Post-Doctoral Researcher/Research Assistant – Irish Centre for Vascular Biology Research Laboratory


Applications are invited for a Post-Doctoral Fellow / Research Assistant positions on The Sickle Vascular Ireland Consortium Project within the Irish Centre for Vascular Biology Research Laboratory led by Prof. James O’Donnell and located in RCSl in Dublin. The research group is an international group, with a strong publication record. Our research focus is in molecular haemostasis and in defining the cross talk between coagulation and inflammation in vivo.

Sickle cell disease (SCD) is an inherited disorder of haemoglobin synthesis that is characterised by a chronic haemolytic anaemia, recurrent episodes of vascular occlusion, and ischaemia-reperfusion injury resulting in organ damage and death.

Globally, more than 1000 children with SCD are born every day. In resource poor countries, half of these children die before reaching five years of age. Even in developed countries, SCD continues to be associated with significant paediatric morbidity with 10% of SCD children in the US developing symptomatic strokes resulting in learning problems and lifelong disabilities. On the basis of this, both the World Health Organization (WHO) and the United Nations (UN) have designated SCD as a global health priority.

Within the Irish Centre for Vascular Biology, we have established Sickle Vascular Ireland Consortium (SiVIC) which unites both the researchers, clinical resources and deep phenotypic data of SCD patients from Crumlin Children’s Hospital in order to investigate the biology involved in SCD vascular occlusion. The aim of this first SiVIC study is to investigate the hypothesis that dysfunction of specific coagulation proteins including von Willebrand Factor and its protease ADAMTS13 in children with SCD may contribute significantly to the microvascular occlusion observed in these patients.

The current project will build upon the group’s significant expertise in investigating crosstalk between coagulation and inflammatory pathways in vascular disease, including malaria ((O’Regan et al, Blood 2016; 127(9):1192-1201). The successful applicant will join an established group of post-doctoral fellows and PhD students working in a productive, collaborative lab.

Application Process:

Please apply online no later than 5pm on 31 January 2020 with your CV and Covering Letter.

Informal Enquiries can be directed to Prof James O’Donnell at

Job Description:

Title:Post-Doctoral Researcher / Research Assistant
Location:The Royal College of Surgeons in Ireland (RCSI)
Salary:Post Doctorate Research Fellow (up to €48,205 p.a. depending on experience).
Contract:Specified purpose contract for up to 3 years
Reporting to:Professor James O'Donnell

Key Duties and Responsibilities may include:

  • Conduct a specified programme of research under the supervision and direction of the Principal Investigator
  • Disseminate the results of the research in which you are engaged in, as directed by the Principal Investigator
  • Carry out administrative work associated with your programme of research
  • Undertake appropriate training and development as required by the Principal Investigator, School and/or College



  • PhD in Molecular Biology/Cell Biology / Immunology / Biochemistry/Genetics or related biological subject
  • Experience in the area of haemostasis, immunology, or vascular biology would be advantageous, but not essential.
  • Strong research record including publications (relative to career stage)
  • Be highly motivated and dynamic
  • Excellent communication and interpersonal skills
  • An ability to work with a multidisciplinary team
  • Be self-motivated, creative and highly competent.
  • Proven ability to communicate complex ideas
  • Ability to ensure that project plans are communicated and that all timelines are met
  • Ability to operate effectively as part of a team – is cordial, tolerant and willing to help others, is co-operative and patient; shares work and information; establishes rapport, can influence and develop effective networks
  • Knowledge of MS Office suite
  • Have a pro-active approach to work, anticipating and resolving problems in advance; have keen attention to detail - from anticipating and addressing issues in advance to understanding requests and delivering quality work with minimal errors
  • Can operate flexibly within a busy environment; can shift focus when required
  • Have strong customer service skills. Be able to communicate with a high level of initiative, tact, diplomacy and confidentiality
  • Display a ‘can-do’ attitude, be committed to RCSI ORI and its development; demonstrate enthusiasm and passion for the role

Apply now