Applications are invited for a Senior Post-Doctoral Fellow position within the Irish Centre for Vascular Biology Research Laboratory led by Prof. James O’Donnell and located in RCSl in Dublin. The research group is an international group, with a strong publication record. Our research focus is in molecular haemostasis and in defining the cross talk between coagulation and inflammation in vivo.
Severe Plasmodium falciparum malaria is responsible for more than 1 million deaths per annum. The majority of these deaths occur in children under the age of 5 years in sub-Saharan Africa. Although effective anti-malarial drugs have been developed, cerebral malaria (CM) is still associated with a case fatality rate of 20%. In addition, up to 25% of children who survive CM suffer significant neurological sequelae including learning difficulties and memory impairment. Consequently, effective new treatment strategies are urgently needed for the management of children presenting with severe malaria.In spite of the significant mortality and morbidity associated with CM, the molecular mechanisms involved in the pathophysiology of severe malaria remain poorly understood. Previous studies have demonstrated that sequestration of P. falciparum-infected erythrocytes (IE) within the microvasculature of the brain plays a key role in the development of CM. A number of specific receptors expressed on EC surfaces are important in regulating IE sequestration. In recent studies, we have identified a role for a coagulation protein called von Willebrand factor (VWF) in regulating IE sequestration and thus malaria pathogenesis (Larkin D et al, PLoS Pathogens 2009; 5(3) e1000349 and Bridges D et al, Blood, 2010; 115(7):1472-1474). In addition, we have shown that VWF-deficient mice are significantly protected against experimental CM (O’Regan et al, Blood 2016; 127(9):1192-1201). Taken together therefore, these parallel studies have defined a novel unexpected role for VWF in modulating malaria pathogenesis, and further suggested that VWF may be a useful therapeutic target to improve prognosis in children with severe malaria.
The current project will build upon these exciting previous data to define the biological mechansisms through which VWF influences the pathogenesis underlying cerebral malaria. In addition, the study will also investigate the efficacy of VWF- targeted therapies in improving the outcomes of cerebral malaria infection. The successful applicant will join an established group of three post-doctoral fellows and three PhD students already working in this area, and will use a wide range of molecular and cell biology techniques during the course of this project. The position is funded for 2 years.
The applicant should have a strong research record including publications (relative to career stage), and be highly motivated and dynamic. Good communication and interpersonal skills are required, as well as an ability to work with a multidisciplinary team. We are looking for someone to start the position as soon as possible.
Please email Professor James O’Donnell (firstname.lastname@example.org) with informal inquiries. Please apply online at www.rcsi.ie/careers with covering Letter and CV containing contact details for 2 references no later than 5pm on Thursday 25 July 2019
|Title:||Senior Post-Doctoral Fellow|
|Location:||The Royal College of Surgeons in Ireland (RCSI)|
|Salary:||Post Doctorate Research Fellow (up to €48,205 p.a. depending on experience).|
|Contract:||Specified purpose contract for up to 2 years|
|Reporting to:||Professor James O'Donnell|
The successful applicant will join an established group of three post-doctoral fellows and three PhD students already working in this area, and will use a wide range of molecular and cell biology techniques during the course of this project.
Applicants should have a PhD in Molecular Biology/Biochemistry/Genetics or related biological subject. Experience in the area of haemostasis, immunology, vascular biology, or malaria would be advantageous, but not essential. Applicants with experience of current molecular biology techniques, protein biochemistry and mouse models of disease are particularly encouraged to apply. The ideal candidate would be self-motivated, creative and highly competent, as evidenced by first author publications in recognised journals.Apply now