The Dermatology Department in Children’s Health Ireland at Crumlin, has a long established research program over the last 15 years. At all stages the research program is supported by the NCRC Children’s Clinical Research Unit (CCRU). Our work centres on the most common inflammatory skin condition in children, namely atopic dermatitis (eczema), on rare genetic skin disorders and, more recently on therapeutic development. Our basic science and discovery research includes genetic research on atopic dermatitis – the NCRC collection comprises DNA from 4,000 children and is the largest in the world. This collection was used for the discovery of the role of filaggrin in atopic dermatitis (eczema). The department has also studied skin barrier function in great detail in eczema using a variety of non-invasive techniques including Raman spectroscopy and tape stripping. We run a number of both investigator-led and industry centred drug trials for children with eczema and for genetic skin disorders such as epidermolysis bullosa.
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| TREAT | A randomised clinical trial to assess the treatment safety and efficacy of oral methotrexate (MTX) vs ciclosporin (CyA) in the treatment of severe recalcitrant atopic eczema (AE) in children | Clinical Trial | King’s College London and Guy’s and St. Thomas’ NHS Foundation Trust | Academic - Investigator Led |
| EASE | Double-blind, Randomised, Vehicle-controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis Bullosa | Clinical Trial | Amryt | Industry Sponsored |
| BADBIR | British Association of Dermatologists Biologic Interventions Register | Non-Interventional Study | University of Manchester | Academic - Collaborative Group |
| AD Real World | A Real World Evaluation to Describe Resource Use for the Management of Moderate to Severe Atopic Dermatitis in Secondary Care for Children and Adolescents Aged 6 to 17 in the Republic of Ireland | Non-Interventional Study | Sanofi | Industry Sponsored |
| VAD | Understanding T-Cell Immunity in Atopic Dermatitis Patients: Relevance to Staphylococcal Aureus Vaccine Design | Non-Interventional Study | ||
| MEASURE AD | Global Cross-Sectional Burden-of- Illness Study in Adolescent and Adult Patients with Atopic Dermatitis. | Non-Interventional Study | AbbVie | Industry Sponsored |
| EPIK-P1 | Retrospective Chart Review Study of Patients with PIK3CA- Related Overgrowth Spectrum (PROS) who have received alpelisib as part of a compassionate use program. | Non-Interventional Study | Novartis | Industry Sponsored |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| Eczema & Food Allergy | Identification of Major Susceptibility Genes for Eczema and Food Allergy | Non-Interventional Clinical Trial | ||
| Whole Exome Sequencing | Whole exome screening and next generation sequencing | Non-Interventional Study | University of Dundee | Academic-Investigator Led |
| Regional Filaggrin | A Study to Investigate Regional Filaggrin Expression | Non-Interventional Study | ||
| DS107E-05 | A prospective, randomised, vehicle-controlled, double-blind, exploratory clinical trial to assess the efficacy and steroid sparing potential of DGLA cream topically applied to early childhood patients with moderate to severe atopic dermatitis | Clinical Trial | Afimmune | Industry Sponsored |
| Overgrowth genetics projects | Clinical and molecular characterization of PIK3Kinase related Overgrowth Syndromes | Non-Interventional Study | Cambridge University | Academic-Investigator Led |
| Vascular malformation projects | Clinical and molecular characterization of hyperkeratotic vascular malformations | Non-Interventional Study | Université Catholique de Louvain | Academic-Investigator Led |
| Inflazome CAPS | MCC950 and derivatives in CAPS patients | Non-Interventional Study | Inflazome Ltd / Trinity College Dublin | Academic - Investigator Led |
| PRiTI | Clinical, immunologic and microbiologic characterisation of early onset atopic eczema: A study to identify factors in disease initiation, severity, flare and resolution. | Non-Interventional Study | ||
| APPLES | A prospective paediatric study to assess the long-term safety of tacrolimus ointment for the treatment of atopic dermatitis. | Non-Interventional Clinical Trial | Astellas Pharma | Industry Sponsored |
| ARQ-092 | A Phase 1/2 Study of ARQ 092 in Patients With Overgrowth Diseases and Vascular Anomalies With Genetic Alterations of the PI3K/AKT Pathway | Clinical Trial | Arqule | Industry Sponsored |
