15,900
Role:PI
Name:Dr Phil Levy
DepartmentDepartment of Pediatrics
Institution:Washington University School of Medicine, Saint Louis, MO
Country:USA
Name:Prof Patrick McNamara
DepartmentNeonatology
Institution:Hospital for Sick Children
Country:Canada

    International Administrative & Research Activities

    2017 – Present: Associate Editor in Pediatric Research (Neonatology Section) – Under Section Editor Dr Ivan D. Frantz III. Tasked with handling paper submissions to Pediatric Research under the Neonatal Haemodynamics / Cardiology heading.

    2017 – 2018: Guest Editor for Frontiers in Pediatrics for a review article series under the heading: Cardiovascular Instability in the Preterm Infant. Tasked with inviting international contributors, peer review, and editorial input.

    2014 – Present: Regular Abstract reviewer for The European Society of Paediatric Research (ESPR) and the European Academy of Paediatric Societies (EAPS)

    2014 – Present: Regular Abstract reviewer for The Society of Paediatric Research (SPR) and the Paediatric Academic Societies (PAS) meeting.

    2016 – Present: European Inhaled Nitric Oxide Registry Steering Committee.

    2015 – Present: Research Presentation Session Chair. Joint European Neonatal Society / ESPR meeting. Budapest, Hungary, September 2015.

    2015 – Present: Executive Management Team member for the HRB Mother & Baby Clinical Trials Network Ireland which is the longest standing CTN in Ireland, with extensive experience in clinical trials and cohort studies. This CTN has a strong track record in collaborative research and in the conduct of large-scale, international, multicentre, randomised controlled trials (RCTs) of diagnostics and interventions in pregnancy and neonates.

    2015 – Present: Advisory Committee Member of the Hemodynamic Club at the Paediatric Academic Society / SPR annual Meeting.

    2014 – Present: Council Member of the Section of Circulation, Oxygen Transport and Haematology of ESPR.

    2014 – Present: European Working Group for Neonatal Echocardiography Training in Europe. This is an ESPR/ESN endeavour to devise guidelines on echocardiography training in Europe for neonatologists and neonatal trainees.

    2012 – Present: Echocardiography Steering Committee, HIP Trial: Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn. The HIP Trial is an EU FP7 funded project that will be the largest multicentre European study in Extremely Low Gestational Age Newborns (ELGANs). 

    Professional Associations

    2012 – Present: Member & Fellow: Royal College of Physicians of Ireland.

    2013 – Present: Member: Society for Paediatrics Research.

    2013 – Present: Member: European Society for Paediatric Research.

    2014 – Present: Founding Member: Irish Neonatal Society.

