Industry


Based at the NCRC, the largest paediatric research centre in Ireland, the Children’s Clinical Research Unit (CCRU) plays a key role in supporting clinical trials and studies at Our Lady’s Children’s Hospital Crumlin (OLCHC) and other paediatric centres.

In existence since 2010, the CCRU has built up substantial experience in the design and conduct of paediatric studies – both academic and commercial. We are acutely aware of the unmet need in children’s health and recognise the critical role that commercial clinical trials play in the development of paediatric medicines and diagnostics.

What we can offer to Industry partners:

Paediatric specific expertise

The largest centre for paediatric clinical trials in Ireland, the CCRU has the following in place:

  •  A team of staff with a broad range of expertise in paediatric clinical research and clinical trial management, including Study Coordination, Research Nursing, Quality & Regulatory Affairs management, Research Pharmacy, Sample Processing and Management, and Data Management
  • GCP Training for all staff and in-house paediatric specific GCP trainers.
  • Quality management systems

See the Clinical Trials & Studies section for details of current and past studies that the CCRU has supported.

High quality research facilities

We have access to high quality research facilities including:

  • Sample preparation area for patient proximate sample management
  • State of the art research laboratory for sample processing and biobanking
  • Pharmacy dispensary with temperature monitoring
  • Administration space for trial monitor
  • Lung Clearance Index (LCI) Machin
Local assistance to Study Sponsors

We understand the challenges associated with paediatric studies, as well as the importance of streamlined study set-up for commercial studies, and offer the following local assistance to study sponsors:

  • Advisory and consultation service regarding paediatric research and local regulatory requirements
  • Support with study feasibility and planning
  • Identification of Principal Investigators and Key Opinion
  • Local liaison service for study start-up
  • Guidance with applications for Research Ethics Committee approval
  • Coordination of clinical trial agreement review, paediatric specific study costing, budget negotiations and local hospital approval
  •  Central multi-centre trial management service
Large Paediatric Population

Ireland currently has the highest proportion of young people across the EU Member States (2016) and the highest birth rate.

As the largest paediatric hospital in Ireland, Our Lady’s Children’s Hospital Crumlin (OLCHC) is responsible nationally for the provision of the majority of quaternary and tertiary healthcare services for children. The hospital also provides secondary care for the local catchment area.

The model of health care in Ireland is based around a hub and spoke model where complex paediatric conditions are gathered in centres of expertise. OLCHC is the national referral centre for a range of specialities including

  • Childhood cancers
  • Haemostasis and thrombosis
  • Cardiac diseases
  • Major burns
  • Cystic fibrosis
  • Clinical genetics
  • Rheumatology
  • Gastroenterology, hepatology and nutrition services.

The centralisation of services for Irish children to one centre increases the potential recruitment pool for clinical studies, particularly for complex conditions.

Networks

Sitting at the heart of paediatric research in Ireland, the NCRC supports research into paediatric diseases at a number of locations in Ireland. We work collaboratively as part of an organised network of paediatric centres and are actively connected to many national and international research networks.

Contact us

For enquiries, please contact the Clinical Research Project Manager Mary Costello.