Applications are invited for a Post-Doctoral Fellow / Research Assistant positions on The Sickle Vascular Ireland Consortium Project within the Irish Centre for Vascular Biology Research Laboratory led by Prof. James O’Donnell and located in RCSl in Dublin. The research group is an international group, with a strong publication record. Our research focus is in molecular haemostasis and in defining the cross talk between coagulation and inflammation in vivo.
Sickle cell disease (SCD) is an inherited disorder of haemoglobin synthesis that is characterised by a chronic haemolytic anaemia, recurrent episodes of vascular occlusion, and ischaemia-reperfusion injury resulting in organ damage and death.
Globally, more than 1000 children with SCD are born every day. In resource poor countries, half of these children die before reaching five years of age. Even in developed countries, SCD continues to be associated with significant paediatric morbidity with 10% of SCD children in the US developing symptomatic strokes resulting in learning problems and lifelong disabilities. On the basis of this, both the World Health Organization (WHO) and the United Nations (UN) have designated SCD as a global health priority.
Within the Irish Centre for Vascular Biology, we have established Sickle Vascular Ireland Consortium (SiVIC) which unites both the researchers, clinical resources and deep phenotypic data of SCD patients from Crumlin Children’s Hospital in order to investigate the biology involved in SCD vascular occlusion. The aim of this first SiVIC study is to investigate the hypothesis that dysfunction of specific coagulation proteins including von Willebrand Factor and its protease ADAMTS13 in children with SCD may contribute significantly to the microvascular occlusion observed in these patients.
The current project will build upon the group’s significant expertise in investigating crosstalk between coagulation and inflammatory pathways in vascular disease, including malaria ((O’Regan et al, Blood 2016; 127(9):1192-1201). The successful applicant will join an established group of post-doctoral fellows and PhD students working in a productive, collaborative lab.
Please apply online no later than 5pm on 31 January 2020 with your CV and Covering Letter.
Informal Enquiries can be directed to Prof James O’Donnell at firstname.lastname@example.org
|Title:||Post-Doctoral Researcher / Research Assistant|
|Location:||The Royal College of Surgeons in Ireland (RCSI)|
|Salary:||Post Doctorate Research Fellow (up to €48,205 p.a. depending on experience).|
|Contract:||Specified purpose contract for up to 3 years|
|Reporting to:||Professor James O'Donnell|