    Research Prizes & Travel Awards

    • Senior Investigator: Irish Neonatal Research Symposium Award: First Prize, Dublin November, 2017. Incidental Findings on Routine Targeted Neonatal Echocardiography Performed in Preterm Infants Less than 29 Weeks Gestation. (Prize €200).
    • Senior Investigator: Finalist in the William Stokes Award, RCPI October 2017. Incidental Findings on Routine Targeted Neonatal Echocardiography Performed in Preterm Infants Less than 29 Weeks Gestation.
    • Senior Investigator: Pediatric Research Early Career Investigator Award in November 2017. None Invasive Continuous Cardiac Output and Cerebral Perfusion Monitoring in Term Infants with Neonatal Encephalopathy: Assessment of Feasibility and Reliability.
    • Senior Investigator: PAS Travel Awards Program for Young Investigators: Sponsored by the Pediatric Academic Societies and Mead Johnson Nutrition. Paediatric Academic Societies Meeting (PAS), San Francisco, CA, May 2017. (Prize $650).
    • Senior Investigator: Winner of the 2017 Clinical Research Awards for Fellows, sponsored by Society for Pediatric Research (SPR) Junior Section, Paediatric Academic Societies Meeting (PAS), San Francisco, CA, May 2017: None Invasive Continuous Cardiac Output and Cerebral Perfusion Monitoring in Term Infants with Neonatal Encephalopathy: Assessment of Feasibility and Reliability. (Prize $1,000)
    • Senior Investigator: Rotunda Hospital Charter Day: Third Prize, Dublin November 2016. Left ventricular rotational mechanics in infants with hypoxic ischemic encephalopathy and preterm infants at 36 weeks postmenstrual age: A comparison with healthy term controls. (Prize €300)
    • Senior Investigator: Irish Neonatal Research Symposium Award: First Prize, Dublin October, 2016. Left ventricular rotational mechanics in infants with hypoxic ischemic encephalopathy and preterm infants at 36 weeks postmenstrual age: A comparison with healthy term controls. (Prize €200)
    • Senior Investigator: Irish Paediatric Association Best Researcher Award: Dublin September, 2016. The Impact of a Hyperdynamic Left Ventricle on Right Ventricular Function Measurements in Preterm Infants with a Patent Ductus Arteriosus. (Prize €1,000)
    • Senior Investigator: Irish Paediatric Association Best Researcher Award: Limerick, May 2015. A Patent Ductus Arteriosus Severity Score Incorporating Markers of Haemodynamic Significance and Left Ventricle Diastolic Function Predicts Chronic Lung Disease. (Prize €1,000)
    • Senior Investigator: Runner up prize for best presentation Irish Neonatal Research Symposium: Dublin November 2015. Use of Near Infra-Red Spectroscopy and Non-Invasive Cardiac Output Monitoring to Assess the Haemodynamic Changes in Infants Undergoing Therapeutic Hypothermia. (Prize €100)
    • Senior Investigator: American Society of Echocardiography Education and research Foundation Travel Grant. May 2014: Feasibility and Reliability of Left Ventricular Torsion Measurement in Preterm Infants Less than 29 Weeks Gestation. (Prize $1,000)
    • Senior Investigator: Irish Neonatal Research Symposium First Prize: Dublin, November 2013. Assessment of Myocardial Performance using Novel Echocardiography Markers in Infants less than 28 weeks gestation and the impact of the transitional circulation. (Prize €200)
    • Collaborator: Gertie Marx Research Competition finalist at the Society of Obstetric Anaesthesia and Perinatology, Puerto Rico, April 2013: Longitudinal Maternal Risk Assessment for Severe Early-Onset Preeclampsia.
    • Finalist in the 2013 Irish Healthcare Innovation Awards: Irish Technology or Products Innovation category. Targeted Neonatal Echocardiography Mobile Phone Application.
    • Principal Investigator PAS Travel Awards Program for Young Investigators: Sponsored by the Pediatric Academic Societies, May 2012: Non-invasive Cardiac Output Monitoring in Neonates Using Bioreactance: A Comparison with Echocardiography. (Prize: $500)
    • Principal Investigator: School of Graduate Studies Conference Grant, University of Toronto: Sponsored by the Pediatric Academic Societies, May 2012: Non-invasive Cardiac Output Monitoring in Neonates Using Bioreactance: A Comparison with Echocardiography. (Prize: $500)
    • Principal Investigator: Winner of Best Neonatal Platform Presentation at the 11th Annual Neonatal and Maternal Fetal Medicine Research Day, Toronto, April 2012: Non-invasive Cardiac Output Monitoring in Neonates Using Bioreactance: A Comparison with Echocardiography.
    • Collaborator: Project winner in the fellow’s section of the 23rd Canadian Fellows and Residents research competition, May 2011: Use of Early Targeted Neonatal Echocardiography (TnECHO) to Predict and Prevent Postoperative Cardio-respiratory Instability Following PDA Ligation.
    • Principal Investigator PAS Travel Awards Program for Young Investigators: Sponsored by the Pediatric Academic Societies, May 2010: Troponin T, BNP, and a PDA scoring system predict neurodevelopmental outcome at 2 years or death before discharge in preterm Infants. (Prize: $500)
    • Principal Investigator: Winner of Best Neonatal Platform Presentation at the Ninth Annual Neonatal and Maternal – Fetal Medicine Research Day‏, Toronto, April 2010.
    • Principal Investigator: Best Overall Paper Presentation, Irish Paediatric Association, November 2007.
    • Principal Investigator: Finalist in David Mitchell Award for Research by the Royal College of Physicians in Ireland. March 2007.
    • Principal Investigator: Best Neonatal Paper Presentation, Irish Perinatal Society Meeting, March 2007.
    • Principal Investigator: Best Short Paper Presentation, Irish Paediatric Association Meeting, May 2006.