Dermatology Trials

The Dermatology Department in Our Lady’s Children’s Hospital, Crumlin, has a long established research program over the last 15 years. At all stages the research program is supported by the NCRC Children’s Clinical Research Unit (CCRU). Our work centres on the most common inflammatory skin condition in children, namely atopic dermatitis (eczema), on rare genetic skin disorders and, more recently on therapeutic development. Our basic science and discovery research includes genetic research on atopic dermatitis – the NCRC collection comprises DNA from 4,000 children and is the largest in the world. This collection was used for the discovery of the role of filaggrin in atopic dermatitis (eczema). The department has also studied skin barrier function in great detail in eczema using a variety of non-invasive techniques including Raman spectroscopy and tape stripping. We run a number of both investigator-led and industry centred drug trials for children with eczema and for genetic skin disorders such as epidermolysis bullosa.

Current Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
PRiTIClinical, immunologic and microbiologic characterisation of early onset atopic eczema: A study to identify factors in disease initiation, severity, flare and resolution.Non-Interventional StudyNCRCAcademic - Investigator Led
TREATA randomised clinical trial to assess the treatment safety and efficacy of oral methotrexate (MTX) vs ciclosporin (CyA) in the treatment of severe recalcitrant atopic eczema (AE) in childrenClinical TrialKing’s College London and Guy’s and St. Thomas’ NHS Foundation TrustAcademic - Investigator Led
APPLESA prospective paediatric study to assess the long-term safety of tacrolimus ointment for the treatment of atopic dermatitis.Non-Interventional Clinical TrialAstellas PharmaIndustry Sponsored
EASEDouble-blind, Randomised, Vehicle-controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis BullosaClinical TrialAmrytIndustry Sponsored
BADBIRBritish Association of Dermatologists Biologic Interventions RegisterNon-Interventional StudyUniversity of ManchesterAcademic - Collaborative Group

Past Trials & Studies

Study NameStudy TitleStudy TypeSponsorSponsor Type
Eczema & Food AllergyIdentification of Major Susceptibility Genes for Eczema and Food AllergyNon-Interventional Clinical TrialNCRC, Wellcome TrustAcademic - Investigator Led
Whole Exome SequencingWhole exome screening and next generation sequencingNon-Interventional StudyNCRC and University of DundeeAcademic - Investigator Led
Regional FilaggrinA Study to Investigate Regional Filaggrin ExpressionNon-Interventional StudyNCRCAcademic - Investigator Led
DS107E-05A prospective, randomised, vehicle-controlled, double-blind, exploratory clinical trial to assess the efficacy and steroid sparing potential of DGLA cream topically applied to early childhood patients with moderate to severe atopic dermatitisClinical TrialAfimmuneIndustry Sponsored
Overgrowth genetics projectsClinical and molecular characterization of PIK3Kinase related Overgrowth SyndromesNon-Interventional StudyNCRC and Cambridge UniversityAcademic - Investigator Led
Vascular malformation projectsClinical and molecular characterization of hyperkeratotic vascular malformationsNon-Interventional StudyNCRC and Université catholique de LouvainAcademic - Investigator Led
Inflazome CAPSMCC950 and derivatives in CAPS patientsNon-Interventional StudyInflazome Ltd / Trinity College DublinAcademic - Investigator Led